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| 1 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 2 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 3 | Filling Pattern of Volcanostratigraphy of Cenozoic Volcanic Rocks in the Changbaishan Area and Possible Future Eruptions显示文摘The Cenozoic volcanostratigraphy in the Changbaishan area had complex building processes.Twenty-two eruption periods have been determined from the Wangtian'e, Touxi, and Changbaishan volcanoes. The complex volcanostratigraphy of the Changbaishan area can be divided into four types of filling patterns from bottom to top. They are lava flows filling in valleys(LFFV), lava flows filling in platform(LFFP), lava flows formed the cone(LFFC), and pyroclastic Flow filling in crater or valleys(PFFC/V). LFFV has been divided into four layers and terminates as a lateral overlap. The topography of LFFV, which is controlled by the landform, is lens shaped with a wide flat top and narrow bottom.LFFP has been divided into three layers and terminates as a lateral downlap. The topography of LFFP is sheet and tabular shaped with a narrow top and wide bottom. It has large width to thickness ratio. It was built by multiple eruptive centers distributed along the fissure. The topography of LFFC, which is located above the LFFP, has a hummocky shape with a narrow sloping top and a wide flat bottom. It terminates as a later downlap or backstepping. It has large width to thickness ratio. It was built by a single eruptive center. The topography of PFFC/V, which located above the LFFC, LFFP, or valley, has the shape of fan and terminates as a lateral downlap or overlap. It has a small width to thickness ratio and was built by a single eruptive center. The filling pattern is controlled by temperature, SiO_2 content,volatile content, magma volume, and the paleolandform. In the short term, the eruptive production of the Changbaishan area is comenditic ash or pumice of a Plinian type eruption. The eruptive volume in future should be smaller than that of the Baguamiao period, and the filling pattern should be PFFC/V,which may cause huge damage to adjacent areas. | TANG Huafeng KONG Tan WU Chengzhi WANG Pujun PENG Xu GAO Youfeng | 2017 | Acta Geologica Sinica(English Edition)2017，91，5： | 4 |
| 4 | IMPROVED ROBUST H-INFINITY ESTIMATION FOR UNCERTAIN CONTINUOUS-TIME SYSTEMS显示文摘完整顺序的柔韧的评估者的设计为连续时间的 polytopic 被调查不明确的系统。主要目的是获得一个稳定的线性评估者以便评价错误系统与规定 H ∞变细水平仍然保持要用体力地稳定。第一,一个简单其他的证明为性能最近建议了的 H ∞的一个改进 LMI 代表被给。基于阻止 Lyapunov 矩阵系统的产品的表演标准动态矩阵,为柔韧的评估者的存在的一个足够的条件以线性矩阵不平等被提供。建议设计策略允许参数依赖者 Lyapunov 功能的使用,这被显示出;因此它不比更早的结果保守。一个数字例子被采用说明可行性;建议设计的优点。 | Aiguo WU Huafeng DONG . Guangren DUAN | 2007 | Journal of Systems Science & Complexity2007，20，3： | 4 |
| 5 | Petrologic indicators of prograde metamorphism in Paleoproterozoic garnet mafic granulites from the Huai'an complex, North China Craton显示文摘Reconstruction of pressure-temperature-time(P-T-t)paths and thermal regimes are essential for inferring tectono-metamorphic processes involved in the formation of metamorphic terranes.However,the P-T information,especially the prograde evolution is generally preserved incompletely due to the fast intra-or inter-grains diffusion under high-temperatures.It may result | Jialin Wu Mingguo Zhai Huafeng Zhang Jinghui Guo Haozheng Wang Wenqiang Yang Hong Zhang Bo Hu | 2018 | Science Bulletin2018，63，2： | 2 |
| 6 | ADAPTABLE DESIGN IN PRODUCT DEVELOPMENT显示文摘一个最新新兴的设计模式,命名同样能适应的设计(广告) 瞄准开发从设计是能适应的到生活以后的周期的产品,被讨论。广告由四个主要阶段组成:当模特儿的产品,设计站台,特定的设计和产品重新设计。一个基于 newprocess 的设计数据模型(PDDM ) 被介绍它根据方便知识抽取的原则被组织,数据表示,布局,分享并且复用。基于 thePDDM,为产品系列开发的一个通用设计平台被建立,它有模块化的字符,参数驱动,变体设计,等等。站台的框架也为产生产品的一个家庭作为概念的结构和全面逻辑组织被建议。广告方法论成功地被适用开发为不同工程的无聊的机器(TBM ) 投射的隧道的一个家庭,与我们的发展中的队的效率极大地被增加。 | WU Qingming MEI Huafeng | 2006 | Chinese Journal of Mechanical Engineering2006，19，3： | 2 |
| 7 | Reassessment of the Distribution of Mantle CO_(2) in the Bohai Sea,China:The Perspective from the Source and Pathway System显示文摘Research on the distribution of mantle CO_(2)should involve comprehensive analysis from CO_(2)source to accumulation.The crust-mantle pathway system is the key controlling factor of the distribution of mantle CO_(2),but has received little attention.The pathway system and controlling factors of CO_(2)distribution in the Bohai Sea are analyzed using data on fault styles and information on the mantle and lithosphere.The relation between volcanic rocks and the distribution of mantle CO_(2)is reassessed using age data for CO_(2)accumulations.The distribution of mantle CO_(2)is controlled by uplift of the asthenosphere and upper mantle,magma conduits in the mantle and fault systems in the crust.Uplifted regions of the asthenosphere are accumulation areas for CO_(2).The area with uplift of the Moho exhibits accumulation of mantle CO_(2)at depth.CO_(2)was mainly derived from vertical migration through the upper mantle and lower crust.The fault style in the upper crust controls the distance of horizontal migration and the locations of CO_(2)concentrations.The distribution of mantle CO_(2)and volcanic rocks are not the same,but both probably followed the same pathways sometimes.Mantle CO_(2)in the Bohai Sea is concentrated in the Bozhong sag and the surrounding area,particularly in a trap that formed before 5.1 Ma and is connected to crustal faults(the Bozhang faults)and lithospheric faults(the Tanlu faults). | TANG Huafeng GUO Tianchan WU Keqiang LIU Zilin XU Jianyong LU Baoliang WANG Pujun | 2022 | Acta Geologica Sinica(English Edition)2022，96，1： | 2 |
| 8 | Research Review on Marine Search and Rescue显示文摘 | CHEN Xinqiang SHI Chaojian WANG Shengzheng WU Huafeng XU Tie KE Ruimin | 2017 | Journal of Shipping and Ocean Engineering2017，7，3： | 2 |
| 9 | A high-sensitivity MEMS gravimeter with a largedynamic range显示文摘Precise measurement of variations in the local gravitational acceleration is valuable for natural hazard forecasting,prospecting,and geophysical studies.Common issues of the present gravimetry technologies include their high cost,high mass,and large volume,which can potentially be solved by micro-electromechanical-system(MEMS)technology.However,the reported MEMS gravimeter does not have a high sensitivity and a large dynamic range comparable with those of the present commercial gravimeters,lowering its practicability and ruling out worldwide deployment.In this paper,we introduce a more practical MEMS gravimeter that has a higher sensitivity of 8μGal/√Hz and a larger dynamic range of 8000 mGal by using an advanced suspension design and a customized optical displacement transducer.The proposed MEMS gravimeter has performed the co-site earth tides measurement with a commercial superconducting gravimeter GWR iGrav with the results showing a correlation coefficient of 0.91. | Shihao Tang Huafeng Liu Shitao Yan Xiaochao Xu Wenjie Wu Ji Fan Jinquan Liu Chenyuan Hu Liangcheng Tu | 2019 | Microsystems & Nanoengineering2019，5，1： | 2 |
| 10 | Microstructure and properties of glycerol plasticized soy protein plastics containing castor oil显示文摘 | Huafeng Tian Wenqian Wu Gaiping Guo Bagen Gaolun Qingqing Jia Aimin Xiang | 2011 | Journal of Food Engineering2011，，3： | 2 |
| 11 | An ACOA-AFSA fusion routing algorithm for underwater wireless sensor network显示文摘 | WU Huafeng CHEN Xinqiang SHI Chaojian | 2012 | International Journal of Distributed Sensor Networks2012，2012，2012： | 1 |
| 12 | Influence of polyol plasticizers on the properties of polyvinyl alcohol films fabrica- ted by melt processing显示文摘 | Wu Wenqian Tian Huafeng Xiang Aimin | 2012 | Journal of Polymers and The Envi- ronment2012，20，1： | 1 |
| 13 | Cost-Effectiveness of Nucleoside Analog Therapy for Hepatitis B in China: A Markov Analysis显示文摘 | Bin Wu Te Li Huafeng Chen Jinfang Shen | 2010 | Value in Health2010，，5： | 1 |
| 14 | Highly regioselective Wittig reactions of cyclic ketones with a stabilized phosphorus ylide under controlled microwave heating显示文摘 | Wu Jinlong Wu Huafeng Wei Shaoyong | 2004 | Tetrahedron Lett2004，45，： | 1 |
| 15 | Creation of hydrophobic materials fabricated from soy protein and natural rubber;Surface,interface,and properties显示文摘 | Tian Huafeng Zhang Lina Wu Qiangxian | 2010 | Macromolecular Materials and Engineering2010，295，5： | 1 |
| 16 | Transfer Learning-Based Image Recognition of Nitrogen and Potassium Nutrient Stress in Rice显示文摘Nitrogen(N) and potassium(K) are essential elements for rice growth. When N and K are in deficient rice, specific symptoms appear on the leaves that are similar and difficult to distinguish with the naked eye. | CHEN Lisu LI Wei FENG Daolun WU Huafeng WANG Ke | 2023 | Rice science2023，30，2： | 1 |
| 17 | Tectonic Evolution and Key Geological Issues of the ProtoSouth China Sea显示文摘There are numerous controversies surrounding the tectonic properties and evolution of the Proto-South China Sea(PSCS).By combining data from previously published works with our geological and paleontological observations of the South China Sea(SCS),we propose that the PSCS should be analyzed within two separate contexts:its paleogeographic location and the history of its oceanic crust.With respect to its paleogeographic location,the tectonic properties of the PSCS vary widely from the Triassic to the mid-Late Cretaceous.In the Triassic,the Paleo-Tethys and the Paleo-Pacific Oceans were the major causes of tectonic changes in the SCS,while the PCSC may have been a remnant sea residing upon Tethys or Paleo-Pacific oceanic crust.In the Jurassic,the Meso-Tethys and the Paleo-Pacific oceans joined,creating a PSCS back-arc basin consisting of Meso-Tethys and/or Paleo-Pacific oceanic crust.From the Early Cretaceous to the midLate Cretaceous,the Paleo-Pacific Ocean was the main tectonic body affecting the SCS;the PSCS may have been a marginal sea or a back-arc basin with Paleo-Pacific oceanic crust.With respect to its oceanic crust,due to the subduction and retreat of the Paleo-Pacific plate in Southeast Asia at the end of the Late Cretaceous,the SCS probably produced new oceanic crust,which allowed the PSCS to formally emerge.At this time,the PSCS was most likely a combination of a new marginal sea and a remnant sea;its oceanic crust,which eventually subducted and became extinct,consisted of both new oceanic crust and remnant oceanic crust from the Paleo-Pacific Ocean.In the present day,the remnant PSCS oceanic crust is located in the southwestern Nansha Trough. | TIAN Zhiwen TANG Wu WANG Pujun ZHAO Zhigang SUN Xiaomeng TANG Huafeng | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 1 |
| 18 | Characteristics of the Density and Magnetic Susceptibility of Rocks in Northern Borneo and their Constraints on the Lithologic Identification of the Mesozoic Rocks in the Southern South China Sea显示文摘Based on the volume magnetic susceptibility and specific gravity measurements and mineral and lithologic identification results for 540 samples,the rock type,density,and magnetic susceptibility of rocks from northern Borneo were analyzed,and the applicability of gravity and magnetic data to the lithologic identification of the Mesozoic strata in the southern South China Sea was assessed accordingly.The results show that there are 3 types and 25 subtypes of rocks in northern Borneo,mainly intermediate-mafic igneous rocks and exogenous clastic sedimentary rocks,with small amounts of endogenous sedimentary rocks,felsic igneous rocks,and metamorphic rocks.The rocks that are very strongly-strongly magnetic and have high-medium densities are mostly igneous rocks,tuffaceous sandstones,and their metamorphic equivalents.The rocks that are weakly magnetic-non-magnetic and have medium-very low densities are mostly conglomerates,sandstones,siltstones,mudstones,and coal.The rocks that are weakly magnetic-diamagnetic and have highmedium densities are mostly limestones and siliceous rocks.The Cenozoic rocks are characterized by low densities and medium susceptibilities;the Mesozoic rocks are characterized by medium densities and medium-high susceptibilities;and the pre-Mesozoic rocks are characterized by high densities and low magnetism.Based on these results and the distribution characteristics of the various rock types,it was found that the pre-Mesozoic rocks produce weak regional gravity anomalies;the Mesozoic sedimentary rocks produce negative regional gravity anomalies;whereas the Mesozoic igneous rocks produce positive regional gravity anomalies;and the Cenozoic igneous rocks produce positive regional gravity anomalies.The regional high magnetic anomalies in the southern part of the South China Sea originate from the Mesozoic mafic igneous rocks and their metamorphic equivalents;and the regional medium magnetic anomalies may be produced by the felsic igneous rocks and their metamorphic equivalents.Accordingly,the identification of the Mesozoic lithology in the southern South China Sea shows that the Mesozoic sedimentary rocks are distributed over a large area of the southern South China Sea.Thus,it is concluded that the Mesozoic strata in this area have the potential for oil and gas exploration. | TANG Huafeng ZHAO Zhigang TIAN Zhiwen LU Baoliang TANG Wu HE Kailun ZHU Chenxi WANG Pujun | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 1 |
| 19 | Influence of Polyol Plasticizers on the Properties of Polyvinyl Alcohol Films Fabricated by Melt Processing显示文摘 | Wu Wenqian Tian Huafeng Xiang Aimin | 2012 | Journal of Polymers and theEnvironment2012，20，1： | 1 |
| 20 | Real-world outcomes of niraparib treatment in patients with ovarian cancer:amulticenter non-interventional study in China显示文摘Dear Editor,Ovarian cancer remains the deadliest among all gynecological cancers.Although most patients at advanced stage respond to initial treatment,the majority experience recurrence[1].It was estimated that 55,342 new cases and 37,519 deaths from ovarian cancer occurred in China annually[2].Contemporarily,the treatment landscape has changed rapidly since the role of poly(adenosine diphosphate-ribose)polymerase inhibitors(PARPi)in ovarian cancer treatmentwas explored.Based on data from the PRIMA/ENGOT-OV26/GOG-3012[3]and ENGOTOV16/NOVA trials[4],niraparib has been approved globally as maintenance therapy for newly diagnosed and platinum-sensitive recurrent ovarian cancer.The indication of niraparib for salvage treatment was based on the results of the QUADRA(NCT02354586)trial[5].Although niraparib has been tested in prospective randomized clinical trials(RCTs),no multicenter study on its real-world application in China had been conducted.Considering the differences in population,accessibility and affordability of drugs,the results of the real-world settings may differ from those of RCTs.Therefore,we conducted this multicenter,non-interventional study at 8 hospitals. | Jin Li Jianhua Yang Huafeng Shou Lin Zhang Xiaohong Huang Xuedong Tang Fei Zheng Fang Liu Hao Wen Huijuan Yang Huaying Wang Ziting Li Xiaojun Chen Xingzhu Ju Xi Cheng Jie Tang Meiqin Zhang Xiaohua Wu | 2023 | Cancer Communications2023，43，6： | 0 |
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