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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Relationship between Physical and Chemical Soil Attributes and Plant Species Diversity in Tropical Mountain Ecosystems from Brazil显示文摘Although the high diversity of plant species in the rupestrian fields has been primarily attributed to the existence of a set of distinct habitats, few studies support this assertion. The present study aimed to further investigate the relationship between physical and chemical attributes of soils with the diversity of plant species in this unique ecosystem. The rupestrian field is a unique vegetation formation that covers some of the southeastern Brazilian mountains in the transition of the Atlantic rain forest and the Cerrado(savanna). Different habitats occur according to soil characteristics(e.g., presence of rocks, sand, fertility, hydrology, etc.). These attributes ultimately influence the vegetation that is highly adapted to the harsh edaphic and climatic mountain conditions. Five distinct habitats were studied by us: rocky outcrops, peat bogs, sandy bogs, quartz gravel fields, and 'cerrado'(savanna). A floristic survey indicated that four families are found at greater frequency: Poaceae, Asteraceae, Cyperaceae, and Leguminosae. The greatest diversity of plant species was found in the rocky outcrops habitat, followed by cerrado, peat bog, quartz gravel grassland, and sandy bogs, respectively. The main difference in the floristic composition among these habitats was related to the dominant species. Trachypogon spicatus(Poaceae) was the most dominant species in the rocky outcrops, Axonopus siccus(Poaceae) in the peat bogs, Lagenocarpus rigidus(Cyperaceae) in the sandy bogs, Schizachyrium tenerum(Poaceae) in the cerrado, while Vellozia sp. 8(Velloziaceae) dominated the vegetation in the quartz gravel grassland. This study demonstrated that physical and chemical soil properties strongly related the diversity of plant species occurring in the different habitats of rupestrian fields. | Ferna de CARVALHO Edward Luis GODOY Francy J. G. LISBOA Fatima Maria de Souza MOREIRA Francisco Adriano de SOUZA Ricardo Luis Louro BERBARA G Wilson FERNES | 2014 | Journal of Mountain Science2014，11，4： | 7 |
| 3 | An Intelligent Harmonic Synthesis Technique for Air-Gap Eccentricity Fault Diagnosis in Induction Motors显示文摘Induction motors(IMs) are commonly used in various industrial applications. To improve energy consumption efficiency, a reliable IM health condition monitoring system is very useful to detect IM fault at its earliest stage to prevent operation degradation, and malfunction of IMs. An intelligent harmonic synthesis technique is proposed in this work to conduct incipient air-gap eccentricity fault detection in IMs. The fault harmonic series are synthesized to enhance fault features. Fault related local spectra are processed to derive fault indicators for IM airgap eccentricity diagnosis. The effectiveness of the proposed harmonic synthesis technique is examined experimentally by IMs with static air-gap eccentricity and dynamic air-gap eccentricity states under different load conditions. Test results show that the developed harmonic synthesis technique can extract fault features effectively for initial IM air-gap eccentricity fault detection. | De Z.Li Wilson Wang Fathy Ismail | 2017 | Chinese Journal of Mechanical Engineering2017，30，6： | 7 |
| 4 | Association of Helicobacter pylori infection and giardiasis: Results from a study of surrogate markers for fecal exposure among children显示文摘AIM: To investigate whether Helicobacter pylori (H pykori)infection is associated with hepatitis A virus (HAV) infection, presence of enteroparasites, and other surrogates of fecal exposure.METHODS: We conducted a cross-sectional study in 121 children consecutively admitted at a pediatric hospital inSalvador, Brazil.H pylori and HAV infection were identified by the presence of serum antibodies. Stool specimens were examined for the presence of ova and parasites. A structured questionnaire inquiring about sanitary conditions and life style was applied to each subject. RESULTS: Fifty-one of the 121 children (42.1%) werefound to be seropositive for H pylori, and 45 (37.2%) for HAV. The seroprevalence ofHpyloriand HAV both increased significantly with age. Cross-tabulation of data showed that 26 (21.5%) were seropositive and 51 (42.1%) were negative for bothHpyloriand HAV antibodies (χ2 = 7.18,OR = 2.8, CI 1.30-5.97). The age adjusted OR for an HAV-infected child being H pylori positive was 2.3 (CI1.02-5.03). The agreement between H pylori and HAVseropositivity was fair (κ = 0.24). After controlling for possible confounding, the variables remaining independently associated with seropositivity to H pyloriwere age,presence of Giardia lamblia in feces (OR = 3.2, 95%CI, 1.1-9.5) and poor garbage disposal quality (OR = 2.4,95%CI, 1.1-5.1).CONCLUSION: Our data suggest that H pylori infection is associated with surrogate markers of fecal exposure. Thus, we conclude that the fecal-oral route is relevant in the transmission of HP among children in an urban setting of a developing country. The association observed between G. lamblia and H pylori infection may have several explanations. Further studies to investigate this relationship are warranted. | Edson Duarte Moreira Jr Victor Bastos Nassri Rafaela Sousa Santos Junísia Ferraz Matos Wilson Andrade de Carvalho Célia Stolve Silvani Círia Santana e Sant'Ana | 2005 | World Journal of Gastroenterology2005，11，18： | 3 |
| 5 | A typology for the classification, description and valuation of ecosystem functions, goods and services显示文摘 | Rudolf S de Groot Matthew A Wilson Roelof M.J Boumans | 2002 | Ecological Economics2002，，3： | 3 |
| 6 | Six-minute walking test performance is associated with survival in cirrhotic patients显示文摘BACKGROUND Patients with cirrhosis are at risk of cirrhotic cardiomyopathy,with resulting cardiac dysfunction and exercise limitations.Six minute walking test(6MWT)assesses functional status and predicts morbidity and mortality in cardiopulmonary diseases.AIM To determine if it associates with mortality by analyzing 6MWT performance in patients with liver cirrhosis.METHODS A cohort of 106 cirrhotic patients was evaluated in the outpatient setting with echocardiogram and 6MWT and follow up for one year to document hepatic decompensation and mortality.The distance in meters was recorded at the end of 6 min(6MWD).RESULTS This cohort had a mean age of 51 years and 56%male;patients were staged as Child A in 21.7%,B 66%and C 12.3%.Walk distance inversely correlated with Child scores,and was significantly reduced as Child stages progresses.Patients who died(10.4%)showed shorter mean 6MWD(P=0.006).Low 6MWD was an independent predictor of mortality(P=0.01).CONCLUSION 6MWT is a noninvasive inexpensive test whose result is related to Child scores and mortality.It is useful to identify patients with liver cirrhosis at high risk of mortality for closer monitoring and potential early intervention. | Carolina Frade M G Pimentel Ana Cristina de Castro Amaral Adriano Miziara Gonzalez Michelle Lai Danielde Oliveira Mota Maria Lucia Gomes Ferraz Wilson Mathias Junior Mario Kondo | 2021 | World Journal of Hepatology2021，13，11： | 2 |
| 7 | 99mTc-DISIDA Uptake in Liver Lesion and Pulmonary Metastases Shown on SPECT/CT in a Patient With Hepatocellular Carcinoma显示文摘 | Cristina Emiko Ueda Wilson André Ichiki Mariana Ferraz de Campos Mazo Ruiz Allan Oliveira Santos Elba Cristina Sá de Camargo Etchebehere | 2014 | Clinical Nuclear Medicine2014，，1： | 2 |
| 8 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 9 | Treatment with intravitreal steroid reduces blood-retinal bar-rier breakdown due to retinal photocoagulation显示文摘 | Wilson CA Berkowitz BA Sato Y Ando N Handa JT de Juan EJr | 1992 | Arch Oph-Mmol1992，110，8： | 1 |
| 10 | The FDA perspective on the develop-ment of stereoisomers显示文摘 | Wilson H De Camp | 1989 | Chirality1989，1，： | 1 |
| 11 | Analysis of exhaled volatile compounds following acute superior mesenteric artery occlusion in a pilot rat study显示文摘 | Jimenez J C De Lano F Wilson J M | 2011 | Ann Vasc Surg2011，25，8： | 1 |
| 12 | Succesful hyperlipidemic pregnancy显示文摘 | Sanderson SL Iverius PH Wilson DE | 1991 | JAMA1991，265，14： | 1 |
| 13 | A typology for the classification description and valuation of ecosystem functions, goods, and services 显示文摘 | DE GROOT R S WILSON M A BOUMANS R M J | 2002 | Ecological Economics2002，41，3： | 1 |
| 14 | All three isoforms of the voltage-dependent anion channel ( VDAC1, VDAC2, and VDAC3) are present in mitochondria from bovine, rabbit, and rat brain显示文摘 | de Cerqueira Cesar M Wilson JE | 2004 | Arch Biochem Biophys2004，422，2： | 1 |
| 15 | Apology for the classification, description and valuation of ecosystem functions显示文摘 | DE GROOT RS WILSON MA BOUMANS R M J | 2010 | Ecol Econ2010，41，： | 1 |
| 16 | Pluriactivity as a Livelihood Strategy in Irish 1:arm Households And Its Role in Rural Development显示文摘 | K1NSELLA J WILSON S DE JONG F | 2002 | Sociologia Ruralis2002，40，49： | 1 |
| 17 | A typology for the classification, description, and valuation of ecosystem functions, goods, and services 显示文摘 | DE GROOT R S WILSON M A BOUMANS R M J | 2002 | Ecological Economics2002，41，： | 1 |
| 18 | A typology for the classification, description and valuation of ecosystem functions, goods and services 显示文摘 | DE GROOT R S WILSON M A BOUMANS R M J | 2002 | Ecological Economics2002，41，3： | 1 |
| 19 | Biosynthesis of soluble carotenoid holoproteins in Escherichia coli 显示文摘 | de Carbon CB Tburotte A Wilson A | 2015 | Sci Rep2015，5，： | 1 |
| 20 | Am allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with the HLA Al,B8,and DR3 alleies显示文摘 | De Vrkes N Plcklt F | 1993 | Exp Med1993，177，： | 1 |
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