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| 1 | The role of autophagy in cardiac hypertrophy显示文摘Autophagy 从更低的优核质在自然被保存到哺乳动物并且是一重要自我吃, degradative processthat 贡献过剩材料的消除。心脏的肥大被过量 proteinsynthesis,增加的 cardiomyocyte 尺寸,和变厚的室的墙首先描绘并且是支持 arrhythmiaand 心失败的一个主要风险因素。在最近的年里, cardiomyocyte autophagy 被认为在控制 hypertrophicresponse 起一个作用。然而,在心脏的肥大的 cardiomyocyte autophagy 的有益或加重的角色仍然是在心脏的肥大的 cardiomyocyte autophagy 的准确机制进一步要求的 controversial.The 学习。在这评论,我们在心脏的肥大与 autophagy 联系的 summarizethe 争吵并且在心脏的肥大的 thedevelopment 提供卓见进 autophagy 的角色。我们断定未来研究应该强调在 autophagy andthe 之间的关系心脏的肥大的不同阶段,以及 autophagic 流动和选择 autophagy。Autophagy 将是为心脏的肥大的一个 potentialtherapeutic 目标。 | Lanfang Li Jin Xu Lu He Lijun Peng Qiaoqing Zhong Linxi Chen Zhisheng Jiang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 30 |
| 2 | miR-503-3p promotes epithelialemesenchymal transition in breast cancer by directly targeting SMAD2 and E-cadherin显示文摘Although progress in clinical and basic research has significantly increased our understanding of breast cancer, little is known about the molecular mechanism underlying breast cancer metastasis. Identification of effective therapeutic targets to prevent breast cancer metastasis is urgently needed. The function of mi R-503-3p has been investigated in other cancers, but its role in breast cancer remains undefined.Here, we found that mi R-503-3p was overexpressed in breast cancer tissue and plasma compared with adjacent normal breast tissue and with plasma from healthy individuals. Moreover, we identified mi R-503-3p to be an oncogene of breast cancer cell proliferation, migration and invasion. Upregulation of mi R-503-3p in breast cancer cells inhibited expression of epithelialemesenchymal transition(EMT)-related protein SMAD2 and the epithelial marker protein E-cadherin by directly binding to their m RNA30 untranslated region, whereas increased expression of mesenchymal marker proteins, including vimentin and N-cadherin. Taken together, our findings support a critical role for mi R-503-3p in induction of breast cancer EMT and suggest that plasma mi R-503-3p may be a useful diagnostic biomarker for breast cancer. | Zitong Zhao Xinyi Fan Lanfang Jiang Zhongqiu Xu Liyan Xue Qimin Zhan Yongmei Song | 2017 | Journal of Genetics and Genomics2017，44，2： | 15 |
| 3 | NEK7: a novel promising therapy target for NLRP3-related inflammatory diseases显示文摘 | Jin Xu Liqun Lu Lanfang Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 12 |
| 4 | Polysaccharides in Sipunculus nudus: Extraction Condition Optimization and Antioxidant Activities显示文摘Marine organisms constitute unlimited resource of bioactive substances due to their high biodiversity and represent a valuable source of new compounds. This study optimized the alkali-extraction conditions and antioxidant activities of soluble polysaccharides from the body wall of Sipunculus nudus. The effects of solid-liquid ratio, extraction duration, extraction temperature, and alkali concentration on the yield of S. nudus polysaccharides(SNP) were examined, according to which the optimal combination of extraction parameters was obtained by an orthogonal test. The relative influencing importance of different extraction parameters on the yield of SNP followed the order as solid-liquid ratio > extraction temperature > alkali concentration > extraction duration. The highest extraction yield, 1.98%, was achieved under an optimal extraction condition: temperature 60℃, solid-liquid ratio 1:6 g mL^(-1), duration 5 h, and alkali(Na OH) mass fraction 6%. The in vitro antioxidant activities examination showed that extracted SNP under this optimized condition had strong power in reducing certain hydroxyl and superoxide radical scavenging abilities. The promising results showed that extracted SNP could be a potent natural antioxidant. | ZHANG Qin DONG Lanfang TONG Tong WANG Qingchao XU Mingzhu | 2017 | Journal of Ocean University of China2017，16，1： | 5 |
| 5 | Boundary Perturbed Problem for Reaction Diffusion Time Delay Equation with Two Parameters显示文摘The singular perturbation problem for reaction diffusion time delay equation with boundary perturbation is considered. Firstly, the outer solution for the initial boundary value problem is constructed. Then, the initial and boundary layer correction terms are obtained using the stretched variables transforms. Finally, the asymptotic behavior of solution for the initial boundary value problem is studied. | XU Yonghong SHI Lanfang MO Jiaqi | 2015 | Wuhan University Journal of Natural Sciences2015，20，2： | 3 |
| 6 | Distribution and origin of high magnetic anomalies at Luobusa Ophiolite in Southern Tibet显示文摘The Luobusa Ophiolite,Southern Tibet,lies in the eastern portion of Indus–Yarlung Zangbo suture zone that separates Eurasia from the Indian continent.An aeromagnetic reconnaissance survey has revealed an EWtrending Yarlung Zangbo River aeromagnetic anomaly zone,and it is considered to be caused mainly by the Indus–Yarlung Zangbo Ophiolite.The Luobusa Ophiolite reflects the eastern portion of the Yarlung Zangbo River aeromagnetic anomaly zone.Conventionally,the ultramafic rock in the Luobusa Ophiolite is considered as the origin of the high magnetic anomalies.However,results from the surface magnetic survey and the magnetic susceptibility measurements from drill cores indicate that the high magnetic anomalies are distributed inhomogeneously in the Luobusa Ophiolite.In some cases,the susceptibility exhibits more than 30 times difference between two sides of the same sample.A fact emerged that the susceptibility of dunite with serpentinization is higher than that of fresh dunite,harzburgite and chromite when we analyzed the measurement results.In order to understand the origin of the high magnetic anomalies,we measured the density and susceptibility of 17 samples,microscopic and electron probe analyses have been performed as well.The result indicates the presence of dunite with serpentinization containing an abundant of micro-fissures filled with magnetite.Olivine has a susceptibility of about 2.7–351(910-5SI),pyroxene about 16–320,and chromite about200–800.All these units feature relatively low susceptibility in ultramafic rock,and only the magnetite is characterized by a high susceptibility of about 200,000(910-5SI).Based on these observations,we conclude that the precipitation of magnetite in the process of serpentinization of the olivine caused by the geological process in the Luobusa Ophiolite is the origin of high magnetic anomalies. | Lanfang He Xiumian Hu Yabing Zha Ligui Xu Yaohui Wang | 2014 | Chinese Science Bulletin2014，59，23： | 2 |
| 7 | Survey of context aware mobile computing research 显示文摘 | Xu Lanfang | 2007 | Computer Science Engineering2007，29，4： | 1 |
| 8 | Improved plasmon-assisted photoelectric conversion efficiency across entire ultraviolet-visible region based on antenna-on zinc oxide/silver three-dimensional nanostructured films显示文摘ZnO 在 photoelectrochemical 水切开,光催化,和光电的设备为应用收到了巨大的注意。然而, ZnO 的光电的变换效率被 photoexcited 电子洞对和宽乐队差距的快速的再结合限制,它允许仅仅要吸收的太阳的光谱的小部分。最近,实质的研究努力试图增加光电的变换效率越过全部紫外可见(紫外力) 由与高贵金属 nanoparticles (NP ) 联合象 ZnO 那样的半导体的光谱。在这研究,我们作为在用途广泛的紫外力的照明下面,光电流在 ZnO/Ag 产生了的 photoelectrodes.We 表演比较一部纯 ZnO 电影和 ZnO/Ag nanostructured 电影的表演三维(3D ) nanostructured 相对在纯 ZnO 电影产生的光电流拍摄增加 3.75 次。我们把高光电流归因于与 Ag NP 的局部性的表面电浆子回声联系的电场的改进,并且到 photoexcited 的创造,它在在 3D nanostructured 电影的高密度是在场的在被转移到 ZnO 的 Ag 的热电子,支持电子洞对分离。我们建议机制在新窗户中解释光电的变换 efficiency.Open | Lijuan Yan Yang Liu Yaning Yan Lanfang Wang Juan Han Yanan Wang Guowei Zhou Mark T. Swihart Xiaohong Xu | 2018 | Nano Research2018，11，1： | 1 |
| 9 | Optimization of cyclical process for CO coupling regeneration reactions 显示文摘 | Wang Baowei Ma Xinbin Xu Genhui Mao Lanfang | 2000 | Computers & Chemical Engineering2000，24，27： | 1 |
| 10 | Apelin/APJ system: a novel promising therapy target for thrombotic diseases显示文摘APJ,它是开始与最靠近的相同作为基因识别了到血管收缩素 II 类型 1 受体,是七 transmembrane G 联合蛋白质的受体。Apelin 是原来从牛的胃摘录孤立的 APJ 的内长的 ligand。有 apelin 的几 isoforms。Apelin preproproteins 包含 77 氨基酸的残余,它能被劈开形成更短的 bioactive isoforms 包括 apelin-36, apelin-17, apelin-13, apelin-12 等等。Apelin/APJ 受体广泛地在中央神经系统和外部纸巾被散布。Apelin/APJ 系统在大量生理、病理学的函数包含。例如, apelin 经由 NO/cGMP-dependent 机制降低血压。Apelin-13 在 cardiomyocytes 维持对 ischemia/reperfusion 短暂的 Ca 2+ 。而且, apelin-13 经由 PI3K/AKT 激活支持房间增长和 angiogenesis [1,2 ] 。 | Lanfang Li Jin Xu Linxi Chen Zhisheng Jiang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 1 |
| 11 | In Vitro and In Vivo Enhancement of Chemoradiation Using the Oral PARP Inhibitor ABT-888 in Colorectal Cancer Cells显示文摘 | Joseph W. Shelton Timothy V. Waxweiler Jerome Landry Huiying Gao Yanbo Xu Lanfang Wang Bassel El-Rayes Hui-Kuo G. Shu | 2013 | International Journal of Radiation Oncology, Biology, Physics2013，，3： | 1 |
| 12 | Effects of Dietary Carbohydrate-lipid Ratio on Growth, Body Composition and Digestive Enzyme Activities of Juvenile Peanut Worm,Sipunculus nudus显示文摘[Objective] This study was conducted to investigate the effects of dietary carbohydrate-lipid( C / L) ratios on growth performance,body composition and digestive enzyme activities of juvenile peanut worm. [Methods]Juvenile peanut worm with average body weight of( 16. 77 ± 0. 40) mg were fed with five isonitrogenous and isoenergetic diets formulated to contain different carbohydrate / lipid( C / L) ratios( 0. 68,1. 02,1. 62,2. 61 or 4. 35) for 8 weeks. [Results] The dietary C / L ratios had no significant effects on survival of juvenile peanut worm( P > 0. 05). With the increasing of dietary C / L ratios,weight growth rate( WGR)and specific growth rate( SGR) increased when dietary C / L ratios were between 0. 68 and 2. 61,and then decreased significantly with dietary C / L ratio further increased. When the dietary C / L ratio was 2. 61( carbohydrate level was 20. 64%,lipid level was 7. 92%) both WGR and SGR produced the maximum value,they were 451. 78 ± 16. 85% and 3. 41 ± 0. 06 % / d,respectively. The dietary C / L ratios had significant effects on body moisture,body protein content and body lipid content( P < 0. 05),but no significant effects on body ash content of juvenile peanut worm( P > 0. 05). Different C / L ratios had significant effects on amylase activity and lipases activity of juvenile peanut worm( P < 0. 05),but no significant effects on protease activity( P > 0. 05). [Conclusion]The regression model analysis showed that the most suitable dietary C / L ratio which can make juvenile peanut worm acquire the best weight growth rate is 2. 42. | Zhang Qin Xu Mingzhu Tong Tong Tong Wanping Dong Lanfang Cheng Guangping Zou Jie Jiang Yan | 2014 | Animal Husbandry and Feed Science2014，6，5： | 0 |
| 13 | Research on the direct damage-based seismic design method of RC frame structures显示文摘 | Lanfang LUO Jing XU | 2013 | International Journal of Technology Management2013，，2： | 0 |
| 14 | Lipid Biomarkers and Their Stable Carbon Isotopes in Ancient Seep Carbonates from SW Taiwan, China显示文摘Four massive brecciated, chimney-like, and slender pipe network carbonate samples(JA-4, JA-5, JX-8 and BG-12) were collected from southwestern Taiwan, which were suggested to have formed as a result of anaerobic oxidization of methane(AOM). Considering that the environmental conditions of the carbonates precipitation and the sources of carbon and organic matter need to be further declared, molecular fossils and compound-specific carbon isotopic investigations of the carbonates were conducted in this study. According to lipid biomarkers of 2,6,10,15,19-pentamethyleicosane(PMI) and squalane diagnostic to methanotrophic archaea, as well as the extremely low δ^(13)C values(as low as -1^(13).4‰) detected in samples JA-4, JA-5 and JX-8, these carbonates were revealed to be a result of AOM. Based on the varied δ^(13)C values of characteristic archaea biomarkers in specific samples, biogenic methane was proposed to be responsible for the formation of samples JA-4 and JA-5, whereas a mixed carbon source of ^(13)C-depleted methane and ^(13)C-enriched residual CO_2 from methanogenesis was suggested for the carbonate of JX-8 due to the co-occurrence of a highly positive δ^(13) C_(carb) value(+8‰) and a moderate ^(13)C depletion of PMI. The low content of AOM-related biomarkers and the absence of indicators for ANME-2 suggested that these carbonates were formed in weak seep settings. By comparison, no typical lipid biomarkers for methanotrophic archaea was detected in carbonate BG-12. The short-chain and long-chain n-alkanes accounted for 30% and 45% of all hydrocarbons, respectively, with a CPI value of 1.2, suggesting that the n-alkanes were derived from both marine organisms and terrestrial inputs. A low thermal maturity could be revealed by the incomplete equilibrium value of the C^(31)αβ 22S/(22S+22R) ratio(0.5), and the carbonate BG-12 was probably deposited in a suboxic condition indicated by a value of Pr/Ph ratio(2.5). | GUAN Hongxiang XU Lanfang WANG Qinxian CHEN Duofu WU Nengyou MAO Shengyi | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 0 |
| 15 | A trust-based method for selection of contractors in construction industry显示文摘 | Jing XU Yanxin LIU Lanfang LUO | 2013 | International Journal of Technology Management2013，，2： | 0 |
| 16 | Receptor-mediated reticulophagy: a novel promising therapy target for diseases显示文摘Autophagy ? 一个高度保存的自我消化过程从更低的优核质正在发怒到哺乳动物。Autophagy 在错误褶层蛋白质总数和损坏细胞器的降级包含,它随后被再使用。在 autophagy 之上被开始,膜结构称为 phagophore, autophagosome 的先锋,逐渐地扩展并且吞没并且为降级把他们送到 vacuole/lysosome 错误褶层蛋白质或损坏细胞器。Autophagy 贡献幸存和死亡的过程。基本 autophagy 为维持细胞的动态平衡是必要的。在正常生理学期间,专业化细胞的功能由清除要求 autophagy 的规定错误褶层蛋白质或损坏细胞器。然而,过多并且 dysregulated autophagy 可以由于从 lysosomes 漏的酶导致 apoptosis 和甚至房间死亡[1 ] 。 | Lanfang Li Jin Xu Linxi Chen Zhisheng Jiang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 0 |
| 17 | Effects of Dietary Carbohydrate Sources on Daily Weight Gain and Digestive Enzyme Activities of Juvenile Peanut Worm(Sipunculus nudus)显示文摘In the study,glucose,sucrose,dextrin,tapioca starch,potato starch,corn starch and gelatinized corn starch were selected to make the diets with same nitrogen and lipid,and Juvenile peanut worms( Sipunculus nudus) were fed with the diets came from different carbohydrate sources,effects of diets with different carbohydrate sources on daily weight gain and digestive enzyme activities of S. nudus were studied. Results showed that diets with different carbohydrate sources had significant influences on daily weight gain and digestive enzyme activities of S. nudus( P < 0. 05). Daily weight gain in gelatinized corn starch group was significantly higher than that in other groups( P < 0. 05); daily weight gain in glucose group was significantly lower than that in other groups( P < 0. 05); daily weight gain in the three ungelatinized starch groups was significantly higher than that in glucose,sucrose and dextrin groups( P < 0. 05). Analysis of digestive enzyme activities showed that dietary carbohydrate sources had significant influences on digestive enzyme activities of S. nudus( P < 0. 05). Protease activities and amylase activities of S. nudus in sucrose group were the highest,which were significantly higher than that in the other groups( P < 0. 05); lipase activities of S. nudus in glucose group were the lowest,which were significantly lower than that in other groups( P < 0. 05). In conclusion,growth-promoting effects of macromolecules carbohydrates( starch) were better than that of disaccharide( sucrose) and monosaccharide( glucose),which of gelatinized starch were better than that of ungelatinized starch. | Zhang Qin Xu Mingzhu Tong Tong Dong Lanfang | 2015 | Animal Husbandry and Feed Science2015，7，6： | 0 |
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