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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | Compositional heterogeneity of crude oil and its origin in the Linnan subsag,Linyi County,Shandong Province显示文摘The Linnan subsag is the main oil producer of the Linpan oil zone. Based on the oil group composition,gas chromatography data and biomarker analysis,it was indicated that crude oils from different oilfields varied greatly in group composition and showed obvious heterogeneities in the aspects of precursor type,crude oil maturity and hydrocarbon depositional environment. According to the characteristics of source rocks,three oil populations can be distinguished,i.e.,the southern,northern and transitional oil populations. Furthermore,on the basis of post-reservoir reworking processes,the medium conditions of hydrocarbon-generating environment and differences in maturity,six oil families and twelve sub-families were distinquished. An integrated study suggested that the fac-tors leading to such heterogeneities in crude oil composition mainly include different source rocks,multi-stage oil/gas charging,geo-chromatographic effects during oil/gas migration,reservoir heterogeneities and various post-reservoir secondary alterations. | CHANG Xiangchun DUAN Yunge CHEN Qingchun MA Lixin | 2008 | Chinese Journal Of Geochemistry2008，27，4： | 3 |
| 3 | Geochemistry and possible origin of petroleum in Palaeozoic reservoirs from Halahatang Depression显示文摘 | Xiangchun Chang T.-G. Wang Qiming Li Bin Cheng Xiaowan Tao | 2013 | Journal of Asian Earth Sciences2013，，： | 2 |
| 4 | Geochemical analysis of mixed oil in the Ordovician reservoir of the Halahatang Depression,Tarim Basin,China显示文摘In this study,12 crude oil samples were collected and analyzed from the Ordovician reservoir in the Halahatang Depression,Tarim Basin,China.Although the density of oil samples varies considerably,based on saturated hydrocarbon gas chromatographic(GC),saturated and aromatic hydrocarbon gas chromatographic-mass spectrometric(GC/MS) and stable carbon isotopic composition analyses,all the samples are interpreted to represent a single oil population with similar characteristics in a source bed or a source kitchen,organic facies and even in oil charge history.The co-existence of a full suite of n-alkanes and acyclic isoprenoids with UCM and 25-norhopanes in the crude oil samples indicates mixing of biodegraded oil with fresher non-biodegraded oil in the Ordovician reservoir.Moreover,according to the conversion diagram of double filling ratios for subsurface mixed crude oils,biodegraded/non-biodegraded oil ratios were determined as in the range from 58/42 to 4/96.Based on oil density and oil mix ratio,the oils can be divided into two groups:Group 1,with specific density>0.88(g/cm3) and oil mix ratio>1,occurring in the north of the Upper Ordovician Lianglitage and Sangtamu Formation pinchout lines,and Group 2,with specific density<0.88(g/cm3) and oil mix ratio<1,occurring in the south of the pinchout lines.Obviously,Group 2 oils with low densities and being dominated by non-biodegraded oils are better than Group 1 oils with respect to quality.It is suggested that more attention should be paid to the area in the south of the Upper Ordovician Lianglitage and Sangtamu Formation pinchout lines for further exploration. | CHENG Bin WANG Tieguan CHANG Xiangchun | 2013 | Chinese Journal Of Geochemistry2013，32，4： | 2 |
| 5 | Maturity assessment of severely biodegraded marine oils from Halaha tang depression in Tarim basin显示文摘 | Chang Xiangchun Wang Tieguan Li Qiming | 2012 | Energy Exploration Ex ploitation2012，30，3： | 1 |
| 6 | Tight sandstone reservoir sensitivity and damage mechanism analysis: A case study from Ordos Basin, China and implications for reservoir damage prevention显示文摘Analysis of reservoir sensitivity to velocity,water,salt,acid,alkali and stress is critical for reservoir protection.To study the tight sandstone reservoir sensitivity at different formation depths(effective stress)and formation water conditions(pH,salinity,and fluid velocity),a series of dynamic core flow tests under different pH,salinity,acid,and effective stress conditions were performed on samples from tight sandstone reservoirs of the Upper Triassic Yanchang 8(T_(3)y^(8))Member and conventional reservoirs of the Middle-Lower Jurassic Yan'an 9(J_(1-2)y^(9))Member in the Ordos Basin.The results indicate that,compared with the conventional reservoirs,the tight sandstone reservoirs are more sensitive to velocity and stress,less sensitive to water,alkali and salinity,and respond better to acid fracturing.In addition,the critical conditions(salinity,velocity,pH,and stress)for pumping drilling,completion,and fracturing fluids into tight sandstone reservoirs were investigated.A combination of scanning electron microscopy coupled with energy-dispersive spectrometry(SEM-EDS),cathodoluminescence(CL),casting thin section(CTS)and nuclear magnetic resonance(NMR)images,high-pressure mercury injection capillary pressure(MICP)measurements as well as X-ray fluorescence spectral(XRF)analyses were employed to analyze the damage mechanisms of the conventional reservoirs(J_(1-2)y^(9))and tight sandstone reservoirs(T_(3)y^(8))caused by fluid invasion.The results suggest that reservoir sensitivity is primarily conditioned by the composition of detrital components and interstitial fillings,petrophysical properties,pore-throat structure,and diagenetic facies.All these factors control the sensitivity types and extent of the reser-voirs.Our results indicate that the poorer the reservoir physical properties,the stronger the reservoir heterogeneity and sensitivity,implying that tight sandstone reservoirs are more susceptible to changes in fluids than conventional reservoirs.This study offers insights into the reservoir damage types and helps to improve the design and implementation of protection measures for tight sandstone reservoir exploration. | Zhongquan Liu Bingbing Shi Tianchen Ge Fenggui Sui Yue Wang Pengfei Zhang Xiangchun Chang Ye Liu Yongrui Wang Zhaoyang Wang | 2022 | Energy Geoscience2022，3，4： | 1 |
| 7 | Geochemistry and origin of deep-seated cracked gas on the northern slope of the Dongying Sag, Shandong Province显示文摘Deep-seated cracked gas exploration was achieved great breakthrough in Es4L of the Minfeng area on the northern slope of the Dongying Sag. Carbon isotopic and molecular compositions studies revealed the characteristics of wet gas and a normal trend of carbon isotopic composition. Empirical cutoff points of δ13C2 and δ13C3 and light hydrocarbon compositions distinguished the cracking gas as sapropelic gas. Variations in i/nC5, i/nC4 and δ13C2 fur-ther confirmed that the gas was cracked from residual kerogen. Source characteristics indicated that the gas was de-rived from mature-highly mature source rocks of Es4 with kerogen type II being dominant mixed with some oil-cracking gas. Burial history modeling indicated that there were two hydrocarbon charging periods in Es4L reser-voirs. The first period refers to the Guantao-Minghuazhen stage dominated by oil charging, while the second period refers to the Minghuazhen stage and has been dominated by cracked gas charging till now. | CHANG Xiangchun HAN Zuozhen XU Youde SHANG Xiaofei YAN Chengpeng | 2011 | Chinese Journal Of Geochemistry2011，30，3： | 1 |
| 8 | Geochemistry and possible origin of petroleum in Palaeozoic reservoirs from Halahatang Depression显示文摘 | Xiangchun Chang T.-G. Wang Qiming Li Bin Cheng Xiaowan Tao | 2013 | Journal of Asian Earth Sciences2013，，： | 1 |
| 9 | Geochemical characteristics of aromatic hydrocarbons in crude oils from the Linnan Subsag, Shandong Province, China显示文摘Abundant aromatic fractions were detected in oils from the Linnan subsag, including aphthalenes, phenanthrenes, triaromatic steroids, biphenyl, fluorenes, dibenzothiophenes, dibenzofuranes, as well as some typical higher plant-sourced compounds, such as pyrene, benzopyrene, fluoranthene, chryaene, benzofluoranthrene, perylene and cadalene. Occurrences of biomarkers indicate that oils from the Linnan subsag are typical terrestrially genetic oils. Developed in the depositional environment is a strong reduction condition typical of brackish-saline lake. Thermal evolution has entered into the mature-high mature stage. | CHANG Xiangchun HAN Zuozhen SHANG Xiaofei YAN Chengpeng | 2011 | Chinese Journal Of Geochemistry2011，30，1： | 1 |
| 10 | A Comparative Study of the Coal-forming Characteristics of Marginal Sea Basins and Epicontinental Sea Basins显示文摘The coal-forming characteristics,as well as the similarities and differences between epicontinental sea basins and continental marginal sea basins developed during different time periods,were analyzed in this study by adopting comparative analysis thoughts and methods.The results obtained in this study revealed that epicontinental basins and marginal sea basins are both characterized by the main development of thin coal seams or extremely thin coal seams.In addition,changes in sea levels were determined to be the main controlling factors for coal formation,and there were similarities in the continent-sea interactions and coal-forming sedimentary systems of the different basins.However,there were also significant differences observed in the sea level change events,basin basement structural characteristics,coal seam stability levels,accumulation and aggregation characteristics,and the migration patterns of coal-forming materials.For example,the marginal sea basins in the South China Sea were found to be characterized by strong tectonic activities,diversity and complexity.The basin structures showed complex patterns of depressions,uplifts and concave or sag uplifts,which tended to lead to greater complexity in the paleogeographic patterns of the coal formations.This had subsequently resulted in complex coal-forming processes and paleogeographic characteristics,in which the coal-forming zones displayed bead-like distributions,and the enrichment areas and centers were scattered.The practical significance of studying the similarities and differences of the coal-forming characteristics between epicontinental basins and marginal sea basins is that the results can potentially be used to guide the predictions of coal-measure coal seam distributions in South China Sea,as well as provide valuable guidance for future explorations of natural gas reservoirs related to coal measures in the South China Sea area. | ZHAO Honggang LI Ying CHANG Xiangchun LI Zengxue LIU Haiyan ZHAO Cunliang | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 1 |
| 11 | Physical-property cutoffs of tight reservoirs by field and laboratory experiments: a case study from Chang 6, 8–9 in Ordos Basin显示文摘Tight sandstone reservoirs are generally characterized by complex reservoir quality,non-Darcy flow,and strong heterogeneity.Approaches utilized for evaluating physical property cutoffs of conventional reservoirs maybe inapplicable.Thus,a comprehensive investigation on physical property cutoffs of tight sandstone reservoirs is crucial for the reserve evaluation and successful exploration.In this study,a set of evaluation approaches take advantage of field operations(i.e.,core drilling,oil testing,and wireline well logging data),and simulation experiments(i.e.,high-pressure mercury injection-capillary pressure(MICP)experiment,oil-water relative permeability experiment,nuclear magnetic resonance(NMR)experiment,and biaxial pressure simulation experiment)were comparatively optimized to determine the physical property cutoffs of effective reservoirs in the Upper Triassic Chang 6,Chang 8 and Chang 9 oil layers of the Zhenjing Block.The results show that the porosity cutoffs of the Chang 6,Chang 8,and Chang 9 oil layers are 7.9%,6.4%,and 8.6%,and the corresponding permeability are 0.08 mD,0.05 mD,and 0.09 mD,respectively.Coupled with wireline well logging,mud logging,and oil testing,the cut-off of the thickness of single-layer effective reservoirs are approximately 3.0 m,3.0 m,and 2.0 m,respectively.Depending on the cutoffs of critical properties,a superimposed map showing the planar distribution of the prospective targets can be mapped,which may delineate the effective boundary of prospective targets for petroleum exploration of tight sandstone reservoirs. | Bingbing SHI Xiangchun CHANG Zhongquan LIU Ye LIU Tianchen GE Pengfei ZHANG Yongrui WANG Yue WANG Lixin MAO | 2021 | Frontiers of Earth Science2021，15，2： | 0 |
| 12 | Multi-affect(ed):improving recommendation with similarity-enhanced user reliability and influence propagation显示文摘Traditional recommendation algorithms predict the latent interest of an active user by collecting rating information from other similar users or items.Recently,more and more recommendation systems attempt to involve social relations to improve recommendation performance.However,the existing works either leave out the user reliability or cannot capture the correlation between two users who are similar but not socially connected.Besides,they also take the trust value between users either 0 or 1,thus degenerating the prediction accuracy.In this paper,we propose an efficient social affect model,multi-affect(ed),for recommendation via incorporating both users'reliability and influence propagation.Specifically,the model contains two main components,i.e.,computation of user reliability and influence propagation,designing of user-shared feature space.Firstly,a reliability calculation strategy based on user similarity is developed for measuring the recommendation accuracy between users.Then,the factor of influence propagation relationship among users is taken into consideration.Finally,the multi-affect(ed)model is developed with user-shared feature space to generate the predicted ratings.Experimental results demonstrate that the proposed model achieves better accuracy than other counterparts recommendation techniques. | Lele HUANG Huifang MA Xiangchun HE Liang CHANG | 2021 | Frontiers of Computer Science2021，15，5： | 0 |
| 13 | Geochemical constraints on mixed source and hydrocarbon filling process in theYingjisu Sag,Tarim Basin,Xinjiang显示文摘The Yingjisu Sag was petroliferous for normal oil, condensate oil, reservoir bitumen and natural gases. Geochemical studies showed that natural gases in the Yingjisu Sag were a gas mixture consisting mainly of Cambrian pyrolysis gas, Jurassic condensate oil in well Yingnan 2 and normal oil in well Tadong 2, reflecting the characteristics of marine-phase gases and oils, while crude oils in well Longkou 1 demonstrated the characteristics of both marine and terrestrial oils, which were derived from lower algae and higher plants. Jurassic oils from wells Longkou 1 and Huayingcan 1 and Cambrian crude oils from well Tadong 2 were derived mainly from Cambrian-Lower Ordovician source rocks. Jurassic and Silurian reservoir bitumens from well Yingnan 2 were biodegradated, suggesting they are of marine and terrestrial origins. The bitumens have similar geochemical characteristics, which are correlated well with Ordovician crude oils from well Tadong 2 and Jurassic condensate oil from well Yingnan 2. Based on the characteristics of tectonic evolution in this area and the analysis of hydrocarbon accumulation, the constraints on the mixed source and hydrocarbon filling process in the Yingjisu Sag were brought forward. | PANG Lingyun CHANG Xiangchun WANG Mingzhen YU Xinghe MA Lixin DUAN Yunge | 2009 | Chinese Journal Of Geochemistry2009，28，3： | 0 |
| 14 | Tectonic activity and earthquake risk in the Chengnanhe fault zone in Weihai city,Shandong province,China,obtained by using an integrated prospecting technique in geophysics and geology显示文摘For city planning and reducing potential earthquake risk,it’s necessary to detect the information of the buried faults in an urban area especially,including the location and activities.An integrated technique with geophysical and geological methods,including the shallow seismic reflection profile,electrical resistivity measurement,geologic borehole section,and exploration trench,was used to detect the Chengnanhe fault,which is one of the two main faults passing through the Weihai urban area in Shandong province,China.The results show that it is a normal fault striking with E-W direction,and it is relatively inactive and stable.By using the thermoluminescence(TL)dating,we found that the Chengnanhe fault initiated in mid-Pleistocene and there was no offset after late Pleistocene.Such an integrated technique with multiple geological and geophysical methods provides a significant assessment of earthquake risk for city planning in urban areas. | Gui-Lin Du Lian-Feng Zhao Xiaobo Tian Shujuan Su Xiangchun Chang Hualin Wang Zhuqing Huo Tao Zhu Yonghua Li | 2021 | Earthquake Science2021，34，2： | 0 |
| 15 | CATALYST DESIGN FOR METHANE DEHYDROGENATION AND BENZENE HYDROGENATION显示文摘Highly active and stable nickel catalyst for dehydrogenation of methane and hydrogenation of benzene is prepared from a precursor with hydrotalcite-like anionic clam structure by coprecipitation. The nickel particles have a narrow size distribution in several nanometers, and have a strong interaction with other components such as Al2O3. This catalyst is highly sensitive to further modification by doping and to reaction condition. On a modified catalyst, benzene hydrogenation to cyclohexane proceeds to complete at 373 K. While on another catalyst, different structured nanocarbons are obtained at moderate temperatures. It is found that the thioresistance of the nickel catalyst in hydrogenation can be improved by doping. | Li Yongdan, Hou Chaopeng, Qin Yuxiang, Meng Xiangchun, Chen Jiuling and Chang Liu (Department of Catalysis Science and Technology School of Chemical Engineering, Tianjin University Tianjin 300072) | 2000 | 化工学报2000，51，S1： | 0 |
| 16 | Recent advances in evaluation, evolution and quantitative characterization of tight reservoirs: Introduction显示文摘Unconventional resources will significantly add to the petro-leum reserves and their contribution to global gas/oil production is expected to increase to 25%over the next two decades.However,unconventional reservoirs of coal methane,shale gas,tight sand-stone gas and gas hydrate have complex pore structures and are typically tight with porosity and permeability much lower than conventional reservoirs(Pang et al.,2022;Yin et al.,2018a,2018b).The characterization of the pore structure and the study of micro-scale multiphase flow mechanism are extremely impor-tant for the understanding of unconventional reservoirs.Recent studies show that emerging methodologies have become the most powerful in characterizing the dynamics of liquids in porous media from the nano-pore to fracture scale. | Xiangchun Chang Shuai Yin | 2022 | Energy Geoscience2022，3，4： | 0 |
| 17 | Characteristics and classification of paleozoic tight reservoirs in the central uplift of the South Yellow Sea Basin显示文摘Several sets of Paleozoic tight reservoirs are developed in the Central Uplift of the South Yellow Sea Basin.A qualitative analysis of the microscopic pore structure of the tight reservoir rocks was carried out through cast thin slice and scanning electron microscopic image observation.Based on reservoir pet-rophysical properties,thirty core samples in the Central Uplift of the South Yellow Sea Basin were selected for high-pressure mercury intrusion(HPMI)analysis,which was then combined with fractal calculation to classify and evaluate the tight reservoirs.The analysis of the HPMI curves and related parameters shows that the Paleozoic tight reservoirs can be divided into three types:Type-A,Type-B and Type-C.Type-A sandstone reservoirs contain pores with size mostly ranging between 0.01 and 0.1 mm,followed by pores with size range of 0.001-0.01 m m,and relatively fewer pores larger than 0.1 m m.The Type-B reservoirs are carbonate rocks with extremely heterogeneous pore size distribution,which is closely related to the development of dissolution pores and microfractures.Type-C sandstone reservoirs are dominated by nanopores and submicron pores that distribute more heterogeneously than pores in Type-A reservoirs.The pore distribution in sandstone reservoirs shows significant fractal characteristics and is closely related to the pore size.The heterogeneity of nanopore distribution has a negative cor-relation with porosity and median pressure and a relatively weak correlation with permeability.Our study has important implications for petroleum exploration in the South Yellow Sea Basin. | Yumao Pang Xingwei Guo Xiangchun Chang Junjian Zhang Jingqi Zhou Laixing Cai | 2022 | Energy Geoscience2022，3，4： | 0 |
| 18 | Geochemical characteristics, genetic types, and controlling factors of natural gas in Jiyang Depression, Bohai Bay Basin (eastern China)显示文摘The Jiyang Depression is an important oil and gas production zone in the Bohai Bay Basin.Through a systematic investigation of the gas components and stable carbon isotopes,the genetic types of natural gas found in the Jiyang Depression were determined,that is,biogas,oilassociated gas,coal-derived gas,high-mature oil-related gas,and mantle-derived carbon dioxide(CO_(2)).From the results,natural gas in the Jiyang Depression can be divided into four groups.Group I,which is distributed in the northwest area,is the only typical oil-associated gas.Group II,distributed in the northeast area,is dominated by oil-associated gas,and involves biogas,coal-derived gas,and high-mature oil-related gas.Group Ⅲ,distributed in the southeast area,has all genetic types of gas that are dominated by oil-associated gas and have mantle-derived CO_(2).Group IV,distributed in the southwest area,is dominated by biogas and involves coal-derived gas and oil-associated gas.The differences in each group illustrate the lateral distribution of the natural gas types is characterized by the eastern and southern areas being more complex than the western and northern areas,the vertical distribution of gas reservoirs has no obvious evolutionary law.The main controlling factor analysis of the spatiotemporal changes of the gas reservoirs revealed that the synergy of geochemical characteristics,thermal evolution of the Shahejie Formation and Carboniferous-Permian source rocks,and sealing properties of various faults are jointly responsible for determining the gas reservoir spatiotemporal changes. | Tianchen GE Xiangchun CHANG Yuan ZHUANG Xiaojun LI | 2022 | Frontiers of Earth Science2022，16，3： | 0 |
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