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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units: a prospective cohort study显示文摘 | WEN Ying JIANG Li XU Yuan QIAN Chuan-yun LI Shu-sheng QIN Tie-he CHEN Er-zhen LIN Jian-dong AI Yu- hang WU Da-wei WANG Yu-shan SUN Ren-hua HU Zhen-jie CAO Xiang-yuan ZHOU Fa-chun HE Zhen-yang ZHOU Li-hua AN You-zhong KANG Yan MA Xiao-chun YU Xiang-you ZHAO Ming-yan XI Xiu-ming DU Bin | 2013 | Chinese Medical Journal2013，，23： | 40 |
| 3 | Inhibition of cerebral ischemia/reperfusion injuryinduced apoptosis:nicotiflorin and JAK2/STAT3 pathway显示文摘Nicotiflorin is a flavonoid extracted from Carthamus tinctorius.Previous studies have shown its cerebral protective effect,but the mechanism is undefined.In this study,we aimed to determine whether nicotiflorin protects against cerebral ischemia/reperfusion injury-induced apoptosis through the JAK2/STAT3 pathway.The cerebral ischemia/reperfusion injury model was established by middle cerebral artery occlusion/reperfusion.Nicotiflorin(10 mg/kg) was administered by tail vein injection.Cell apoptosis in the ischemic cerebral cortex was examined by hematoxylin-eosin staining and terminal deoxynucleotidyl transferase d UTP nick end labeling assay.Bcl-2 and Bax expression levels in ischemic cerebral cortex were examined by immunohistochemial staining.Additionally,p-JAK2,p-STAT3,Bcl-2,Bax,and caspase-3 levels in ischemic cerebral cortex were examined by western blot assay.Nicotiflorin altered the shape and structure of injured neurons,decreased the number of apoptotic cells,down-regulates expression of p-JAK2,p-STAT3,caspase-3,and Bax,decreased Bax immunoredactivity,and increased Bcl-2 protein expression and immunoreactivity.These results suggest that nicotiflorin protects against cerebral ischemia/reperfusion injury-induced apoptosis via the JAK2/STAT3 pathway. | Guang-qiang Hu Xi Du Yong-jie Li Xiao-qing Gao Bi-qiong Chen Lu Yu | 2017 | Neural Regeneration Research2017，12，1： | 40 |
| 4 | Epidemiology of respiratory distress and the illness severity in late preterm or term infants: a prospective multi-center study显示文摘背景呼吸悲痛的严厉与新生的预后被联系。这研究试图近来探索临床的特征,治疗学的干预和短期的结果要求了的 preterm 或术语婴儿呼吸支持,并且比较不同的病严厉评价 tools.Methods 的用法第三级的医院里的七个新生的特别护理单位被招募。从 2008 年 11 月到 2009 年 10 月,在 34 星期的 gestational 出生的出生不满一月的婴儿变老,在 72 小时年龄承认了,为呼吸支持要求连续积极航线压力(CPAP ) 或机械通风被注册。包括人口统计的变量,内在的疾病,复杂并发症,治疗学的干预和短期的结果的临床的数据是镇定的。所有婴儿被在风险新生儿(橡树子) 的尖锐照顾划分成三个组呼吸分数 5, 5-8,和 8 .Results 在学习时期, 503 新生的迟了的 preterm 或学期婴儿期间要求了呼吸支持。吝啬的 gestational 年龄是(36.8 ? 湥牧獯敳 ? 湩 ? 眠吗? | MA Xi'ao-lu XU Xue-feng CHEN Chao YAN Chao-ying LIU Ya-ming LIU Ling XIONG Hong SUN Hui-qing LAI Jian-pu YI Bin SHI Jing-yun DU Li-zhong | 2010 | Chinese Medical Journal2010，，20： | 31 |
| 5 | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is an aggressive human cancer with increasing incidence worldwide.Multiple efforts have been made to explore pharmaceutical therapies to treat HCC,such as targeted tyrosine kinase inhibitors,immune based therapies and combination of chemotherapy.However,limitations exist in current strategies including chemoresistance for instance.Tumor initiation and progression is driven by reprogramming of metabolism,in particular during HCC development.Recently,metabolic associated fatty liver disease(MAFLD),a reappraisal of new nomenclature for nonalcoholic fatty liver disease(NAFLD),indicates growing appreciation of metabolism in the pathogenesis of liver disease,including HCC,thereby suggesting new strategies by targeting abnormal metabolism for HCC treatment.In this review,we introduce directions by highlighting the metabolic targets in glucose,fatty acid,amino acid and glutamine metabolism,which are suitable for HCC pharmaceutical intervention.We also summarize and discuss current pharmaceutical agents and studies targeting deregulated metabolism during HCC treatment.Furthermore,opportunities and challenges in the discovery and development of HCC therapy targeting metabolism are discussed. | Danyu Du Chan Liu Mengyao Qin Xiao Zhang Tao Xi Shengtao Yuan Haiping Hao Jing Xiong | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 27 |
| 6 | A highly active oxygen evolution electrocatalyst: Ultrathin CoNi double hydroxide/CoO nanosheets synthesized via interface-directed assembly显示文摘成本效率、稳定的氧进化 electrocatalyst 为改进精力存储和变换效率是必要的。此处, 2D nanosheets 与随机 cross-linked CoNi 分层的双氢氧化物(LDH ) 并且小咕咕叫 nanocrystals 被设计并且综合经由在在空中的 situ 减小和 interfacedirected 汇编。CoNi LDH/CoO nanosheets 的形成被归因于界面的紧张驾驶的含水的 metaloxide 簇的强壮的挤出。获得了松开、多孔的 nanosheets 由于众多的缺点的存在展出了低 crystallinity。由于在金属 3d 和 O 2p 之间的轨道的杂交, orbitals,和电子在在场的 CoNi LDH 通过 NiOCo,很多个公司和 Ni 原子在金属原子之间转一个高 +3 原子价。在氧进化反应(OER ) 的高密度的这些唯一的特征结果活跃地点,改进与的亲密关系哦 和催化剂,并且为离子吸附和运输导致一个大可存取的表面区域和可渗透的隧道。因此,产生 nanosheets 向 OER 展出了高催化的活动。CoNi LDH/CoO 在碱的媒介展示了 1.48 V 的一个低发作潜力,并且在 10 妈据獥漠 ? 楬桧 ?L 潳灲楴湯漠 ? 桴 ? 的当前的密度要求了仅仅 300 mV 的过电位 ?? 潢瑴浯摥琠慲獮業瑴湡散吗?? | Jun Wu Zhiyu Ren Shichao Du Lingjun Kong Bowen Liu Wang Xi Jiaqing Zhu Honggang Fu | 2016 | Nano Research2016，9，3： | 25 |
| 7 | A new scoring system for assessment of liver function after successful hepatectomy in patients with hepatocellular carcinoma显示文摘BACKGROUND:Whether a major liver resection is safe has been judged mainly from the patient's hepatic reserve.However,a safe limit for liver resection does not exist yet.This study aimed to construct a new scoring system as a guide to determine a safe limit for liver resection and avoid liver dysfunction after hepatectomy.METHODS:Eighty-six patients with hepatocellular carcinoma who had undergone hepatectomy in West China Hospital from March 2007 to June 2010 were reviewed.The patients were classified according to the levels of total bilirubin after hepatectomy and the parameters in the perioperative period were compared.Receiver operating characteristic (ROC) analysis was made to assess the liver function compensatory (LFC) value to predict liver dysfunction of the patients after hepatectomy.LFC value is defined as the preoperative KICG value×22.487+standard remnant liver volume (SRLV)×0.020.RESULTS:Patients were classified into group Ⅰ (normal group,n=69) and group Ⅱ (with total bilirubin >85.5 μmol/L for 7 days after hepatectomy,n=17) based on the levels of total bilirubin after hepatectomy.Group II was further divided into two subgroups:recovered subgroup (n=14) and fatal subgroup (n=3).There were no significant differences in preoperative data or intraoperative findings except the indocyanine green test parameters (KICG and ICG R15) and SRLV.ROC analysis showed that the sensitivity and specificity of an LFC value ≤13.01 were 94.1% and 82.6% respectively for predicting liver dysfunction of the patients after hepatectomy.CONCLUSIONS:The LFC value appears to be a good predictor of postoperative liver dysfunction in patients who undergo hepatectomy for HCC.An expected LFC value of 13.01 seems to be a safe limit for liver resection. | Zheng-Gui Du,Bo Li,Yong-Gang Wei,Jie Yin,Xi Feng and Xi Chen Department of Liver and Vascular Surgery,West China Hospital,Sichuan University,Chengdu 610041,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 23 |
| 8 | Z-ligustilide attenuates lipopolysaccharide-induced proinflammatory response via inhibiting NF-KB pathway in primary rat microglia显示文摘 | Jing WANG Jun-rong DU Yu WANG Xi KUANG Cheng-yuan WANG | 2010 | Acta Pharmacologica Sinica2010，31，7： | 22 |
| 9 | Early changes of procalcitonin predict bacteremia in patients with intensive care unit-acquired new fever显示文摘 | SHI Yan DU Bin XU Ying-chun RUI Xi DU Wei WANG Yao | 2013 | Chinese Medical Journal2013，，10： | 18 |
| 10 | Splenic hamartoma: case report and review of literature显示文摘脾的 hamartoma 是由正常脾的元素的异常混合物组成的良性的畸形性。近似有肿瘤的病人的一半由尸体或脾切除术偶然无征状、诊断。肿瘤相关的肾的 hematological anddermatological 畸形能被肿瘤的移动对待。与包括额外膜的 glomerulonephritis, membrano-proliferativeglomerulonephritis 和肾的腺癌的肾的疾病有关的脾的 hamartoma 以前被报导了。在 2002 年 12 月,我们与由偶然检测的肾的骨盆的石头复杂的脾的 hamartoma 对待一个病人 byultrasonography。 | JIA Hong-bo LI Ying-ping HAN De-en LIU Yao ZHANG Bin WU De-quan CHEN Xi JIANG Ying ZHENG Long-xian DU Jin-rong JIANG Xue-hai | 2006 | Chinese Medical Journal2006，，16： | 13 |
| 11 | Use of curcumin in diagnosis,prevention,and treatment of Alzheimer's disease显示文摘This review summarizes and describes the use of curcumin in diagnosis,prevention,and treatment of Alzheimer's disease.For diagnosis of Alzheimer's disease,amyloid-β and highly phosphorylated tau protein are the major biomarkers.Curcumin was developed as an early diagnostic probe based on its natural fluorescence and high binding affinity to amyloid-β.Because of its multi-target effects,curcumin has protective and preventive effects on many chronic diseases such as cerebrovascular disease,hypertension,and hyperlipidemia.For prevention and treatment of Alzheimer's disease,curcumin has been shown to effectively maintain the normal structure and function of cerebral vessels,mitochondria,and synapses,reduce risk factors for a variety of chronic diseases,and decrease the risk of Alzheimer's disease.The effect of curcumin on Alzheimer's disease involves multiple signaling pathways:anti-amyloid and metal iron chelating properties,antioxidation and anti-inflammatory activities.Indeed,there is a scientific basis for the rational application of curcumin in prevention and treatment of Alzheimer's disease. | Min Chen Zhi-Yun Du Xi Zheng Dong-Li Li Ren-Ping Zhou Kun Zhang | 2018 | Neural Regeneration Research2018，13，4： | 13 |
| 12 | Dental caries and first permanent molar pit and fissure morphology in 7-to 8-year-old children in Wuhan,China显示文摘To obtain the caries experience and,plaque accumulation severity and pit and fissure morphology in first permanent molars in 7-8 children in Wuhan,as a reasonable prediction of caries risk and preventive attention in the future,a convenient sample of five primary schools in the vicinity of the Wuhan University School and Hospital of Stomatology was drawn.Two calibrated examiners orally examined all present grade 2 children in the classroom,using standard caries plaque and tooth morphology criteria.Dental caries was scored at enamel(D 2) and dentine(D 3) for tooth and surface level.Independent variables were age,gender and school.Data analysis used analysis of variance and t-test.The sample comprised 1 043 7-and 8-year-olds.The prevalence of dental caries in permanent dentition was 8.7% and in primary dentition,68.7%.Mean Decayed,Missing,Filled Teeth/S(DMFT/S) scores were 0.11 and 0.14,respectively.Mean dmft/s scores were 2.8 and 5.0.The d-component constituted 75% of the d 3 mft index,while enamel carious lesions constituted 36% of the total number of carious lesions(d 2,3-component).Prevalence of medium and deep pits and fissures was 84.6%.Prevalence of medium and severe plaque accumulation was 67.4%.Prevalence of dental caries in the deciduous and permanent dentitions of 7-to 8-year-old children was high.Deep pits and fissures in high caries risk children should be sealed. | Jin-Dong Wang Xi Chen Jo Frencken Min-Quan Du Zhi Chen | 2012 | International Journal of Oral Science2012，4，3： | 13 |
| 13 | China Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design显示文摘 | Rachel P Dreyer Xi Li Xue Du Nicholas S Downing Li Li Hai-Bo Zhang Fang Feng Wen-Chi Guan Xiao Xu Shu-Xia Li Zhen-Qiu Lin Frederick A Masoudi John A Spertus Harlan M Krumholz Li-Xin Jiang | 2016 | Chinese Medical Journal2016，，1： | 13 |
| 14 | Target classification with low-resolution radar based on dispersion situations of eigenvalue spectra显示文摘Most low-resolution radar systems, especially ground surveillance radar systems, work at relatively low pulse repeat frequency (PRF) and with short time-on-target (TOT) (duration in scanning). Low PRF leads to Doppler ambiguity and short TOT results in low Doppler resolution, which poses a problem to target classification with low-resolution radar based on the jet engine modulation (JEM) characteristic of radar echo. From the pattern classification viewpoint, we propose a method of using dispersion situations of JEM eigenvalue spectra to categorize aeroplanes into three kinds, namely turbojet aircraft, prop aircraft and helicopter. We analyze the mathematical model of JEM echoes consisting of a series of line spectra and regard them as a sum of several series of harmonious waves. Classification features can be extracted based on the harmonious wave sum model. Some schemes for extracting features from echoes within or between pulses are proposed. Low-dimensional features are extracted to reduce computation burden. Our methods do not compensate for the fuselage echoes and are insensitive to the variation of fuselage Doppler. The feasibility of our methods is demonstrated by simulation experiment. | CHEN Feng, LIU HongWei, DU Lan & BAO Zheng National Laboratory of Radar Signal Processing, Xidian University, Xi’an 710071, China | 2010 | Science China(Information Sciences)2010，53，7： | 12 |
| 15 | Ultrasonic-assisted Oxidation Leaching of Nickel Sulfide Concentrate显示文摘The feasibility of oxidation leaching process of nickel from nickel sulfide ore and the form of different components in the lixivium has been studied at first. The method of leaching nickel sulfide concentration directly by oxidants with existence of ultrasonic has been advanced. The process of leaching nickel from nickel sulfide concentration by using the system of persulfate and silver has been determined. The influence of different factors on the leaching rates of nickel,such as with and without ultrasonic,the concentration of Na2S2O8,liquid-solid ratio and the concentration of AgNO3 have been explored. The results show that:(1) in the oxidative leaching system,nickel can be leached completely as Ni2+ or NiSO4(aq.) from nickel sulfide concentration in theory;(2) the nicopyrite can not exist steadily in the persulfate acid leaching system,but Ni2+can. Meanwhile,sulfur may be existed steadily in the leaching process;(3) nicopyrite with much lower electrostatic potential may be leached earlier than chalcopyrite and sideropyrite;and(4) the overall reaction rate of the leaching process can be enhanced with ultrasonic radiation,but it does not change the mechanism of leaching. The more oxidant concentration or higher liquid-solid ratio is,the higher leaching percentage of nickel. The leaching percentage of nickel can be increased significantly by adding a small amount of AgNO3 during the leaching processes. Under the same conditions,the higher concentration of AgNO3 is,the higher leaching yields of nickel will be obtained. | XUE Juanqin LU Xi DU Yewei MAO Weibo WANG Yujie LI Jingxian | 2010 | Chinese Journal of Chemical Engineering2010，18，6： | 12 |
| 16 | Effects of Angelica dahurica on obesity and fatty liver in mice显示文摘Angelica dahurica(A. dahurica) is a traditional Chinese medicinal plant being used in clinical practice. The present study demonstrated that A. dahurica could reduce white-fat weight in high-fat-diet hyperlipidemic mice, decrease total cholesterol and triglyceride concentrations in the livers of both high-fat-diet and Triton WR1339 induced hyperlipidemic mice, and enhance the total hepatic lipase activities of them. These findings were further supported by the results derived from the experiments with Hep G2 cells in vitro. In addition, the proteins related to lipids metabolism were investigated using LC-MS/MS, indicating that genes of lipid metabolism and lipid transport were regulated by A. dhurica. The results from LC-MS/MS were further conformed by Western blot and real time PCR assays. A. dahurica could down-regulate the expression of catalase(CAT) and sterol carrier protein2(SCP2) and up-regulate the expression of lipid metabolism related genes-lipase member C(LIPC) and peroxisome proliferator-activated receptor gamma(PPARγ). In the Triton WR1339 mouse liver and Hep G2 cells in vitro, A. dahurica was able to increase the expression of LIPC and PPARγ, confirming the results from in vivo experiments. Imperatorin showed the same activity as A. dahurica, suggesting it was one of the major active ingredients of the herb. In conclusion, our work represented a first investigation demonstrating that A. dahurica was able to regulate lipid metabolism and could be developed as a novel approach to fighting against fatty liver and obesity. | LU Xi YUAN Zhi-Yi YAN Xiao-Jin LEI Fan JIANG Jing-Fei YU Xuan YANG Xiu-Wei XING Dong-Ming DU Li-Jun | 2016 | Chinese Journal of Natural Medicines2016，14，9： | 11 |
| 17 | Soil Aggregate Stability and Iron and Aluminium Oxide Contents Under Different Fertiliser Treatments in a Long-Term Solar Greenhouse Experiment显示文摘Soil in greenhouses is likely to suffer a gradual decline in aggregate stability. Determination of the effects of different fertiliser practices on soil aggregate stability is important for taking advantage of solar greenhouses. Soil aggregate stability and iron(Fe) and aluminium(Al) oxide contents were investigated in a 26-year long-term fertilisation experiment in greenhouse in Shenyang, China,under eight fertiliser treatments: manure(M), fertiliser N(FN), fertiliser N with manure(MN), fertiliser P(FP), fertiliser P with manure(MP), fertiliser NP(FNP), fertiliser NP with manure(MNP), and control without any fertiliser(CK). A wet sieving method was used to determine aggregate size distribution and water-stable aggregates(WSA), mean weight diameter and geometric mean diameter as the indices of soil aggregate stability. Different fertiliser treatments had a statistically significant influence on aggregate stability and Fe and Al oxide contents. Long-term application of inorganic fertilisers had no obvious effects on the mass proportion of aggregates. By contrast, manure application significantly increased the mass proportion of macroaggregates at the expense of microaggregates. All treatments, with the exception of FNP, significantly increased the stability of macroaggregates but decreased that of microaggregates when compared with CK. Aggregation under MP and MN was better than that under M and MNP; however,no significant differences were found among inorganic fertiliser treatments(i.e., FN, FP, and FNP). A positive relation was found between pyrophosphate-extractable Fe and WSA(r = 0.269), but no significant relations were observed between other Fe and Al oxides and aggregate stability. | YIN Yan WANG Li LIANG Chenghua XI Fengming PEI Zhongjian DU Liyu | 2016 | Pedosphere2016，26，5： | 11 |
| 18 | Epidemiology of Sepsis-3 in a sub-district of Beijing: secondary analysis of a population-based database显示文摘Background: With the publication of Sepsis-3 definition, epidemiological data based on Sepsis-3 definition from middle-income countries including China are scarce, which prohibits understanding of the disease burden of this newly defined syndrome in these settings. The purpose of this study was to describe incidence and outcome of Sepsis-3 in Yuetan sub-district of Beijing and to estimate the incidence rate of Sepsis-3 in China. Methods: The medical records of all adult residents hospitalized from July 1, 2012 to June 30, 2014 in Yuetan sub-district of Beijing were reviewed. Patients with sepsis-3 and severe sepsis/septic shock were identified. The incidence rates and mortality rate of sepsis-3 and sepsis/septic shock were calculated, incidence rates and in-hospital mortality rates were normalized to the population distribution in the 2010 National Census. Population incidence rate and case fatality rate between sexes were compared with the Z test, as the data conformed to Poisson distribution. Results: Of the 21,191 hospitalized patients, 935 patients were diagnosed with Sepsis-3, and 498 cases met severe sepsis/septic shock criteria. The crude annual incidence rate of Sepsis-3 in Yuetan sub-district was 363 cases per 100,000 population, corresponding to standardized incidence rates of 236 cases per 100,000 population per year, respectively. The overall case fatality rate of Sepsis-3 was 32.0%, the crude population mortality rates of Sepsis-3 was 116 cases per 100,000 population per year, the standardized mortality rate was 67 cases per 100,000 population per year, corresponding to a speculative extrapolation of 700,437 deaths in China. The incidence rate and mortality rate of Sepsis-3 were significantly higher in males, elderly people, and patients with more comorbidities. The 62.1% of patients with Sepsis-3 had community-acquired infections, compared with 75.3% of infected patients without Sepsis-3 (P < 0.001). The most common infection in patients with Sepsis-3 was lower respiratory tract infection. When compared with patients with Sepsis-3, patients diagnosed as severe sepsis/septic shock were more likely to have higher case fatality rate (53.4% vs. 32.0%, P < 0.001) Conclusions: This study found the standardized incidence rate of 236 cases per 100,000 person-year for Sepsis-3, which was more common in males and elderly population. This corresponded to about 2.5 million new cases of Sepsis-3 per year, resulting in more than 700,000 deaths in China. | Hong-Cheng Tian Jian-Fang Zhou Li Weng Xiao-Yun Hu Jin-Min Peng Chun-Yao Wang Wei Jiang Xue-Ping Du Xiu-Ming Xi You-Zhong An Mei-Li Duan Bin Du 无 | 2019 | Chinese Medical Journal2019，，17： | 9 |
| 19 | Regional soil moisture simulation for Shaanxi Province using SWAT model validation and trend analysis显示文摘The soil moisture in Shaanxi Province,a region with complex topography,is simulated using the distributed hydrological model Soil Water Assessment Tool(SWAT).Comparison and contrast of modeled and observed soil moisture show that the SWAT model can reasonably simulate the long-term trend in soil moisture and the spatiotemporal variability of soil moisture in the region.Comparisons to NCEP/NCAR and ERA40 reanalysis of soil moisture show that the trend of variability in soil moisture simulated by SWAT is more consistent with the observed.SWAT model results suggested that high soil moisture in surface soil layers appears in the southern Shaanxi with high vegetation cover,and the Qinling mountainous region with frequent orographic precipitation.In deeper soil layers,high soil moisture appears in the river basins and plains.The regional soil moisture showed a generally decreasing trend on all soil layers from 1951 to 2004,with a stronger and significant decreasing trend in deeper soil layers,especially in the northern parts of the province. | LI MingXing1,2,MA ZhuGuo1 & DU JiWen3 1 Key Laboratory of Regional Climate-Environment Research for Temperate East Asia,Institute of Atmospheric Physics,Chinese Academy of Sciences,Beijing 100029,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3 Shaanxi Administration of Meteorology,Xi’an 710014,China | 2010 | Science China Earth Sciences2010，53，4： | 9 |
| 20 | Inconsistent seasonal variation of antibiotics between surface water and groundwater in the Jianghan Plain:Risks and linkage to land uses显示文摘Antibiotics are widely used in humans and animals,but their transformation from surface water to groundwater and the impact of land uses on them remain unclear.In this study,14 antibioticswere systematically surveyed in a complex agricultural area in Central China.Results indicated that the selected antibiotic concentrations in surface waters were higher in winter(average:32.7 ng/L)than in summer(average:17.9 ng/L),while the seasonal variation in groundwaters showed an opposite trend(2.2 ng/L in dry winter vs.8.0 ng/L in summer).Macrolides were the predominant antibiotics in this area,with a detected frequency of over 90%.A significant correlation between surface water and groundwater antibiotics was only observed in winter(R^(2)=0.58).This study further confirmed the impact of land uses on these contaminants,with optimal buffer radii of 2500 m in winter and 500 m in summer.Risk assessment indicated that clarithromycin posed high risks in this area.Overall,this study identified the spatiotemporal variability of antibiotics in a typical agricultural area in Central China and revealed the impact of land uses on antibiotic pollution in aquatic environments. | Xi Liu Zhi Wang Lu Zhang Weiying Fan Chao Yang Enhua Li Yun Du Xuelei Wang | 2021 | Journal of Environmental Sciences2021，33，11： | 9 |
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