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| 1 | Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes显示文摘 | Xiao-Lei Shi Yimeng Gao YupengYan HuchengMa Lulu Sun Pengyu Huang Xuan Ni Ludi Zhang Xin Zhao Haozhen Ren Dan Hu Yan Zhou Feng Tian Yuan Ji Xin Cheng Guoyu Pan Yi-Tao Ding LijianHui | 2016 | Cell Research2016，26，2： | 31 |
| 2 | Molecular mechanism of hepatitis B virus X protein function in hepatocarcinogenesis显示文摘Many factors are considered to contribute to hepatitis B virus(HBV)-associated hepatocellular carcinoma(HCC),including products of HBV,HBV integration and mutation,and host susceptibility. HBV X protein(HBx) can interfere with several signaling pathways associated with cell proliferation and invasion,and HBx C-terminal truncation has been suggested to impact the development of HCC. This review focuses on the pathological functions of HBx in HBV-induced hepatocarcinogenesis. As a transactivator,HBx can affect regulatory non-coding RNAs(nc RNAs),including micro RNAs and long nc RNAs. HBx is also involved in epigenetic modification and DNA repair. HBx interacts with various signal-transduction pathways,such as the p53,Wnt,and nuclear factor-κB pathways. We conclude that HBx hastens the development of hepatoma. | Ming Geng Xuan Xin Li-Quan Bi Lu-Ting Zhou Xiao-Hong Liu | 2015 | World Journal of Gastroenterology2015，21，38： | 24 |
| 3 | High levels of serum interleukin-6 increase mortality of hepatitis B virus-associated acute-on-chronic liver failure显示文摘BACKGROUND Patients with hepatitis B virus-associated acute-on-chronic liver failure(HBVACLF)present a complex and poor prognosis.Systemic inflammation plays an important role in its pathogenesis,and interleukin-6(IL-6)as a pro-inflammatory cytokine is related with severe liver impairment and also plays a role in promoting liver regeneration.Whether serum IL-6 influences HBV-ACLF prognosis has not been studied.AIM To determine the impact of serum IL-6 on outcome of patients with HBV-ACLF.METHODS We performed a retrospective study of 412 HBV-ACLF patients.The findings were analyzed with regard to mortality and the serum IL-6 level at baseline,as well as dynamic changes of serum IL-6 within 4 wk.RESULTS The serum IL-6 level was associated with mortality.Within 4 wk,deceased patients had significantly higher levels of IL-6 at baseline than surviving patients[17.9(7.3-57.6)vs 10.4(4.7-22.3),P=0.011].Patients with high IL-6 levels(>11.8 pg/mL)had a higher mortality within 4 wk than those with low IL-6 levels(≤11.8 pg/mL)(24.2%vs 13.2%,P=0.004).The odds ratios calculated using univariate and multivariate logistic regression were 2.10(95%confidence interval[CI]:1.26-3.51,P=0.005)and 2.11(95%CI:1.15-3.90,P=0.017),respectively.The mortality between weeks 5 and 8 in patients with high IL-6 levels at 4 wk was 15.0%,which was significantly higher than the 6.6%mortality rate in patients with low IL-6 levels at 4 wk(hazard ratio=2.39,95%CI:1.05-5.41,P=0.037).The mortality was 5.0%in patients with high IL-6 levels at baseline and low IL-6 levels at 4 wk,7.5%in patients with low IL-6 levels both at baseline and at 4 wk,11.5%in patients with low IL-6 levels at baseline and high IL-6 levels at 4 wk,and 16.7%in patients with high IL-6 levels both at baseline and at 4 wk.The increasing trend of the mortality rate with the dynamic changes of IL-6 was significant(P for trend=0.023).CONCLUSION A high level of serum IL-6 is an independent risk factor for mortality in patients with HBV-ACLF.Furthermore,a sustained high level or dynamic elevated level of serum IL-6 indicates a higher mortality. | Chao Zhou Ning Zhang Ting-Ting He Yao Wang Li-Fu Wang Yong-Qiang Sun Jing Jing Jing-Jing Zhang Shuang-Nan Fu Xuan Wang Xiao-Xiao Liang Xin Li Man Gong Jun Li | 2020 | World Journal of Gastroenterology2020，26，30： | 15 |
| 4 | Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger显示文摘Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid. | YIN Zhi Na WU Wen Jia SUN Chong Zhen LIU Hui Fan CHEN Wen Bo ZHAN Qi Ping LEI Zhuo Gui XIN Xuan MA Juan Juan YAO Kun MIN Tian ZHANG Meng Meng WU Hui | 2019 | Biomedical and Environmental Sciences2019，32，1： | 14 |
| 5 | Clinical practice guidelines for breast cancer implantable intravenous infusion ports:Chinese Society of Breast Surgery practice guidelines 2021显示文摘To standardize the clinical application of implantable intravenous(IV)ports,the Chinese Society of Breast Surgery(CSBrS)of the Chinese Medical Association has identified the key clinical issues through literature research and expert discussion and evaluated the relevant evidence with reference to the grading of recommendations assessment,development,and evaluation.The CSBrS formulated the clinical practice guidelines to provide a reference for physicians specializing in breast cancer and other fields. | Li Ma Zhi-Cheng Ge Ling Xin Ying-Xin Wang Yan-Shou Zhang Tian-Tian Tang Guo-Xuan Gao Qian Liu Xuan Zhao Yun-Jiang Liu Xiang Qu 无 | 2021 | Chinese Medical Journal2021，，16： | 11 |
| 6 | Ultrathin Al2O3-coated reduced graphene oxide membrane for stable lithium metal anode显示文摘Lithium(Li) metal has been considered as the most attractive anode materials for Li-ion batteries(LIBs)due to its high theoretic specific capacity. The formation of unstable solid electrolyte interphase(SEI) and dendritic Li on the metal anode, however, hindered its practical application. Herein, to address the issues, a Li-free electrode with ultrathin Al_2O_3 coated on reduced graphene oxide(rGO) membrane that covers a Cu foil current collector was developed. The composite electrode exhibits excellent interfacial protection of lithium metal deposited between Cu foil and rGO electrochemically. Firstly, it affords good Li^+ permeability from the electrolyte. Secondly, the ultrathin Al_2O_3 has sufficient mechanical strength to inhibit the penetration of Li dendrite. Li metal was observed uniformly deposited between rGO membrane and Cu collector, and stable cycle performance of Li plating/stripping with Coulombic efficiency of ~91.75% at the 100 th cycle is achieved in organic carbonate electrolyte without any additives. | Fan Zhang Fei Shen ZhaoYang Fan Xin Ji Bin Zhao ZhouTing Sun YingYing Xuan XiaoGang Han | 2018 | Rare Metals2018，37，6： | 11 |
| 7 | Association between the presence of H pylori in the liver and hepatocellular carcinoma: A meta-analysis显示文摘AIM: To evaluate the arguments for and against the possible roles of H pylori in hepatocellular carcinoma (HCC). METHODS: We performed a systematic review of all relevant studies published in the literature. A total of 103 clinical trials and reports were identified, but only 10 trials qualified under our selection criteria. A meta-analysis was carried out by a biostatistician according to the Cochrane Reviewers’ Handbook recommended by The Cochrane Collaboration.RESULTS: Nine case-control studies and one retrospective cross sectional study were included in the final analysis. Overall the prevalence of H pylori infection was 53.3% (129 of 242) in cases and 10.4% (29 of 280) in controls, and the summary odds ratio for the association of H pylori infection with the risk for HCC (using the fixed-effects model, which accounted for the homogeneity across the 10 studies) was determined to be 13.63 (95% CI, 7.90-23.49).CONCLUSION: Our analysis showed a positive association between H pylori infection and the risk of HCC, with an indication of possible publication bias and possible confounders due to study designs that showed results of less pronounced associations. | Shi-Ying Xuan Yong-Ning Xin An-Jin Chen Quan-Jiang Dong Xin Qiang Ning Li Ming-Hua Zheng Hua-Shi Guan | 2008 | World Journal of Gastroenterology2008，14，2： | 10 |
| 8 | Isolated superior mesenteric artery dissection: case for conservative treatment and endovascular repair显示文摘 | WU Bin ZHANG Jian YIN Ming-di WANG Lei SONG Jin-qiu LI Xuan YANG Dong DUAN Zhi-quan XIN Shi-jie | 2009 | Chinese Medical Journal2009，，2： | 10 |
| 9 | Helicobacter infection in hepatocellular carcinoma tissue显示文摘瞄准:调查 Helicobacter 种类(Helicobacter spp ) 是否能在肝细胞被检测癌(HCC ) 织物。方法:从有组织病理学说诊断的肝细胞癌(HCC ) 的 28 个病人的肝样品被学习。有另外的肝疾病的 22 个病人(5 与肝损伤, 7 与多孔的肝缝血管瘤, 6 与肝包囊并且 4 与肝石病) ,有胃的癌症的 25 个病人, 15 与结肠的癌症并且 15 与子宫的肌瘤用作控制。二活体检视从每个病人被获得。一个人为 Helicobacter spp 是有教养的。并且 DNA 的抽取,其它为扫描电子显微镜学(SEM ) 和原位杂交作好准备。样品在有微氧气的技术的哥伦比亚琼脂平皿上是有教养的。Helicobacter spp。被聚合酶链反应(PCR ) 与 Helicobacter spp 在从学习题目的活体检视检测。16S rRNA 教材。放大产品被南部的杂交识别并且进一步定序。而且,另外的基因(休假 A, cagA ) 为 Helicobacter pylori (H pylori ) 的 specific 被 PCR 也检测。Helicobacter spp。被 SEM 在活体检视观察。传播电子显微镜学(TEM ) 被执行识别有教养的积极 Helicobacter spp。Helicobacter spp 的存在。被原位杂交检测证实 Helicobacter 的类型。结果:在 HCC 和胃的癌症织物有教养的 Helicobacter 的积极的率是 10.7%(3/28 ) 并且 24%(6/25 ) 分别地。Helicobacter 微生物被典型外观在克在 TEM 上染色,积极 urease 和典型殖民地形态学上进一步识别。细菌被 SEM 在二件 HCC 样品的邻近的 hepatocytes 观察。球菌的数字比杆菌的大。细菌也在四件胃的癌症样品被发现。PCR 证明 HCC 和胃的癌症样品的积极的率分别地是 60.7% 和 72% ,当控制是 negative (P<0.01 ) 时。放大 PCR 的产品被南部的杂交识别并且定序。到 H pylori 的 16S rRNA 的相同是 97.80% 。样品被原位杂交为 Helicobacter spp 验证。16S rRNA-mRNA 并且证明是 H pylori 积极。在 HCC 和胃的癌症(P>0.05 ) 之间没有统计意义,但是 HCC 和控制的积极的率有统计意义(P<0.01 ) 。3 件仅仅 HCC 样品和 cagA 基因的 2 件胃的癌症样品被检测。任何一个都没在二个组为休假 A 与教材样品反应。至于 H pylori 的遗传型,类型 II 在类型上有偏爱我。结论:Helicobacter 感染在 HCC 病人的肝纸巾存在。Helicobacter spp。感染与 HCC 被联系,它需要进一步的研究。 | Shi-Ying Xuan Ning Li Xin Qiang Rong-Rong Zhou Yong-Xin Shi Wen-Jie Jiang | 2006 | World Journal of Gastroenterology2006，12，15： | 9 |
| 10 | Mycoplasma pneumoniae Macrolide Resistance and MLVA Typing in Children in Beijing,China,in 2016:Is It Relevant?显示文摘Objective The aim of this study is to investigate the macrolide resistance rate and molecular type with multiple-locus variable-number tandem-repeat analysis(MLVA)of Mycoplasma pneumoniae of Beijing in 2016 in pediatric patients.Methods Real-time quantitative polymerase chain reaction(PCR)was used to identify M.pneumoniae,and MLVA was performed.The domain V of the 23 S rRNA was sequenced to detect macrolide-resistant point mutations.We also investigated the activities of antibiotics against M.pneumoniae isolates in vitro.Results The PCR detection rate of M.pneumoniae in children in Beijing was 40%,and the macrolide resistance rate was 66%.The A2063 G mutation in the 23 S rRNA V region is the dominant mutation(137/146,93.84%),whereas the A2064 G mutation is rare(9/146,6.16%).Seventy-three samples were typed successfully by MLVA typing,including 86.3%(63/73)were MLVA type 4-5-7-2,and 13.7%(10/73)were MLVA type 3-5-6-2.No other types were found.No strains were resistant to levofloxacin or tetracycline.Conclusion In 2016,a specific decrease in the macrolide resistance rate occurred in Beijing.The detection rate and macrolide resistance rate of outpatients are lower than those of inpatients.The A2063 G mutants M.pneumoniae have high levels of resistance to erythromycin and azithromycin.The primary MLVA type is 4-5-7-2,followed by 3-5-6-2.No other MLVA types were detected.No strains resistant to tetracycline or levofloxacin were found in vitro. | DOU Hai Wei TIAN Xiu Jun XIN De Li WEI Ran ZHOU Wei WANG Hong QIN Xuan Guang SHAO Jun Yan XU Bao Ping GE Li Xia SHI Da Wei | 2020 | Biomedical and Environmental Sciences2020，33，12： | 9 |
| 11 | Specific HLA-DQB1 alleles associated with risk for development of hepatocellular carcinoma:A meta-analysis显示文摘AIM:To evaluate the association of human leukocyte antigen(HLA)-DQB1 alleles with hepatocellular carcinoma(HCC) through meta-analysis of published data.METHODS:Case-control studies on HLA-DQB1 allele association with HCC published up to January 2010 were included in the analyses.The odds ratios(ORs) of HLADQB1 allele distributions in HCC patients were analyzed and compared with healthy controls.The meta-analysis software REVMAN 5.0 was applied for investigating heterogeneity among individual studies and for summarizing all the studies.A meta-analysis was performed using fixed-effect or random-effect methods,depending on the absence or presence of significant heterogeneity.Seven case-control studies containing 398 cases and 594 controls were included in the final analysis.RESULTS:Among the five family alleles,two(DQB1*02 and DQB1*03) were found to be significantly associated with the risk of HCC.The combined OR for the association of DQB1*02 and DQB1*03 allele with the risk for HCC was 1.78(95% CI:1.05-3.03,P = 0.03) and 0.65(95% CI:0.48-0.89,P = 0.007),respectively.Among the 13 specific alleles,two(DQB1*0502 and DQB1*0602) were significantly associated with risk of HCC.The combined OR for the association of DQB1*0502 and DQB1*0602 allele with the risk for HCC was 1.82(95% CI:1.14-2.92,P = 0.01) and 0.58(95% CI:0.36-0.95,P = 0.03),respectively.No significant association was established for other HLA-DQB1 family alleles and specific alleles.CONCLUSION:Our results support the hypothesis that specific HLA-DQB1 allele families and alleles might influence the susceptibility or resistance to HCC,although it needs further investigations. | Yong-Ning Xin Zhong-Hua Lin Xiang-Jun Jiang Shu-Hui Zhan Quan-Jiang Dong Qing Wang Shi-Ying Xuan | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 12 | Lack of association between apolipoprotein C3 gene polymorphisms and risk of nonalcoholic fatty liver disease in a Chinese Han population显示文摘AIM:To investigate the association between two polymorphisms of apolipoprotein C3(APOC3)and risk of nonalcoholic fatty liver disease(NAFLD)in a Chinese Han population.METHODS:Genotypes for rs2854116 and rs2854117in APOC3 and the known rs738409 in patatin-like phospholipase domain-containing protein 3(PNPLA3)in 390patients with NAFLD and 409 control subjects were determined by sequencing and polymerase chain reaction analysis.Serum lipid profiles were determined using biochemical methods,and an index of insulin resistance(IR,HOMA-IR),serum APOC3 concentrations and total antioxidant status(TAS)were also assessed.RESULTS:No significant differences in genotype and allele frequencies of rs2854116 and rs2854117 were found between the NAFLD population and the controls(P>0.05).The OR for the association between-455Cand-482T allele carriers and the risk of NAFLD were1.06(95%CI:0.72-1.57,P>0.05)and 1.00(95%CI:0.68-1.48,P>0.05),respectively.The variant carriers did not have a significantly increased risk of NAFLD or elevated clinical and biochemical parameters such as APOC3 concentrations,IR(1.42±0.43 vs 1.48±0.52,P>0.05),liver enzymes and TAS(13.94±2.01vs 14.38±1.92,P>0.05)compared with the controls.Moreover,the results were similar when testing was carried out independent of the genetic variation in PNPLA3.CONCLUSION:The two polymorphisms of the APOC3gene are not associated with a risk of NAFLD,or with lipid profiles,IR and oxidative stress in the Chinese Han population. | Tong-Hong Niu Man Jiang Yong-Ning Xin Xiang-Jun Jiang Zhong-Hua Lin Shi-Ying Xuan | 2014 | World Journal of Gastroenterology2014，20，13： | 7 |
| 13 | Synthesis and bioassay of β-(1,4)-D-mannans as potential agents against Alzheimer's disease显示文摘 | Ru-wei JIANG Xiao-guang DU Xuan ZHANG Xin WANG Ding-yu HU Tao MENG Yue-lei CHEN Mei-yu GENG Jing-kang SHEN | 2013 | Acta Pharmacologica Sinica2013，34，12： | 7 |
| 14 | Lung-protective Ventilation in Patients with Brain Injury: A Multicenter Cross-sectional Study and Questionnaire Survey in China显示文摘 | Xu-Ying Luo Ying-Hong Hu Xiang-Yuan Cao Yan Kang Li-Ping Liu Shou-Hong Wang Rong-Guo Yu Xiang-You Yu Xia Zhang Bao-Shan Li Zeng-Xiang Ma Yi-Bing Weng Heng Zhang De-Chang Chen Wei Chen Wen-Jin Chen Xiu-Mei Chen Bin Du Mei-Li Duan Jin Hu Yun-Feng Hoang Gui-Jun Jia Li-Hong Li Yu-Min Liang Bing-Yu Qin Xian-Dong Wang Jian Xiong Li-Mei Yan Zheng-Ping Yang Chen-Ming Dong Dong-Xin Wang Qing-Yuan Zhan Shuang-Lin FU Lin Zhao Qi-Bing Huang Ying-Guang Xie Xiao-Bo Huang Guo-Bin Zhang Wang-Bin Xu Yuan Xu YaLing Liu He-Ling Zhao Rong-Qing Sun Ming Sun Qing-Hong Cheng Xin Qu Xiao-Feng Yang Ming Xu Zhong-Hua Shi Han Chen Xuan He Yan-Lin Yang Guang-Qiang Chen Xiu-Mei Sun Jian-Xin Zhou | 2016 | Chinese Medical Journal2016，，14： | 6 |
| 15 | Multi-center Study of Enteral Feeding Practices in Hospitalized Late Preterm Infants in China显示文摘Objective To investigate the current enteral feeding practices in hospitalized late preterm infants in the Beijing area of China. Methods A multi-center, cross-sectional study was conducted. Infants born after 34 weeks and before 37 weeks of gestation were enrolled from 25 hospitals in the Beijing area of China from October 2015 to October 2017. Data on enteral feeding practices were collected and analyzed. Results A total of 1,463 late preterm infants were enrolled, with a mean gestational age(GA) of 35.6(34.9, 36.1) weeks. The percentage of exclusive breastfeeding was 4.5% at the initiation of enteral feeding but increased to 14.4% at discharge. When human milk was not available, most infants(46.1%) were fed with preterm infant formula. The rate of exclusive human milk feeding in infants born at 34 weeks gestation was higher than at discharge(21.1% of infants born at 34 weeks' GA versus 12.1% of infants born at 35 weeks' GA versus 12.3% of infants born at 36 weeks' GA, P < 0.001). Only 28.4% of late preterm infants achieved full enteral feeding at discharge, and only 19.2% achieved 120 kcal/(kg·d) by enteral feeding at discharge. Importantly, 40.5% of infants did not regain the birth weight at discharge. Conclusion Enteral feeding support of late preterm infants has not been standardized to achieve optimal growth. Moreover, the human milk feeding rate was low, and many late preterm infants did not achieve the goal of enteral feeding and failed to regain birth weight at the time of discharge. More aggressive enteral feedings protocols are needed to promote human milk feeding and optimize growth for late preterm infants. | QUAN Mei Ying LI Zheng Hong WANG Dan Hua SCHIBLER Kurt YANG Li LIU Jie QIN Xuan Guang ZHANG Xin HAN Tong Yan ZHANG Wei | 2018 | Biomedical and Environmental Sciences2018，31，7： | 6 |
| 16 | PNPLA3 I148M variant in nonalcoholic fatty liver disease:Demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis显示文摘Patatin-like phospholipase domain-containing 3(PNPLA3 or adiponutrin) displays anabolic and catabolic activities in lipid metabolism,and has been reported to be significantly associated with liver fat content.Variousstudies have established a strong link between the 148 isoleucine to methionine protein variant(I148M) of PNPLA3 and liver diseases,including nonalcoholic fatty liver disease(NAFLD).However,detailed demographic and ethnic characteristics of the I148 M variant and its role in the development of nonalcoholic fatty liver fibrosis have not been fully elucidated.The present review summarizes the current knowledge on the association between the PNPLA3 I148 M variant and NAFLD,and especially its role in the development of nonalcoholic fatty liver fibrosis.First,we analyze the impact of demographic and ethnic characteristics of the PNPLA3 I148 M variant and the presence of metabolic syndrome on the association between PNPLA3 I148 M and NAFLD.Then,we explore the role of the PNPLA3 I148 M in the development of nonalcoholic fatty liver fibrosis,and hypothesize the underlying mechanisms by speculating a pro-fibrogenic network.Finally,we briefly highlight future research that may elucidate the specific mechanisms of the PNPLA3 I148 M variant in fibrogenesis,which,in turn,provides a theoretical foundation and valuable experimental data for the clinical management of nonalcoholic fatty liver fibrosis. | Li-Zhen Chen Yong-Ning Xin Ning Geng Man Jiang Ding-Ding Zhang Shi-Ying Xuan | 2015 | World Journal of Gastroenterology2015，21，3： | 6 |
| 17 | Differences in clinical features of Crohn's disease and intestinal tuberculosis显示文摘AIM: To investigate the clinical features of Crohn's disease(CD) and intestinal tuberculosis(ITB) with a scoring system that we have developed.METHODS: A total of 25 CD and 40 ITB patients were prospectively enrolled from August 2011 to July 2012.Their characteristics and clinical features were recorded. Laboratory, endoscopic, histologic and radiographic features were determined. The features with a high specificity were selected to establish a scoring system. The features supporting CD scored +1, and those supporting ITB scored-1; each patient received a final total score. A receiver operating characteristic(ROC) curve was used to determine the best cut-off value for distinguishing CD from ITB.RESULTS: Based on a high specificity of differentiating between CD and ITB, 12 features, including longitudinal ulcers, nodular hyperplasia, cobblestone-like mucosa, intestinal diseases, intestinal fistula, the target sign, the comb sign, night sweats, the purified protein derivative test, the interferon-γ release assay(T-SPOT.TB), ring ulcers and ulcer scars, were selected for the scoring system. The results showed that the average total score of the CD group was 3.12 ± 1.740, the average total score of the ITB group was-2.58 ± 0.984, the best cutoff value for the ROC curve was-0.5, and the diagnostic area under the curve was 0.997, which was statistically significant(P < 0.001). The patients whose total scores were higher than-0.5 were diagnosed with CD; otherwise, patients were diagnosed with ITB. Overall, the diagnostic accuracy rate and misdiagnosis rate of this scoring system were 97% and 3%, respectively. CONCLUSION: Some clinical features are valuable for CD and ITB diagnosis. The described scoring system is key to differentiating between CD and ITB. | Xin Huang Wang-Di Liao Chen Yu Yi Tu Xiao-Lin Pan You-Xiang Chen Nong-Hua Lv Xuan Zhu | 2015 | World Journal of Gastroenterology2015，21，12： | 6 |
| 18 | Glutamate Impairs Mitochondria Aerobic Respiration Capacity and Enhances Glycolysis in Cultured Rat Astrocytes显示文摘Objective To study the effect of glutamate on metabolism, shifts in glycolysis and lactate release in rat astrocytes. Methods After 10 days, secondary cultured astrocytes were treated with 1 mmol/L glutamate for 1 h, and the oxygen consumption rates(OCR) and extra cellular acidification rate(ECAR) was analyzed using a Seahorse XF 24 Extracellular Flux Analyzer. Cell viability was then evaluated by MTT assay. Moreover, changes in extracellular lactate concentration induced by glutamate were tested with a lactate detection kit. Results Compared with the control group, treatment with 1 mmol/L glutamate decreased the astrocytes' maximal respiration and spare respiratory capacity but increased their glycolytic capacity and glycolytic reserve. Further analysis found that 1-h treatment with different concentrations of glutamate(0.1-1 mmol/L) increased lactate release from astrocytes, however the cell viability was not affected by the glutamate treatment. Conclusion The current study provided direct evidence that exogenous glutamate treatment impaired the mitochondrial respiration capacity of astrocytes and enhanced aerobic glycolysis, which could be involved in glutamate injury or protection mechanisms in response to neurological disorders. | YAN Xu SHI Zhong Fang XU Li Xin LI Jia Xin WU Min WANG Xiao Xuan JIA Mei DONG Li Ping YANG Shao Hua YUAN Fang | 2017 | Biomedical and Environmental Sciences2017，30，1： | 6 |
| 19 | A three-microRNA panel in serum as novel biomarker for papillary thyroid carcinoma diagnosis显示文摘Background:Accumulating evidence has revealed that circulating microRNAs(miRNAs)can serve as non-invasive biomarkers for cancer diagnosis.This study aimed to identify differentially expressed miRNAs in serum which might become potential biomarkers for non-invasive diagnosis of papillary thyroid carcinoma(PTC).Methods:The experiment was carried out between 2015 and 2017.In the screening stage,the Exiqon miRNA quantitative real-time polymerase chain reaction(qPCR)panel was applied to select candidate miRNAs.In the following training,testing,and external validation stages,the serum samples of 100 patients and 96 healthy controls(HCs)were analyzed to compare the expression levels of the identified miRNAs.The areas under the receiver operating characteristic curves(AUCs)were calculated to assess the diagnostic value of the identified signature.Results:Three miRNAs(miR-25-3p,miR-296-5p,and miR-92a-3p)in serum were consistently up-regulated in PTC patients compared with HCs.A three-miRNA panel was constructed by logistic regression analysis and showed better diagnostic performance than a single miRNA for PTC detection.The AUCs of the panel were 0.727,0.771,and 0.862 for the training,testing,and external validation stage,respectively.Meanwhile,the panel showed stable capability in differentiating PTC patients from patients with benign goiters,with an AUC as high as 0.969.For further exploration,the three identified miRNAs were analyzed in tissue samples(23 PTC vs.23 HCs)and serum-derived exosomes samples(24 PTC vs.24 HCs),and the altered expression in the tumor also indicated their close relationship with PTC disease.Conclusion:We identify a three-miRNA panel in serum which might serve as a promising biomarker for PTC diagnosis. | Xuan Zou Feng Gao Zhi-Yan Wang Huo Zhang Qing-Xie Liu Lin Jiang Xin Zhou Wei Zhu | 2020 | Chinese Medical Journal2020，，21： | 6 |
| 20 | Inhibitory effects of sunitinib on ovalbumin-induced chronic experimental asthma in mice显示文摘背景酷氨酸 kinase 发信号串联在过敏航线发炎的致病起一个关键作用。Sunitinib,一个 multitargeted 受体酷氨酸 kinase 禁止者,被报导了施加有势力 immunoregulatory,反煽动性并且反纤维变性效果。我们调查了 sunitinib 是否能压制航线发炎,航线 hyperresponsiveness (AHR ) ,和在长期的气喘的一个鼠科的模型改变的航线的前进。方法 Ovalbumin (卵) 敏化老鼠长期地与 aerosolized 卵被质问 8 个星期。一些老鼠每天 intragastrically 在卵挑战的时期期间与 sunitinib (40 mg/kg ) 被管理。12 个小时在最后卵质问以后,老鼠为航线发炎, AHR 并且航线改变的发展被评估。全部的浆液免疫球蛋白 E (IgE ) 和在 bronchoalveolar lavage 液体(BALF ) 的 Th2 cytokines (interieukin (IL )-4 和 IL-13 ) 的层次被 ELISA 测量。在肺的 phosphorylated c 工具包蛋白质的表示被弄污的 immunoprecipitation/Western (IP/WB ) 检测 analysis.Results Sunitinib 显著地禁止了在长期的试验性的气喘改变的嗜曙红的航线发炎,坚持的 AHR 和航线。它减少了全部的浆液 IgE 和 BALF Th2 cytokines 的层次并且也降低了在改变的 airways.Conclusions Sunitinib 的 c 工具包蛋白质可以禁止的 phosphorylated 的表达式航线发炎, AHR 并且航线改变的开发。它对气喘的预防或处理潜在地有益。 | HUANG Mao LIU Xuan DU Qiang YAO Xin YIN Kai-sheng | 2009 | Chinese Medical Journal2009，，9： | 5 |
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