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| 1 | Effects of disinhibition on spatiotemporal pattern of neuronal first recruitment in neuronal networks显示文摘The propagation of neuronal activities is a key feature to understanding information processing in networks. The analysis based on first-spikes of bursts in turn plays an important role in the research of neuronal activity propagation. Our focus here is to investigate how spatiotemporal patterns of neuronal first-spikes are affected by disinhibition. Multi-electrode arrays were used to record stimulation-evoked bursts of multiple neurons in randomly cultured neuronal networks. Both the precise timing of and the rank relationships between first-spikes were analyzed. Compared with evoked bursts in the network's native state, the precise first-spike latencies in its dis-inhibited state are more consistent and the propagation of its bursting activities is much faster. Additional points of interest are that disinhibited neuronal networks can be evoked to generate stable and distinguishable neuronal first recruitment spatiotemporal patterns specific to the stimulation site, and that the disinhibition may cause the original spatiotemporal patterns to change in a heterogeneous manner with regards to different propagation pathways. | Liangbin Pana,b,c,1, Xindong Songa,b,c,1, Guangxin Xiang a,b,c, Jing Zhua,b,c, Jing Cheng a,b,c,d,a Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, China b Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China c National Engineering Research Center for Beijing Biochip Technology, 18 Life Science Parkway, Beijing 102206, China d State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 6 |
| 2 | HETEROPHYLLIN-A AND B,TWO CYCLOPEPTIDES,FROM THE ROOTS OF PSEUDOSTELLARIA HETEROPHYLLA显示文摘Two cyclopeptides,heterophyllin A and B,have been isolated from the rootsof Pseudostellaria heterophylla.Their structures were elucidated by chemical,spectroscopic,and enzymatic methods. | Ning Hua TAN Shou Xun ZHAO a Department of Phytochemistry,China Pharmaceutical University,Nanjing,210009 Jun ZHOU Hong Jie ZHANG De Zu WANG Chang Xiang CHEN Xiao Zhu LIU b Laboratory of Phytochemistry,Kunming Institute of Botany,Academia Sinica,Kunming,650204 | 1992 | Chinese Chemical Letters1992，3，8： | 4 |
| 3 | A novel method for Co(Ⅱ) and Cu(Ⅱ) analysis by capillary electrophoresis with chemiluminescence detection显示文摘Based on the fact that some metal ions can catalyze the chemiluminescence(CL)reaction of luminol with K3Fe(CN)6,a novel capillary electrophoresis CL method was developed for the determination of Co(Ⅱ)and Cu(Ⅱ).The separation was carried out with a 10 mmol/L sodium acetate solution containing 0.8 mmol/L luminol and 2.0 mmol/Lα-HIBA(adjusted to pH 4.8 by HAc solution).The post-capillary reagent was 2.0 mmol/L K3Fe(CN)6 which was adjusted to pH 13.0 by NaOH solution.Under the optimum conditions,the detection limits(S/N=3)for Co(Ⅱ)and Cu(Ⅱ)were 7.5×10-11mol/L and 7.5×10-9mol/L,with the linear range of 7.5×10-9mol/L to 1.0×10-6mol/L and 7.5×10-8mol/L to 5.0×10-5mol/L, respectively. | Xiao Ming Guo~a Xiang Dong Xu~(a,b) Hui Jing Zhang~a Yong Gang Hu~(a,*) Jie Zhang~a a Institute of Environmental Science & Engineering,Huazhong University of Science and Technology,Wuhan 430074,China b Department of Chemistry,Huazhong University of Science and Technology,Wuhan 430074,China | 2007 | Chinese Chemical Letters2007，18，9： | 3 |
| 4 | EGF promotes mammalian cell growth by suppressing cellular senescence显示文摘 | Peter B Alexander Lifeng Yuan Pengyuan Yang Tao Sun Rui Chen Handan Xiang Jiekai Chen Haoyu Wu Daniel R Radiloff Xiao-Fan Wang | 2015 | Cell Research2015，25，1： | 3 |
| 5 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 6 | Hydrothermal preparation of boehmite nanorods by selective adsorption of sulfate显示文摘 | He T B Xiang L Zhu S L | 2008 | Langmuir2008，24，： | 1 |
| 7 | Liquid chromatography-tandem mass/mass spec- trometry method for the quantification of rabeprazole in human plasma and application to a pharmacokinetic study显示文摘 | Yu L Deng H Xiang B | 2010 | Armeimittelforschung2010，60，5： | 1 |
| 8 | Slurry phase Fischer-Tropsch synthesis over manganese-promoted iron ultrafine particle catalyst显示文摘 | BAI L XIANG H W LI Y W HAN Y Z ZHONG B | 2002 | Fuel2002，81，1112： | 1 |
| 9 | Plant paralog to viral movement protein that potentiates transport of mRNA into the phloem 显示文摘 | Xoconostle-Cázares B Xiang Y Ruiz-Medrano R | 1999 | Science1999，283，1： | 1 |
| 10 | Preparation of poly( vinylidene fluoride) (pvdf) ultraliltration membrane modified by nano-sized alumina (Al2O3) and its antifouling research显示文摘 | Yan L Li Y S Xiang C B | 2005 | Polymer2005，46，： | 1 |
| 11 | Initial deposition mechanism of electroless nickel plating on magnesium alloys显示文摘 | Xiang Y H Hu W B Liu X K | 2001 | Trans IMF2001，79，1： | 1 |
| 12 | Soya food intake and risk of endometrial cancer among Chinese women in Shanghai: population based case - control study 显示文摘 | XU W H ZHENG W XIANG Y B ct al | 2004 | Br Med J2004，328，7451： | 1 |
| 13 | Liquid chromatography - tandem mass/mass spectrometry method for the quantification of rabeprazole inhuman plasma and application to a pharmacokinetic study 显示文摘 | Yu L Deng H Xiang B | 2010 | Arzneimittelforschung2010，60，： | 1 |
| 14 | Dexmedetomidine Controls Systemic Cytokine Levels through the Cholinergic Anti-inflammatory Pathway显示文摘 | Xiang H Hu B Li Z | 2014 | Inflammation2014，37，5： | 1 |
| 15 | Microwave-hydrothermal preparation and visible-light photoactivity of plasmonic photocatalyst Ag-Ti O2nanocomposite hollow spheres显示文摘 | Xiang Q Yu J Cheng B | 2010 | Chemistry-An Asian Journal2010，5，6： | 1 |
| 16 | Dexmedetomidine controlssystemic cy- tokine levels through the cholinergic anti-inflammatorypathway 显示文摘 | Xiang H Hu B Li Z | 2014 | Inflammation2014，37，5： | 1 |
| 17 | Influence of chain ordering on the selectivity of dipalmitoylphosphatidylcholine bilayer membranes for permeant size and shape显示文摘 | Xiang T X Anderson B D | 1998 | Biophys J1998，75，6： | 1 |
| 18 | Effects of Achyranthes bidentata polysaccharldes on inter]eukin-1 and tumor necrosis factor-alpha production from mouse peritoneal macrophages显示文摘 | Xiang D B Li X Y | 1993 | Acta Pharmacologica Sinica1993，14，： | 1 |
| 19 | Effects of sintering temperature on fine-grained tungsten heavy alloy produced by high-energy ball milling assisted spark plasma sintefing显示文摘 | DING L XIANG D P LI Y Y LI C LI J B | 2012 | International Journal of Refractory Metals and Hard Materials2012，33，： | 1 |
| 20 | Expression and functional ana- lysis of beta-adrenoceptor subtypes in rabbit submandibular gland 显示文摘 | Li YM Zhang Y Xiang B | 2006 | Life Sci2006，79，22： | 1 |
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