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	题名	作者	年代	出处	被引量
1	Pyrrolidine dithiocarbamate reduces ischemia-reperfusion injury of the small intestine显示文摘AIM: To evaluate whether pyrrolidine dithiocarbamate (PDTC), an enhancer of HO production, attenuates intestinal IR injury.METHODS: Eighteen male rats were randomly allocated into three groups: (a) sham; (b) IR, consisting of 30 min of intestinal ischemia, followed by 2-h period of reperfusion; and (c) PDTC treatment before IR. Intestinal microvascular perfusion (IMP) was monitored continuously by laser Doppler fiowmetry. At the end of the reperfusion, serum samples for lactate dehydrogenase (LDH) levels and biopsies of ileum were obtained. HO activity in the ileum was assessed at the end of the reperfusion period.RESULTS: At the end of the reperfusion in the IR group,IMP recovered partially to 42.5% of baseline (P<0.05vs sham), whereas PDTC improved IMP to 67.3% of baseline (P<0.01 vs IR). There was a twofold increase in HO activity in PDTC group (2 062.66±106.11) as compared to IR (842.3±85.12) (P<0.001). LDH was significantly reduced (P<0.001) in PDTC group (585.6±102.4)as compared to IR group (1 973.8±306.5). Histological examination showed that the ileal mucosa was significantly less injured in PDTC group as compared with IR group.CONCLUSION: Our study demonstrates that PDTC improves the IMP and attenuates IR injury of the intestine possibly via HO production. Additional studies are warranted to evaluate the clinical efficacy of PDTC in the prevention of IR injury of the small intestine.	Ismail H Mallick Wen-Xuan Yang Marc C Winslet Alexander M Seifalian	2005	World Journal of Gastroenterology2005，11，46：	8
2	Apoptosis and colorectal cancer: implications for therapy显示文摘	Shi Yu Yang Kevin M. Sales Barry Fuller Alexander M. Seifalian Marc C. Winslet	2009	Trends in Molecular Medicine2009，，5：	2
3	Human liver cancer cells and endothelial celb incorporate iodises oil显示文摘	Dhillon AP Winslet MC	1996	Br J Cancer1996，，73：	1
4	Ischemia-reperfusion injury of the intestine and protective strategies against injury 显示文摘	Mallick I H Yang W Winslet M C	2004	Dig DisSci2004，49，9：	1
5	Relationship of diagnostic serum amylase levels to aetiology and severity of acute pancreatitis显示文摘	Winslet M C Hall C London N J M	1992	Gut1992，33，：	1
6	Iodized oil in the treatment of hepatocellular carcinoma 显示文摘	Bhattacharya S Novell J R Winslet M C	1994	Br J Surg1994，81，11：	1
7	REVIEW: Ischemia—Reperfusion Injury of the Intestine and Protective Strategies Against Injury显示文摘	Ismail Hameed Mallick Wenxuan Yang Marc C. Winslet Alexander M. Seifalian	2004	Digestive Diseases and Sciences2004，，9：	1
8	Tumor vasculatur-apotential therapeutic target显示文摘	Baillie CT Winslet MC Bradley N	1995	Br J Cancer1995，27，：	1
9	Ischemia-reperfusion injury of the intestine and protective strategies against injury显示文摘	Mallick IH Yang W Winslet MC	2004	Dig Dis Sci2004，49，9：	1
10	Impact of HIV and AIDS on surgical practice显示文摘	Dua RS Wajed SA Winslet MC	2007	Ann R Coll Surg Engl2007，89，4：	1
11	Wernicke's encephalopathy in association with complicated acute pancreatitis and morbid obesity显示文摘	Winslet MC Donovon IA Aitchison F	1990	Br J Clin Pract1990，44，12：	1
12	Ischemiareperfu- sion injury of the intestine and protective strategies against injury 显示文摘	Mallick IH Yang W Winslet MC	2004	Dig Dis Sci2004，49，：	1
13	Vascular complications of pancreatitiss显示文摘	Mallick IH Winslet MC	2004	J Pancreas2004，5，5：	1
14	Tumor vasculaturapotential therapeutic target显示文摘	Winslet MC Bradley NJ	1995	Br J Cancer1995，27，3：	1
15	Proliferation and p53expression in anal cancer precursor lesions显示文摘	Mullerat J Deroide F Winslet MC	2003	Anticancer Res2003，23，3：	1
16	Ischemia-reperfu- sion injury of the intestine and protective strategies against injury显示文摘	Mallick IH Yang W Winslet MC	2004	Dig Dis Sci2004，49，：	1
17	Discrimination is not impaired by excision of the anal transition zone after restorative prostocolectomy显示文摘	Winslet MC Yoshioka K	1987	Br J Surg1987，74，：	1
18	Tumor vasculature-a potential therapeutic target显示文摘	Baillie CT Winslet MC Bradley NJ	1995	Br J Cancer1995，72，：	1
19	Ischemia-reperfusion injury of the intestine and protective strategies against injury 显示文摘	Mallick IH Yang W Winslet MC	2004	Dig Dis Sei2004，49，9：	1
20	Ischemia-reperfusion injury of the intestine and protective strategies against injury显示文摘	Mallick IH Yang W Winslet MC		Digestive Diseases and Sciences0，，：	1

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