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| 1 | Avian influenza A(H7N9)virus:from low pathogenic to highly pathogenic显示文摘OriginalTranslation The avian influenza A(H7N9)virus is a zoonotic virus that is closely associated with live poultry markets.It has caused infections in humans in China since 2013.Five waves of the H7N9 influenza epidemic occurred in China between March 2013 and September 2017.H7N9 with low-pathogenicity dominated in the first four waves,whereas highly pathogenic H7N9 influenza emerged in poultry and spread to humans during the fifth wave,causing wide concern.Specialists and officials from China and other countries responded quickly,controlled the epidemic well thus far,and characterized the virus by using new technologies and surveillance tools that were made possible by their preparedness efforts.Here,we review the characteristics of the H7N9 viruses that were identified while controlling the spread of the disease.It was summarized and discussed from the perspectives of molecular epidemiology,clinical features,virulence and pathogenesis,receptor binding,T-cell responses,monoclonal antibody development,vaccine development,and disease burden.These data provide tools for minimizing the future threat of H7N9 and other emerging and re-emerging viruses,such as SARS-CoV-2. | William J.Liu Haixia Xiao Lianpan Dai Di Liu Jianjun Chen Xiaopeng Qi Yuhai Bi Yi Shi George F.Gao Yingxia Liu | 2021 | Frontiers of Medicine2021，15，4： | 4 |
| 2 | Genomic characterizations of H4 subtype avian influenza viruses from live poultry markets in Sichuan province of China, 2014–2015显示文摘Dear Editor,Avian influenza viruses (AIVs) have posed a serious threat to poultry production and public health. To date, more than fourteen AIV subtypes that are able to infect human beings have been documented. Also, it is suggested that new subtypes may be reported in the future, owing to the migration of wild birds and live poultry transportation (Gao, 2018).Poultry may act as a potential incubator for novel subtypes of avian influenza virus (Bi et al., 2016a; Bi et al., 2016b; Liu et al., 2014a; Su et al., 2017). Up to date, the H7N9 AIV emerged in February 2013 has caused 1,567 human cases,with a fatality rate of 39.2%(http://www.who.int/influenza/ | Chuansong Quan Ting Huang Xiuwei Chen Jie Zhang Qianli Wang Cheng Zhang Tiyan Zhang Lijun Zhou Liumei Shu Chunrong Long Lei Yang Xunbo Du Yingze Zhao Peipei Liu Hao Song Weifeng Shi Yuhai Bi Qiang Lv William J.Liu George F.Gao | 2018 | Science China(Life Sciences)2018，61，9： | 4 |
| 3 | On the Centenary of the Spanish Flu: Being Prepared for the Next Pandemic显示文摘Influenza is one of the oldest infectious diseases affecting humans. Every influenza pandemic in history has ended with disastrous outcomes regarding public health and the social economy. This year marks the 100th anniversary of the Spanish flu (H1N1) outbreak of 1918, which is recognized as the most lethal natural event in recent history. | William J.Liu Yuhai Bi Dayan Wang George F.Gao | 2018 | Virologica Sinica2018，33，6： | 3 |
| 4 | Boron doped graphdiyne:A metal-free peroxidase mimetic nanozyme for antibacterial application显示文摘The abuse of conventional antibiotics leads to increasing bacterial resistance.Nanozyme is a new kind of ultra-efficient and safe nanomaterial with intrinsic enzyme-like activities,showing remarkable potential as a next generation nanobactericide.Graphdiyne(GDY)is a burgeoning two-dimensional(2D)carbon allotrope with intriguing physicochemical properties,holding a great promise as a metal-free nanozyme.In this study,a boron doped GDY nanosheet(B-GDY)was constructed to simulate the performance of peroxidase(POD).By promoting the decomposition of H_(2)O_(2) to produce reactive oxygen species(ROS),the bactericidal efficacies against both Gram-positive and Gram-negative bacteria were substantially enhanced attributed to the extremely high catalytic activity of B-GDY.In-depth density functional theory(DFT)calculations illuminate that doping of boron can introduce more active B-defect sites as well as lower Gibbs free energy during the H_(2)O_(2) decomposition reaction.Notably,B-GDY contributes to significant wound healing and excellent biocompatibility,reducing the biological burden.The design of this nanozyme opens a new avenue for the development of alternative antibiotics. | Xuelong Bi Qiang Bai Lina Wang Fanglin Du Manhong Liu William W.Yu Siheng Li Jiaqiang Li Zhiling Zhu Ning Sui Jin Zhang | 2022 | Nano Research2022，15，2： | 2 |
| 5 | Genetic and Phylogenetic Characterization of a Chikungunya Virus Imported into Shenzhen, China显示文摘Dear Editor,Chikungunya virus(CHIKV)is a mosquito-borne virus belonging to the family Togaviridae,genus Alphavirus,and was first isolated in Tanzania in the 1950s(Silva and Dermody 2017;Weaver and Lecuit 2015).Human infections with CHIKV typically result in a rapid-onset febrile disease,with symptoms that include fever,headache,rash,severe joint and muscle pain,as well as prolonged periods of disability in some patients(Weaver and Lecuit 2015;Silva and Dermody 2017). | Yang Yang Zhixiang Xu Haixia Zheng Jingdong Song Ying Wu Zhou Tong Jing Yuan Gary Wong William J.Liu Yuhai Bi Yingxia Liu George F.Gao | 2020 | Virologica Sinica2020，35，1： | 2 |
| 6 | Youth risk behavior surveillance-United States,1999显示文摘 | Kann L Kinchen SA Williams BI | 2000 | MMWR CDC Surveill Summ2000，49，： | 1 |
| 7 | Youth risk behavior surveillance State and local YRBSS coordinators 显示文摘 | Kann L Kinchen SA Williams BI | 2000 | J Sch Health2000，70，7： | 1 |
| 8 | Vulnerability analysis for large - scale and congested road networks with demand uncertainty显示文摘 | Bi YuChen William H K L Agachai Sumalee | 2012 | Transportation Research Part A2012，，46： | 1 |
| 9 | Efficient Photochemical Water Splitting by a Chemically Modified n -- TiO2 显示文摘 | Shahed UMK Mofareh A William BI | 2002 | Science2002，297，： | 1 |
| 10 | A role for Rho and Rac in secretagogue in- duced amylase release by pancreatic acini 显示文摘 | Bi Y Williams A | 2005 | Am J Physiol2005，289，1： | 1 |
| 11 | Youth risk behavior surveillance-United States, 1999 显示文摘 | KANN L KINCHEN SA WILLIAMS BI | 2000 | MMWR CDC Surveill Summ2000，49，5： | 1 |
| 12 | Adaptation of metabolism and evaporative water loss along an aridity gradient显示文摘 | Tieleman BI Williams JB Bloomer P | | 0，，： | 1 |
| 13 | Rho and Rac promote acinar morphological changes, actin reorganization, and amylase secretion显示文摘 | Bi Y Page S L Williams J A | 2005 | Am J Physiol Gastrointest Liver Physiol2005，289，3： | 1 |
| 14 | Patterns of AFLP variation in a core subset of cultivated hexaploid oat germplasm显示文摘 | Yong Bi Fu Gregory W Peterson David Williams | 2005 | Theoretical and Applied Genetics2005，111，： | 1 |
| 15 | Phenotypic flexibility in cutaneous water loss and lipids of the stratum corneum 显示文摘 | Haugen M J Tieleman BI Williams JB | 2003 | J Exp Biol2003，206，20： | 1 |
| 16 | Youth risk behavior surveillance-United States,1999显示文摘 | Kann L Kinchen SA Williams BI | 2000 | MMWR CDC Surveill Summ2000，49，5： | 1 |
| 17 | Prevalence of hydrogen peroxide - producing Lactobacillus species in normal women and women with bacterial vaginosis 显示文摘 | Eschenbach DA Davick PR Williams BI | 1989 | J Clin Microbiol1989，27，： | 1 |
| 18 | Medical tourism: Outsourcing surgery显示文摘 | William Bies Lefteris Zacharia | 2007 | Mathematical and Computer Modelling2007，，7： | 1 |
| 19 | Heat waves and climate change: applying the health belief model to identify predictors of risk perception and adaptive behaviors in Adelaide, Australia 显示文摘 | Akompab DA Bi P Williams S | 2013 | Int J Enviiron Res Public Health2013，10，： | 1 |
| 20 | Medical tourism:Outsourcing surgery显示文摘 | William Bies Lefteris Zacharia | 2007 | Mathematical and Computer Modelling2007，46，78： | 1 |
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