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| 1 | C-reactive protein is a prognostic indicator in patients with perihilar cholangiocarcinoma显示文摘AIM: To evaluate prognostic indicators for the outcome of patients with perihilar extrahepatic cholangiocarcinoma in an unselected cohort. METHODS: We retrospectively analyzed 98 patients with perihilar cholangiocarcinoma. Twenty-three patients (23.5%) underwent tumor resection. Patients with non- resectable tumors underwent either transpapillary or percutaneous transhepatic biliary drainage. Additionally, 32 patients (32.7%) received photodynamic therapy (PDT) and 18 patients (18.4%) systemic chemotherapy. Predefined variables at the time of diagnosis and characteristics considering the mode of treatment were entered into a Cox’s proportional hazards model. Included in the analysis were age, tumor stage following the modified Bismuth-Corlette classification, bilirubin, prothrombin time (PT), C-reactive protein (CRP), carbohydrate antigen 19-9 (CA19-9), history of weight loss, surgical resection, chemotherapy and PDT. RESULTS: The Kaplan-Meier estimate of overall median survival was 10.5 (95%CI: 8.4-12.6) mo. In the univariate analysis, low Bismuth stage, low CRP and surgical resection correlated significantly with better survival. In the multivariate analysis, only CRP (P = 0.005) and surgical resection (P = 0.029) were found to be independently predictive of survival in the cohort. Receiver operating characteristic (ROC) analysis identified a CRP level of 11.75 mg/L as the value associated with the highest sensitivity and specificity predicting a survival > 5 mo. Applying Kaplan-Meier analysis, patients with a CRP < 12 mg/L at the time of diagnosis had a signifi cantly longer median survival than patients with higher values (16.2 vs 7.6 mo; P = 0.009).CONCLUSION: This retrospective analysis identif ied CRP level at the time of diagnosis as a novel indicator for the prognosis of patients with perihilar cholangiocarcinoma. It should be evaluated in future prospective trials on this entity. | Thomas Gerhardt Sabine Milz Michael Schepke Georg Feldmann Martin Wolff Tilman Sauerbruch Franz Ludwig Dumoulin | 2006 | World Journal of Gastroenterology2006，12，34： | 5 |
| 2 | Complicated fecal microbiota transplantation in a tetraplegic patient with severe Clostridium difficile infection显示文摘A 65-year-old male suffering from acute spinal cord injury leading to incomplete tetraplegia presented with severe recurrent Clostridium difficile(C. difficile) infection subsequent to antibiotic treatment for pneumonia. After a history of ineffective antimicrobial therapies, including metronidazole, vancomycin, fidaxomicin, rifaximin and tigecycline, leading to several relapses, the patient underwent colonoscopic fecal microbiota transplantation from his healthy son. Four days subsequent to the procedure, the patient showed a systemic inflammation response syndrome. Without detecting an infectious cause, the patient received antimicrobial treatment, including tigecycline, metronidazole, vancomycin via polyethylene glycol and an additional enema for a period of seven days, leading to a prompt recovery and no reported C. difficile infection relapse during a 12 wk follow up. | Thorsten Brechmann Justyna Swol Veronika Knop-Hammad Jrg Willert Mirko Aach Oliver Cruciger Wolff Schmiegel Thomas A Schildhauer Uwe Hamsen | 2015 | World Journal of Gastroenterology2015，21，12： | 3 |
| 3 | STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo显示文摘 | Melanie Spitzner Birte Roesler Christian Bielfeld Georg Emons Jochen Gaedcke Hendrik A. Wolff Margret Rave‐Fr?nk Frank Kramer Tim Beissbarth Julia Kitz Jürgen Wienands B. Michael Ghadimi Reinhard Ebner Thomas Ried Marian Grade | 2014 | Int J Cancer2014，，4： | 2 |
| 4 | Theory and application of passive SAW radio transponders as sensors 显示文摘 | Gerd scholl Thomas Ostertag Holger Scherr Ulrich Wolff Frank Schmidt | 1998 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control1998，45，5： | 1 |
| 5 | Dielectric properties of highly filled thermoplastics for printed circuit boards显示文摘 | Thomas Apeldorn C. Keilholz F. Wolff‐Fabris V. Altst?dt | 2012 | J. Appl. Polym. Sci2012，，6： | 1 |
| 6 | Elective groin irradiation is not indicated for patients with adenocarcinoma of the rectum extending to the anal canal显示文摘 | Noah Taylor Christopher Crane John Skibber Barry Feig Lee Ellis Jean-Nicholas Vauthey Stanley Hamilton Karen Cleary Ronelle Dubrow Thomas Brown Robert Wolff Paulo Hoff Nicholas Sanfilippo Nora Janjan | 2001 | International Journal of Radiation Oncology Biology Physics2001，，3： | 1 |
| 7 | Molecular characterization and spatial expression of the sunflower ABP1gene显示文摘 | Thomas C Meyer D Wolff M | 2003 | Plant Molecular Biology2003，52，5： | 1 |
| 8 | Molecular characterizationand spatial expression of the sunflower ABP1 gene 显示文摘 | Thomas C Meyer D Wolff M | 2003 | PlantMol Biol2003，52，5： | 1 |
| 9 | Molecular characterization and spatial expression of the sunflower ABP1 gene显示文摘 | Thomas Clement Meyer Denise Wolff Michel | 2003 | Plant Molecular Biology2003，52，： | 1 |
| 10 | Canaloplasty: Circumferential viscodilation and tensioning of Schlemm canal using a flexible microcatheter for the treatment of open-angle glaucoma in adults显示文摘 | Richard A. Lewis Kurt von Wolff Manfred Tetz Norbert Koerber John R. Kearney Bradford J. Shingleton Thomas W. Samuelson | 2009 | Journal of Cataract & Refractive Surgery2009，，5： | 1 |
| 11 | Contractile hyporesponsiveness of hepatic arteries in humans with cirrhosis: Evidence for a receptor-specific mechanism显示文摘 | Michael Schepke J?rg Heller Sebastian Paschke Julia Thomas Martin Wolff Markus Neef Max Malago Gerhard J. Molderings Ulrich Spengler Tilman Sauerbruch | 2001 | Hepatology2001，，5： | 1 |
| 12 | Molecular characterization and spatial expression of the sunflower ABP1 gene显示文摘 | Thomas C Meyer D Wolff M | 2003 | Plant Molecular Biology2003，52，： | 1 |
| 13 | Search algorithm for minium reliability index of earth slopes显示文摘 | Ahmed M Hassan Thomas F Wolff | 1999 | Journal of Geotechnical and Geoenvironmental Engineering1999，125，4： | 1 |
| 14 | Endometrial osteopontin, a ligand of β 3 -integrin, is maximally expressed around the time of the “implantation window”显示文摘 | Michael von Wolff Thomas Strowitzki Veronika Becker Claudia Zepf Siamak Tabibzadeh Christian J Thaler | 2001 | Fertility and Sterility2001，，4： | 1 |
| 15 | The 8,2 ka event from Greenland ice cores显示文摘 | Thomas E R Wolff E W Mulvaney R | 2007 | Quaternary Science Reviews2007，26，12： | 1 |
| 16 | Molecular characterization and spatial expression of the sunflower ABPI gene显示文摘 | Thomas Clement Meyer Denise Wolff Michel | 2003 | Plant Molecular Biology2003，52，： | 1 |
| 17 | Endometrial osteopontin, a ligand of beta3-integrin, is maximally ex- pressed a round the time of the ' implantation window' 显示文摘 | yon Wolff M Thomas S Veronika B | 2001 | Fertil Steril2001，76，： | 1 |
| 18 | Multimodality Therapy Offers a Chance for Cure in Patients with Pancreatic Adenocarcinoma Deemed Unresectable at First Operative Exploration显示文摘 | Mark J. Truty Ryan M. Thomas Matthew H. Katz Jean-Nicolas Vauthey Christopher Crane Gaury R. Varadhachary Robert A. Wolff James L. Abbruzzese Jeffrey E. Lee Jason B. Fleming | 2012 | Journal of the American College of Surgeons2012，，1： | 1 |
| 19 | Molecular characterization and spatial expression of the sunflower ABPI gene显示文摘 | Thomas C Meyer D Wolff M | 2003 | Plant Molecular Biology2003，52，4： | 1 |
| 20 | Academic quality improvement program:using quality improvement as tool for the accreditation of nursing edueation显示文摘 | Carroll V S Thomas G De Wolff D | 2006 | Qual Manag Health Care2006，15，4： | 1 |
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