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| 1 | Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs.3 doses in young women显示文摘A new HPV-16/18 bivalent vaccine expressed by the Escherichia coli has been proven to be efficacious in adult women.A randomized,immunogenicity noninferiority study of this candidate vaccine was conducted in December 2015 in China.Girls aged 9–14 years were randomized to receive 2 doses at months 0 and 6(n=301)or 3 doses at months 0,1 and 6(n=304).Girls aged 15–17 years(n=149)and women aged 18–26 years(n=225)received 3 doses.The objectives included noninferiority analysis of the IgG geometric mean concentration(GMC)ratio(95%CI,lower bound>0.5)to HPV-16 and HPV-18 at month 7 in girls compared with women.In the per-protocol set,the GMC ratio of IgG was noninferior for girls aged 9–17 years receiving 3 doses compared with women(1.76(95%CI,1.56,1.99)for HPV-16 and 1.93(95%CI,1.69,2.21)for HPV-18)and noninferior for girls aged 9–14 years receiving 2 doses compared with women(1.45(95%CI,1.25,1.62)for HPV-16 and 1.17(95%CI,1.02,1.33)for HPV-18).Noninferiority was also demonstrated for neutralizing antibodies.The immunogenicity of the HPV vaccine in girls receiving 3 or 2 doses was noninferior compared with that in young adult women. | Yue-Mei Hu Meng Guo Chang-Gui Li Kai Chu Wen-Gang He Jing Zhang Jian-Xiang Gu Juan Li Hui Zhao Xiang-Hong Wu Bi-Zhen Lin Zhi-Jie Lin Xing-Mei Yao Ya-Fei Li Fei-Xue Wei Yue Huang Ying-Ying Su Feng-Cai Zhu Shou-Jie Huang Hui-Rong Pan Ting Wu Jun Zhang Ning-Shao Xia | 2020 | Science China(Life Sciences)2020，63，4： | 19 |
| 2 | YAP promotes osteogenesis and suppresses adipogenic differentiation by regulatingβ-catenin signaling显示文摘YAP(yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo pathway, a conserved pathway for the development and size control of multiple organs. The exact function of YAP in bone homeostasis remains controversial. Here we provide evidence for YAP's function in promoting osteogenesis, suppressing adipogenesis, and thus maintaining bone homeostasis.YAP is selectively expressed in osteoblast(OB)-lineage cells. Conditionally knocking out Yap in the OB lineage in mice reduces cell proliferation and OB differentiation and increases adipocyte formation, resulting in a trabecular bone loss. Mechanistically, YAP interacts with β-catenin and is necessary for maintenance of nuclear β-catenin level and Wnt/β-catenin signaling. Expression of β-catenin in YAP-deficient BMSCs(bone marrow stromal cells) diminishes the osteogenesis deficit. These results thus identify YAP-β-catenin as an important pathway for osteogenesis during adult bone remodeling and uncover a mechanism underlying YAP regulation of bone homeostasis. | Jin-Xiu Pan Lei Xiong Kai Zhao Peng Zeng Bo Wang Fu-Lei Tang Dong Sun Hao-han Guo Xiao Yang Shun Cui Wen-Fang Xia Lin Mei Wen-Cheng Xiong | 2018 | Bone Research2018，6，2： | 19 |
| 3 | Oroxindin inhibits macrophage NLRP3 inflammasome activation in DSS-induced ulcerative colitis in mice via suppressing TXNIP-dependent NF-κB pathway显示文摘Oroxindin is a flavonoid isolated from the traditional Chinese medicine Huang-Qin,which has shown various pharmacological activities including anti-inflammatory,antitumor,antioxidant,etc.Thus far,the effect of oroxindin on colonic inflammation and the underlying mechanism remain unknown.In this study,we investigated the tissue distribution of oroxindin and its therapeutic effects on ulcerative colitis(UC)as well as the underlying mechanisms.UC model was established in mice by administrating dextran sulfate sodium(DSS)in drinking water for 7 d.We first showed that oroxindin was largely absorbed by the colon as an active ingredient after normal mice received Huang-Qin-Tang,a traditional Chinese medicine decoction.UC mice were then treated with oroxindin(12.5,25,50 mg-kg^-1·d^-1,i.g.)for 10 d.We found that oroxindin treatment greatly suppressed massive macrophages infiltration and attenuated pathological changes in colonic tissue.Furthermore,oroxindin treatment significantly inhibited the generation of IL-13 and IL-18 in the colon via inhibiting the nucleotide-binding oligomerization domain-like receptor 3(NLRP3)inflammasome formation and activation.In cultured macrophages,LPS induced NLRp3 inflammasome formation and caspase-1 activation,which were suppressed by oroxindin(12.5-50μM).In LPS-treated macrophages,oroxindin dose-dependently restored the expression of TXNIP protein,leading to suppressing TXNIP-dependent NF-κB activation.In conclusion,these results demonstrate that oroxindin could be absorbed by the colon and attenuate inflammatory responses via inhibiting NLRP3 inflammasome formation and activation,which is related to the inhibitory effect on TXNIP-dependent NF-κB-signaling pathway.Hence,oroxindin has the potential of becoming an effective drug for treating UC. | Qi Liu Rui Zuo Kai Wang Fei-fei Nong Ya-jun Fu Shao-wei Huang Zeng-feng Pan Yi Zhang Xia Luo Xiang-liang Deng Xiao-xue Zhang Lian Zhou Yang Chen | 2020 | Acta Pharmacologica Sinica2020，41，6： | 15 |
| 4 | Clinical profiles and outcomes of acute type A aortic dissection and intramural hematoma in the current era: lessons from the first registry of aortic dissection in China显示文摘Background::Acute type A aortic dissection(ATAAD)and acute type A intramural hematoma(ATAIMH)are life-threatening diseases with high mortality.To better understand their clinical features in the Chinese population,we analyzed the data from the first Registry of Aortic Dissection in China(Sino-RAD)to promote the understanding and management of the diseases.Methods::All patients with ATAAD and ATAIMH enrolled in Sino-RAD from January 1,2012 to December 31,2016 were involved.The data of patients’selection,history,symptoms,management,outcomes,and postoperation complications were analyzed in the study.The continuous variables were compared using the Student’s t test for normal distributions and the Mann-Whitney U test for non-normal distributions.Categorical variables were compared using the Chi-square test or Fisher exact test.Results::A total of 1582 patients with ATAAD and 130 patients with ATAIMH were included.The mean age of all patients was 48.4 years.Patients with ATAAD were significantly younger than patients with ATAIMH(48.9 years vs.55.6 years,P<0.001).For the total cohort,males were dominant,but the male ratio of patients with ATAAD was significantly higher compared to those with ATAIMH(P=0.01).The time range from the onset of symptom to hospitalization was 2.0 days.More patients of ATAIMH had hypertension than that of ATAAD(82.3%vs.67.6%,P<0.05).Chest and back pain were the most common clinical symptoms.Computerized tomography(CT)was the most common initial diagnostic imaging modality.84.7%received surgical treatment and in-hospital mortality was 5.3%.Patients with ATAAD mainly received surgical treatment(89.6%),while most patients with ATAIMH received medical treatment(39.2%)or endovascular repair(35.4%).Conclusions::Our study suggests that doctors should comprehensively use clinical examination and genetic background screening for patients with ATAAD and ATAIMH and further shorten the time range from symptoms onset to intervention,achieving early diagnosis and treatment,thereby reducing the mortality rate of patients with aortic dissection in China.We should standardize the procedures of aortic dissection treatment and improve people’s understanding.Meanwhile,the curing and transferring efficiency should also be improved. | Wei-Xun Duan Wei-Guang Wang Lin Xia Chao Xue Bo Yu Kai Ren Wei Yi Hong-Liang Liang Xiao-Chao Dong Jian Zuo Jin-Cheng Liu Shi-Qiang Yu Ding-Hua Yi | 2021 | Chinese Medical Journal2021，，8： | 15 |
| 5 | Establishment and preliminery use of hepatitis Bvirus preS1/2 antigen assay显示文摘 | CHEN Kun, HAN Bao Guang, MA Xian Kai, ZHANG He Qiu, MENG Li, WANG Guo Hua, XIA Fang, SONG Xiao Guo and LING Shi Gan | 1999 | World Journal of Gastroenterology1999，5，6： | 14 |
| 6 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 7 | Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China显示文摘In order to evaluate the performance of a molecular Hain line probe assay(Hain LPA)for rapid detection of rifampicin and isoniazid resistance of Mycobacterium tuberculosis in China。 | LI Qiang DONG Hai Yan PANG Yu XIA Hui OU Xi Chao ZHANG Zhi Ying LI Jun Chen ZHANG Jian Kang HUAN Shi Tong CHIN Daniel P KAM Kai Man ZHAO Yan Lin | 2015 | Biomedical and Environmental Sciences2015，28，6： | 13 |
| 8 | Method of oxygen-enriched two-stage underground coal gasification显示文摘二阶段的地下的煤气化被学习改进 syngas 的热量的价值并且扩大煤气的生产时间。用充实氧的二阶段的煤气化方法的模型测试被执行。生产的气体的作文,二个阶段的时间比率,和温度地的角色被分析。充实氧的二阶段的气化弄短的结果表演第一个阶段的时间并且延长第二个阶段的时间。喂 30% , 35% , 40% , 45% , 60% ,或 80% 的集中分别地给了 1:0.12, 1:0.21, 1:0.51, 1:0.64, 1:0.90,和 1:4.0 的时间比率(第二上演的第一个阶段) 的氧。在蒸气注射以后的温度领域的冷却的率从大约 19.127.4 与时间减少了吗?? | Liu Hongtao Chen Feng Pan Xia Yao Kai Liu Shuqin | 2011 | Mining Science and Technology2011，21，2： | 11 |
| 9 | Characteristics of the HIV/AIDS Epidemic in Women Aged 15-49 Years from 2005 to 2012 in China显示文摘Objective To describe the characteristics of the HIV/AIDS epidemic in women aged 15-49 years in China. Methods HIV/AIDS cases from 2005 to 2012 that fulfilled the inclusion and exclusion criteria were identified on the Chinese HIV/AIDS case reporting system. Descriptive and spatial analyses were performed. Results A total of 103,559 female HIV/AIDS cases were included in our study. Based on the descriptive analysis, between 2005 and 2012, the proportion of heterosexually acquired HIV infection among women(15-49 years) increased rapidly from 35.8% to 87.4%. Approximately 60% of these cases were infected through non-marital heterosexual contact. Among older women(40-49 years), a slightly increasing trend was identified. The spatial analysis detected ‘hot spots' in the Xinjiang, Yunnan, Sichuan, Guangxi, and Chongqing provinces. The epidemic trends in these areas were predominately driven by heterosexual transmission. Conclusion Non-marital heterosexual contact is a very important factor in the HIV/AIDS epidemic in women aged 15-49 years, and the HIV infection rate in older women is increasing. Several epidemic hot spots were detected in northwestern and southwestern China. Efficient interventions are needed to control the spread of HIV/AIDS among women living in these areas. | ZHANG Xia Yan HUANG Tao FENG Yi Bing LI Meng CHEN Fang Fang LI Yin Ge JIN Shan Shan BU Kai WANG Lu | 2015 | Biomedical and Environmental Sciences2015，28，10： | 10 |
| 10 | Anlotinib suppresses lymphangiogenesis and lymphatic metastasis in lung adenocarcinoma through a process potentially involving VEGFR-3 signaling显示文摘Objective:Lymphatic metastasis is one of the leading causes of malignancy dispersion in various types of cancer.However,few anti-lymphangiogenic drugs have been approved for clinical use to date.Therefore,new therapies to block lymphangiogenesis are urgently required.Methods:Immunohistochemistry,immunofluorescence,Western blot,migration assays,and lymphangiogenesis and lymphatic metastasis assays were used.Results:Anlotinib,a receptor tyrosine kinase inhibitor,suppressed the rate of new metastatic lesions(31.82%in the placebo arm and 18.18%in the anlotinib arm)in patients with advanced lung adenocarcinoma who were enrolled in our ALTER-0303 study.D2-40+-lymphatic vessel density was strongly correlated with disease stage,metastasis,and poor prognosis in 144 Chinese patients with lung adenocarcinoma.In mice bearing A549EGFP tumors,tumor lymphatic vessel density,tumor cell migration to lymph nodes,and the number of distant metastatic lesions were lower in the anlotinib group than in the controls.Anlotinib inhibited the growth and migration of human lymphatic endothelial cells(hLECs)and lymphangiogenesisin vitro andin vivo.Treatment of hLECs with anlotinib downregulated phosphorylated vascular endothelial growth factor receptor 3(VEGFR-3).Conclusions:Anlotinib inhibits lymphangiogenesis and lymphatic metastasis,probably through inactivating VEGFR-3 phosphorylation.The results indicate that anlotinib may be beneficial for treatment in avoiding lymphangiogenesis and distant lymphatic metastasis in lung adenocarcinoma.(Trial registration:ALTER0303;NCT02388919;March 17,2015.) | Tingting Qin Zhujun Liu Jing Wang Junling Xia Shaochuan Liu Yanan Jia Hailin Liu Kai Li | 2020 | Cancer Biology & Medicine2020，17，3： | 9 |
| 11 | Assessing validation of dual fluoroscopic image matching method for measurement of in vivo spine kinematics显示文摘针的结构的功能的背景精确知识是批评的理解影响针的病理的 biomechanical 因素。许多研究在 vitro 并且在 vivo.However 调查了人的脊椎的运动,决心在 vivo ,在生理的装载条件下面的 vertebrae 的运动在因为当前的技术的限制和 spine.Methods 的复杂解剖的生物医学的设计为仍然是挑战在 vitro 确认,一个人的腰部的标本与钢祷告是嵌入的并且由一台通用测试机器( UTM )搬到已知的距离。双 fluoroscopic 系统被用来捕获脊骨运动并且复制动人的距离。为在 vivo 确认,当忍受重量时,一个生活题目在各种各样的位置移动了脊骨。荧光屏被用来复制在里面 vivo 脊骨位置 5 次。在五大小的翻译和取向的标准差被用来评估技术的重覆性。脊椎的轮廓与匹配技术的金属性的标记匹配的精确性是 compared.Results 人的腰部的标本的翻译位置能与吝啬的精确性被决定不到 0.35 公里和吝啬的重覆性为匹配的图象的 0.36 公里技术。在在自由(6DOF ) 的 vivo 人脊骨六度复制 kinematics 的方法的重覆性是在翻译的不到 0.43 公里并且不到 0.65 ?????? 吗?? | BAI Jian-qiang HU Yong-cheng DULi-qing HE Jing-liang LIU Kai LIU Zhongjun XIA Qun | 2011 | Chinese Medical Journal2011，，11： | 9 |
| 12 | Inventory of mangrove wetlands in the Pearl River Estuary of China using remote sensing显示文摘Mangrove forests have important ecological functions in protecting the environment. However, the mangrove wetlands have been largely lost because of intensified human activities in the study area. Remote sensing can be conveniently used for the inventory of mangrove forests because field investigation is very difficult. In this study, a knowledge-based system is developed to retrieve spatio-temporal dynamics of mangrove wetlands using multi-temporal remote sensing data. Radar remote sensing data are also used to provide complementary information for the quantitative analysis of mangrove wetlands. Radar remote sensing is able to penetrate mangrove forests and obtain the trunk information about mangrove structures. The integration of radar remote sensing with optical remote sensing can significantly improve the accuracies of classifying mangrove wetland types and estimating wetland biomass. | LI xia YEH Anthony LIU Kai WANG Shugong | 2006 | Journal of Geographical Sciences2006，16，2： | 8 |
| 13 | Astaxanthin promotes M2 macrophages and attenuates cardiac remodeling after myocardial infarction by suppression inflammation in rats显示文摘Background:Cardiac remodeling after acute myocardial infarction(AMI)is an important process.The present study aimed to assess the protective effects of astaxanthin(ASX)on cardiac remodeling after AMI.Methods:The study was conducted between April and September 2018.To create a rat AMI model,rats were anesthetized,and the left anterior descending coronary artery was ligated.The rats in the ASX group received 10 mg·kg-1·day-1 ASX by gavage for 28 days.On the 1st day after AMI,but before ASX administration,six rats from each group were sacrificed to evaluate changes in the heart function and peripheral blood(PB)levels of inflammatory factors.On the 7th day after AMI,eight rats from each group were sacrificed to evaluate the PB levels of inflammatory factors and the M2 macrophage count using both immunofluorescence(IF)and flow cytometry(FC).The remaining rats were observed for 28 days.Cardiac function was examined using echocardiography.The inflammatory factors,namely,tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and IL-10,were assessed using enzyme-linked immunosorbent assay.The heart weight/body weight(BW),and lung weight(LW)/BW ratios were calculated,and myocardial fibrosis in the form of collagen volume fraction was measured using Masson trichrome staining.Hematoxylin and eosin(H&E)staining was used to determine the myocardial infarct size(MIS),and TdT-mediated dUTP nick-end labeling staining was used to analyze the myocardial apoptosis index.The levels of apoptosis-related protein,type I/III collagen,transforming growth factorβ1(TGF-β1),metalloproteinase 9(MMP9),and caspase 3 were assessed by Western blotting.Unpaired t-test,one-way analysis of variance,and non-parametric Mann-Whitney test were used to analyze the data.Results:On day 1,cardiac function was worse in the ASX group than in the sham group(left ventricular end-systolic diameter[LVIDs]:0.72±0.08 vs.0.22±0.06 cm,t=-11.38;left ventricular end-diastolic diameter[LVIDd]:0.89±0.09 vs.0.48±0.05 cm,t=-9.42;end-systolic volume[ESV]:0.80[0.62,0.94]vs.0.04[0.03,0.05]mL,Z=-2.89;end-diastolic volume[EDV]:1.39[1.03,1.49]vs.0.28[0.22,0.32]mL,Z=-2.88;ejection fraction[EF]:0.40±0.04 vs.0.86±0.05,t=10.00;left ventricular fractional shortening[FS]rate:0.19[0.18,0.20]%FS vs.0.51[0.44,0.58]%FS,Z=-2.88,all P<0.01;n=6).The levels of inflammatory factors significantly increased(TNF-α:197.60[133.89,237.94]vs.50.48[47.2157.10]pg/mL,Z=-2.88;IL-1β:175.23[160.74,215.09]vs.17.78[16.83,19.56]pg/mL,Z=-2.88;IL-10:67.64[58.90,71.46]vs.12.33[11.64,13.98]pg/mL,Z=-2.88,all P<0.01;n=6).On day 7,the levels of TNF-αand IL-1βwere markedly lower in the ASX group than in the AMI group(TNF-α:71.70[68.60,76.00]vs.118.07[106.92,169.08]pg/mL,F=42.64;IL-1β:59.90[50.83,73.78]vs.151.60[108.4,198.36]pg/mL,F=44.35,all P<0.01,n=8).Conversely,IL-10 levels significantly increased(141.84[118.98,158.36]vs.52.96[42.68,74.52]pg/mL,F=126.67,P<0.01,n=8).The M2 macrophage count significantly increased(2891.42±211.29 vs.1583.38±162.22,F=274.35,P<0.01 by immunofluorescence test;0.96±0.18 vs.0.36±0.05,F=46.24,P<0.05 by flowcytometry test).On day 28,cardiac function was better in the ASX group than in the AMI group(LVIDs:0.50[0.41,0.56]vs.0.64[0.56,0.74]cm,Z=-3.60;LVIDd:0.70[0.60,0.76]vs.0.80[0.740.88]cm,Z=-2.96;ESV:0.24[0.18,0.45]vs.0.58[0.44,0.89]mL,Z=-3.62;EDV:0.76[0.44,1.04]vs.1.25[0.82,1.46]mL,Z=-2.54;EF:0.60±0.08 vs.0.50±0.12,F=160.48;%FS:0.29[0.24,0.31]vs.0.20[0.17,0.21],Z=-4.43,all P<0.01;n=16).The MIS and LW/BW ratio were markedly lower in the ASX group than in the AMI group(myocardial infarct size:32.50±1.37 vs.50.90±1.73,t=23.63,P<0.01,n=8;LW/BW:1.81±0.15 vs.2.17±0.37,t=3.66,P=0.01,n=16).The CVF was significantly lower in the ASX group than in the AMI group:12.88±2.53 vs.28.92±3.31,t=10.89,P<0.01,n=8.The expression of caspase 3,TGF-β1,MMP9,and type I/III collagen was lower in the ASX group than in the AMI group(caspase 3:0.38±0.06 vs.0.66±0.04,t=8.28;TGF-β1:0.37±0.04 vs.0.62±0.07,t=6.39;MMP9:0.20±0.06 vs.0.40±0.06,t=4.62;type I collagen:0.42±0.09 vs.0.74±0.07,t=5.73;type III collagen:0.13±0.02 vs.0.74±0.07,t=4.32,all P<0.01;n=4).Conclusions:ASX treatment after AMI may promote M2 macrophages and effectively attenuate cardiac remodeling by inhibiting inflammation and reducing myocardial fibrosis. | Xia Pan Kai Zhang Cheng Shen Xi Wang Long Wang Ya-Yi Huang | 2020 | Chinese Medical Journal2020，，15： | 8 |
| 14 | Heat Transfer Characteristics of Boiler Convective Heating Surface Under Pressurized Oxygen-fuel Combustion Conditions显示文摘增压富氧燃烧是一项极具前景的减排CO2新技术。对增压富氧燃烧条件下,对流受热面换热特性进行研究具有重要的意义。该文以一台实际300MW等级机组煤粉锅炉为计算对象,采用维里方程及Chun等的计算方法计算确定增压富氧燃烧烟气物性,采用宽带关联k模型计算富氧燃烧烟气辐射特性。进行了常规空气燃烧以及φ(O2):φ(CO2)=21:79、φ(O2):φ(CO2)=30:70两种比例的0.1、0.5、1.0、1.5、6 MPa五种压力下增压富氧燃烧各对流受热面的热力计算,分析了增压富氧燃烧条件烟气压力变化对各受热面换热特性的影响。研究结果表明:随烟气压力的升高,烟气流速下降,但烟气的Re却基本保持不变,对流换热系数有所增加。增压富氧燃烧烟气的辐射换热系数比空气燃烧烟气辐射换热系数大。实现同样的换热量,增压富氧燃烧条件下(φ(O2):φ(CO2)=21:79、φ(O2):φ(CO2)=30:70)对流受热面所需换热面积比常规空气燃烧条件下少。 | Gao Zhengyang Xia Ruiqing Yan Weiping Ma Kai Feng Wenhui Zhang Bowen | 2012 | 中国电机工程学报2012，32，23： | 8 |
| 15 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 16 | Regulating Zn Deposition via an Artificial Solid–Electrolyte Interface with Aligned Dipoles for Long Life Zn Anode显示文摘Aqueous zinc ion batteries show prospects for next-generation renewable energy storage devices.However,the practical applications have been limited by the issues derived from Zn anode.As one of serious problems,Zn dendrite growth caused from the uncontrollable Zn deposition is unfavorable.Herein,with the aim to regulate Zn deposition,an artificial solid–electrolyte interface is subtly engineered with a perovskite type material,BaTiO3,which can be polarized,and its polarization could be switched under the external electric field.Resulting from the aligned dipole in BaTiO3 layer,zinc ions could move in order during cycling process.Regulated Zn migration at the anode/electrolyte interface contributes to the even Zn stripping/plating and confined Zn dendrite growth.As a result,the reversible Zn plating/stripping processes for over 2000 h have been achieved at 1 mA cm^(−2) with capacity of 1 mAh cm−2.Furthermore,this anode endowing the electric dipoles shows enhanced cycling stability for aqueous Zn-MnO2 batteries.The battery can deliver nearly 100%Coulombic efficiency at 2 Ag^(−1) after 300 cycles. | Kai Wu Jin Yi Xiaoyu Liu Yang Sun Jin Cui Yihua Xie Yuyu Liu Yongyao Xia Jiujun Zhang | 2021 | Nano-Micro Letters2021，13，5： | 8 |
| 17 | A synergetic strategy based on laser surface texturing and lubricating grease for improving the tribological and electrical properties of Ag coating under current-carrying friction显示文摘Herein,a series of Ag coatings with different micro‐dimples were fabricated on copper surfaces by laser surface texturing(LST)and magnetron sputtering.Multilayer graphene lubricating grease(MGLG)was prepared using multilayer graphene as an additive.The textured Ag coatings and MGLG were characterized.Moreover,the tribological and electrical performances of the textured Ag coatings under MGLG lubrication were investigated in detail.Results demonstrated that the textured Ag coating with an appropriate dimple diameter could exhibit improved tribological and electrical properties when compared to the non‐textured Ag coating under MGLG lubrication.The characterization and analysis of the worn surfaces suggest that the synergetic effect of LST and MGLG contributes to these excellent tribological and electrical properties. | Zhengfeng CAO Yanqiu XIA Chuan CHEN Kai ZHENG Yi ZHANG | 2021 | Friction2021，9，5： | 7 |
| 18 | Effects of nitrogen form on growth,CO_2 assimilation,chlorophyll fluorescence,and photosynthetic electron allocation in cucumber and rice plants显示文摘Cucumber and rice plants with varying ammonium (NH4+) sensitivities were used to examine the effects of different nitrogen (N) sources on gas exchange, chlorophyll (Chl) fluorescence quenching, and photosynthetic electron allocation. Compared to nitrate (NO3-)-grown plants, cucumber plants grown under NH4+-nutrition showed decreased plant growth, net photosynthetic rate, stomatal conductance, intercellular carbon dioxide (CO2) level, transpiration rate, maximum photochemical efficiency of photosystem II, and O2-independent alternative electron flux, and increased O2-dependent alternative electron flux. However, the N source had little effect on gas exchange, Chl a fluorescence parameters, and photosynthetic electron allocation in rice plants, except that NH4+-grown plants had a higher O2-independent alternative electron flux than NO3--grown plants. NO3- reduction activity was rarely detected in leaves of NH4+-grown cucumber plants, but was high in NH4+-grown rice plants. These results demonstrate that significant amounts of photosynthetic electron transport were coupled to NO3- assimilation, an effect more significant in NO3-- grown plants than in NH4+-grown plants. Meanwhile, NH4+-tolerant plants exhibited a higher demand for the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) for NO3- reduction, regardless of the N form supplied, while NH4+-sensitive plants had a high water-water cycle activity when NH4+ was supplied as the sole N source. | Yan-hong ZHOU Yi-li ZHANG Xue-min WANG Jin-xia CUI Xiao-jian XIA Kai SHI Jing-quan YU | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，2： | 7 |
| 19 | Spatiotemporal simulation and predication of heavy metal(loid) concentrations in coal chemical industrial areas with a soil environmental capacity model显示文摘Heavy metal (loid)(HM) accumulation in the soil and the HM spatiotemporal distribution have important implication for soil pollution prevention and remediation. The present study investigated the concentrations and spatiotemporal distributions of lead (Pb), mercury (Hg), cadmium (Cd), chromium (Cr) and arsenic (As) in the topsoil of a coal chemical plant in Ningxia Aulonomous region (Ningxia), China. Topsoil samples (/?= 153) were obtained using the checkerboard method, and the HM concentrations were determined. The soil residual rates of the five HMs were measured with leaching experinients and were applied in a soil environmental capacity model to predict the quarHitiHive variation of the HM concentrations. The predicted results were employed to estimate the HM spatiotemporal distribution within 2() years with the Kriging technique. The number of sampling sites, where all five HM concentratio ns exceed their corresponding background values in Ningxia, would be increased from 0 to 90% within 1() years of the plant operation. In addition, Pb and Cd were distributed along the traffic routes. Mercury and As were distributed near fuel gas emission vents. Chromium was mainly accumulated in slag dumps. The study may provide the theoretical and practical foun d at ion for future HM pollution control in coal chemical plants. | Kai Zhang Jiajun Yang Yuning Ji Yu Xia | 2018 | International Journal of Coal Science & Technology2018，5，4： | 6 |
| 20 | Progress on design and related R&D activities for the water-cooled breeder blanket for CFETR显示文摘The water-cooled ceramic breeder (WCCB) blanket is one of the blanket candidates for Chinese fusion engineering testing reactor (CFETR) and is being developed at the Institute of Plasma Physics, Chinese Academy of Sciences (ASIPP). This paper reviews design and evolution of the WCCB blanket for CFETR, and presents a new WCCB blanket design according to the latest CFETR core parameters (major and minor radii are R = 7.2 m and a = 2.2 m, respectively) and missions. This new design is expected to satisfy multiple CFETR operation modes of 0.2, 0.5, 1.0, and 1.5 GW fusion power and achieve tritium self-sufficiency. The feasibility of the updated blanket design is evaluated from the aspects of neutronics and thermo-hydraulics. Furthermore, the research and development (R&D) activities supporting to the WCCB blanket for CFETR are reported, including the design code, the water loop experiments, the pebble bed modeling and experiments, and the components fabrication technology. | Songlin Liu Xiaoman Cheng Xuebin Ma Lei Chen Kecheng Jiang Xia Li Hui Bao Jichao Wang Wanjing Wang Changhong Peng Peng Lu Min Li Kai Huang | 2019 | Theoretical & Applied Mechanics Letters2019，9，3： | 6 |
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