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| 1 | A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases--Wuhan,China 2019−2020显示文摘Emerging and re-emerging pathogens are great challenges to the public health(1).A cluster of pneumonia cases with an unknown cause occurred in Wuhan starting on December 21,2019.As of January 20,2020,a total of 201 cases of pneumonia in China have been confirmed.A team of professionals from the National Health Commission and China CDC conducted epidemiological and etiological investigations.On January 3,2020,the first complete genome of the novelβgenus coronaviruses(2019-nCoVs)was identified in samples of bronchoalveolar lavage fluid(BALF)from a patient from Wuhan by scientists of the National Institute of Viral Disease Control and Prevention(IVDC)through a combination of Sanger sequencing,Illumina sequencing,and nanopore sequencing.Three distinct strains have been identified,the virus has been designated as 2019-nCoV,and the disease has been subsequently named novel coronavirus-infected pneumonia(NCIP). | Wenjie Tan Xiang Zhao Xuejun Ma Wenling Wang Peihua Niu Wenbo Xu George F.Gao Guizhen Wu | 2020 | China CDC weekly2020，2，4： | 95 |
| 2 | Glacial distribution and mass balance in the Yarlung Zangbo River and its influence on lakes显示文摘Glaciers in the Yarlung Zangbo River witness severe glacial retreat nowadays,which gives important influence on lake processes in the region.We have studied glacial distribution,glacial mass balance and found large deficit in glacial mass and its impact in the region.Our study also integrated the variation in glacial-fed lakes of the Nam Co and Ranwu Lake,and presented an initial assessment of the impact of glacial mass balance on lakes.The study has shown a significant contribution of glacial melting to recent lake expansion and lake level rising. | YAO TanDong LI ZhiGuo YANG Wei GUO XueJun ZHU LiPing KANG ShiChang WU YanHong YU WuSheng | 2010 | Chinese Science Bulletin2010，55，20： | 34 |
| 3 | Tri-Co Robot: a Chinese robotic research initiative for enhanced robot interaction capabilities显示文摘Since the invention of the first industrial robot in 1959, the missions of robots have evolved from basic mechanical transfer or assistance to a diverse range of tasks through close interactions with environment, their human counterparts and robot peers. Through adaptation to uncertain and dynamic environments. | Han Ding Xuejun Yang Nanning Zheng Ming Li Yinan Lai Hao Wu | 2018 | National Science Review2018，5，6： | 24 |
| 4 | Spatial and vertical variations of perfluoroalkyl substances in sediments of the Haihe River,China显示文摘The levels of six perfluoroalkyl substances(PFASs) in surface sediment and their vertical variations in dated sediment cores from the Haihe River were investigated; studied substances included perfluorooctanoic acid(PFOA),perfluorononanoic acid(PFNA),perfluorooctane sulfonate(PFOS),perfluorodecanoic acid(PFDA),perfluoroundecanoic acid(PFUnA),and perfluorododecanoic acid(PFDoA). Results showed that the total PFAS concentration in surface sediment ranged between 0.52 and 16.33 ng/g dry weight(dw) with an average of3.47 ng/g dw,with PFOS and PFOA as the dominant PFASs. In general,the PFAS concentrations in the mainstream increased from the upper to the lower reaches,except that a drop occurred downstream of the Erdao dam. Although the PFASs in the sediment cores did not show a clear decreasing or increasing trend with depth,the three cores had a similar vertical variation.The PFAS levels were relatively low in the surface sediment,and reached the first high point at8–20 cm as a result of the wide use of PFASs from 1990 to 2000. After that the PFAS levels decreased,and then increased to a second high point at about 40–48 cm,which might be caused by the leaching of PFASs in sediment. Because PFASs have hydrophilic groups and relatively high solubility,the PFASs will transfer from the upper to lower layers of sediment when water infiltration occurs,leading to the fluctuation of PFAS levels in sediment cores. This study suggests that both the temporal variation of sources and transfer processes of PFASs in sediments are important factors influencing the vertical variation of PFASs in sediment cores. | Xiuli Zhao Xinghui Xia Shangwei Zhang Qiong Wu Xuejun Wang | 2014 | Journal of Environmental Sciences2014，26，8： | 8 |
| 5 | Contribution of atmospheric nitrogen deposition to diffuse pollution in a typical hilly red soil catchment in southern China显示文摘Atmospheric nitrogen(N) deposition is currently high and meanwhile diffuse N pollution is also serious in China. The correlation between N deposition and riverine N export and the contribution of N deposition to riverine N export were investigated in a typical hilly red soil catchment in southern China over a two-year period. N deposition was as high as 26.1 to55.8 kg N/(ha·yr) across different land uses in the studied catchment, while the riverine N exports ranged from 7.2 to 9.6 kg N/(ha·yr) in the forest sub-catchment and 27.4 to30.3 kg N/(ha·yr) in the agricultural sub-catchment. The correlations between both wet N deposition and riverine N export and precipitation were highly positive, and so were the correlations between NH4+-N or NO3--N wet deposition and riverine NH4+-N or NO3--N exports except for NH4+-N in the agricultural sub-catchment, indicating that N deposition contributed to riverine N export. The monthly export coefficients of atmospheric deposited N from land to river in the forest sub-catchment(with a mean of 14%) presented a significant positive correlation with precipitation, while the monthly contributions of atmospheric deposition to riverine N export(with a mean of 18.7% in the agricultural sub-catchment and a mean of 21.0% in the whole catchment) were significantly and negatively correlated with precipitation. The relatively high contribution of N deposition to diffuse N pollution in the catchment suggests that efforts should be done to control anthropogenic reactive N emissions to the atmosphere in hilly red soil regions in southern China. | Jianlin Shen Jieyun Liu Yong Li Yuyuan Li Yi Wang Xuejun Liu Jinshui Wu | 2014 | Journal of Environmental Sciences2014，26，9： | 7 |
| 6 | Pathogenic effects of biofilm with chronic pseudomonas aeruginosa lung infection in rats显示文摘Objective:To establish an animal model of P.aeruginosa biofilm associated with chronic pulmonary infection and investigate the pathogenic effects of biofilm.Methods:Experiments in vitro,measuring the MICS,MBCS of levofloxacin(LFX),ceftazidime(CAZ)in PAO579 in alginate beads and planktonic PAO579.Rats were challenged with 0.1 ml of PAO579(109CFU/ml)in alginate beads or 0.1 ml of planktonic PAO579(109 CFU/ml),3,7,14 days after challenging,bacteriological,pathological features were observed.Results:The MICS,MBCS of LFX,CAZ in PAO579 in alginate beads were higher than those in planktonic PAO579 in vitro.CFU/lung in alginate beads group was significantly higher than that in planktonic bacteria group(P = 0.002,P = 0.004,P = 0.002,respectively);macroscopic lung pathology and the inflammation in alginate beads group were significantly more severe compared to those in planktonic bacteria group in vivo.Conclusion:P.aeruginosa biofilm protected bacterium from killing of antibiotics and might mediate the host immune damage in the lung tissue and made bacterium evade the host immune defense. | Ping Yan Yiqiang Chen Zhijun Song Hong Wu Jinliang Kong Xuejun Qin | 2008 | Journal of Nanjing Medical University2008，22，1： | 7 |
| 7 | Carbon-based derivatives from metal-organic frameworks as cathode hosts for Li–S batteries显示文摘Lithium-sulfur batteries(Li–S batteries) are promising candidates for the next generation high-energy rechargeable Li batteries due to their high theoretical specific capacity(1672 m Ahg-1) and energy density(2500 Wh kg-1). The commercialization of Li–S batteries is impeded by several key challenges at cathode side, e.g. the insulating nature of sulfur and discharged products(Li2S 2 and Li2S), the solubility of long-chain polysulfides and volume variation of sulfur cathode upon cycling. Recently, the carbonbased derivatives from metal-organic frameworks(MOFs) has emerged talent in their utilization as cathode hosts for Li–S batteries. They are not only highly conductive and porous to enable the acceleration of Li +/e-transfer and accommodation of volumetric expansion of sulfur cathode during cycling, but also enriched by controllable chemical active sites to enable the adsorption of polysulfides and promotion of their conversion reaction kinetics. In this review, based on the types of MOFs(e.g. ZIF-8, ZIF-67, Prussian blue, Al-MOF, MOF-5, Cu-MOF, Ni-MOF), the synthetic methods, formation process and morphology, structural superiority of MOFs-derived carbon frameworks along with their electrochemical performance as cathode host in Li–S batteries are summarized and discussed. | Qingping Wu Xuejun Zhou Jun Xu Fahai Cao Chilin Li | 2019 | Journal of Energy Chemistry2019，28，11： | 7 |
| 8 | A benchmark test of boson sampling on Tianhe-2 supercomputer显示文摘Boson sampling, thought to be intractable classically, can be solved by a quantum machine composed of merely generation, linear evolution and detection of single photons. Such an analog quantum computer for this specific problem provides a shortcut to boost the absolute computing power of quantum computers to beat classical ones. However, the capacity bound of classical computers for simulating boson sampling has not yet been identified. Here we simulate boson sampling on the Tianhe-2 supercomputer, which occupied the first place in the world ranking six times from 2013 to 2016. We computed the permanent of the largest matrix using up to 312 000 CPU cores of Tianhe-2, and inferred from the current most efficient permanent-computing algorithms that an upper bound on the performance of Tianhe-2 is one 50-photon sample per ~100 min. In addition, we found a precision issue with one of two permanent-computing algorithms. | Junjie Wu Yong Liu Baida Zhang Xianmin Jin Yang Wang Huiquan Wang Xuejun Yang | 2018 | National Science Review2018，5，5： | 6 |
| 9 | Bushen Qiangjin capsule(补肾强筋胶囊) inhibits the Wnt/β-catenin pathway to ameliorate papain-induced knee osteoarthritis in rats显示文摘OBJECTIVE:To evaluate the molecular mechanism underlying the beneficial effect of Bushen Qiangjin capsule(补肾强筋胶囊,BSQJ),a Traditional Chinese Medicine,on knee osteoarthritis(KOA).METHODS:In the present study,32 female Sprague-Dawley rats were randomly divided into four groups:control,KOA,high-dose BSQJ(H-BSQJ),and low-dose BSQJ(L-BSQJ).After successfully establishing the KOA model by intra-articular injection of papain,H-BSQJ and L-BSQJ groups were intragastrically administered 0.243 and 0.122 g/kg BSQJ,respectively,daily for 6 weeks.At the end of the experiment,knee articular cartilage tissues of rats were collected for evaluation by hematoxylin and eosin staining,Safranin O-Fast Green staining,and terminal deoxynucleotidyl transferase-mediated d UTP nick-end labeling assay.Serum interleukin-1βand tumor necrosis factor-αlevels of rats were detected with an enzyme-linked immunosorbent assay method.Gene expression of Wnt-4,β-catenin,Frizzled-2,glycogen synthase kinase-3β(GSK-3β),cysteinyl aspartate-specific proteinases 3 and 9(caspases 3 and 9),collagen typeⅡalpha 1(Col2 a1),and matrix metalloproteinases 1 and 13(MMP-1 and MMP-3)of rat knee articular cartilage was quantified by reverse transcription-quantitative polymerase chain reaction analysis.Wnt-4,β-catenin,Frizzled-2,GSK-3β,cleaved caspase-3,and cleaved caspase-9 protein expression in rat knee articular cartilage was determined by western blot analysis.RESULTS:BSQJ obviously reduced pathological damage and matrix degradation of articular cartilage in KOA rats.Compared with the KOA group,H-BSQJ rats exhibited downregulated m RNA and protein expression of Wnt-4,β-catenin,Frizzled-2,and caspase-3,as well as upregulated m RNA and protein expression of GSK-3β.In addition,H-BSQJ significantly increased m RNA expression of Col2 a1 and decreased m RNA expression of MMP-1 and MMP-13.CONCLUSION:BSQJ exerted a beneficial effect on KOA by a mechanism involving downregulation of the Wnt/β-catenin pathway,which inhibited both cartilage extracellular matrix degradation and chondrocyte apoptosis to ameliorate KOA in rats. | YAO Nan CHEN Guocai LU Yanyan XU Xuemeng ZHAO Chuanxi HUANG Xuejun LIU Wengang PENG Sha WU Huai | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 5 |
| 10 | Review of Theory and Methods of Image Segmentation显示文摘Image segmentation refers to the technique and process of partitioning a digital image into multiple segments based on image characteristics so as to extract the object of interest from it. It is a key step from image processing to image analysis. In the mid-1950 s,people began to study image segmentation. For decades,various methods for image segmentation have been proposed. In this paper,traditional image segmentation methods and some new methods appearing in recent years were reviewed. Thresholding segmentation methods,region-based,edge detection-based and segmentation methods based on specific theoretical tools were introduced in detail. | Xuejun WU | 2018 | Agricultural Biotechnology2018，7，4： | 5 |
| 11 | 氮沉降模拟实验亟待研究大气氨浓度增加的影响显示文摘大气活性氮污染及其过量沉降是全球变化重要议题。为研究氮沉降对自然生态系统结构和功能的影响,基于喷淋加氮的控制实验在草地或林下广泛开展。该实验体系假定氮沉降是通过增加土壤氮的有效性从而影响整个生态系统,没有考虑植被与大气活性氮的相互作用,也未能反映氮沉降以干沉降为主的自然过程。考虑到大气氨是氮沉降的主要前体物,且全球氨气浓度呈现上升趋势,未来的氮沉降模拟实验亟待研究氨气干沉降的重要影响,以期更加完整的刻画大气氮沉降过程及其生态环境效应。 | PAN Yuepeng TIAN Shili WU Dianming XU Wen ZHU Xiaying LIU Chunyan LI Dejun FANG Yunting DUAN Lei LIU Xuejun WANG Yuesi | 2020 | Atmospheric and Oceanic Science Letters2020，13，3： | 5 |
| 12 | Discovery and implications of catenary-bead subaqueous dunes显示文摘Measurements of topography at the segment of bifurcation between the South Channel and North Channel in the Yangtze Estuary were conducted, and a new type of subaqueous dune was discovered. This structure, newly defined as a catenary-bead dune, consists of a catenary dune and its associated elliptical pit bedform. Based on this finding, the nomenclature of 'morphology of dune associated with accompanying bedform' is first proposed. The measured data indicate a mean height and wavelength of 1.29 m and 31.89 m, respectively; wavelength/height ratio(L/H) of 14 to 56; and elliptical pits of mean and maximum depth 0.98 m and 1.98 m, respectively. Flow information was obtained using an Acoustic Doppler Current Profile(ADCP), and the bed material components were gathered with a bottom sampler. The results show mean flood and ebb velocities of 0.27 and 0.78 m s?1, respectively, with shorter duration of flood tide than ebb tide. The silt, very fine sand, and fine sand fractions were within the ranges 21.6–23.4%, 28.2–32.2%, and 39.7–41.6%, respectively, revealing complex bed material composition. Water depth at the study site varies from 13 to 17 m. This finding will enrich the study of dunes and provide important data for geomorphological research. Moreover, the results are significant for engineering applications to estuaries. | ZHENG Shu Wei CHENG He Qin WU Shuai Hu LIU Gao Wei LU XueJun XU WenXiao | 2016 | Science China Earth Sciences2016，59，3： | 5 |
| 13 | Application of a Support Vector Machine Algorithm to the Safety Precaution Technique of Medium-low Pressure Gas Regulators显示文摘In the gas pipeline system, safe operation of a gas regulator determines the stability of the fuel gas supply, and the medium-low pressure gas regulator of the safety precaution system is not perfect at the present stage in the Beijing Gas Group; therefore, safety precaution technique optimization has important social and economic significance. In this paper, according to the running status of the medium-low pressure gas regulator in the SCADA system, a new method for gas regulator safety precaution based on the support vector machine(SVM) is presented. This method takes the gas regulator outlet pressure data as input variables of the SVM model, the fault categories and degree as output variables, which will effectively enhance the precaution accuracy as well as save significant manpower and material resources. | HAO Xuejun AN Xaioran WU BO HE Shaoping | 2018 | Journal of Thermal Science2018，27，1： | 5 |
| 14 | A Novel Resource Allocation Algorithm based on Downlink and Uplink Decouple Access Scheme in Heterogeneous Networks显示文摘Traditional cellular network requires that a user equipment(UE) should associate to the same base station(BS) in both the downlink(DL) and the uplink(UL). Based on dual connectivity(DC) introduced in LTE-Advanced R12, DL/UL decouple access scheme has been proposed, which is especially suitable for heterogeneous networks(Het Nets). This paper is the pioneer to take the DL/UL decouple access scheme into consideration and develop a novel resource allocation algorithm in a two-tier Het Net to improve the total system throughput in the UL and ease the load imbalance between macro base stations(MBSs) and pico base stations(PBSs). A model is formulated as a nonlinear integer programming, and the proposed algorithm is a sub-optimal algorithm based on the graph theory. First, an undirected and weighted interference graph is obtained. Next, the users are grouped to let users with large mutual interferences to be assigned to different clusters. Then, the users in different clusters are allocated to different resource blocks(RBs) by using the Hungarian algorithm. Simulation results show that the proposed algorithm can provide great promotions for both the total system throughput and the average cell edge user throughput and successfully ease the load imbalance between MBSs and PBSs. | Laiwei Jiang Xuejun Sha Xuanli Wu Naitong Zhang | 2016 | China Communications2016，13，6： | 4 |
| 15 | Revisiting the Concentration Observations and Source Apportionment of Atmospheric Ammonia显示文摘While China’s Air Pollution Prevention and Control Action Plan on particulate matter since 2013 has reduced sulfate significantly,aerosol ammonium nitrate remains high in East China.As the high nitrate abundances are strongly linked with ammonia,reducing ammonia emissions is becoming increasingly important to improve the air quality of China.Although satellite data provide evidence of substantial increases in atmospheric ammonia concentrations over major agricultural regions,long-term surface observation of ammonia concentrations are sparse.In addition,there is still no consensus on whether agricultural or non-agricultural emissions dominate the urban ammonia budget.Identifying the ammonia source by nitrogen isotope helps in designing a mitigation strategy for policymakers,but existing methods have not been well validated.Revisiting the concentration measurements and identifying source apportionment of atmospheric ammonia is thus an essential step towards reducing ammonia emissions. | Yuepeng PAN Mengna GU Yuexin HE Dianming WU Chunyan LIU Linlin SONG Shili TIAN Xuemei LÜ Yang SUN Tao SONG Wendell WWALTERS Xuejun LIU Nicholas AMARTIN Qianqian ZHANG Yunting FANG Valerio FERRACCI Yuesi WANG | 2020 | Advances in Atmospheric Sciences2020，37，9： | 4 |
| 16 | Efficacy of miacalcic in treating a hypercalcemia crisis caused by Williams-Beuren syndrome显示文摘Williams-Beuren syndrome (WBS) is a hereditary disease involving multiple systems due to microdeletion of chromosome 7q11.23.The deleted region in most patients is approximately 1.55 Mb,including 26-28 genes.The incidence of WBS in live-born children is roughly 1/7 500-1/25 000.1 The majority of WBS cases are sporadic;inheritance is autosomal dominant.The clinical manifestations of WBS include aortic valve stenosis alone or combined with other cardiovascular malformations,characteristic facies (full peri-orbital region,flat and short nose,upward pointingnose,long philtrum,wide mouth thick lips,and disorders of the teeth),temporary hypercalcemia,developmental retardation associated with mild-to-moderate dysgnosia,and personality changes.Salmon calcitonin (miacalcic) is widely used in the treatment of adult hypercalcemia crisis. | Gu Yi Gong Chunxiu Shen Ying Wu Di Liang Xuejun Chang Bo Liu Ying Wang Yi | 2014 | Chinese Medical Journal2014，，13： | 4 |
| 17 | Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana显示文摘Here,we report the identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge,Guyana.In March 2019,14 employees of Chongqing Bosai Mining Company,China,working in a manganese mining of Guyana,had unexplained fever,and two of them died.We obtained lung and brain tissues as well as the blood samples from the two deceased cases(patient No.1 and 2),and bronchoscopy lavages and cerebrospinal fluid samples from one severe case(patient No.3),respectively.All samples were tested by pathological examination,high-throughput sequencing,and real-time PCR.Pathological detection showed the presence of spore-like structures in the lung tissue of patient No.1,indicating a fungal infection in this patient.Nanopore sequencing identified the existing of H.capsulatum in the lung tissue sample within 13 h.Next-generation sequencing identified specific fragments of H.capsulatum in all of the samples tested(lung,brain and blood serum from the deceased cases,and plasma from the severe case).Real-time PCR assays did not reveal any viral infection related to transmission from bat feces.We conclude that H.capsulatum was the causative pathogen of this disease cluster based on epidemiologic,clinical,pathological and nucleic acid evidence. | Ji Wang Weimin Zhou Hua Ling Xiaoping Dong Yi Zhang Jiandong Li Yong Zhang Jingdong Song William J.Liu Yang Li Ruiqing Zhang Wei Zhen Kun Cai Shuangli Zhu Dongyan Wang Jinbo Xiao Yigang Tong Wenli Liu Lihua Song Wei Wu Yang Liu Xiang Zhao Ruihuan Wang Sheng Ye Jing Wang Roujian Lu Baoying Huang Fei Ye Wenwen Lei Rongbao Gao Qi Shi Cao Chen Jun Han Wenbo Xu George F.Gao Xuejun Ma Guizhen Wu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 18 | A memristor-based architecture combining memory and image processing显示文摘Image processing is a type of memory-access-intensive application and is applied in many fields.Logic operations are very simple ones in image processing.During these operations,memory access takes a majority of the total time consumed,which puts a great pressure on memory access speed and bandwidth.However,in traditional von Neumann architecture,memory access is the inherent bottleneck of the system;that is,the speed of memory’s data supply is far lower than the data request of processor.Memristor is considered to be the fourth circuit element after resistor,capacitor and inductor.It has the capacity of both processing and memory,which supplies a new idea for solving the'memory wall'problem.In this paper,memristor is used to build an architecture combining computing and memory,where the memory has the ability to handle some simple image processing operations.This architecture can reduce readings and writings of memory effectively,which saves memory bandwidth thus improving the efficiency of the system.Logic operations of images are considered in this paper to validate the architecture.The experimental results and theoretical analysis indicate that the architecture can reduce memory access effectively. | ZHOU Jing YANG XueJun WU JunJie ZHU Xuan FANG XuDong HUANG Da | 2014 | Science China(Information Sciences)2014，57，5： | 3 |
| 19 | Bottom Currents Observed in and Around a Submarine Valley on the Continental Slope of the Northern South China Sea显示文摘Bottom currents at about 1000 m depth in and around a submarine valley on the continental slope of the northern South China Sea were studied by a 14-month long experiment from July 2013 to September 2014. The observations reveal that bottom currents are strongly influenced by the topography, being along valley axis or isobaths. Power density spectrum analysis shows that all the currents have significant peaks at diurnal and semi-diurnal frequencies. Diurnal energy is dominant at the open slope site, which is consistent with many previous studies. However, at the site inside the valley the semi-diurnal energy dominates, although the distance between the two sites of observation is quite small(11 km) compared to a typical horizontal first-mode internal tide wavelength(200 km). We found this phenomenon is caused by the focusing of internal waves of certain frequencies in the valley. The inertial peak is found only at the open slope site in the first deployment but missing at the inside valley site and the rest of the deployments. Monthly averaged residual currents reveal that the near-bottom currents on the slope flow southwestward throughout the year except in August and September, 2013, from which we speculate that this is a result of the interaction between a mesoscale eddy and the canyon/sag topography. Currents inside the valley within about 10 mab basically flow along slope and in the layers above the 10 mab the currents are northwestward, that is, from the deep ocean to the shelf. The monthly mean current vectors manifest an Ekman layer-like vertical structure at both sites, which rotate counter-clockwise looking from above. | WU Lunyu XIONG Xuejun LI Xiaolong SHI Maochong GUO Yongqing CHEN Liang | 2016 | Journal of Ocean University of China2016，15，6： | 3 |
| 20 | Clinical features and predictors of remission in children under the age of 7 years with Graves’disease显示文摘Importance:Graves’disease(GD)is rare in children under the age of 7 years.Children with this disease exhibit greater thyrotoxicity at diagnosis and require a longer course of medical therapy,compared with pubertal and postpubertal children and adults.Objective:To investigate the clinical features and identify predictors of remission in children under the age of 7 years with GD.Methods:This retrospective study included 77 children who were diagnosed with GD under the age of 7 years and were treated in the Department of Endocrinology,Beijing Children’s Hospital from 2010 to 2018.Clinical manifestations,laboratory data,and follow-up records were collected for all patients.Children who achieved remission of treatment with methimazole were compared with those who had persistent disease to identify which variables were associated with remission;multiple logistic regression and Cox regression analyses were used to evaluate interactions among predictive variables.Results:Sixty-three boys and 14 girls were included;the median age at diagnosis was 4.2 years(interquartile range:3.2-5.3 years).Forty-six(56.7%)patients had no family history of thyroid disease,17 patients had family history of thyroid disease and 14 patients with unknown family history.Of the 77 patients,18(23.4%)patients achieved remission of treatment with methimazole and 59 patients did not;moreover,51(66.2%)had Graves’ophthalmopathy.Univariate analyses revealed no significant differences between the remission group and non-remission group in terms of age at diagnosis,sex,initial goiter size,or initial thyroid hormone concentration.However,there were a trend of correlation between the initial level of thyroid peroxidase antibody(TPOAb)and remission status(univariate analysis OR 1.002,P=0.038;multivariate analysis OR 1.004,P=0.019).Similar results were observed in univariate analysis of the initial thyrotropin receptor antibody(TRAb)level,but this association was not significant in multivariate analysis.Cox regression analyses revealed that children with high TRAb level required longer duration of remission,compared with low TRAb level(OR 0.950,95%CI 0.904-0.997,P=0.037).Interpretation:Initial TRAb level was an independent predictor of remission outcome in young children under the age of 7 years with GD.Initial TRAb level may predict the likelihood of remission in patients with young-age-of-onset GD. | Yi Gu Xuejun Liang Ming Liu Di Wu Wenjing Li Bingyan Cao Yuchuan Li Chang Su Jiajia Chen Chunxiu Gong | 2020 | Pediatric Investigation2020，4，3： | 3 |
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