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329篇 您的检索式:作者名="Xiaogang Zhang"
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1Anaerobic microbiologically influenced corrosion mechanisms interpreted using bioenergetics and bioelectrochemistry: A review显示文摘Microbiologically influenced corrosion(MIC) is a major cause of corrosion damages, facility failures, and financial losses, making MIC an important research topic. Due to complex microbiological activities and a lack of deep understanding of the interactions between biofilms and metal surfaces, MIC occurrences and mechanisms are difficult to predict and interpret. Many theories and mechanisms have been proposed to explain MIC. In this review, the mechanisms of MIC are discussed using bioenergetics, microbial respiration types, and biofilm extracellular electron transfer(EET). Two main MIC types, namely EET-MIC and metabolite MIC(M-MIC), are discussed. This brief review provides a state of the art insight into MIC mechanisms and it helps the diagnosis and prediction of occurrences of MIC under anaerobic conditions in the oil and gas industry.Yingchao Li Dake Xu Changfeng Chen Xiaogang Li Ru Jia Dawei Zhang Wolfgang Sand Fuhui Wang Tingyue Cu 2018Journal of Materials Science & Technology2018,34,10:43
2Overtopping breaching of cohesive homogeneous earth dam with different cohesive strength显示文摘In consideration of the range of clay content of Chinese earth dams, the world's highest prototype tests have been made to research on the effects of cohesive strength of filling of cohesive homogeneous earth dam on breach formation. Three breach mechanisms were presented, they were the source-tracing erosion of dam body with the form of 'multilevel headcut', 'two-helix flow' erosion of dam crest and collapse of breach sidewalls due to instability. It can be concluded that the cohesive strength of filling of earth dam has great effect on breach formation. When the cohesive strength is bigger, the breach process becomes slower, and the peak outflow and the final width and depth of breach become smaller. The main character of the breach formation is head cutting and dumping collapse. When the cohesive strength is smaller, the breach process becomes faster, and the peak outflow, the final width and depth of breach become bigger. The main character of the breach formation is single level head cutting and shearing collapse.ZHANG JianYun LI Yun XUAN GuoXiang WANG XiaoGang LI Jun 2009Science China(Technological Sciences)2009,52,10:34
3Mechanical properties and corrosion behavior of selective laser melted 316L stainless steel after different heat treatment processes显示文摘Irregular grains, high interfacial stresses and anisotropic properties widely exist in 3D-printed metallic materials, and this paper investigated the effects of heat treatment on the microstructural, mechanical and corrosion properties of 316 L stainless steel fabricated by selective laser melting. Sub-grains and low-angle boundaries exist in the as-received selective laser melted(SLMed) 316 L stainless steel. After heat treatment at 1050℃, the sub-grains and low-angle boundaries changed slightly, and the stress state and strength decreased to some extent due to the decrease of dislocation density. After heat treatment at 1200℃, the grains became uniform, and the dislocation cells vanished, which led to a sharp decline in the hardness and strength. However, the ductility was improved after recrystallization heat treatment.The passive film thickness and corrosion potential of the SLMed 316 L stainless steel decreased after heat treatment, and the pitting potential also decreased due to the accelerated transition from metastable to steady-state pitting;this accelerated transition was caused by the presence of weak passive films at the enlarged pores after heat treatment, especially for an adequate solid solution treatment.Decheng Kong Chaofang Dong Xiaoqing Ni Liang Zhang Jizheng Yao Cheng Man Xuequn Cheng Kui Xiao Xiaogang Li 2019Journal of Materials Science & Technology2019,35,7:23
4Overlying strata movement rules and safety mining technology for the shallow depth seam proximity beneath a room mining goaf显示文摘Aiming at the shallow depth seam proximity beneath a room mining goaf, due to that the shallow depth seam is exploited using the longwall mining and overlain by thin bedrock and thick loose sands, many accidents are likely to occur, including roof structure instability, roof step subsidence, damages of shield supports, and the face bumps triggered by the large area roof weighting, resulting in serious threats to the safety of underground miners and equipment. This paper analyses the overlying strata movement rules for the shallow seams using the physical simulation, the 3DEC numerical simulation and the field measurements. The results show that, in shallow seam mining, the overburden movement forms caved zone and fractured zone, the cracks develop continuously and reach the surface with the face advancing, and the development of surface cracks generally goes through four stages. With the application of loose blasting of residual pillars, reasonable mining height, and roof support and management, the safe, efficient and high recovery rate mining has been achieved in the shallow depth seam proximity beneath a room mining goaf.Wang Fangtian Zhang Cun Zhang Xiaogang Song Qi 2015International Journal of Mining Science and Technology2015,25,1:20
5Endoscopy dissection of small stromal tumors emerged from the muscularis propria in the upper gastrointestinal tract:Preliminary study显示文摘AIM:To investigate the feasibility and safety of the treatment of an upper gastrointestinal(GI) submucosal tumor with endoscopic submucosal dissection(ESD).METHODS:A total of 20 patients with esophageal and gastric submucosal tumors emerged from the muscular layer identified by endoscopic ultrasonography were collected from January 2009 to June 2010.Extramural or dumbbell-like lesions were excluded by an enhanced computerized tomography(CT) scan.All patients had intravenous anesthesia with propofol and then underwent the ESD procedure to resect these submucosal tumors.The incision was closed by clips as much as possible to decrease complications,such as bleeding or perforation,after resection of the tumor.All the specimens were collected and evaluated by hematoxylin,eosin and immunohistochemical staining,with antibodies against CD117,CD34,desmin,α-smooth muscle actin and vimentin to identify the characteristics of the tumors.Fletch's criteria was used to evaluate the risk of gastrointestinal stromal tumors(GISTs).All patients underwent a follow-up endoscopy at 3,6 and 12 mo and CT scan at 6 and 12 mo.RESULTS:The study group consisted of 5 men and 15 women aged 45-73 years,with a mean age of 60.2 years.Three tumors were located in the esophagus,9 in the gastric corpus,4 in the gastric fundus,3 lesions in the gastric antrum and 1 in the gastric angulus.Apart from the one case in the gastric angulus which was abandoned due to being deeply located in the serosa,94.7%(18/19) achieved complete gross dissection by ESD with operation duration of 60.52±30.32 min.The average maximum diameter of tumor was 14.8±7.6 mm,with a range of 6 to 30 mm,and another lesion was ligated by an endoscopic ligator after most of the lesion was dissected.After pathological and immunohistochemical analysis,12 tumors were identified as a GI stromal tumor and 6 were leiomyoma.Mitotic count of all 12 GIST lesions was fewer than 5 per 50 HPF and all lesions were at very low(9/12,75.0%) or low risk(3/12,25.0%) according to Fletch's criteria.Procedure complications mainly included perforation and GI bleeding;perforation occurred in 1 patient and conservative treatment succeeded by a suturing clip and no post-operative GI bleeding occurred.All patients were followed up for 6.5±1.8 mo(range,3-12 mo) by endoscopy and abdominal CT.Local recurrence and metastasis did not occur in any patient.CONCLUSION:ESD shows promise as a safe and feasible technique to resect esophageal and gastric submucosal tumors and the incidence of complications was very low.Clinical studies with more subjects and longer follow-up are needed to confirm its treatment value.Zhi-Gang Huang Xue-Song Zhang Shi-Liang Huang XiaoGang Yuan 2012World Journal of Gastrointestinal Endoscopy2012,4,12:18
6Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs显示文摘Jun Song Juan Zhong Xiaogang Guo Yongqiang Chen Qingjian zou Jiao Huang Xiaoping Li Quanjun Zhang Zhiwu Jiang Chengcheng Tang Huaqiang Yang Tao Liu Peng Li Duanqing Pei Liangxue Lai 2013Cell Research2013,23,8:15
7Structure and photocatalytic properties of TiO_2-Graphene Oxide intercalated composite显示文摘TiO2-Graphene Oxide intercalated composite (TiO2-Graphene Oxide) has been successfully prepared at low temperature (80°C) with graphite oxide (GO) and titanium sulfate (Ti(SO4)2) as initial reactants.GO was firstly exfoliated by NaOH and formed single and multi-layered graphite oxide mixture which can be defined as graphene oxide,[TiO]2+ induced by the hydrolysis of Ti(SO4)2 diffused into graphene oxide interlayer by electrostatic attraction.The nucleation and growth of TiO2 crystallites took place at low temperature and TiO2-Graphene Oxide composite was successfully synthesized.Furthermore,the photocatalytic properties of TiO2-Graphene Oxide under the irradiation of UV light were also studied.The results show that the degradation rate of methyl orange is 1.16 mg min-1 g-1(refer to the efficiency of the initial 15 min).Compared with P25 powder,this kind of intercalation composite owns much better efficiency.On the other hand,the reusable properties and stable properties of TiO2-Graphene Oxide intercalated composite are also discussed in this paper.At last,crystalline structure,interface status,thermal properties and microscopic structure of TiO2-Graphene Oxide were characterized by X-ray diffraction (XRD),X-ray photoelectron spectroscopy (XPS),thermogravimetric analysis (TGA),field emission scanning electron microscopy (FESEM) and high-resolution Transmission Electron Microscopy (HRTEM).Also,we have analyzed major influencing factors and mechanism of the composite structures which evidently improve the photocatalytic properties.ZHANG Qiong HE YunQiu CHEN XiaoGang HU DongHu LI LinJiang YIN Ting JI LingLi 2011Chinese Science Bulletin2011,56,3:14
8Relationship between electrochemical characteristics and SCC of X70 pipeline steel in an acidic soil simulated solution显示文摘Stress corrosion cracking (SCC) of X70 pipeline steel in simulated solution of the acidic soil in Yingtan in China was investigated using slow strain rate test (SSRT), SEM and potentiodynamic polarization technique. Experiment results indicate that X70 steel is highly susceptible to SCC as applied potential reduces, which is manifested in loss of toughness and brittle fracture. Constant polarization current can detect the occurrence of SCC. The lower the polarization current is the sooner stress corrosion cracking occurs. The SCC mechanisms are different at varying potentials. When potential is higher than open circuit potential, anodic process controls SCC, whereas when potential is far lower than open circuit potential, cathodic process controls SCC, and between these two potential regions, a combined electrochemical process controls the SCC. Stress or strain has a synergistic effect with electrochemical reactions to accelerate the cathodic hydrogen evolution process, which makes the X70 pipeline steel to be more susceptible to SCC.Zhiyong LIU Xiaogang LI Yingrui ZHANG Cuiwei DU Guoli ZHA 2009Acta Metallurgica Sinica(English Letters)2009,22,1:13
9COVID-19 Super Spreading Event Amongst Elderly Individuals—Jilin Province,China,January 2021显示文摘Summary What is already known on this topic?Clusters of COVID-19 cases often happened in small settings(e.g.,families,offices,school,or workplaces)that facilitate person-to-person virus transmission,especially from a common exposure.What is added by this report?On January 10 and 11,2021,an individual gave three product promotional lectures in Tonghua City.Laishun Yao Mingyu Luo Tiewu Jia Xingang Zhang Zhulin Hou Feng Gao Xin Wang Xiaogang Wu Weihua Cheng Guoqian Li Jing Lu Bing Zhao Tao Li Enfu Chen Dapeng Yin Biao Huang 2021China CDC weekly2021,3,10:13
10Understanding environmental impacts on initial atmospheric corrosion based on corrosion monitoring sensors显示文摘Atmospheric corrosion monitoring(ACM)sensors were employed to study the initial atmospheric corrosion of carbon steels over a one-month period in six outdoor dynamic atmospheric environments in China.Based on the~250,000 corrosion data sets collected,the environmental impacts of relative humidity,temperature and rainfall on the initial corrosion behavior of carbon steels were investigated.The results showed that rainfall was the strongest environmental factor influencing the initial atmospheric corrosion rate.Relative humidity significantly influenced the corrosion of carbon steels in low-precipitation environments and non-rainfall period.Zibo Pei Xuequn Cheng Xiaojia Yang Qing Li Chenhan Xia Dawei Zhang Xiaogang Li 2021Journal of Materials Science & Technology2021,,5:12
11Ultrathin Al2O3-coated reduced graphene oxide membrane for stable lithium metal anode显示文摘Lithium(Li) metal has been considered as the most attractive anode materials for Li-ion batteries(LIBs)due to its high theoretic specific capacity. The formation of unstable solid electrolyte interphase(SEI) and dendritic Li on the metal anode, however, hindered its practical application. Herein, to address the issues, a Li-free electrode with ultrathin Al_2O_3 coated on reduced graphene oxide(rGO) membrane that covers a Cu foil current collector was developed. The composite electrode exhibits excellent interfacial protection of lithium metal deposited between Cu foil and rGO electrochemically. Firstly, it affords good Li^+ permeability from the electrolyte. Secondly, the ultrathin Al_2O_3 has sufficient mechanical strength to inhibit the penetration of Li dendrite. Li metal was observed uniformly deposited between rGO membrane and Cu collector, and stable cycle performance of Li plating/stripping with Coulombic efficiency of ~91.75% at the 100 th cycle is achieved in organic carbonate electrolyte without any additives.Fan Zhang Fei Shen ZhaoYang Fan Xin Ji Bin Zhao ZhouTing Sun YingYing Xuan XiaoGang Han 2018Rare Metals2018,37,6:11
12Indirectly extruded biodegradable Zn-0.05wt%Mg alloy with improved strength and ductility: In vitro and in vivo studies显示文摘As compared to permanent orthopedic implants for load-bearing applications, biodegradable orthopedic implants have the advantage of no need for removing after healing, but they suffer from the 'trilemma' problem of compromising among sufficiently high mechanical properties, good biocompatibility and proper degradation rate conforming to the growth rate of new bones. In the present work, in vitro and in vivo studies of a Zn-0.05 wt%Mg alloy(namely, Zn-0.05 Mg alloy) were conducted with pure Zn as a control. The Zn-0.05 Mg alloy is composed of a small amount of Mg_2 Zn11 phase embedded in the refined Zn matrix with an average grain size of ~20 μm. The addition of 0.05 wt% Mg into Zn significantly increases the ultimate tensile strength up to 225 MPa and the elongation to fracture to 26%, but has little influence on the in vitro degradation rate. Both Zn and Zn-0.05 Mg alloy exhibit homogeneous in vitro degradation with a rate of about 0.15 mm/year. Based on the cytotoxicity evaluation, Zn and Zn-0.05 Mg alloy do not induce toxicity to L-929 cells, indicating that they have little toxicity to the general functions of the animal. An in vivo biocompatibility study of Zn and Zn-0.05 Mg alloy samples by placing them in a rabbit model for 4.12 and 24 weeks, respectively did not show any inflammatory cells, and demonstrated that new bone tissue formed at the bone/implant interface, suggesting that Zn and Zn-0.05 Mg alloy promote the formation of new bone tissue. The in vivo degradation of Zn and Zn-0.05 Mg alloy does not bring harm to the important organs and their cell structures. More interestingly, Zn and Zn-0.05 Mg alloy exhibit strong antibacterial activity against Escherichia coli and Staphylococcus aureus. The above results clearly demonstrate that the Zn-0.05 Mg alloy could be a potential biodegradable orthopedic implant material.Chi Xiao Liqing Wang Yuping Ren Shineng Sun Erlin Zhang Chongnan Yan Qi Liu Xiaogang Sun Fenyong Shou Jingzhu Duan Huang Wang Gaowu Qin 2018Journal of Materials Science & Technology2018,34,9:11
13A Two-step Estimation Method of Troposphere Delay with Consideration of Mapping Function Errors显示文摘Mapping function errors are usually not taken into consideration, when space geodetic data observed by VLBI, GNSS and some other techniques are utilized to estimate troposphere delay, which could, however, probably bring non-ignorable errors to solutions. After analyzing the variation of mapping function errors with elevation angles based on several-year meteorological data, this paper constructed a model of this error and then proposed a two-step estimation method of troposphere delay with consideration of mapping function errors. The experimental results indicate that the method put forward by this paper could reduce the slant path delay residuals efficiently and improve the estimation accuracy of wet tropospheric delay to some extent.Haopeng FAN Zhongmiao SUN Liping ZHANG Xiaogang LIU 2020Journal of Geodesy and Geoinformation Science2020,3,1:11
14Output Characteristics of a Series Three-port Axial Piston Pump显示文摘Driving a hydraulic cylinder directly by a closed-loop hydraulic pump is currently a key research area in the field of electro-hydraulic control technology,and it is the most direct means to improve the energy efficiency of an electro-hydraulic control system.So far,this technology has been well applied to the pump-controlled symmetric hydraulic cylinder.However,for the differential cylinder that is widely used in hydraulic technology,satisfactory results have not yet been achieved,due to the asymmetric flow constraint.Therefore,based on the principle of the asymmetric valve controlled asymmetric cylinder in valve controlled cylinder technology,an innovative idea for an asymmetric pump controlled asymmetric cylinder is put forward to address this problem.The scheme proposes to transform the oil suction window of the existing axial piston pump into two series windows.When in use,one window is connected to the rod chamber of the hydraulic cylinder and the other is linked with a low-pressure oil tank.This allows the differential cylinders to be directly controlled by changing the displacement or rotation speed of the pumps.Compared with the loop principle of offsetting the area difference of the differential cylinder through hydraulic valve using existing technology,this method may simplify the circuits and increase the energy efficiency of the system.With the software SimulationX,a hydraulic pump simulation model is set up,which examines the movement characteristics of an individual piston and the compressibility of oil,as well as the flow distribution area as it changes with the rotation angle.The pump structure parameters,especially the size of the unloading groove of the valve plate,are determined through digital simulation.All of the components of the series arranged three distribution-window axial piston pump are designed,based on the simulation analysis of the flow pulse characteristics of the pump,and then the prototype pump is made.The basic characteristics,such as the pressure,flow and noise of the pumps under different rotation speeds,are measured on the test bench.The test results verify the correctness of the principle.The proposed research lays a theoretical foundation for the further development of a new pump-controlled cylinder system.ZHANG Xiaogang QUAN Long YANG Yang WANG Chengbin YAO Liwei 2012Chinese Journal of Mechanical Engineering2012,25,3:10
15Power Matching and Energy Efficiency Improvement of Hydraulic Excavator Driven with Speed and Displacement Variable Power Source显示文摘Mobile machinery energy efficiency and emission pollution are the national and worldwide issues. This paper contributes in solving these problems by applying a speed variable power source. Unfortunately, almost all of the speed variable systems have the dynamic response problem when the motor starts with full load or heavy load. To address this problem, a hydraulic accumulator is used to balance the load of the power source for assisting starting of the motor and a matching method combined with speed and displacement control of the pump is proposed to improve the energy efficiency and dynamic performance simultaneously under different working conditions. Also, the power source/valve combined control strategy of an independent metering system is designed to realize flow matching of the whole system. Firstly, a test system is established to study the dynamic performance and energy efficiency of the speed variable power source with an auxiliary accumulator. Working performance and energy consumption of the power source under different rotating speeds and different loads are studied. And then, the hydraulic excavator test rig with the proposed system is constructed. Furthermore, the working performance of the excavator with the speed-fixed and speed-variable strategy are studied comparatively. Results show that, compared with fixed-speed strategy, the electric power consumption during the idle period and partial load condition can be reduced about 2.05 kW and 1.37 kW. The energy efficiency of speed variable power source is about 40%-71%, which is higher than that of the fixed-speed power source by 3%–10%.Lei Ge Long Quan Xiaogang Zhang Zhixin Dong Jing Yang 2019Chinese Journal of Mechanical Engineering2019,32,6:10
16Ground Surface Ruptures and Near-Fault,Large-Scale Displacements Caused by the Wenchuan Ms8.0 Earthquake Derived from Pixel Offset Tracking on Synthetic Aperture Radar Images显示文摘The 12 May 2008 Wenchuan Ms8.0 earthquake produced surface displacements along the causative fault,the Yingxiu-Beichuan Fault,which are up to several meters near the fault.Because of the large gradient,satellite synthetic aperture radar(SAR) interferometric data are strongly incoherent;the usual SAR interferometry method does not allow such displacements to be measured.In the present study,we employed another approach,the technique based on pixel offset tracking,to solve this problem.The used image data of six tracks are from the Advanced Land Observing Satellite,Phased Array type L-band Synthetic Aperture Radar(ALOS/PALSAR) dataset of Japan.The results show that the entire surface rupture belt is 238 km long,extending almost linearly in a direction of 42° north-east.It is offset left laterally by a north-west-striking fault at Xiaoyudong,and turns at Gaochuan,where the rupture belt shifts toward the south by 5 km,largely keeping the original trend.In terms of the features of the rupture traces,the rupture belt can be divided into five sections and three types.Among them,the Beichuan-Chaping and Hongkou-Yingxiu sections are relatively complex,with large widths and variable traces along the trend.The Pingtong-Nanba and Qingping-Jingtang sections appear uniform,characterized by straight traces and small widths.West of Yingxiu,the rupture traces are not clear.North of the rupture belt,surface displacements are 2.95 m on average,mostly 2-3.5 m,with 7-9 m the maximum near Beichuan.South of the rupture belt,the average displacement is 1.75 m,dominated by 1-2 m,with 3-4 m at a few sites.In the north,the displacements in the radar line of sight are of subsidence,and in the south,they are uplifted,in accordance with a right-slip motion that moves the northern wall of the fault to the east,and the southern wall to the west,respectively.Along the Guanxian-Jiangyou Fault,there is a uplift zone in the radar line of sight,which is 66 km long,1.5-6 km wide,and has vertical displacements of approximately 2 m,but no observable rupture traces.QU Chunyan SHAN Xinjian LIU Yunhua ZHANG Guohong SONG Xiaogang ZHANG Guifang GUO Liming HAN Yufei 2012Acta Geologica Sinica(English Edition)2012,86,2:10
17Corrosion Mechanism of Corrosion-Resistant Steel Developed for Bottom Plate of Cargo Oil Tanks显示文摘A new type of corrosion-resistant steel consisting of ferrite and bainite phases was developed for cargo oil tanks of crude oil tankers. The corrosion rate of this new steel was 0.22 mm/a, which was equivalent to ca. 1/5 of the criterion ( ≤ 1 mm/a) for corrosion-resistant steels. The composition and element distribution of the corrosion products were investigated by micro-Raman spectrometry and energy dispersive spectrometer. The results demonstrated that the corrosion product was composed of α-FeOOH, Fe3O4 and a continuous Cu enrichment layer. This kind of corrosion product was protective to the steel matrix and accounted for the enhancement of the corrosion resistance of the new developed steel.Feilong SUN Xiaogang LI Fan ZHANG Xuequn CHENG Cheng ZHOU Nianchun WU Yuqun YIN Jinbin ZHAO 2013Acta Metallurgica Sinica(English Letters)2013,26,3:9
18Effect of pH Value on Stress Corrosion Cracking of X70 Pipeline Steel in Acidic Soil Environment显示文摘The effect of pH value on the stress corrosion cracking(SCC) of API X70 pipeline steel in simulated acidic soil solutions was investigated by using slow strain rate test,electrochemical polarization curves,electrochemical impedance spectroscopy,and scanning electron microscopy.pH plays an important role in the susceptibility and electrochemical mechanism of SCC.The pH higher than 5 has no significant effect on electrochemical processes.By contrast,the pH lower than 5 intensifies cathodic hydrogen evolution reactions,thus increasing the cathodic current and corrosion potential.Under different pH values,the SCC mechanism of X70 pipeline steel varies among anodic dissolution(AD),hydrogen embrittlement(HE),and the combination of AD and HE(AD + HE) with variations of applied potential.At-850 mV SCE,the SCC mechanism is HE if pH is less than 4 or AD + HE if pH value is more positive.Zhiyong LIU Cuiwei DU Xin ZHANG Fuming WANG Xiaogang LI 2013Acta Metallurgica Sinica(English Letters)2013,26,4:9
19Iron-based oxygen carriers in chemical looping conversions:A review显示文摘A solid oxygen carrier is usually applied in a chemical looping conversion process to transfer oxygen from the gaseous oxygen source to the fuel,which can avoid the direct contact of these two reactants and hence decrease the energy penalty of separation.Among the solid oxygen carriers,iron-based oxygen carrier is an attractive option due to its inherent properties of low cost and environmentally-friendly.Several processes such as chemical looping combustion(CLC),chemical looping gasification(CLG),chemical looping reforming(CLR),and chemical looping hydrogen generation(CLHG)have been proposed and investigated based on the iron-based oxygen carrier.In this review,the relevant researches on the iron-based oxygen carrier are summarized,which include the characteristics of iron oxides,the preparations of the iron-based oxygen carrier based on the iron ores and some other low-cost iron contained materials,and their applications in the continuous operated chemical looping conversion processes.It is expected to provide a better understanding for the development and utilization of iron-based oxygen carrier in the practical chemical looping processes.Zhongliang Yu Yanyan Yang Song Yang Qian Zhang Jiantao Zhao Yitian Fang Xiaogang Hao Guoqing Guan 2019Carbon Resources Conversion2019,2,1:9
20LncRNA Nron regulates osteoclastogenesis during orthodontic bone resorption显示文摘Activation of osteoclasts during orthodontic tooth treatment is a prerequisite for alveolar bone resorption and tooth movement.However,the key regulatory molecules involved in osteoclastogenesis during this process remain unclear.Long noncoding RNAs(lnc RNAs)are a newly identified class of functional RNAs that regulate cellular processes,such as gene expression and translation regulation.Recently,lnc RNAs have been reported to be involved in osteogenesis and bone formation.However,as the most abundant noncoding RNAs in vivo,the potential regulatory role of lnc RNAs in osteoclast formation and bone resorption urgently needs to be clarified.We recently found that the lnc RNA Nron(long noncoding RNA repressor of the nuclear factor of activated T cells)is highly expressed in osteoclast precursors.Nron is downregulated during osteoclastogenesis and bone ageing.To further determine whether Nron regulates osteoclast activity during orthodontic treatment,osteoclastic Nron transgenic(Nron c TG)and osteoclastic knockout(Nron CKO)mouse models were generated.When Nron was overexpressed,the orthodontic tooth movement rate was reduced.In addition,the number of osteoclasts decreased,and the activity of osteoclasts was inhibited.Mechanistically,Nron controlled the maturation of osteoclasts by regulating NFATc1 nuclear translocation.In contrast,by deleting Nron specifically in osteoclasts,tooth movement speed increased in Nron CKO mice.These results indicate that lnc RNAs could be potential targets to regulate osteoclastogenesis and orthodontic tooth movement speed in the clinic in the future.Ruilin Zhang Junhui Li Gongchen Li Fujun Jin Zuolin Wang Rui Yue Yibin Wang Xiaogang Wang Yao Sun 2020International Journal of Oral Science2020,12,2:9
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