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| 1 | CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells显示文摘 | Xiaojuan Liu Yongping Zhang Chen Cheng Albert W Cheng Xingying Zhang Na Li Changqing Xia Xiaofei Wei Xiang Liu Haoyi Wang | 2017 | Cell Research2017,27,1: | 40 |
| 2 | 二甲双胍通过沉默MATE1表达富集在细胞内选择性抑制KRAS突变转移性结肠癌显示文摘结肠癌(CRC)是常见癌症之一,转移是导致死亡的主要原因。近期研究发现一线化疗药物伊立替康或奥沙利铂联合表皮生长因子受体(EGFR)靶向药物可将转移性结直肠癌(mCRC)患者中位总体生存期提高2年以上。然而,KRAS突变的结肠癌患者(约30%~50%)表现对EGFR靶向药物的耐药性。因此,EGFR靶向药物不能用于KRAS突变的mCRC患者治疗。前期多项研究指出二甲双胍具有抗肿瘤作用,且服用二甲双胍与患者良好预后密切相关。然而,多项回顾性研究发现二甲双胍与癌症患者预后不相关,关于二甲双胍对肿瘤的治疗作用及分子机制尚存在诸多问题和分歧。 | 安华英(编译) Xie J Xia L Xiang W | 2020 | 中华医学杂志2020,100,32: | 5 |
| 3 | Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease显示文摘 | Tan W C Xiang X Qiu D | 2003 | Am J Med2003,115,4: | 2 |
| 4 | QoS routing based on genetic algorithm显示文摘 | Xiang F Junzhou L Jieyi W | 1999 | Computer Communications1999,22,1516: | 2 |
| 5 | Electrochemical deposited amorphous FeNi hydroxide electrode for oxygen evolution reaction显示文摘The electrodeposition approach is significant in electrode fabrication for practical application.Herein,the electrodeposited amorphous NiFe hydroxide species for oxygen evolution reaction (OER) in water splitting reaction is demonstrated by revealing the synergistic effect influenced by the support electrode of Fe and Ni foil and the contents of Fe and Ni in the electrolyte.All the electrodeposited samples have an amorphous structure and similar profiles of binding energy and chemical states for Fe and Ni as characterized by the spectroscopic techniques.While the support effect and Fe/Ni synergistic effect are indeed observed for the varied catalytic performances observed for the different electrodes;the Ni foil supported catalyst exhibits much higher performance than that of the Fe foil supported catalyst,and the different redox potentials of Ni species in the different Fe/Ni electrode resulting from the Fe–Ni synergism are observed in the cyclic voltammetry curve analysis.The surface roughness and the electrochemical surface area are also influenced by the support effect and the Fe/Ni ratio in the plating electrolyte.The optimal electrode shows a very low overpotential of~200 mV to reach 10 mA cm^(-2),and very high catalytic stability by the consecutive cyclic voltammetry measurements and 20 h stability test.Though it has the largest electrochemical surface area,the highest catalytic efficiency for these active sites is also indicated by the specific activity and turnover frequency polarization curves.The current work shows the effective experience for the electrodeposited Fe/Ni based catalysts in large-scale fabrication,which can be more practical for hydrogen generation in the alkaline water electrolysis. | Zhengzhi Yin Runze He Yongcai Zhang Ligang Feng Xiang Wu Thomas Wågberg Guangzhi Hu | 2022 | Journal of Energy Chemistry2022,31,6: | 2 |
| 6 | The effect of bone morphogeneticprotein on osseointegration of titanium implants显示文摘 | Baolin L Yan J | 1993 | J Oral Maxillofac Surg1993,57,6: | 1 |
| 7 | Hydrogen-induced degradation in CaCu3Ti4O12 ceramics 显示文摘 | Chen W P Xiang W Guo M S | 2006 | J Alloys Compounds2006,422,: | 1 |
| 8 | Energy efficient clustering al- gorithm for maximizing lifetime of wireless sensor networks 显示文摘 | Xiang M Shi W R Jiang C J | 2010 | In- ternational Journal of Electronicsand Communications2010,64,5: | 1 |
| 9 | Slurry phase Fischer-Tropsch synthesis over manganese-promoted iron ultrafine particle catalyst显示文摘 | BAI L XIANG H W LI Y W HAN Y Z ZHONG B | 2002 | Fuel2002,81,1112: | 1 |
| 10 | Removal of heavy metals from anaerobically digested sewage sludge by isolated indigenous iron-oxidizing bacteria显示文摘 | Xiang L Chan L C Wong J W C | 2000 | Chemosphere2000,41,: | 1 |
| 11 | On essential component of the set of Nash equilibrium points显示文摘 | YU J XIANG S W | 1999 | Nonlinear Analysis1999,38,: | 1 |
| 12 | Initial deposition mechanism of electroless nickel plating on magnesium alloys显示文摘 | Xiang Y H Hu W B Liu X K | 2001 | Trans IMF2001,79,1: | 1 |
| 13 | QoS Routing Based on Genetic Algorithm显示文摘 | Xiang F Junzhou L Jieyi W | 1999 | Computer Communications1999,22,15: | 1 |
| 14 | Crystallization and preliminary crystallographic studies of a novel antifungal protein with five disulfide bridges from Eucommia ulmoides Oliver显示文摘 | XIANG Y HUANG R H LIU W | 2002 | Acta Crystallogr D Biol Crystallogr2002,58,: | 1 |
| 15 | Cloud Securtiy Defence to Protect Chmd Computing Against HTTP-Dos and XML-Dos Attacks 显示文摘 | Chonka A Xiang Y Zhou W | 2011 | Journal of Network and Computer Applications2011,34,4: | 1 |
| 16 | Recognition of human activities using SVM multi-class classifier显示文摘 | Qian H Mao Y Xiang W | 2010 | Pattern Recognition Letters2010,31,2: | 1 |
| 17 | Synthesis and prop- erties of nanosilica-relnforced polyurethane for grouting 显示文摘 | Xiang X J Qian J W Yang W Y | 2006 | Journal of Apply Polymer Science2006,100,6: | 1 |
| 18 | Soya food intake and risk of endometrial cancer among Chinese women in Shanghai: population based case - control study 显示文摘 | XU W H ZHENG W XIANG Y B ct al | 2004 | Br Med J2004,328,7451: | 1 |
| 19 | Prevalence of metabolic syndrome (MetS) in Chinese subjects gradually increased with impaired glucose homeostasis:a ticenter,clinical based,cross-sectional study显示文摘 | XIANG Y HUANG G ZHOU W | | 0,,01: | 1 |
| 20 | PAPR Reduction of OFDM Signals Using Partial Transmit Sequences with Low Computational Complexity显示文摘 | Jiang T Xiang W Richardson P C | 2007 | IEEE Transactions on Broadcasting2007,53,3: | 1 |