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| 1 | Advances in hepatocellular carcinoma: Nonalcoholic steatohepatitis-related hepatocellular carcinoma显示文摘An increase in the prevalence of obesity and diabetes mellitus has been associated with the rise in non-alcoholic fatty liver disease(NAFLD). Two-thirds of the obese and diabetic populations are estimated to develop NAFLD. Currently, NAFLD is the most common etiology for chronic liver disease globally. The clinical spectrum of NAFLD ranges from simple steatosis, an accumulation of fat greater than 5% of liver weight, to nonalcoholic steatohepatitis(NASH), a more aggressive form with necroinflammation and fibrosis. Among the patients who develop NASH, up to 20% may advance to cirrhosis and are at risk for complications of end-stage liver disease. One of the major complications observed in patients with NASH-related cirrhosis is hepatocellular carcinoma(HCC), which has emerged as the sixth most common cancer and second leading etiology of cancer-related deaths worldwide. The incidence of HCC in the United States alone has tripled over the last three decades. In addition, emerging data are suggesting that a small proportion of patients with NAFLD may be at higher risk for HCC in the absence of cirrhosis - implicating obesity and diabetes mellitus as potential risk factors for HCC. | Fauzia Z Khan Ryan B Perumpail Robert J Wong Aijaz Ahmed | 2015 | World Journal of Hepatology2015，7，18： | 10 |
| 2 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 3 | Converting relational database into XML documents with DOM显示文摘 | Fong J Wong H K Cheng Z | 2003 | Information and Software Technology2003，45，6： | 1 |
| 4 | Ultraviolet spontaneous and stimulated emissions from ZnO microcrystallite thin films at room temperature 显示文摘 | Zu P Tang Z K Wong G K L | 1997 | Solid State Commun1997，，103： | 1 |
| 5 | A transmitting boundary for transient wave analysis显示文摘 | Wong H L Yang B P | 1984 | Science Sinica Series A1984，27，： | 1 |
| 6 | 显示文摘 | Zhang Z Handa Y P | 1998 | J Polym Sci Part B: Polym Phys1998，36，12： | 1 |
| 7 | General models for the supplier's all-unit quantity discount policy 显示文摘 | Weng Z K Wong R T | 1993 | Naval Research Logistics (S0894-069X)1993，40，6： | 1 |
| 8 | Isolation and characterization endophytic bacteria from Sedum alfredii Hance and their potential to promote phytoextraction of zinc polluted soil 显示文摘 | LONG X X CHEN X M CHEN Y G WONG J W WEI Z B WU Q T | 2010 | World Journal Microbiology Biotechnology2010，27，： | 1 |
| 9 | Recent advancement on technical requirements for grid integration of wind power显示文摘 | Liu X G Xu Z Wong K P | 2013 | Journal of Modern Power System and Clean Energy2013，1，3： | 1 |
| 10 | Clq/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepeatic glucose output显示文摘 | Peterson JM Wei Z Wong GW | 2010 | J Biol Chem2010，285，39： | 1 |
| 11 | Structures and electrochromic properties of tungsten oxide films prepared by magnetron sputtering显示文摘 | Yang T S Lin Z R Wong M S | 2005 | Applied Surface Science2005，252，5： | 1 |
| 12 | Phosphorescent Platinum (II) Complexes Derived from Multifunctional Chromophores: Synthesis, Structures, Photophysics, and Electroluminescence 显示文摘 | H Z Wong W Y Yu X Y | 2006 | Inorg Chem2006，45，10： | 1 |
| 13 | A transmitting boundary for transient wave analysis 显示文摘 | Liao Z P Wong H L Yang B P | 1984 | Scientia Sinica (Series A)1984，27，4： | 1 |
| 14 | Protein tyrosine kinase - dependent modulation of voltage- dependent potassium channels by genistein in rat cardiac ventricular myocytes显示文摘 | Gao Z Lau CP Wong TM | 2004 | Cell Signal2004，16，3： | 1 |
| 15 | Room-temperature Ultraviolet Laser Emission from Selfassembled ZnO Microcrystallite Thin Films 显示文摘 | Tang Z K Wong G K L Yu P | 1998 | Appl Phys Lett1998，72，25： | 1 |
| 16 | Modularity analysis and eommonality design: a framework for the top-down platform and produet family design 显示文摘 | LIU Z WONG Y S LEE K S | 2010 | lnt J Produetion Res2010，48，12： | 1 |
| 17 | Integral sliding- mode direct torque control of doubly-fed induction generators under unbalanced grid voltage 显示文摘 | CHEN S Z CHEUNG N WONG K C | 2010 | IEEE Trans on Energy Conversion2010，25，2： | 1 |
| 18 | Aerosol single scattering albedo estimated across China from a combination of ground and satellite measurements显示文摘 | Lee K Li Z Wong M | | 0，，： | 1 |
| 19 | Dysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication 显示文摘 | Gun Z Tilburgs T Wong B | 2014 | Proceedings of the National Academy of Sciences of the United States of America2014，111，14： | 1 |
| 20 | Biodegradation ability and dioxgenase genes of PAH-degrading Sphingomonas and Mycobacterium strains isolated from mangrove sediments显示文摘 | GUO C DANG Z WONG Y | 2010 | International Biodeterioration&Biodegradation2010，64，6： | 1 |
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