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| 1 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 2 | Synthesis and characterization of Y- doped SnO2 as sensor materials 显示文摘 | Li Chao Bi Lei Fang Shanming Xu Jiaqiang Gui Yanghai Wu Shide Chen Rongfeng | 2007 | Journal of Rare Earths2007，25，： | 1 |
| 3 | NH_(4)Cl-assisted preparation of single Ni sites anchored carbon nanosheet catalysts for highly efficient carbon dioxide electroreduction显示文摘Single-atomic transition metal-nitrogen codoped carbon(M-N-C)are efficient substitute catalysts for noble metals to catalyze the electrochemical CO_(2) reduction reaction(CO_(2)RR).However,the uncontrolled aggregations of metal and serious loss of nitrogen species constituting the M-N_(x) active sites are frequently observed in the commonly used pyrolysis procedure.Herein,single-atomic nickel(Ni)-based sheet-like electrocatalysts with abundant Ni-N_(4) active sites were created by using a novel ammonium chloride(NH_(4)Cl)-assited pyrolysis method.Spherical aberration correction electron microscopy and X-ray absorption fine structure analysis clearly revealed that Ni species are atomically dispersed and anchored by N in Ni-N_(4) structure.The addition of NH_(4)Cl optimized the mesopore size to 7-10 nm and increased the concentrations of pyridinic N(3.54 wt%)and Ni-N_(4)(3.33 wt%)species.The synergistic catalytic effect derived from Ni-N_(4) active sites and pyridinic N species achieved an outstanding CO_(2) RR performance,presenting a high CO Faradaic efficiency(FE_(CO))up to 98% and a large CO partial current density of 8.5 mA cm^(-2) at a low potential of-0.62 V vs.RHE.Particularly,the FE_(CO) maintains above 80% within a large potential range from -0.43 to -0.73 V vs.RHE.This work provides a practical and feasible approach to building highly active single-atomic catalysts for CO_(2) conversion systems. | Dan Ping Feng Yi Guiwei Zhang Shide Wu Shaoming Fang Kailong Hu Ben Bin Xu Junna Ren Zhanhu Guo | 2023 | Journal of Materials Science & Technology2023，，11： | 0 |
| 4 | Low-temperature superplasticity of ZK40 magnesium alloy processed using equal channel angular pressing显示文摘Microstructure evolution and superplastic behaviors of ZK40 magnesium alloy were investigated in the temperature range of 473~623 K. Transmission electron microscopy (TEM) was used to study the microstructure changes, twinning occurred significantly after being processed by equal channel angular pressing (ECAP) for one pass through the die, the mean grain size was 5.6μm. Finer grains can be obtained after further processing through ECAP, the average grain size of the alloy processed by ECAP for three passes was as low as 0.8 μm; this alloy exhibited low temperature superplasticity at 473~523 K, elongations obtained at the same initial strain rate of 1×10-3 s-1 were 260% at 473 K and 612% at 523 K, respectively. Corresponding values for the ZK40 alloy processed by ECAP for only one pass were 124% at 473 K and 212% at 523 K, respectively; poor superplastic behavior of this material was related to the long-range stresses associated with the non-equilibrium grain boundaries within the coarse grains. The incompatibility between fine and coarse grains was thought to be unfavorable to the improvement of superplasticity. | Li LIN Lijia CHEN Wei WU ZHENG Liu Teng LIU Shiding WU | 2004 | China Foundry2004，1，1： | 0 |
| 5 | Smart control system for the precision cultivation of black fungus显示文摘Black fungus,with high nutritional and medicinal value,has been cultivated in China for a long time,and Heilongjiang alone accounts for about 40%of the global output.At present,the cultivation of black fungus derives mainly from the inheritance of relatively primitive practices and experience of farmers,resulting in inconsistent quality of fungus.In this study,a smart control system for the precision cultivation of black fungus was designed by using intelligent detection and control technology.The system includes a precision culture test environment and remote control system.The precision cultivation environment contains four sub-independent environments.The key parameters such as temperature,humidity,and light behavior were collected and can be adjusted individually,according to the precision cultivation stages.The intelligent remote control system included a controller cabinet,sensors unit,temperature control unit,humidity control unit,light control unit,and information transmitting unit.The controller cabinet includes a key controller which can auto-control the temperature,humidity,and lightly adjust components according to the precision cultivation conditions and processing.The temperature sensors were installed in a 3D array close to the fungus bags about 5 cm in rooms.The light tape was installed on the six walls and also had three colors(Red,Blue,and Green)which could be controlled independently in each room.The control strategy through the analysis of the data collected by all sensors,the current cultivate situation of the cultivation environment was obtained,and the heater,fan,light,and nozzle were regulated according to the strategy to maintain a suitable precision cultivation environment for fungus.To verify the feasibility of the precision cultivation processing and control system,the test result shows that the error of temperature control was about 0℃-1℃,the error of humidity control was about 1%-4%,and the error of illuminance control was about 0-50 lx;All the verification results show that the control system for precision cultivation has high precision and can meet the needs of exploring the'Black 29'fungus cultivation experiment environment.Based on the orthogonal experiment,the best combination of the temperature and humidity for each growth stage was also investigated in this study,further proving the reliability and feasibility of the control system for the precision cultivation of Auricularia auricula. | Yongcheng Jiang Jianjun Li Yang Li Shide Li Xin Song Haiyun Wu Shiwei Zhu | 2023 | International Journal of Agricultural and Biological Engineering2023，16，1： | 0 |
| 6 | Designing interstitial boron-doped tunnel-type vanadium dioxide cathode for enhancing zinc ion storage capability显示文摘Chemical doping is a powerful method to intrinsically tailor the electrochemical properties of electrode materials.Here,an interstitial boron-doped tunnel-type VO_(2)(B)is constructed via a facile hydrothermal method.Various analysis techniques demonstrate that boron resides in the interstitial site of VO_(2)(B)and such interstitial doping can boost the zinc storage kinetics and structural stability of VO_(2)(B)cathode during cycling.Interestingly,we found that the boron doping level has a saturation limit peculiarity as proved by the quantitative analysis.Notably,the 2 at.%boron-doped VO_(2)(B)shows enhanced zinc ion storage performance with a high storage capacity of 281.7 mAh g^(-1) at 0.1 A g^(-1),excellent rate performance of 142.2 mAh g^(-1) at 20 A g^(-1),and long cycle stability up to 1000 cycles with the capacity retention of 133.3 mAh g^(-1) at 5 A g^(-1).Additionally,the successful preparation of the boron-doped tunneltype α-MnO_(2) further indicates that the interstitial boron doping approach is a general strategy,which supplies a new chance to design other types of functional electrode materials for multivalence batteries. | Shiwen Wang Hang Zhang Kang Zhao Wenqing Liu Nairui Luo Jianan Zhao Shide Wu Junwei Ding Shaoming Fang Fangyi Cheng | 2023 | Carbon Energy2023，5，8： | 0 |
| 7 | DISTRIBUTION OF HYDROGEN NEAR NOTCH TIP UNDER MODE Ⅰ LOADING显示文摘Distribution of hydrogen near crack tiphas long been recognized as a major factor inhydrogen induced cracking.It governs manyaspects,such as the location where the prima-ry crack occurs,the way that crack propa-gates,etc.Therefore understanding of distri-bution of hydrogen near crack tip is of im-portant significance.The first relationship be- | WU Shiding CHEN Lian Institute of Metal Research,Academia Sinica,Shenyang,ChinaLIU Minzhi Chengdu University of Science and Technology,Chengdu,China WU Shiding,Institute of Metal Research,Academia Sinica,Shenyang 110015,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，5： | 0 |
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