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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Computer Enhanced Separation of Compound Classes in Fuel Mixtures Using a Combined LC-MS Approach显示文摘 | Hoesterey B L McClennen W H Winding W | 1985 | Amer Chem Soc Div Fuel Chem Prepr1985，30，1： | 1 |
| 3 | Design and application of decision support systems for integrated water management:lessons to be learnt显示文摘 | de Kok J L Wind H G | 2003 | Physics and Chemistry of the Earth2003，28，： | 1 |
| 4 | DataWare: sea clutter and small boat radar reflectivity databases 显示文摘 | WIND H J CILLIERS J E HERSEI34AN P L | 2010 | IEEE Signal Processing Magazine2010，，： | 1 |
| 5 | A 1463 gene cattle-human comparative map with anchor points defined by human genome sequence coordinates显示文摘 | Everts-van der Wind A Kata S R Band M R Rebeiz M Larkin D M Everts R E Green C A Liu L Natarajan S Goldammer T Lee J H McKay S Womack J E Lewin H A | 2004 | Genome Res2004，14，7： | 1 |
| 6 | Nitrification and low temperature in a raw water reservoir and rapid sand fihers显示文摘 | Kors L J Moorman H N Wind A P M | 1998 | War Sci Technol1998，37，2： | 1 |
| 7 | Nitrification and low temperature in a raw water reservoir and rapid sand filters显示文摘 | Kors L J Moorman H N Wind A P M | 1998 | Wat Sci Technol1998，37，2： | 1 |
| 8 | Employment-based social capital,job stress,and employee burnout:A public child welfare em- ployee structural model显示文摘 | Boyas J Wind L H | 2010 | Children Youth Servi Rev2010，32，3： | 1 |
| 9 | Interdisciplinary modeling:gaps and bridges显示文摘 | WIND H G DE KOK J L | 2002 | Marine Policy2002，26，4： | 1 |
| 10 | Dispersal and movement mechanisms of Phytophthora capsici Sporanoia显示文摘 | GRANKE L L WiNDS'rAM S T HOCH H C | 2009 | Phytopathology2009，99，1： | 1 |
| 11 | Dataware: sea clutter and small boat radar reflectivity databases显示文摘 | De Wind H J Cilliers J E and Hersehnan P L | 2010 | IEEE Signal Processing Magazine2010，27，2： | 1 |
| 12 | Isolation and characterization of novel bacterial strains exhibiting ligninolytic potential显示文摘 | Bandounas L Wierckx N J de Winde J H | 2011 | BMC Biotechnol2011，11，： | 1 |
| 13 | Systematic review of enhanced recovery programmes in colonic surgery显示文摘 | Wind J Polle S W Fung Kon J in P H et a l | 2006 | Br J Surg2006，93，7： | 1 |
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