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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Atrophy of the left dorsolateral prefrontal cortex is associated with poor performance in verbal fluency in elderly poststroke women显示文摘This study aimed to investigate the association between atrophy in the prefrontal cortex with executive function and verbal fluency in elderly male and female patients poststroke.Thirty elderly female patients with non-aphasic ischemic stroke aged ≥ 60 years and 30 age-matched non-aphasic male patients with ischemic stroke were recruited.Automatic magnetic resonance imaging segmentation was used to assess the volume of the whole prefrontal cortex,along with its subdivisions:anterior cingulate cortex,orbitofrontal cortex and dorsolateral prefrontal cortex.The Semantic Verbal Fluency Test was administered at 3 and 15 months poststroke.At 3 months poststroke,left dorsolateral prefrontal cortex volume was significantly correlated with Verbal Fluency Test score in female patients only(partial coefficient = 0.453,P = 0.045),after controlling for age,education,diabetes,neurological deficit,white matter lesions volume,as well as the location and volume of infarcts.At 15 months poststroke,there remained a significant association between the left dorsolateral prefrontal cortex volume and Verbal Fluency Test(partial coefficient = 0.661,P = 0.001) and between the left prefrontal cortex volume and Verbal Fluency Test(partial coefficient = 0.573,P = 0.004) in female patients after the same adjustments.These findings indicate that atrophy of the left dorsolateral prefrontal cortex contributes to the impairment of verbal fluency in elderly female patients with stroke.Sex differences may be present in the neuropsychological mechanisms of verbal fluency impairment in patients with stroke. | Yang-Kun Chen Wei-Min Xiao Defeng Wang Lin Shi Winnie CW Chu Vincent CT Mok Ka Sing Wong Gabor S Ungvari Wai Kwong Tang | 2013 | Neural Regeneration Research2013，8，4： | 2 |
| 3 | Human ICE/CED-3 Protease Nomenclature显示文摘 | Emad S Alnemri David J Livingston Donald W Nicholson Guy Salvesen Nancy A Thornberry Winnie W Wong Junying Yuan | 1996 | Cell1996，，2： | 2 |
| 4 | Plexus blocks for lower extremity surgery 显示文摘 | Winnie AP Ramamurthy S Dnrrani Z | 1974 | Anesthesiol Rev1974，1，： | 1 |
| 5 | Characterization system for resonant micro-and nanocantilevers 显示文摘 | Rasmus S Anja B Winnie S | 2005 | Review of Scientific Instruments2005，76，12： | 1 |
| 6 | Impact of gold mining on the environment and human health:a case study in the Migori gold belt,Kenya显示文摘 | Jason S O Winnie V M Monica A O | 2002 | Environmental Geochemistry and Health2002，24，： | 1 |
| 7 | Factor structure and psychometric properties of the Connor--Davidson resilience scale among Chinese adolescents显示文摘 | YU X N JOSEPH T F LAU WINNIE W S MAK | 2011 | Comprehensive Psychiatry2011，52，2： | 1 |
| 8 | Mobile geographic information services (M- GIS )-technology that changes the way we navigate our world 显示文摘 | Winnie S M Tang Jan Selwood | 2002 | ISPRS2002，，： | 1 |
| 9 | The inguinal paravascular technic of lumbar plexus anesthesia: the '3-in-1 block' 显示文摘 | Winnie AP Ramamurthy S Durrani Z | 1973 | Anesth Analg1973，52，6： | 1 |
| 10 | Interscalene cervical plexus block: a single-injection technic显示文摘 | Winnie AP Ramamurthy S Durrani Z | 1974 | Anesthesia & Analgesia1974，54，3： | 1 |
| 11 | Robbert Sanderm Social predictors of recovery in late middle-aged and older persons after injury to the extremities:a prospective study显示文摘 | Gertrudis I Winnie S Adelita V | 2001 | J Gerontol2001，56，4： | 1 |
| 12 | Plexus blocks for lower extremity surgery:new answers to old problems显示文摘 | WINNIE A P RAMAMURTHY S DURANI Z | | 0，，： | 1 |
| 13 | The inguinal paravascular technie of lumbar plexus anesthesia the'3 in l'block显示文摘 | Winnie AP Ramamurthy S Durrani Z | 1973 | Anesth Analg1973，52，： | 1 |
| 14 | The inguinal paravascular technique of lumbar plexus anesthesia: the '3 in 1 ' block 显示文摘 | Winnie AP Ramamurthy S Durrani Z | 1973 | Anesth Analg1973，52，： | 1 |
| 15 | Plexus block for lower extremity surgery显示文摘 | Winnie AP Ramanmrthy S Durrani Z | 1974 | Anesth Rev1974，，1： | 1 |
| 16 | High connectivity among argali sheep from Afghanistan and adjacent countries: inferences from neutral and candidate gene microsatellites 显示文摘 | Luikart G~ Amish S J Winnie J | 2011 | Conservation Genetics2011，12，4： | 1 |
| 17 | Induction of tumor necrosis factor and interleukin-1 by purified staphylococcal toxic shock syndrome toxin 1 requires the presence of both monocytes and T lymphocytes 显示文摘 | RAYMOND H S WINNIE W S ALEX H C | 1992 | Infection and Immunity1992，60，7： | 1 |
| 18 | The incidence of deepvein thrombosis in women undergoing cesarean delivery显示文摘 | Winnie W S Raymond O P Ann B C | 2009 | ThrombosisResearch2009，123，3： | 1 |
| 19 | The ing- uinal paravascular technic of lumbar plexus anesthesia: the '3 in l'block显示文摘 | WINNIE A P RAMAMURTHY S DURRANI Z | 1973 | AnesthAnalg1973，52，6： | 1 |
| 20 | The inguinal para-vascular technic of lumbar plexus anesthesia:the '3-in-1 block' 显示文摘 | Winnie AP Ramamuahy S Dunaai Z | 1973 | Anesth Analg1973，52，6： | 1 |
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