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| 1 | Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy显示文摘Primary ovarian insufficiency(POI)is an ovarian dysfunction that affects more than 1%of women and is characterized by hormone imbalances that afflict women before the age of 40.The typical perimenopausal symptoms result from abnormal levels of sex hormones,especially estrogen.The most prevalent treatment is hormone replacement therapy(HRT),which can relieve symptoms and improve quality of life.However,HRT cannot restore ovarian functions,including secretion,ovulation,and fertility.Recently,as part of a developing field of regenerative medicine,stem cell therapy has been proposed for the treatment of POI.Thus,we recapitulate the literature focusing on the use of stem cells and biomaterials for POI treatment,and sum up the underlying mechanisms of action.A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies. | Sichen Zhang Dashuai Zhu Xuan Mei Zhenhua Li Junlang Li Mengjie Xie Halle Jiang Williams Lutz Shaowei Wang Ke Cheng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 2 | Mesoporous Ag nanocubes synthesized via selectively oxidative etching at room temperature for surface- enhanced Raman spectroscopy显示文摘Silver nanocubes enriched with {100} facets have been extensively used for surface-enhanced Raman scattering. Herein, we report a new water-phase synthesis method for weU-defined Ag nanocubes with tunable sizes via a two-step procedure at room temperature. First, irregularly shaped Ag nanoparticles (INPs) were prepared by reducing silver ammonia solution using ethylal. Second, the agglomerated INPs were selectively etched with HNO3 and C1- to yield {100} facet-rich mesoporous Ag nanocubes. The mechanism of Ag-nanocube formation and growth was investigated in detail by elucidating the involved chemical reactions and physical changes at each step during the synthesis. The addition of C1- anions was responsible for facilitating Ag nanoparticle growth by removing surface-adsorbed Ag+ species, thereby eliminating inter-particle repulsive forces. This agglomeration was found crucial for the subsequent selective oxidation of Ag nanoparticles because the protective agent used, polyvinylpyrrolidone (PVP), was the most effective one for adsorption on the surfaces of Ag nanoparticles of size greater than approximately 50 nm. Importantly mesopores were found inside the Ag nanocubes; this can be attributed to the unavoidable imperfect packing during the agglomeration of INPs. The newly prepared Ag nanocubes were further used to enhance the Raman signal of rhodamine 6G, which is capable of reducing the detection limitation to 10-16 mol·L-1. | Lin Gan Meijia Yang Xi Ke Guofeng Cui Xudong Chen Shiva Gupta William Kellogg Drew Higgins Gang Wu | 2015 | Nano Research2015，8，7： | 4 |
| 3 | Noninferiority clinical trial comparing the bowel cleansing efficacy of sodium phosphate tablets(Quiklean®)with a polyethylene glycol/bisacodyl kit显示文摘BACKGROUND Efficient bowel cleansing is essential for a successful colonoscopy,but the ideal cleansing agent,volume,and pharmaceutical dosage form have yet to be determined.Small-volume cleansers enhance patient compliance.AIM To compare the bowel cleansing efficacy of 32-tablet sodium phosphate(Quiklean®)with 2-L polyethylene glycol(PEG)/bisacodyl(Klean-Prep/Dulcolax®)under identical dietary recommendations.METHODS This multicenter,randomized,parallel-group,noninferiority clinical trial enrolled 472 outpatients,randomized 456 subjects,and scheduled 442 subjects to undergo colonoscopy(Quiklean®=222 and Klean-Prep/Dulcolax®=220).After bowel preparation,a colonoscopist performed the colonoscopy with video recorded for rating.The primary efficacy endpoint was the bowel cleansing quality using the Aronchick Scale.The secondary endpoints were the bowel cleansing efficacy of three colon segments,tolerability and acceptability,safety using the Ottawa bowel preparation scale,questionnaires by subjects,and monitoring of adverse events.RESULTS Success rates(Excellent+Good)of the bowel cleansing quality by Aronchick Scale were 98.6%(n=205)and 97.6%(n=204)in the Quiklean®and Klean-Prep/Dulcolax®groups,respectively.Quiklean®demonstrated noninferiority over Klean-Prep/Dulcolax®in colon cleansing efficacy.Quicken showed better tolerability and acceptability in the overall experience(was rated as excellent;24.0%vs 17.2%;P=0.0016)and the taste of the study preparation(was rated as excellent,23.1%vs 13.4%;P<0.0001)than Klean-Prep/Dulcolax®.Safety profiles did not differ between the two groups.Our data indicate that Quiklean®is an adequate,well-tolerated bowel cleansing preparation compared with the standard comparator Klean-Prep/Dulcolax®.CONCLUSION Quiklean®is sodium phosphate tablets available on Taiwan’s market for bowel preparation;it potentially offers patients an alternative to standard large-volume bowel preparation regimens and may,therefore,increase positive attitudes toward colonoscopies and participation rates. | Shih-Ya Hung Hung-Chang Chen Tao-Wei Ke Jiann-Hwa Chen Koung-Hung Hsiao Hwei-Ming Wang Hua-Che Chiang Sheng-Chi Chang Yi-Chang Chen Ming-Hao Hsieh Yuan-Yao Tsai Yo-Wen Hsieh William Tzu-Liang Chen | 2021 | World Journal of Gastroenterology2021，27，5： | 4 |
| 4 | Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure model显示文摘瞄准:Sildenafil, phosphodiesterase 5 (PDE5 ) 禁止者,被显示了在心失败施加有益的效果。这研究的目的是测试 sildenafil 是否压制了横向小管的(T 小管) 在左改变室(LV ) 失败并且从而提供治疗学的 benefits.Methods:一个压力导致超载的鼠科的心失败模型被胸的大动脉的 banding (标签) 在老鼠建立。在标签以后的一天,鼠标收到了 sildenafil (100 mg· kg −1·d−1, sc ) 或为 5 个星期盐。在处理的结束, echocardiography 被用来检验 LV 功能。然后,未经触动的心外面被把并且把房间放在 Langendorff 灌注为在 situ 从 epicardial myocytes.Results 的 T 小管超微结构的共焦的成像:标签外科导致了改变的显著 T 小管伴随的心失败。Sildenafil 处理显著地稀释了导致标签的心脏的肥大和充血的心失败,改进了 LV 可收缩的功能,并且保存了在 LV cardiomyocytes 的 T 小管正直。但是 sildenafil 处理显著地没影响房间膨胀。LV T 小管结构的完整与心脏的肥大被相关(R 2=0.74, P< 0.01 ) 并且全球 LV 功能(R 2=0.47, P< 0.01 ).Conclusion:Sildenafil 有效地改善在标签老鼠改变的 LV T 小管,揭示在心失败位于 sildenafil 的治疗学的好处下面的新奇机制。 | Chun-kai HUANG Bi-yi CHEN Ang GUO Rong CHEN Yan-qi ZHU William KUTSCH KE Jiang HONG Long-sheng SONG | 2016 | Acta Pharmacologica Sinica2016，37，4： | 2 |
| 5 | Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases显示文摘 | Sung-Jun Park Faiyaz Ahmad Andrew Philp Keith Baar Tishan Williams Haibin Luo Hengming Ke Holger Rehmann Ronald Taussig Alexandra L. Brown Myung K. Kim Michael A. Beaven Alex B. Burgin Vincent Manganiello Jay H. Chung | 2012 | Cell2012，，3： | 2 |
| 6 | Documenting the current definitions of chronic pelvic pain : implications for research 显示文摘 | Williams RE Hartmann KE Steege JF | 2004 | Obstet Gynecol2004，103，： | 1 |
| 7 | Enhanced effect of combining human cardiac stem cells and bone marrow mesanchy- mal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction显示文摘 | Williams AR Hatzistergos KE Addicott B | 2013 | Circulation2013，127，2： | 1 |
| 8 | Characterization of rpsL and rrs mutations in streptomycin-resistant Mycobacterium tuberculosis isolates from diverse geographic localities显示文摘 | Sreevatsan S Pan X Stockbauer KE Williams DL Kreiswirth BN Musser JM | 1996 | Antimicrob Agents Chemother1996，40，4： | 1 |
| 9 | Food refusal in chil- drena review of the literature显示文摘 | Williams KE Field DG Seiverling L | 2010 | Res Dev Disabil2010，31，3： | 1 |
| 10 | Demonstration of a bilateral projection from the rostral nucleus of the solitary tract to the medial parabrachial nucleus in rats显示文摘 | Murphy DM Reynolds KE | 1996 | Brain Res1996，737，12： | 1 |
| 11 | Optimization models of sound systems using genetic algorithms 显示文摘 | Jinyun Ke Mieko Ogura William S-Y Wang | 2003 | Computational Linguistics2003，29，1： | 1 |
| 12 | Outcomes of 6906 patients undergoing parcutuneous coronary intervention in the era of drug-eluting stents:report of the DES cover Registry显示文摘 | Williams DO Abbott JD Kip KE | 2006 | Circulation2006，114，20： | 1 |
| 13 | Mood disorders and fertility in women:a critical review of the literature and implications for future research显示文摘 | Williams KE Marsh WK Rasgon NL | 2007 | Hum Heprod Update2007，13，6： | 1 |
| 14 | Positron emission tomography of patients with head and neck carcinoma before and after high dose radiation显示文摘 | Greven KE William DW Keges JW | 1994 | Cancer1994，74，： | 1 |
| 15 | A review of the scientific evidence for biofilms in wounds显示文摘 | Percival SL Hill KE Williams DW | 2012 | Wound Repair Regen2012，20，5： | 1 |
| 16 | Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells显示文摘 | Chae HD Lee KE Williams DA | | 0，，02： | 1 |
| 17 | Influence of postoperative treatment on survival in patients with uterine papillary serous carcinoma显示文摘 | Bancher-Todesca D Neunteufel W Williams KE | 1998 | Gynecol Oncol1998，71，： | 1 |
| 18 | Prevalence and characteristics of irritable bowel syndrome among women with chromic pelvic pain显示文摘 | Williams RE Hartmann KE Sandier R | 2004 | Obset Gynecol2004，104，： | 1 |
| 19 | Selective osteal salpingography and transvaginal catheter dilatation in the diagnosis and treatment of follopian tube obstruction 显示文摘 | Lang KE Dunaway HE William JR | 1990 | AJR1990，154，4： | 1 |
| 20 | Differences in verbal memory performance in postmenopausal women receiving hormone therapy:17β-estradiol versus conjugated equine estrogens显示文摘 | Wroolie TE Kenna HA Williams KE | 2011 | Am J Geriatr Psychiatry2011，19，9： | 1 |
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