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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 3 | The epidemiology of human trichinellosis in China during 2000- 2003 显示文摘 | Wang ZQ Cui J Xu BL | 2006 | Acta Trop2006，97，3： | 1 |
| 4 | Baicalin induces hu- man mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo 显示文摘 | Xu XF Cai BL Guan SM | 2011 | Invest New Drugs2011，29，4： | 1 |
| 5 | Metagenomic analysis of fe ver, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus显示文摘 | Xu BL Liu LC Huang XY | 2011 | PLoS Pathog2011，7，10： | 1 |
| 6 | Metagenomic analysis of fever, thromborytopenia and leukopenia syndrome (FTLS) in Henan Province,China:discovery of a new bunyavirus显示文摘 | Xu BL Liu Lc Huang XY | 2011 | PloS Pathog2011，7，10： | 1 |
| 7 | Intraeranial Artery Athe- rosclerosis and Lumen Dilation in cerebral small-vessel diseases:a high-resolution MRI study显示文摘 | Xu W H Li bl L Niu J W | 2014 | CNS Neurosci Ther2014，20，4： | 1 |
| 8 | Metagenomic analysis offever, thrombocytopenia and leukopenia syndrome ( FTLS) inHenan Province, China: discovery of a new bunyavirus 显示文摘 | XU BL LIU LC HUANG XY | 2011 | PLoSPathog2011，7，00： | 1 |
| 9 | Demineralized bone matrix gelatin as scaffold for osteochondral tissue engineering显示文摘 | Xu DL Li JN Gary BL | 2006 | Bio- materials2006，27，11： | 1 |
| 10 | Images of deep neck space infection and the clinical significance显示文摘 | Wang B Gao BL Xu GP | 2014 | Acta radiologica2014，55，8： | 1 |
| 11 | Studies of poly( ethylene glycol) modification of HM-3 polypeptides显示文摘 | Zhou K Zhu BL Xu HM | 2010 | Bioconjugate chemistry2010，20，5： | 1 |
| 12 | The epidemiology of human trichinellosis in China during 2000-2003显示文摘 | Wang ZQ Cui J Xu BL | 2005 | Acta Trop2005，，： | 1 |
| 13 | Site-specific modification of antiangiogenesis peptide HM-3 by polyethylene glycol molecular weight of 20 kDa显示文摘 | Zhu BL Xu HM Zhao LM | 2010 | Journal of Biochemistry2010，148，3： | 1 |
| 14 | The epidemiology of humans trichinello- sis in China during 2000 -2003 显示文摘 | Wang ZQ Cui J Xu BL | 2006 | Acta trop2006，97，3： | 1 |
| 15 | Metagenomic analysis of fever,thrombocytopenia and leukopenia syndrome (FTLS) in Henan province,China:discovery of a new bunyavirus显示文摘 | Xu BL Liu LC Huang XY | 2011 | PLoS Pathog2011，7，10： | 1 |
| 16 | Systematic review on Epstein- Barr virus (EBV) DNA in diagnosis of nasopharyngeal carcinoma in Asian populations 显示文摘 | Han BL Xu XY Zhang CZ | 2012 | Asian Pac J Cancer Prev2012，13，6： | 1 |
| 17 | Pulmonmy cryplococcosis in non AIDS patients 显示文摘 | Yu JQ Tang KJ Xu BL | 2012 | Braz J Infect Dis2012，16，6： | 1 |
| 18 | Diagnosticvalue of alpha-fetoprotein-L3 and Golgi protein 73 in hep- atocellular carcinomas with low AFP levels显示文摘 | Xu WJ Guo BL Han YG | 2014 | Turnout Biol2014，35，12： | 1 |
| 19 | SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase 显示文摘 | Bennett BL Sasaki DT Murray BW O'Leary EC Sakata ST Xu W | 2001 | Proc Natl Acad Sci USA2001，98，13： | 1 |
| 20 | Chromium(Ⅵ) reduction by hydrogen sulfide in aqueous media: stoichiometry and kinetics显示文摘 | Kim C Zhou QH Deng BL Thornton EC Xu HF | 2001 | Environmental Science and Technology2001，35，11： | 1 |
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