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| 1 | Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication,metabolite traits,and antiinflammatory effects显示文摘Foxtail millet(Setaria italica),which was domesticatedfromthewild speciesgreenfoxtail(Setaria viridis),isa richsource of phytonutrientsfor humans.To evaluate how breeding changed themetabolome offoxtail millet grains,we generated and analyzed the datasets encompassing the genomes,transcriptomes,metabolomes,and anti-inflammatory indices from 398 foxtail millet accessions.We identified hundreds of common variants that influence numerous secondary metabolites.We observed tremendous differences in natural variations of the metabolites and their underlying genetic architectures between distinct sub-groups of foxtail millet.Furthermore,we found that the selection of the gene alleles associated with yellow grains led to altered profiles of metabolites such as carotenoids and endogenous phytohormones.Using CRiSPR-mediated genome editing wevalidated the function of PHYTOENE SYNTHASE1(PSY1)gene in affecting milletgrain colorand quality.Interestingly,our in vitro cell inflammation assays showed that 83 metabolites in millet grains have anti-inflammatory effects.Taken together,ourmulti-omics study illustrates how the breeding history of foxtail millet has shaped its metabolite profile.The datasets we generated in this study also provide important resources for further understanding how millet grain quality is affected by different metabolites,laying the foundations for future millet genetic research and metabolome-assisted improvement. | Xukai Li Jianhua Gao Jingyi Song Kai Guo Siyu Hou Xingchun Wang Qiang He Yanyan Zhang Yakun Zhang Yulu Yang Jiaoyan Tang Hailang Wang Staffan Persson Mingquan Huang Lishuai Xu Linlin Zhong Dongqin Li Yongming Liu Hua Wu Xianmin Diao Peng Chen Xiaowen Wang Yuanhuai Han | 2022 | Molecular Plant2022，15，8： | 8 |
| 2 | A benchmark test of boson sampling on Tianhe-2 supercomputer显示文摘Boson sampling, thought to be intractable classically, can be solved by a quantum machine composed of merely generation, linear evolution and detection of single photons. Such an analog quantum computer for this specific problem provides a shortcut to boost the absolute computing power of quantum computers to beat classical ones. However, the capacity bound of classical computers for simulating boson sampling has not yet been identified. Here we simulate boson sampling on the Tianhe-2 supercomputer, which occupied the first place in the world ranking six times from 2013 to 2016. We computed the permanent of the largest matrix using up to 312 000 CPU cores of Tianhe-2, and inferred from the current most efficient permanent-computing algorithms that an upper bound on the performance of Tianhe-2 is one 50-photon sample per ~100 min. In addition, we found a precision issue with one of two permanent-computing algorithms. | Junjie Wu Yong Liu Baida Zhang Xianmin Jin Yang Wang Huiquan Wang Xuejun Yang | 2018 | National Science Review2018，5，5： | 6 |
| 3 | Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness显示文摘Tonic signaling of chimeric antigen receptor(CAR),i.e.,the spontaneous CAR activation in the absence of tumor antigen stimulation,is considered to be a pivotal event controlling CAR-T efficacy.However,the molecular mechanism underlying the spontaneous CAR signals remains elusive.Here,we unveil that positively charged patches(PCPs)on the surface of the CAR antigenbinding domain mediate CAR clustering and result in CAR tonic signaling.For CARs with high tonic signaling(e.g.,GD2.CAR and CSPG4.CAR),reducing PCPs on CARs or boosting ionic strength in the culture medium during ex vivo CAR-T cell expansion minimizes spontaneous CAR activation and alleviates CAR-T cell exhaustion.In contrast,introducing PCPs into the CAR with weak tonic signaling,such as CD19.CAR,results in improved in vivo persistence and superior antitumor function.These results demonstrate that CAR tonic signaling is induced and maintained by PCP-mediated CAR clustering.Notably,the mutations we generated to alter the PCPs maintain the antigen-binding affinity and specificity of the CAR.Therefore,our findings suggest that the rational tuning of PCPs to optimize tonic signaling and in vivo fitness of CAR-T cells is a promising design strategy for the nextgeneration CAR. | Jian Chen Shizhen Qiu Wentao Li Kun Wang Yu Zhang Han Yang Baichuan Liu Guangfei Li Li Li Min Chen Junjie Lan Jiahua Niu Peijie He Lei Cheng Gaofeng Fan Xin Liu Xianmin Song Chenqi Xu Haitao Wu Haopeng Wang | 2023 | Cell Research2023，33，5： | 2 |
| 4 | Hydrogels for bone organoid construction:From a materiobiological perspective显示文摘Bone organoids,which simulate and construct special organs in vitro with complex biological func-tions based on tissue engineering technology,provide dramatically realistic models for bone regenerative medicine development and lay the foundation for a new therapeutic strategy.The matrix microenviron-ment around tissues and cells plays a key role in the physiological functions and phenotypes of bone organoids.Traditionally,the commercially available Matrigel has been widely applied for organoid cul-tures.However,Matrigel is still facing challenges,including xenogenous origins and variable composi-tion.To address these issues,newly developed hydrogels become an appropriate candidate to alternate Matrigel for bone organoid culture.In this review,we summarized the development and limitations of ECM-based matrix(Matrigel)in the bone organoid cultures.Then we highlighted various hydrogel al-ternatives,including PEG,collagen,alginate,gelatin,chitosan,skin fibroin,and DNA derivative hydrogels,which have shown a promising application in bone tissue engineering and organoid cultures.Additionally,the effects of material properties(stiffness,viscoelasticity,charge,et al.)in hydrogels on cell culture and bone organoid culture were deeply investigated.Finally,we predicted that hydrogel-based biomaterials have a great potential for the construction and application of bone organoids. | Shunli Wu Xianmin Wu Xiuhui Wang Jiacan Su | 2023 | Journal of Materials Science & Technology2023，，5： | 2 |
| 5 | Optimum designof a 3-RRR planar parallel manipulator with a singularity-freeworkspace显示文摘 | GAO Mingwang ZHANG Xianmin WU Zhi-wei | 2011 | Applied Mechanics and Materials2011，，86： | 1 |
| 6 | An inspection and classification method for chip solder joints using color grads and boolean rules显示文摘 | Wu Fupei Zhang Xianmin | 2014 | Robotics and Computer-Integrated Manufacturing2014，30，5： | 1 |
| 7 | Optimum design of a 3 - RRR planar parallel manipulator with a singularity-free workspace显示文摘 | Gao Mingwang Zhang Xianmin Wu Zhiwei | 2011 | Applied Mechanics and Materials2011，86，： | 1 |
| 8 | Solderjoint inspection based on neural network combined withgenetic algorithm显示文摘 | Wu Hao Zhang Xianmin KuangYongcong | 2013 | Optik2013，124，20： | 1 |
| 9 | An Adaptive Wavelet 2 dimension Watermarking Algo rithm for Remote Sensing Images 显示文摘 | Wang Xianmin Guan Zequn Wu Chenhan | 2005 | Electronic Imaging and Multimedia Technology2005，4，： | 1 |
| 10 | Resistive switching and artificial synaptic performances of memristor based on low-dimensional bismuth halide perovskites显示文摘Zero-dimensional(0D)-Cs_(3)Bi_(2)I_(9),two-dimensional(2D)-Cs_(3)Bi_(2)Br_(9),and one-dimensional(1D)-Cs3Bi2Cl9 perovskite films have been successfully grown on indium tin oxide(ITO)glass substrates,which were used to fabricate memristors with the structure of Al/Cs_(3)Bi_(2)X_(9)(X=I,Br,and Cl)/ITO glass.The current three types of memristors exhibited bipolar resistive switching behaviors.Both the endurance and retention time tests clearly demonstrated the excellent stability of present devices.Especially,the ON/OFF ratio of the 0D-Cs_(3)Bi_(2)I_(9)device is close to 104 at the reading voltage of 0.1 V,which is nearly 100 and 1000 times larger than those of the 1D-Cs3Bi2Cl9 device and the 2D-Cs_(3)Bi_(2)Br_(9)device,respectively.The activation energy of halide vacancies in the Cs_(3)Bi_(2)X_(9)(X=I,Br,and Cl)films was calculated using the density functional theory by considering a minimum migration path,demonstrating the dimensionality of the Cs_(3)Bi_(2)X_(9)(X=I,Br,and Cl)film affected the formation and rupture of conductive filaments.Moreover,the short-term plasticity and long-term plasticity of biological synapse were simulated by evaluating the conductance responses of Al/Cs_(3)Bi_(2)X_(9)(X=I,Br,and Cl)/ITO devices under various voltage pulses in detail.The duration time of long-term plasticity in all the present devices can last for up to 250 s.The 0D-Cs_(3)Bi_(2)I_(9)device showed both the highest spikeduration-dependent plasticity and paired-pulse facilitation indexes compared to the other two devices.Additionally,the 0DCs_(3)Bi_(2)I_(9)device successfully established the associative learning behavior by simulating the Pavlov’s dog experiment. | Feifei Luo Yanzhao Wu Junwei Tong Fubo Tian Xianmin Zhang | 2023 | Nano Research2023，16，7： | 1 |
| 11 | Optimal placement and active vibration control for piezoelectric smart flexible cantilever plate显示文摘 | Qiu Zhicheng Zhang Xianmin Wu Hongxin | 2007 | Journal of Sound and Vibration2007，301，： | 1 |
| 12 | Simulation study on water quality based on sediment release flume experiment in Lake Taihu, China显示文摘 | Kaiming Hu Yong Pang Hua Wang Xianmin Wang Xinwei Wu Kun Bao Qi Liu | 2011 | Ecological Engineering2011，，4： | 1 |
| 13 | Optimal placement and active vibration control for piezoelectric smart flexible cantilever plate 显示文摘 | QIU Zhicheng ZHANG Xianmin WU Hongxin | 2007 | J Sound Vib2007，301，： | 1 |
| 14 | Characterization of refractive index distribution of polymer optical fiber显示文摘A focusing method is developed to characterize the refractive index profile of polymer optical fiber (POF). Based on the refractive index profile the theoretical bandwidth and the core index exponent a (a > 0) of POF are calculated. The results show that the value of theoretical bandwidth agrees well with the experimental data. | DAI Xinhua AI Xicheng LIU Zhimin YANG Mingjun YANG Guangying HAN Buxing XU Jian ZHANG Xianmin WU Xin | 2002 | Chinese Science Bulletin2002，47，12： | 1 |
| 15 | Genetic variation in exon 10 of the BPI gene is associated with Escherichia coli F18 susceptibility in Sutai piglets显示文摘 | Lu Liu Jing Wang Qiaohui Zhao Chen Zi Zhengchang Wu Xianmin Su Yongjiu Huo Guoqiang Zhu Shenglong Wu Wenbin Bao | 2013 | Gene2013，，1： | 1 |
| 16 | Optimal placement and active vibration control for piezoelectric smart flexible cantilever plate显示文摘 | Qiu Zhicheng Zhang Xianmin Wu Hongxin | 2007 | Journal of Sound and Vibration2007，301，35： | 1 |
| 17 | Optimum design of a 3-RRR planar parallel manipulator with a singularity-free work space显示文摘 | GAO Mingwang ZHANG Xianmin WU Zhiwei | 2011 | Applied Mechanics and Materials2011，86，： | 1 |
| 18 | Identification of no pollen 1 provides a candidate gene for heterosis utilization in foxtail millet(Setaria italica L.)显示文摘Male sterility is a common biological phenomenon in plant kingdom and has been used to generate male-sterile lines, which are important genetic resources for commercial hybrid seed production. Although increasing numbers of male-sterility genes have been identified in rice(Oryza sativa) and Arabidopsis(Arabidopsis thaliana), few male-sterility-related genes have been characterized in foxtail millet(Setaria italica). In this study, we isolated a male-sterile ethyl methanesulfonate-generated mutant in foxtail millet, no pollen 1(sinp1), which displayed abnormal Ubisch bodies, defective pollen exine and complete male sterility. Using bulk segregation analysis, we cloned SiNP1 and confirmed its function with CRISPR/Cas9 genome editing. SiNP1 encoded a putative glucose-methanol-choline oxidoreductase.Subcellular localization showed that the SiNP1 protein was preferentially localized to the endoplasmic reticulum and was predominantly expressed in panicle. Transcriptome analysis revealed that many genes were differentially expressed in the sinp1 mutant, some of which encoded proteins putatively involved in carbohydrate metabolism, fatty acid biosynthesis, and lipid transport and metabolism, which were closely associated with pollen wall development. Metabolome analysis revealed the disturbance of flavonoids metabolism and fatty acid biosynthesis in the mutant. In conclusion, identification of SiNP1 provides a candidate male-sterility gene for heterosis utilization in foxtail millet and gives further insight into the mechanism of pollen reproduction in plants. | Wei Zhang Hui Zhi Sha Tang Haoshan Zhang Yi Sui Guanqing Jia Chuanyin Wu Xianmin Diao | 2021 | The Crop Journal2021，9，6： | 1 |
| 19 | Effects of Different Treatments on Seed Germination of Bupleurum chinensis显示文摘 | HOU Guangxin LIANG Hao ZHAO Min CHEN Cuiguo MENG Xianmin ZHAO Jiansuo WU Zhanhui | 2018 | Journal of Life Sciences2018，12，3： | 0 |
| 20 | A straight-forward seed production technology system for foxtail millet(Setaria italica)显示文摘For autogamous crops, a precondition for using heterosis is to produce sufficient pure male-sterile female parents that can be used to produce hybrid seeds. To date, cytoplasmic male sterility(CMS)and environment-sensitive genic male sterility(EGMS) have been used commercially to exploit heterosis for autogamous species. However, neither CMS nor EGMS has been established for foxtail millet(Setaria italica). Here, we report on the establishment and application of a seed production technology(SPT) system for this crop.First, we established a Ds Red-based SPT system,but found that it was unsuitable because it required the use of a fluorescent device for seed sorting. Instead, we constructed an SPT system with de novo betalain biosynthesis as the selection marker. This allowed us to distinguish transgenic seeds with the naked eye, thereby facilitating the identification of SPT maintainer line seeds. In this system, a seed sorter was not required to obtain sufficient seeds. The key point of the strategy is that the seed pool of the SPT maintainer line is propagated by artificial identification and harvesting of male-fertile individuals in the field, and the male-sterile line seed pool for hybrid production is produced and propagated by free pollination of male-sterile plants with the SPT maintainer line. In a field experiment, we obtained 423.96 kg male-sterile line seeds per acre,which is sufficient to plant 700.18 acres of farmland for hybrid seed production or male-sterile line reproduction. Our study therefore describes a powerful tool for hybrid seed production in foxtail millet, and demonstrates how the SPT system can be used for a small-grained crop with high reproduction efficiency. | Wei Zhang Xiantao Qi Hui Zhi Yushuang Ren Linlin Zhang Yuanzhu Gao Yi Sui Haoshan Zhang Sha Tang Guanqing Jia Chuanxiao Xie Chuanyin Wu Xianmin Diao | 2023 | Journal of Integrative Plant Biology2023，65，9： | 0 |
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