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| 1 | Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg^(+)/HBeAg^(-) mothers显示文摘Vertically transmitted hepatitis B virus(HBV)usually causes chronic infection.While combined active–passive immunoprophylaxis in neonates of hepatitis B surface antigen-positive(HBsAg1)mothers at birth prevents vertical transmission,it is not yet clear whether neonates encounter the virus or its products in the absence of hepatitis B e antigen(HBeAg).This study was undertaken to investigate HBV antigen-specific T-cell responses in vaccinated neonates of HBsAg1/HBeAg2 mothers.Blood was collected from 46 HBsAg1 mothers and their neonates(subjects)as well as 24 age-matched controls.All neonates of HBsAg1 mothers received appropriate immunoprophylaxis,and HBsAg and hepatitis B surface antibody(anti-HBs)antibody titers were determined after completion of the vaccination course.Peripheral blood mononuclear cells(PBMCs)from infants at birth,1 and 6 months of age were stimulated with recombinant HBsAg,hepatitis B core antigen(HBcAg)and mitogen,and interferon(IFN)-c concentrations were determined by ELISA.HBsAg-induced production of IL-2,IL-5,IL-6 and IL-10 was assessed using a cytometric bead array kit on cells from 6-month-old neonates post-vaccination.All neonates were HBsAg2 and responded to vaccination.Increased IFN-c production following HBcAg stimulation was seen in 30.4%of neonates born to HBsAg1/HBeAg2 mothers.Subjects demonstrated significantly higher IL-2 production post-HBsAg stimulation,whereas IL-5,IL-6 and IL-10 cytokine responses were not significantly different.Almost one-third of uninfected neonates developed viral antigen-induced IFN-c production,suggesting that they had been exposed to virions or viral derivatives.This encounter,however,did not impair their T-cell responses to vaccination. | Lemonica Koumbi Antonio Bertoletti Vassiliki Anastasiadou Maria Machaira Winnie Goh Nikolaos G Papadopoulos Dimitris A Kafetzis Vassiliki Papaevangelou | 2010 | Cellular & Molecular Immunology2010，7，6： | 4 |
| 2 | Anxiety, depression and quality of life among Chinese breast cancer patients during adju- vant therapy显示文摘 | Winnie KW Marsh G Ling WM | 2010 | Eur J Oneol Nuts2010，14，1： | 1 |
| 3 | Anxiety,depression and quality of life among Chinese breast cancer patients during adjuvant therapy显示文摘 | Winnie KW Marsh G Ling WM | 2010 | Eur J Oncol Nuts2010，14，1： | 1 |
| 4 | Anxiety, depression and quali- ty of life among Chinese breast cancer patients during adjuvant thera- py 显示文摘 | Winnie KW Marsh G Ling WM | 2010 | Eur J Oncol Nurs2010，14，1： | 1 |
| 5 | Anxiety, depres-sion and quality of life among Chinese breast cancer patients duringadjuvant therapy显示文摘 | WINNIE K W MARSH G LING W M | 2010 | Eur J Oncol Nurs2010，14，1： | 1 |
| 6 | The symptoms cluster of fatigue,pain,anxiety,and depression and effect on the quality of life of women receiving treatment for breast cancer: A multicenter study显示文摘 | Winnie KWS Marsh G Ling WM | 2009 | ()neology Nursing Forum2009，36，20： | 1 |
| 7 | Anxiety, depression and quality of life among Chinese breast cancer patients during adjuvant therapy 显示文摘 | Winnie KW Marsh G Ling WM | 2010 | Eur J Oncol Nurs2010，14，1： | 1 |
| 8 | High connectivity among argali sheep from Afghanistan and adjacent countries: inferences from neutral and candidate gene microsatellites 显示文摘 | Luikart G~ Amish S J Winnie J | 2011 | Conservation Genetics2011，12，4： | 1 |
| 9 | Anxiety,depression and quality of life among Chinese breast cancer patients during adjuvant therapy显示文摘 | Winnie KW Marsh G Ling WM | | 0，，： | 1 |
| 10 | Anti-inflammatory pharmacotherapy for wheezing in preschool children 显示文摘 | KADITIS A G WINNIE G SYROGIANNOPOULOS G A | 2007 | Pediatric pulmonology2007，42，5： | 1 |
| 11 | Anti-inflammatory treatment for reeurrent wheezing in the first five yearsof life显示文摘 | Kaditis AG Gourgoulianis K Winnie G | 2003 | Pediatr Pulmonol2003，35，： | 1 |
| 12 | Anxiety, depres- sion and quality of life among Chinese breast cancer pa- tients during adjuvant therapy显示文摘 | Winnie KW Marsh G Ling WM | 2010 | Eur J Oncol Nurs2010，14，1： | 1 |
| 13 | A study on the treatment of water containing cyclohexanone and cyclohexano by activated sludge process显示文摘 | G Babu Winny Varghcse | 2000 | Journal of Scientific & Industrial Research2000，59，6： | 1 |
| 14 | Anxiety,depression and quality of life among Chinese breast cancer patients during adjuvant therapy显示文摘 | Winnie KW Marsh G Ling WM | 2010 | Eur J Oncol Nurs2010，14，1： | 1 |
| 15 | Anti inflammatory treatment for recurrent wheezing in the first five years of life 显示文摘 | KADITIS A G GOURGOULIANIS K WINNIE G | 2003 | Pediatr Pulmonol2003，35，4： | 1 |
| 16 | Video cystometry in youny infants with renal dilation with a history of urinary tract infeetion显示文摘 | Wen J G Yeung C K Winnie C W | 2001 | Uro Res2001，29，： | 1 |
| 17 | Anti-inflammatory treatment for recurrent wheezing in the first five years of life 显示文摘 | Kaditis AG Gourgoulianis K Winnie G | 2003 | Pediatr Pulmonol2003，35，4： | 1 |
| 18 | High connectivity among argali sheep from Afghanistan and adjacent countries: Inferences from neutral and candidate gene microsatellites 显示文摘 | Luikart G Amish S J Winnie J | 2011 | Conserv Genet2011，12，： | 1 |
| 19 | Anxiety,depression and quality of life among Chinese breast cancer patients during adjuvant therapy显示文摘 | Winnie KW Marsh G Ling WM | | 0，，1： | 1 |
| 20 | From n-gram to skipgram to concgram 显示文摘 | Winnie C Chris G Martin W | 2006 | International Journal of Corpus Linguistics2006，11，4： | 1 |
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