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| 1 | Progress in achieving high-performance piezoresistive and capacitiveflexible pressure sensors: A review显示文摘Electronic skin(e-skin) and flexible wearable devices are currently being developed with broad application prospects. Transforming electronic skin(e-skin) into true ¨skin¨is the ultimate goal. Tactile sensing is a fundamental function of skin and the development of high-performance flexible pressure sensors is necessary to realize thus. Many reports on flexible pressure sensors have been published in recent years,including numerous studies on improving sensor performance, and in particular, sensitivity. In addition,a number of studies have investigated self-healing materials, multifunctional sensing, and so on. Here,we review recent developments in flexible pressure sensors. First, working principles of flexible pressure sensors, including piezoresistivity, capacitance, and piezoelectricity, are introduced, as well as working mechanisms such as triboelectricity. Then studies on improving the performance of piezoresistive and capacitive flexible pressure sensors are discussed, in addition to other important aspects of this intriguing research field. Finally, we summarize future challenges in developing novel flexible pressure sensors. | Wufan Chen Xin Yan | 2020 | Journal of Materials Science & Technology2020，36，8： | 19 |
| 2 | The non-canonical Hippo/Mst pathway in lymphocyte development and functions显示文摘正规 Hippo/Mst 小径,原来在果蝇发现了,以它在支持 apoptosis,禁止房间增长和 tumorigenesis,并且调整织物的功能著名新生。然而,新兴的证据证明多重不在经典中的河马发信号小径也在许多其他的生物过程的规定被含有。最近的研究揭示了那 Mst1/2, Hippo/Mst 小径的核心 kinases 为 T 房间开发,功能,幸存, trafficking,和 homing 被要求,并且也在 autoimmunity 的规定包含了。在这评论,我们讨论在淋巴细胞开发和功能表明小径的不在经典中的 Hippo/Mst 的角色。 | Xingrong Du Alan Yu Wufan Tao | 2015 | Acta Biochimica et Biophysica Sinica2015，47，1： | 8 |
| 3 | Unsupervised segmentation of medical image based on difference of mutual information显示文摘In the scope of medical image processing, segmentation is important and difficult. There are still two problems which trouble us in this field. One is how to determine the number of clusters in an image and the other is how to segment medical images con- taining lesions. A new segmentation method called DDC, based on difference of mutual information (dMI) and pixon, is proposed in this paper. Experiments demonstrate that dMI shows one kind of intrinsic relationship between the segmented image and the original one and so it can be used to well determine the number of clusters. Furthermore, multi-modality medical images with lesions can be automatically and successfully seg- mented by DDC method. | LU Qingwen CHEN Wufan | 2006 | Science in China(Series F)2006，49，4： | 4 |
| 4 | Decreased activity of RCAN1.4 is a potential risk factor for congenital heart disease in a Han Chinese population显示文摘Dear Editor, Congenital heart disease (CHD)is a major birth defect worldwide.However,the aetiology of CHD remains unclear and the detailed molecular mechanisms underlying CHD pathogenesis have not been fully understood.The human regulator of calcineudn (RCAN1)gene is highly expressed in human hearts and brains (Fuentes et ai.,1995)and composed of seven exons that are alternatively spliced and/or transcribed by differential promoters to produce different isoforms (Fig.1A)(Yang et al.,2000). | Liangping Cheng Peiqiang Li He Wang Xueyan Yang Huiming Zhou Wufan Tao Jie Tian Hongyan Wang | 2018 | Protein & Cell2018，9，12： | 3 |
| 5 | LHCGR and ALMS1 defects likely cooperate in the development of polycystic ovary syndrome indicated by double-mutant mice显示文摘Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovary and LHCGR deficiency causes infertility without typical PCOS phenotypes.ALMS1 is implicated in obesity and hyperandrogenism,the common phenotypes among PCOS patients.Through whole-exome sequencing of 22 PCOS families and targeted candidate gene sequencing of additional 65 sporadic PCOS patients,we identified potential causative mutations in LHCGR and ALMS1 in a sibling-pair PCOS family and three sporadic PCOS patients.The expression of LHCGRL638 P in granulosa-like tumor cell line(KGN)cells promoted cyclic adenosine monophosphate production and granulosa cell proliferation,indicating that LHCGRL638 P is an activating mutation.Lhcgr~(L642 P/L642 P)mice showed an irregular estrous cycle,reduced follicles with dynamic folliculogenesis,and increased testosterone(T),estradiol(E2),and dehydroepiandrosterone.Lhcgr~(+/L642 P)AIms1~(+/PB)mice displayed increased T and E2 but decreased late secondary and preovulatory follicles.We showed that activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology,whereas ALMS1 deficiency may promote anovulatory infertility via elevated androgens,suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes,characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity. | Li Yu Lina Wang Wufan Tao Wenxiang Zhang Shuanghao Yang Jian Wang Jia Fei Rui Peng Yiming Wu Xiumei Zhen Hong Shao Weiyue Gu Rong Li Bai-Lin Wu Hongyan Wang | 2021 | Journal of Genetics and Genomics2021，48，5： | 3 |
| 6 | New approach to the automatic segmentation of coronary artery in X-ray angiograms显示文摘For the segmentation of X-ray angiograms (XRA), the essential feature and the prior knowledge of angiographic image were analyzed, and a multi-feature based fuzzy recognition (MFFR) algorithm was proposed to infer the local vessel structure in this paper. Guided by the prior knowledge of artery vessel, a probability tracking operator (PTO) can rapidly track along the artery tree, and walk across the weak region or gaps because of disturbance or preprocessing to angiographic image. Another, the accurate measurement of the vascular axis-lines and diameters can be synchronously implemented in the tracking process. To correctly evaluate the proposed method, a simulated image of CAT and some clinical XRA images were used in the experimentations. The algorithms performed better than the conven- tional one: given one start-point, on average 92.7% of the visible segments or branches was automatically delineated; the correctness ratio of vessel structure inference reached to 90.0% on the average. | ZHOU ShouJun YANG Jun CHEN WuFan WANG YongTian | 2008 | Science in China(Series F)2008，51，1： | 3 |
| 7 | DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway显示文摘Wnt signaling pathways,including the canonical Wnt/β-catenin pathway,planar cell polarity pathway,and Wnt/Ca2+signaling pathway,play important roles in neural development during embryonic stages.The DVL genes encode the hub proteins for Wnt signaling pathways.The mutations in DVL2 and DVL3 were identified from patients with neural tube defects(NTDs),but their functions in the pathogenesis of human neural diseases remain elusive.Here,we sequenced the coding regions of three DVL genes in 176 stillborn or miscarried fetuses with NTDs or Dandy-Walker malformation(DWM)and 480 adult controls from a Han Chinese population.Four rare mutations were identified:DVL1 p.R558 H,DVL1 p.R606 C,DVL2 p.R633 W,and DVL3 p.R222 Q.To assess the effect of these mutations on NTDs and DWM,various functional analyses such as luciferase reporter assay,stress fiber formation,and in vivo teratogenic assay were performed.The results showed that the DVL2 p.R633 W mutation destabilized DVL2 protein and upregulated activities for all three Wnt signalings(Wnt/β-catenin signaling,Wnt/planar cell polarity signaling,and Wnt/Ca2+signaling)in mammalian cells.In contrast,DVL1 mutants(DVL1 p.R558 H and DVL1 p.R606 C)decreased canonical Wnt/β-catenin signaling but increased the activity of Wnt/Ca2+signaling,and DVL3 p.R222 Q only decreased the activity of Wnt/Ca2+signaling.We also found that only the DVL2 p.R633 W mutant displayed more severe teratogenicity in zebrafish embryos than wild-type DVL2.Our study demonstrates that these four rare DVL mutations,especially DVL2 p.R633 W,may contribute to human neural diseases such as NTDs and DWM by obstructing Wnt signaling pathways. | Lingling Liu Weiqi Liu Yan Shi Ling Li Yunqian Gao Yunping Lei Richard Finnell Ting Zhang Feng Zhang Li Jin Huili Li Wufan Tao Hongyan Wang | 2020 | Journal of Genetics and Genomics2020，47，6： | 2 |
| 8 | Image denoising using modified Perona-Malik model based on Directional Laplacian显示文摘 | Guo Jichang Chen Wufan Zhang Wenxue | 2013 | Signal Processing2013，93，： | 1 |
| 9 | Finite element analysis of gradient z -coil induced eddy currents in a permanent MRI magnet显示文摘 | Xia Li Ling Xia Wufan Chen Feng Liu Stuart Crozier Dexin Xie | 2010 | Journal of Magnetic Resonance2010，，1： | 1 |
| 10 | The New Algorithm of Color Image Edge Detection显示文摘 | Chen Wufan Lu Xianqing Chen Jianjun etal | 1995 | Sciencein China(Serie A)1995，25，2： | 1 |
| 11 | Design and hovering control of a twin rotor tail-sitter UAV显示文摘The tail-sitter unmanned aerial vehicles (UAVs)combine the vertical takeoff and landing (VTOL)capabilities of rotary-wing UAVs and the efficient long-distance flight capability of fixed-wing UAVs.When compared with other hybrid aircraft configurations such as tilt-rotor [1] and tilt-wing [2]UAVs, the tail-sitter UAV possesses the simplest configuration and requires no extra mechanisms for performing the VTOL maneuver. This brings several benefits including high payload and low susceptibility to malfunctions. | Wufan WANG Jihong ZHU Minchi KUANG Xiaming YUAN Yunfei TANG Yaqing LAI Lyujie CHEN Yunjie YANG | 2019 | Science China(Information Sciences)2019，62，9： | 1 |
| 12 | A Study on how to Promote the Business En- vironment Competitiveness of China's Household Appliance Export Enterprise Take the Example of 'Haier' 显示文摘 | Ni Wufan | 2009 | Journal Cam- bridge Studies2009，，3： | 1 |
| 13 | Strategic thinking on improving the environmental competitiveness of Chinese enterprises显示文摘Environmental competitiveness, price competitiveness and non-price competitiveness make up the undivided vital part of product’s competitiveness. Environmental competitiveness can not only help improve the enterprise’s key competitiveness directly, but also strengthen it indirectly by improving the products’ price competitiveness and non-price competitiveness effectively. Instead of being confined to the product itself, there are several elements that can determine and influence the product’s environmental competitiveness, including the manufacturing process, the management of enterprises, the life circle of the products, etc. Measuring these elements by setting “environmental suitable degree”, and building up the echelon model to evaluate the environmental competitiveness can help us see about the standard of the enterprises’ environmental competitiveness. Though many of the national enterprises have price competitiveness to some extend, restricted by all kinds of elements like systems, techniques, policy, the enterprises are weak in environmental competitiveness. Beginning with systems redesign, carrying out the sustainable development, strengthening inner enter- prises management, making more efforts on technique innovation, and widely publicizing and teaching the ecological concept, Chinese national enterprises can improve their environmental competitiveness and improve their key competitiveness. | Ni Wufan | 2006 | Ecological Economy2006，2，4： | 1 |
| 14 | Design of sliding mode controller for a class of fractional-order chaotic systems显示文摘 | Yin Chun Zhong Shouming Chen Wufan | 2012 | Communications in Nonlinear Science and Numerical Simulation2012，17，1： | 1 |
| 15 | Adaptive Denoising by Singular Value Decomposition显示文摘 | Yanmin He Tao Gan Wufan Chen Houjun Wang | | 0，，04： | 1 |
| 16 | Nonlocal Prior Bayesian Tomographic Reconstruction显示文摘 | Yang Chen Jianhua Ma Qianjin Feng Limin Luo Pengcheng Shi Wufan Chen | 2008 | Journal of Mathematical Imaging and Vision2008，，2： | 1 |
| 17 | Introduction of an electronic aneroid sphygmomanometer that could meet both professional and unprofessional demands显示文摘 | Xin Xuegang Chen Wufan | 2010 | Medical & Biological Engineering & Computing2010，48，8： | 1 |
| 18 | Bayesian statistical reconstruction for low-dose X-ray computed tomography using an adaptive-weighting nonlocal prior显示文摘 | Yang Chen Dazhi Gao Cong Nie Limin Luo Wufan Chen Xindao Yin Yazhong Lin | 2008 | Computerized Medical Imaging and Graphics2008，，7： | 1 |
| 19 | A new algorithm of edge detection for color image显示文摘 | Chen Wufan Lu Xianqing | 1995 | Generalized Fuzzy Operator Sciencein China (series A)1995，38，10： | 1 |
| 20 | Adaptively Regularized Constrained Total Least-Squares Image Restoration显示文摘 | Chen Wufan Chen Ming Zhou Jie | 2000 | IEEE Trans on Image Processing2000，9，4： | 1 |
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