|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 2 | Animal experiment study of modified bionic collagen membrane显示文摘 | Zheng Guicheng Liang Huanyou Wu Zhiling | 2012 | Chin J Stomatol Res (Electronic Edition)2012，6，3： | 1 |
| 3 | Specific Regulation of m^(6)A by SRSF7 Promotes the Progression of Glioblastoma显示文摘Serine/arginine-rich splicing factor 7(SRSF7),a known splicing factor,has been revealed to play oncogenic roles in multiple cancers.However,the mechanisms underlying its oncogenic roles have not been well addressed.Here,based on N6-methyladenosine(m^(6)A)co-methylation network analysis across diverse cell lines,we find that the gene expression of SRSF7 is positively correlated with glioblastoma(GBM)cell-specific m^(6)A methylation.We then indicate that SRSF7 is a novel m^(6)A regulator,which specifically facilitates the m^(6)A methylation near its binding sites on the mRNAs involved in cell proliferation and migration,through recruiting the methyltransferase complex.Moreover,SRSF7 promotes the proliferation and migration of GBM cells largely dependent on the presence of the m^(6)A methyltransferase.The two m^(6)A sites on the mRNA for PDZ-binding kinase(PBK)are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2).Together,our discovery reveals a novel role of SRSF7 in regulating m^(6)A and validates the presence and functional importance of temporal-and spatial-specific regulation of m^(6)A mediated by RNA-binding proteins(RBPs). | Yixian Cun Sanqi An Haiqing Zheng Jing Lan Wenfang Chen Wanjun Luo Chengguo Yao Xincheng Li Xiang Huang Xiang Sun Zehong Wu Yameng Hu Ziwen Li Shuxia Zhang Geyan Wu Meisongzhu Yang Miaoling Tang Ruyuan Yu Xinyi Liao Guicheng Gao Wei Zhao Jinkai Wang Jun Li | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 4 | The ecological response of natural phytoplankton population and related metabolic rates to future ocean acidification显示文摘Ocean acidifi cation(OA)and global warming-induced water column stratification can signifi cantly alter phytoplankton-related biological activity in the marine ecosystem.Yet how these changes may play out in the tropical Indian Ocean remains unclear.This study investigated the ecological and metabolic responses of the different phytoplankton functional groups to elevated CO_(2) partial pressure and nitrate deficiency in two different environments of the eastern Indian Ocean(EIO).It is revealed that phytoplankton growth and metabolic rates are more sensitive to inorganic nutrients rather than CO_(2).The combined interactive effects of OA and N-limitation on phytoplankton populations are functional groupspecific.In particular,the abundance and calcification rate of calcifying coccolithophores are expected to be enhanced in the future EIO.The underlying mechanisms for this enhancement may be ascribed to coccolithophore’s lower carbon concentrating mechanisms(CCMs)efficiency and OA-induced[HCO^(-)_(3)]increase.In comparison,the abundance of non-calcifying microphytoplankton(e.g.,diatoms and dinoflagellates)and primary productivity would be inhibited under those conditions.Diff erent from previous laboratory experiments,interspecifi c competition for resources would be an important consideration in the natural phytoplankton populations.These combined factors would roughly determine calcifying coccolithophores as“winners”and non-calcifying microphytoplankton as“losers”in the future ocean scenario.Due to the large species-specific differences in phytoplankton sensitivity to OA,comprehensive investigations on oceanic phytoplankton communities are essential to precisely predict phytoplankton ecophysiological response to ocean acidification. | Haijiao LIU Yuying ZHAO Chao WU Wenzhe XU Xiaodong ZHANG Guicheng ZHANG Satheeswaran THANGARAJ Jun SUN | 2022 | Journal of Oceanology and Limnology2022，40，3： | 0 |
| 5 | Morphology, ultrastructure and phylogeny of Cyanothece sp. (Cyanobacteriaceae: Cyanophyceae) isolated from the eastern Indian Ocean显示文摘One strain of unicellular greenish algae embedded by mucilage was successfully isolated from equatorial area in the Indian Ocean. Microscopic observation, ultrastructure features and genetic identification confirmed that the strain was closely related to Cyanothece sp., which was a cyanobacteria species with great ecological significance.Cells were solitary with oval or bacilliform shapes. Diameters of this strain were relatively small, ranging from 2.5 to 6.5 μm on average. Ultrastructure of cells was simple. Thylakoids were arranged parietal and keritomized content were observed in the thylakoid region. Various electron-transparent granules with low electron-dense region as well as cyanophycin or glycogen granules-like organelle and carbonxysomes were also observed. For pigment composition, the dominant pigments were chlorophyll a, β-Carotene, Zeaxanthin and an unknown pigment, contributing 23.8%, 26.1%, 14.7% and 15.7% to total pigments respectively. The phylogenetic analysis of16 S rRNA gene and nif H gene confirmed that Strain EIO409 was closely related with Cyanothece sp.. | ZHANG Xiaodong YANG Shuang SUN Jun WU Chao WANG Jing ZHANG Guicheng DING Changling | 2018 | Acta Oceanologica Sinica2018，37，10： | 0 |
| 6 | Epidemiological and Clinical Characteristics of COVID-19 in Adolescents and Young Adults显示文摘BACKGROUND Adolescents and young adults might play a key role in the worldwide spread of Coronavirus Disease 2019(COVID-19)because they are more likely to be involved in overseas study,business,work,and travel.However,the epidemiological and clinical characteristics remain unknown. | Jiaqiang Liao Shibing Fan Jing Chen Jianglin Wu Shunqing Xu Yuming Guo Chunhui Li Xianxiang Zhang Chuansha Wu Huaming Mou Chenxi Song Feng Li Guicheng Wu Jingjing Zhang Lian Guo Huawen Liu Jinglong Lv Lixin Xu Chunhui Lang | 2020 | The Innovation2020，1，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员