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| 1 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 4 | Long-term tree productivity of a South Carolina coastal plain forest across a hydrology gradient显示文摘Aims In recent years,there has been an increased interest in examining changes in forest systems in response to drought,flooding,hurricanes and climate change.In the southern United States,forested wetlands are of special interest because of the extent of these forests.Coastal plain forested wetlands are among the most vulnerable to these climatic impacts.One of the problems in developing management practices for these coastal areas is the difficulty in adequately describing productivity relations and predicting how the structure and function of these communities might be affected by natural or anthropogenic disturbances.Community response to environmental change often occurs over a period of years,and the majority of reported studies are for 1–3 years in duration.This study documents long-term changes(10 years)in structure,composition and growth along a catena of high water table forested sites of an ancient beach ridge landscape in coastal South Carolina.Methods Aboveground net primary production(ANPP)of trees was monitored from 2000 to 2009 on three sites within a longleaf pine-swamp blackgum forest system on the southern end of theWaccamaw Neck area of Georgetown County,SC.Permanent study plots(20325 m)were established across a moisture gradient(Dry,Intermediate,and Wet).Water levels were continuously monitored,litterfall was measured monthly and growth of trees>10 cm diameter at breast height was monitored on an annual basis.Annual litterfall and tree production values were summed to provide estimates of ANPP.Important Findings The study site was under severe drought conditions July 2001 through late summer 2002 and again in 2007.Diameter growth was affected in all three sites,but with different patterns.It seems that diameter growth in the Wet site was more sensitive to drought conditions in 2001–02 and 2007 than either Dry or Intermediate sites.While droughts did not seem to have a significant impact on litterfall in the Wet site,litterfall in the Intermediate site was more sensitive to the drought than either Dry or Wet sites.ANPP was significantly lower in both Intermediate and Wet sites in 2001 at<602 g/m2.Highest ANPP(>1000 g/m2)occurred in the Intermediate and Wet sites in 2003 following a return to more normal water levels at the end of the drought.Maximum tree production occurred on the Wet site in 2003(657 g/m2),which exceeded total ANPP of any site in 2001.In the Dry site,ANPP remained relatively consistent throughout the study when compared to Wet and Intermediate sites.While litterfall estimates are well defined with 3–5 years of data,data collection is continuing to assess impact of drought on stem growth across the gradient,which is still not clear with 10 years of data. | William H.Conner Bo Song Thomas M.Williams Jeffery T.Vernon | 2011 | Journal of Plant Ecology2011，4，1： | 2 |
| 5 | Occupational Health Risk Assessment of Benzene,Toluene,and Xylene in Shanghai显示文摘Objective This study was designed to conduct a retrospective and systematic occupational health risk assessment(OHRA)of enterprises that used benzene,toluene,and xylene(BTX)in Shanghai,China.Methods All data for the study were obtained from 1,705 occupational health examination and evaluation reports from 2013 to 2017,and a semiquantitative model following Chinese OHRA guidelines(GBZ/T 298-2017)was applied for the assessment.Results The selected enterprises using BTX were mainly involved in manufacturing of products.Using the exposure level method,health risk levels associated with exposure to BTX were classified as medium,negligible,or low.However,the risk levels associated with benzene and toluene were significantly different according to job types,with gluers and inkers exhibiting greater health risks.For the same job type,the health risk levels assessed using the comprehensive index method were higher than those using the exposure level method.Conclusion Our OHRA reveals that workers who are exposed to BTX still face excessive health risk.Additionally,the risk level varied depending on job categories and exposure to specific chemicals.Therefore,additional control measures recommended by OHRA guidelines are essential to reduce worker exposure levels. | WANG Tong Shuai SONG Bo SUN Qing Hua LIN Yong Xin SUN Yuan SUN Pin JIA Xiao Dong William W.Au MEI Can Hua XIA Zhao Lin | 2021 | Biomedical and Environmental Sciences2021，34，4： | 2 |
| 6 | Regulation of Wnt signaling by Sox proteins: XSox17α/βand XSox3 physically interact with β-catenin显示文摘 | Barish GD Williams BO | 1999 | Mol Cell1999，4，： | 1 |
| 7 | SOST and DKK:antagonists of LRP family signaling as targets for treating bone disease显示文摘 | Mason JJ Williams BO | 2010 | J Osteoporos2010，4，： | 1 |
| 8 | Wnt signaling, stem cells, and the cellular origin of breast cancer显示文摘 | Lindvall C Bu W Williams BO | 2007 | Stem Cell Rev2007，3，2： | 1 |
| 9 | Dualeffects of macrophage inflammatory protein-la onosteolysis and tumor burden in the murine 5TGM1model of myeloma bone disease显示文摘 | Oyajobi BO Franchin G Williams PJ | 2003 | Blood2003，102，： | 1 |
| 10 | Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-eatenin显示文摘 | Zorn AM Barish GD Williams BO | 1999 | Mol Cell1999，4，4： | 1 |
| 11 | Where Wnts went:the exploding field of Lrp5 and Lrp6 signaling in bone显示文摘 | Williams BO Insogna KL | 2009 | J Bone Mineral Res2009，24，： | 1 |
| 12 | Regulation of Wnt/lS-catenin signaling within and from osteocytes 显示文摘 | Burgers TA Williams BO | 2013 | Bone2013，54，： | 1 |
| 13 | Regulation of Wnt/beta-catenin signaling within and from osteocytes显示文摘 | BURGERS TA WILLIAMS BO | 2013 | Bone2013，54，2： | 1 |
| 14 | Global physical activity levels: surveillance progress, pitfalls, and prospects显示文摘 | Pedro C Hallal Lars Bo Andersen Fiona C Bull Regina Guthold William Haskell Ulf Ekelund | 2012 | The Lancet2012，，9838： | 1 |
| 15 | A global synthesis of the effectiveness and ecological impacts of management interventions for Spartina species显示文摘Invasions by Spartina species pose serious threats to global coastal ecosystems.Although many studies have examined the effectiveness and ecological impacts of invasive Spartina management,no comprehensive global synthesis has been conducted to assess the effects of management on Spartina per se and on wider non-targets.Here,we conducted a global meta-analysis of 3,459 observations from 102 studies to quantify the effects of different management interventions(physical,chemical,biological,and integrated control)on Spartina per se and native biodiversity and environments.We found that physical measures quickly suppressed Spartina but that their effectiveness declined over time.By contrast,chemical measures decreased the abundance and growth of Spartina to a lesser degree in the early stage,but the effectiveness increased over time.Different management measures did not significantly decrease the diversity of native biota on the whole,but native-plant diversity significantly decreased with time after physical control.Different management measures did not affect abiotic factors differently.These results support the use of chemical measures to control invasive Spartina,although their effectiveness would depend on the time since the management intervention.Addressing the problem of Spartina regrowth following physical control requires improved techniques.We hold that initial states of invaders and subsequent environmental changes after management interventions should be weighed in evaluating control efficacy. | Shengyu Wang Philip A.Martin Yan Hao William J.Sutherland Gorm E.Shackelford Jihua Wu Ruiting Ju Wenneng Zhou Bo Li | 2023 | Frontiers of Environmental Science & Engineering2023，17，11： | 1 |
| 16 | Porphyry Cu deposits linked to episodic growth of an underlying parental magma chamber显示文摘Saindak is one of the typical porphyry Cu deposits(PCDs)in the Chagai magmatic arc in Pakistan.Ore-forming porphyries at Saindak PCD are mainly composed of tonalite.Here,we use geochemistry of apatite enclosed in plagioclase phenocrysts from the ore-forming tonalite to constrain the releasing and recharging processes of S and Cl in the underlying parental magma chamber during PCD mineralization.Although apatite inclusions have homogeneous intra-grain S and Cl compositions,there is significant inter-grain S and Cl variations in apatite inclusions located from core to rim in the hosting plagioclase.Such inter-grain S and Cl variation in apatites are coupled with the core-to-rim trends of An,FeO and Mg contents of the hosting plagioclase phenocryst.It indicates that the Saindak PCD likely formed by episodic injection of primitive magmas during the growth of an underlying magma chamber,rather than by one major injection or by addition of mafic melt derived from different source region.Each primitive melt injection introduced essential ore-forming materials such as S and Cl,which were rapidly and effectively released to the coexisting fluids,causing mineralization.Once primitive melt injection stops,signaling the end of growth of underlying magma chamber,mineralization will cease quickly although the hydrothermal system can still survive for a long time.However,the later released fluids are relatively depleted in ore-forming materials,and thus have lower capability to generate mineralization.Accordingly,predominant porphyry-type mineralizations occurred during the growth rather than waning stage of a magmatic system. | Yuanchuan ZHENG Lu WANG Chuandong XUE Bo XU Abdul GHAFFAR Zhusen YANG Yongjun LU Limin ZHOU William L.GRIFFIN Zengqian HOU | 2020 | Science China Earth Sciences2020，63，11： | 1 |
| 17 | Regulation of Wnt/13-catenin signaling within and from osteoeytes 显示文摘 | Burgers TA Williams BO | 2013 | Bone2013，54，2： | 1 |
| 18 | Where Wnts Went: the exploding field of Lrp5 and Lrp6 signaling in bone显示文摘 | Williams BO Insogna KL | 2009 | J Bone Miner Res2009，24，2： | 1 |
| 19 | Wnt signaling, stem cells, and the cellular origin of breast cancer显示文摘 | Lindvall C Bu W Williams BO | 2007 | Stem Cell Rev2007，3，2： | 1 |
| 20 | Insights into the mechanisms of sclerostin action inregulating bone mass accrual 显示文摘 | Williams BO | 2014 | J Bone Miner Res2014，29，1： | 1 |
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