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| 1 | Genome survey uncovers the secrets of sex and lifestyle in caterpillar fungus显示文摘The caterpillar fungus Ophiocordyceps sinensis (best known as Cordyceps sinensis) mummifies ghost moth larvae exclusively in Tibetan Plateau alpine ecosystems. Touted as 'Himalayan Viagra', the fungus is highly prized due to its medical benefits and dwindling supplies. Attempts to culture the sexual fruiting-body have failed and the huge market demand has led to severe devastation of local ecosystems and to the fungus heading towards extinction. By genome sequencing, we establish that unlike related insect pathogens O. sinensis contains two compatible mating-type genes in its genome and is self-fertile, i.e. homothallic. However, sexual processes are only initiated under native environmental conditions. O. sinensis resembles biotrophic plant pathogens in having a genome shaped by retrotransposon-driven expansions. The resulting changes in gene content suggest that O. sinensis has a biphasic pathogenic mechanism beginning with stealth pathogenesis in early host instars. O. sinensis is the first psychrophilic fungus sequenced and is adapted to extreme cold with putative antifreeze proteins and mechanisms for increasing lipid accumulation and fatty acid unsaturation. We hypothesize that for the inbreeding O. sinensis the massive proliferation of retrotransposons provides a tradeoff between the advantages of increased genetic variation independent of sexual recombination and deletion of genes dispensable for its specialized pathogenic lifestyle. | HU Xiao ZHANG YongJie XIAO GuoHua ZHENG Peng XIA YongLiang ZHANG XingYu ST LEGER Raymond J LIU XingZhong WANG ChengShu | 2013 | Chinese Science Bulletin2013，58，23： | 26 |
| 2 | Association of farnesyl diphosphate synthase polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis显示文摘 | Liu Y Li M Zhou PR Xing XP Xia WB Xu L Liu H J Zhang ZL LiaoEY Chen DC Liu J Tao TZ Wu W | 2014 | Chinese Medical Journal2014，，4： | 16 |
| 3 | Surveillance-response systems: the key to elimination of tropical diseases显示文摘Tropical diseases remain a major cause of morbidity and mortality in developing countries.Although combined health efforts brought about significant improvements over the past 20 years,communities in resource-constrained settings lack the means of strengthening their environment in directions that would provide less favourable conditions for pathogens.Still,the impact of infectious diseases is declining worldwide along with progress made regarding responses to basic health problems and improving health services delivery to the most vulnerable populations.The London Declaration on Neglected Tropical Diseases(NTDs),initiated by the World Health Organization’s NTD roadmap,set out the path towards control and eventual elimination of several tropical diseases by 2020,providing an impetus for local and regional disease elimination programmes.Tropical diseases are often patchy and erratic,and there are differing priorities in resources-limited and endemic countries at various levels of their public health systems.In order to identify and prioritize strategic research on elimination of tropical diseases,the‘First Forum on Surveillance-Response System Leading to Tropical Diseases Elimination’was convened in Shanghai in June 2012.Current strategies and the NTD roadmap were reviewed,followed by discussions on how to identify and critically examine prevailing challenges and opportunities,including inter-sectoral collaboration and approaches for elimination of several infectious,tropical diseases.A priority research agenda within a‘One Health-One World’frame of global health was developed,including(i)the establishment of a platform for resource-sharing and effective surveillance-response systems for Asia Pacific and Africa with an initial focus on elimination of lymphatic filariasis,malaria and schistosomiasis;(ii)development of new strategies,tools and approaches,such as improved diagnostics and antimalarial therapies;(iii)rigorous validation of surveillance-response systems;and(iv)designing pilot studies to transfer Chinese experiences of successful surveillance-response systems to endemic countries with limited resources. | Ernest Tambo Lin Ai Xia Zhou Jun-Hu Chen Wei Hu Robert Bergquist Jia-Gang Guo Jürg Utzinger Marcel Tanner Xiao-Nong Zhou | 2014 | Infectious Diseases of Poverty2014，3，1： | 14 |
| 4 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 5 | Surveillance and response systems for elimination of tropical diseases: summary of a thematic series in Infectious Diseases of Poverty显示文摘The peer-reviewed journal Infectious Diseases of Poverty provides a new platform to engage with,and disseminate in an open-access format,science outside traditional disciplinary boundaries.The current piece reviews a thematic series on surveillance-response systems for elimination of tropical diseases.Overall,22 contributions covering a broad array of diseases are featured–i.e.clonorchiasis,dengue,hepatitis,human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AIDS),H7N9 avian influenza,lymphatic filariasis,malaria,Middle East respiratory syndrome(MERS),rabies,schistosomiasis and tuberculosis(TB).There are five scoping reviews,a commentary,a letter to the editor,an opinion piece and an editorial pertaining to the theme“Elimination of tropical disease through surveillance and response”.The remaining 13 articles are original contributions mainly covering(i)drug resistance;(ii)innovation and validation in the field of mathematical modelling;(iii)elimination of infectious diseases;and(iv)social media reports on disease outbreak notifications released by national health authorities.Analysis of the authors’affiliations reveals that scientists from the People’s Republic of China(P.R.China)are prominently represented.Possible explanations include the fact that the 2012 and 2014 international conferences pertaining to surveillance-response mechanisms were both hosted by the National Institute of Parasitic Diseases(NIPD)in Shanghai,coupled with P.R.China’s growing importance with regard to the control of infectious diseases.Within 4 to 22 months of publication,three of the 22 contributions were viewed more than 10000 times each.With sustained efforts focusing on relevant and strategic information towards control and elimination of infectious diseases,Infectious Diseases of Poverty has become a leading journal in the field of surveillance and response systems in infectious diseases and beyond. | Xia Zhou Peiling Yap Marcel Tanner Robert Bergquist Jürg Utzinger Xiao-Nong Zhou | 2016 | Infectious Diseases of Poverty2016，5，1： | 12 |
| 6 | Anatomic structural study of cerebellopontine angle via endoscope显示文摘在颅骨底依靠寻找内视镜的技术的可能的解剖基础的背景最低限度地侵略的外科是争论的。这研究的目的是在 cerebellopontine 角度区域观察在主要的血容器和神经之间的空间关系并且为侧面、以后的颅骨底提供解剖基础经由内视镜的 retrosigmoid 锁眼 approach.Methods 的最低限度地侵略的外科这研究在三十个弄干的成年颅骨上被进行测量空间关系在之中出现以后的头部的窝的多骨的标记,并且为 retrosigmoid 锁眼 ap 定位最适当的钻区域在直径与 2.0 厘米在这个点上集中的一个洞对在 cerebellopontine 角度暴露相关结构合适。 Retrosigmoid 锁眼途径罐头减少小脑上的压力并且有效地暴露相关结构它包括面部神经, vestibulocochlear 神经,三叉的神经,舌与喉的神经,迷走神经神经,附件神经,舌下神经神经,前面的劣等的小脑的动脉,以后的劣等的小脑的动脉和迷宫的动脉,内诊镜 retrosigmoid 途径上的准确地点能避免在最低限度地侵略的外科期间拖小脑的 etc.Conclusions 。retrosigmoid 锁眼途径的申请将扩大内视镜的技术的申请。 | XIA Yin LI Xi-ping HAN De-min ZHENG Jun LONG Hai-shan SHI Jin-feng Department of Otolaryngology,Beijing Tongren Hospital,Capital Medical University Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University),Ministry of Education,Beijing 100730,China (Xia Y,Li XP,Han DM,Zheng J,Long HS and Shi JF) | 2007 | Chinese Medical Journal2007，，20： | 7 |
| 7 | 二甲双胍通过沉默MATE1表达富集在细胞内选择性抑制KRAS突变转移性结肠癌显示文摘结肠癌(CRC)是常见癌症之一,转移是导致死亡的主要原因。近期研究发现一线化疗药物伊立替康或奥沙利铂联合表皮生长因子受体(EGFR)靶向药物可将转移性结直肠癌(mCRC)患者中位总体生存期提高2年以上。然而,KRAS突变的结肠癌患者(约30%~50%)表现对EGFR靶向药物的耐药性。因此,EGFR靶向药物不能用于KRAS突变的mCRC患者治疗。前期多项研究指出二甲双胍具有抗肿瘤作用,且服用二甲双胍与患者良好预后密切相关。然而,多项回顾性研究发现二甲双胍与癌症患者预后不相关,关于二甲双胍对肿瘤的治疗作用及分子机制尚存在诸多问题和分歧。 | 安华英(编译) Xie J Xia L Xiang W | 2020 | 中华医学杂志2020，100，32： | 5 |
| 8 | Integrative taxonomy of the Russet Bush Warbler Locustella mandelli complex reveals a new species from central China显示文摘Background: The Russet Bush Warbler Locustella(previously Bradypterus) mandelli complex occurs in mountains in the eastern Himalayas, southern China, Vietnam, the Philippines, and Indonesia. The taxonomy has been debated,with one(L. seebohmi) to four(L. seebohmi, L. mandelli, L. montis and L. timorensis) species having been recognised.Methods: We used an integrative approach, incorporating analyses of morphology, vocalizations and a molecular marker, to re-evaluate species limits in the L. mandelli complex.Results: We found that central Chinese L. mandelli differed from those from India through northern Southeast Asia to southeast China in plumage, morphometrics and song. All were easily classified by song, and(wing + culmen)/tail ratio overlapped only marginally. Both groups were reciprocally monophyletic in a mitochondrial cytochrome b(cytb) gene tree, with a mean divergence of 1.0 ± 0.2%. They were sympatric and mostly altitudinally segregated in the breeding season in southern Sichuan province. We found that the Mt Victoria(western Myanmar) population differed vocally from other L. mandelli, but no specimens are available. Taiwan Bush Warbler L. alishanensis was sister to the L. mandelli complex, with the most divergent song. Plumage, vocal and cytb evidence supported the distinctness of the south Vietnamese L. mandelli idonea. The Timor Bush Warbler L. timorensis, Javan Bush Warbler L.montis and Benguet Bush Warbler L. seebohmi differed distinctly in plumage, but among-population song variation in L. montis exceeded the differences between some populations of these taxa, and mean pairwise cytb divergences were only 0.5–0.9%. We also found that some L. montis populations differed morphologically.Conclusions: We conclude that the central Chinese population of Russet Bush Warbler represents a new species,which we describe herein, breeding at mid elevations in Sichuan, Shaanxi, Hubei, Hunan and Guizhou provinces.The taxonomic status of the other allopatric populations is less clear. However, as they differ to a degree comparable with that of the sympatric L. mandelli and the new species, we elevate L. idonea to species status, and retain L. seebohmi and L. montis as separate species, the latter with timorensis as a subspecies. Further research should focus on different populations of L. montis and the Mt Victoria population of L. mandelli. | Per Alstrom Canwei Xia Pamela C Rasmussen Urban Olsson Bo Dai Jian Zhao Paul J Leader Geoff J Carey Lu Dong Tianlong Cai Paul I Holt Hung Le Manh Gang Song Yang Liu Yanyun Zhang Fumin Lei | 2015 | Chinese Birds2015，，2： | 4 |
| 9 | A New Perspective about Climate Change显示文摘 | K. B. Mao Y. Ma T.R. Xu Q. Liu J Q. Han L. Xia X. Y. Shen T. J. He | 2015 | 地球科学期刊(中英文版)2015，5，1： | 4 |
| 10 | A novel orthotopic and metastatic mouse model of breast cancer in human mammary microenvironment(摘要)显示文摘 | Wang, J Xia, TS Liu, XA Ding, Q Du, Q Yin, H Wang, S | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 4 |
| 11 | Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells显示文摘尽管发信号的 Activin/Nodal 调整人的胚胎的茎(ES ) 的 pluripotency 细胞,这个发信号怎么在老鼠 ES 细胞行动,仍然保持大部分不清楚。调查这,我们证实了房间拥有活跃调停 Smad2 的 Activin/Nodal 发信号的那老鼠 ES 并且发现调停 Smad2 的 Activin/Nodal 发信号为自强维护是非必需的,但是向 mesendoderm 系为合适的区别被要求。到进内在的机制的获得卓见,联系 Smad2 的基因被染色体宽的染色质 immunoprecipitation 薄片分析识别。结果证明在 Smad2 绑定和 Activin/Nodal 发信号调整之间有 transcriptional 关联,并且发展相关的基因在 Smad2 固定的目标之中被充实。我们进一步在 Activin/Nodal-Smad2 小径下游地行动的老鼠 ES 房间的 mesendoderm 区别作为一个关键播放器识别了 Tapbp。一起拿,我们的调查结果建议发信号的调停 Smad2 的 Activin/Nodal 通过相应发展管理者表示的直接调整安排鼠标 ES 房间的 mesendoderm 系承诺。 | Teng Fei Shanshan Zhu Kai Xia Jianping Zhang Zhongwei Li Jing-Dong J Han Ye-Guang Chen | 2010 | Cell Research2010，20，12： | 4 |
| 12 | 血浆7-酮胆固醇与冠状动脉疾病患者心血管结局和总死亡率的关系显示文摘7-酮胆固醇(7-ketocholesterol,7-KC)是胆固醇氧化产物的一种形式,在动物动脉粥样硬化模型的形成中起重要作用。该文研究人员试图确定循环7-KC与稳定型冠状动脉疾病(coronary artery disease,CAD)患者的临床心血管结局和总死亡率的关系。 | 刘莉 叶鹏 Song J Wang D Chen H Huang X Zhong Y Jiang N Chen C Xia M | 2017 | 中华高血压杂志2017，25，6： | 4 |
| 13 | Towards a global One Health index: a potential assessment tool for One Health performance显示文摘Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge. | Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou | 2022 | Infectious Diseases of Poverty2022，11，3： | 3 |
| 14 | Dietary supplementation of Bacillus subtilis influenced intestinal health of weaned pigs experimentally infected with a pathogenic E. coli显示文摘Background: There is growing evidence to support the beneficial effects of supplementing direct-fed microbials(DFM) on performance, health status, and immune responses of weaned pigs. Therefore, the objective of this study was to investigate dietary supplementation of Bacillus subtilis(DSM 25841) on growth performance, diarrhea, gut permeability and immunity of weaned pigs experimentally infected with a pathogenic F-18 Escherichia coli(E. coli).Results: The F18 E. coli infection reduced(P < 0.05) growth performance and intestinal villi height, whereas increased(P < 0.05) diarrhea and transcellular and paracellular permeability in the jejunum compared with non-challenged control. Supplementation of Bacillus subtilis linearly enhanced average daily gain of E. coli infected pigs from d 0 to 5 post-inoculation(PI)(P < 0.05) and d 0 to 11 PI(P = 0.058). Supplementation of high dose of Bacillus subtilis reduced(P < 0.05) both transcellular and paracellular permeability on d 5 and d11 PI compared with the E. coli infected pigs fed with control diet. E. coli infection up-regulated(P < 0.05)the m RNA expression of SLC5 A10(soluble carrier family 5 member 10) and MUC2(mucin 2) on d 5 PI, but down-regulated(P < 0.05) expression of SLC5 A10, MUC2, and CLDN1 on d 11 PI in jejunal mucosa when pigs were fed with the control diet. Supplementation of Bacillus subtilis linearly up-regulated(P < 0.05) the m RNA expression of CFTR and ZO1 on d 5 PI and SLC5 A10 and MUC2 on d 11 PI in jejunal mucosa of E. coli infected pigs. In addition, E. coli infection increased(P < 0.05) the m RNA expression of several immune genes(IL1 A, IL1 B, and IL7 on d 5 PI, and IL1 B, IL6, IL7, and TNF on d 11 PI) in the ileal mucosa of weaned pigs. Inclusion of Bacillus subtilis to control diet linearly down-regulated gene expression of IL1 A on d 5 PI(P = 0.07) and IL6 on d 11 PI(P < 0.05) in ileal mucosa of E. coli infected pigs.Conclusions: Supplementation of Bacillus subtilis(DSM 25841) enhanced growth rate and improved gut barrier function of weaned pigs experimentally infected with a pathogenic E. coli. | Kwangwook Kim Yijie He Xia Xiong Amy Ehrlich Xunde Li Helen Raybould Edward R.Atwill Elizabeth A.Maga Jens JΦrgensen Yanhong Liu | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 3 |
| 15 | Anti-N-methyl-D-aspartate receptor encephalitis that aggravates after acinetobacter baumannii pneumonia:A case report显示文摘We report an atypical case of anti-N-methyl-D-aspartate receptor encephalitis(ANMDARE). A 27-year-old man diagnosed with ANMDARE received immunotherapy and had a good recovery. However, within one month, he developed severe status epilepticus and decreased level of conscience with new hyperpyrexia and dyspnea, and was admitted to the emergency intensive care unit. Acinetobacter baumanii were found in the sputum culture; and anti-NMDAR antibodies were positive(titer: 1/80) in the cerebrospinal fluid. Repeated immunotherapy was administered with antibacterial agents, and the patient recovered except for mild psychiatric sequelae. This is the first report of ANMDARE that aggravates after acinetobacter baumannii pneumonia. Awareness and knowledge of this disorder should be extended, especially in the emergency medicine community. | Cheng C Wang Da J Li Yi Q Xia Kai Liu | 2017 | World Journal of Clinical Cases2017，5，9： | 3 |
| 16 | The conversion factor of K_(eff) to K_(3.7) in thermoluminescence dating显示文摘In the fine-grain TL dating the full o dose must be converted into the equivalent P dose. The conversion is finished by Keff-value, which is an effective or effectiveness. But the Keff can not be measured directly for each sample and only the external radiative efficiency K3.7 can be measured. In order to obtain the Keff a special study for the conversion factor of Keff to K3.t has been made using the ultrathin TLD. The results show that the conversion factor of tile TLD for archaeological samples is 0.847, which is in agreement with calculated value 0.85. | Wang Wei-Da Zhou Zhi-Xin Xia Jun-Ding (Research Laborotory for Conservation and Archaeology, Shanghai Museum, Shanghai 200951)Leung P L Stokes M J(Department of Physics and Materials Science, City University of Hong Kong) | 1998 | Nuclear Science and Techniques1998，9，4： | 3 |
| 17 | Comparison of promoters for the murine and human P-selectin genes suggests species-specific and conserved mechanisms for transcriptional regulation in endothelial cells显示文摘 | Pan J Xia L McEver RP | 1998 | J Biol Chem1998，273，10： | 2 |
| 18 | Molecular genetic analysis of response of three soil microbial communities to the application of 2,4-D 显示文摘 | Xia X Bollinger J Ogram A | 1995 | Molecular Ecology1995，4，： | 2 |
| 19 | Design of prefilters for discrete multiwavelet transforms 显示文摘 | Xia X G Geronimo J Suter B | 1996 | IEEE Trans on Signal Processing1996，44，1： | 2 |
| 20 | Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis显示文摘 | Guy D Eslick Lynette L.-Y Lim Julie E Byles Harry H-X Xia Nicholas J Talley | 1999 | The American Journal of Gastroenterology1999，，： | 2 |
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