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| 1 | Surgical outcomes of mini-open Wiltse approach and conventional open approach in patients with single-segment thoracolumbar fractures without neurologic injury显示文摘This study aimed to introduce a novel mini-open pedicle screw fixation technique via Wiltse approach,and compared it with the traditional posterior open method.A total of 72 cases of single-segment thoracolumbar fractures without neurologic injury underwent pedicle screw fixation via two different approaches.Among them,37 patients were treated using posterior open surgery,and 35 patients received mini-open operation via Wiltse approach.Crew placement accuracy rate,operative time,blood loss,postoperative drainage,postoperative hospitalization time,radiation exposure time,postoperative improvement in R value,Cobb's angle and visual analog scale(VAS)scores of the two methods were compared.There were no significant differences in the accuracy rate of pedicle screw placement,radiation exposure and postoperative R value and Cobb's angle improvement between the two groups.However,the mini-open method had obvious advantages over the conventional open method in operative time,blood loss,postoperative drainage,postoperative hospitalization time,and postoperative improvement in VAS.The mini-open pedicle screw technique could be applied in treatment of single-segment thoracolumbar fracture without neurologic injury and had advantages of less tissue trauma,short operative and rehabilitative time on the premise of guaranteed accuracy rate and no increased radiation exposure. | Haijun Li Lei Yang Hao Xie Lipeng Yu Haifeng Wei Xiaojian Cao | 2015 | The Journal of Biomedical Research2015，29，1： | 43 |
| 2 | Effects of dietary protein/energy ratio on growth performance,carcass trait,meat quality,and plasma metabolites in pigs of different genotypes显示文摘Background:The protein/energy ratio is important for the production performance and utilization of available feed resources by animals.Increased protein consumption by mammals leads to elevated feed costs and increased nitrogen release into the environment.This study aimed to evaluate the effects of dietary protein/energy ratio on the growth performance,carcass traits,meat quality,and plasma metabolites of pigs of different genotypes.Methods:Bama mini-pigs and Landrace pigs were randomly assigned to two dietary treatment groups(Chinese conventional diet with low protein/energy ratio or National Research Council diet with high protein/energy ratio;n = 24 per treatment) in a 2x2 factorial arrangement.Blood and muscle samples were collected at the end of the nursery,growing,and finishing phases.Results:We observed significant interactions(P< 0.05) between breed and diet for total fat percentage,intramuscular fat(IMF) content,protein content in biceps femoris(BF) muscle,and plasma urea nitrogen(UN) concentration in the nursery phase;for average daily gain(ADG),average daily feed intake(ADFI),dry matter,IMF content in psoas major(PM) muscle,and plasma total protein and albumin concentrations in the growing phase;and for drip loss and plasma UN concentration in the finishing phase.Breed influenced(P < 0.05) growth performance,carcass traits,and meat quality,but not plasma metabolites.Throughout the trial,Landrace pigs showed significantly higher(P < 0.05) ADG,ADFI,dressing percentage,lean mass rate,and loin-eye area than did Bama mini-pigs,but significantly lower(P< 0.05)feed/gain ratio,fat percentage,backfat thickness,and IMF content.Dietary protein/energy ratio influenced the pH value,chemical composition of BF and PM muscles,and plasma activities of glutamic-pyruvic transaminase and gamma-glutamyl transpeptidase,and plasma concentration of UN.Conclusions:Compared with Landrace pigs,Bama mini-pigs showed slower growth and lower carcass performance,but had better meat quality.Moreover,unlike Landrace pigs,the dietary protein/energy ratio did not affect the growth performance of Bama mini-pigs.These results suggest that,in swine production,low dietary protein/energy ratio may be useful for reducing feed costs and minimizing the adverse effects of ammonia release into the environment. | Yingying Liu Xiangfeng Kong Guoli Jiang Bi'e Tan Jinping Deng Xiaojian Yang Fengna Li Xia Xiong Yulong Yin | 2015 | Journal of Animal Science and Biotechnology2015，6，4： | 37 |
| 3 | Activated carbon adsorption of quinolone antibiotics in water:Performance,mechanism,and modeling显示文摘The extensive use of antibiotics has led to their presence in the aquatic environment, and introduces potential impacts on human and ecological health. The capability of powdered activated carbon(PAC) to remove six frequently used quinolone(QN) antibiotics during water treatment was evaluated to improve drinking water safety. The kinetics of QN adsorption by PAC was best described by a pseudo second-order equation, and the adsorption capacity was well described by the Freundlich isotherm equation. Isotherms measured at different p H showed that hydrophobic interaction, electrostatic interaction,and π–π dispersion force were the main mechanisms for adsorption of QNs by PAC. A p H-dependent isotherm model based on the Freundlich equation was developed to predict the adsorption capacity of QNs by PAC at different p H values. This model had excellent prediction capabilities under different laboratory scenarios. Small relative standard derivations(RSDs), i.e., 0.59%–0.92% for ciprofloxacin and 0.09%–3.89% for enrofloxacin,were observed for equilibrium concentrations above the 0.3 mg/L level. The RSDs increased to 11.9% for ciprofloxacin and 32.1% for enrofloxacin at μg/L equilibrium levels, which is still acceptable. This model could be applied to predict the adsorption of other chemicals having different ionized forms. | Hao Fu Xuebing Li Jun Wang Pengfei Lin Chao Chen Xiaojian Zhang I.H.(Mel)Suffet | 2017 | Journal of Environmental Sciences2017，29，6： | 25 |
| 4 | Definition of the core zone of the “westerlies-dominated climatic regime”, and its controlling factors during the instrumental period显示文摘The term 'westerlies-dominated climatic regime' describes the pattern of precipitation/moisture variations between westerliesdominated arid Central Asia(ACA) and mid-latitude monsoon-dominated Asia on decadal to multi-millennial time scales. However, no attempts have been made to define its core region and the possible physical mechanisms responsible during the period of instrumental observations. The present study investigates the spatiotemporal variations of summer and winter precipitation on interannual to decadal time scales over mid-latitudes of the Eurasian continent using Empirical Orthogonal Function(EOF) analysis. Our results suggest the existence of an opposing pattern of summer precipitation variations between ACA and mid-latitude monsoon-dominated Asia and Mediterranean on decadal time scales. Based on these results, the core region influenced by the westerlies is outlined, including arid central Asia and Xinjiang in China(36°–54°N, 50°–90°E). By using monthly NCEP-NCAR reanalysis, the relationship between the 'westerlies-dominated climatic regime' and atmospheric circulation were also analyzed. The combination of the zonal climatic teleconnection pattern and anomalous Indian Summer Monsoon Precipitation(ISMP) causes the precipitation characteristics of the 'westerlies-dominated climatic regime' precipitation pattern. In addition, the Atlantic Multidecadal Oscillation(AMO) may also have an important effect on the 'westerlies-dominated climatic regime'. | HUANG Wei CHEN JianHui ZHANG XiaoJian FENG Song CHEN FaHu | 2015 | Science China Earth Sciences2015，58，5： | 24 |
| 5 | Interannual precipitation variations in the mid-latitude Asia and their association with large-scale atmospheric circulation显示文摘This study analyzed the spatial differences of the precipitation variations in the mid-latitude Asia and their possible physical mechanisms during 1960–2009.The annual precipitation showed an opposite variations between the westerlies-dominated arid Central Asia(ACA)and monsoon-dominated North China(NC)during the study period.Given the different contributions of seasonal precipitation to annual total precipitation in ACA and NC,the atmospheric circulation anomalies during the major precipitation seasons(winter in ACA/summer in NC)were analyzed.In winter,negative North Atlantic Oscillation may cause negative height anomalies over the north side and positive anomalies over the south side of the ACA.Together,the enhanced pressure gradient and anomalous westerly wind brings more water vapor to ACA,and leaves less precipitation in NC.In summer,the low-pressure anomalies in Northeast China,along with a weaker summer monsoon and negative height anomalies in Eastern Europe together contribute to reduced(excessive)summer precipitation in NC(ACA).The interactions between ENSO and NAO may result in the opposite precipitation variations between ACA and NC.A significant 2–3-year cycle is identified in ACA,which is linked to the variations of westerly circulation in the middle troposphere. | HUANG Wei CHEN FaHu FENG Song CHEN JianHui ZHANG XiaoJian | 2013 | Chinese Science Bulletin2013，58，32： | 21 |
| 6 | Understanding the genetic and epigenetic architecture in complex network of rice flowering pathways显示文摘尽管 flowering 时间控制的分子的基础很好在长天(LD ) 内被把,种 Arabidopsis,它在短天(SD ) 内大部分仍然是未知的植物米饭。瑞斯 flowering 时间(标题日期) 是为季节改编和谷物产量的一个重要农学的特点,它被基因、环境的因素影响。在最后十年期间,作为被识别的、著名进步在探索上被取得了的成花素的性质,成花素基因表示怎么样,遗传上控制。然而,在象 FLOWERING 那样的某些关键 flowering 综合者的 Arabidopsis 表示,地点 C (FLC ) 和 FLOWERING 地点 T (英尺) 被各种各样的染色质修正 epigenetically 也调整几乎不在这个方面上在米饭被知道直到很最近。这评论在米饭 flowering 时间控制总结了基因网络和染色质修正的进展,试图给一个完全的看法基因并且在米饭 flowering 小径的复杂网络的 epigenetic 建筑学。 | Changhui Sun Dan Chen Jun Fang Pingrong Wang Xiaojian Deng Chengcai Chu | 2014 | Protein & Cell2014，5，12： | 19 |
| 7 | Variable-step integration method for milling chatter stability prediction with multiple delays显示文摘This paper analyzes the stability of milling with variable pitch cutter and tool runout cases characterized by multiple delays,and proposes a new variable-step numerical integration method for efficient and accurate stability prediction. The variable-step technique is emphasized here to expand the numerical integration method,especially for the low radial immersion cases with multiple delays. First,the calculation accuracy of the numerical integration method is discussed and the variable-step algorithm is developed for milling stability prediction for single-delay and multiple-delay cases,respectively. The milling stability with variable pitch cutter is analyzed and the result is compared with those predicted with the frequency domain method and the improved full-discretization method. The influence of the runout effect on the stability boundary is investigated by the presented method. The numerical simulation shows that the cutter runout effect increases the stability boundary,and the increasing stability limit is verified by the milling chatter experimental results in the previous research. The numerical and experiment results verify the validity of the proposed method. | ZHANG XiaoJian XIONG CaiHua DING Ye XIONG YouLun | 2011 | Science China(Technological Sciences)2011，54，12： | 17 |
| 8 | Impact of disinfection on drinking water biofilm bacterial community显示文摘Disinfectants are commonly applied to control the growth of microorganisms in drinking water distribution systems. However, the effect of disinfection on drinking water microbial community remains poorly understood. The present study investigated the impacts of different disinfectants(chlorine and chloramine) and dosages on biofilm bacterial community in bench-scale pipe section reactors. Illumina MiS eq sequencing illustrated that disinfection strategy could affect both bacterial diversity and community structure of drinking water biofilm. Proteobacteria tended to predominate in chloraminated drinking water biofilms, while Firmicutes in chlorinated and unchlorinated biofilms. The major proteobacterial groups were influenced by both disinfectant type and dosage. In addition, chloramination had a more profound impact on bacterial community than chlorination. | Zilong Mi Yu Dai Shuguang Xie Chao Chen Xiaojian Zhang | 2015 | Journal of Environmental Sciences2015，27，11： | 16 |
| 9 | Quasi-real-time simulation of rotating drum using discrete element method with parallel GPU computing显示文摘Real-time simulation of industrial equipment is a huge challenge nowadays. The high performance and fine-grained parallel computing provided by graphics processing units (GPUs) bring us closer to our goals. In this article, an industrial-scale rotating drum is simulated using simplified discrete element method (DEM) without consideration of the tangential components of contact force and particle rotation. A single GPU is used first to simulate a small model system with about 8000 particles in realtime, and the simulation is then scaled up to industrial scale using more than 200 GPUs in a 1D domain-decomposition parallelization mode. The overall speed is about 1/11 of the real-time. Optimization of the communication part of the parallel GPU codes can speed up the simulation further, indicating that such real-time simulations have not only methodological but also industrial implications in the near future. | Ji Xu Huabiao Oi Xiaojian Fang Liqiang Lu Wei Ge Xiaowei Wang Ming xu Feiguo Chen xianfeng He Jinghai Li | 2011 | Particuology2011，9，4： | 16 |
| 10 | Position and complications of pedicle screw insertion with or without image-navigation techniques in the thoracolumbar spine:a meta-analysis of comparative studies显示文摘Computer-navigated pedicle screw insertion is applied to the thoracic and lumbar spine to attain high insertion accuracy and a low rate of screw-related complications.However,some in vivo and in vitro studies have shown that no advantages are gained with the use of navigation techniques compared to conventional techniques.Additionally,inconsistent conclusions have been drawn in various studies due to different population characteristics and methods used to assess the accuracy of screw placement.Moreover,it is not clear whether pedicle screw insertion with navigation techniques decreases the incidence of screw-related complications.Therefore,this study was sought to perform a meta-analysis of all available prospective evidence regarding pedicle screw insertion with or without navigation techniques in human thoracic and lumbar spine.We considered in vivo comparative studies that assessed the results of pedicle screw placement with or without navigation techniques.PubMed,Ovid MEDLINE and EMBASE databases were searched.Three published randomized controlled trials(RCTs) and nine retrospective comparative studies met the inclusion criteria.These studies included a total of 732 patients in whom 4,953 screws were inserted.In conclusion,accuracy of the position of grade I,II,III and IV screws and complication rate related to pedicle screw placement were significantly increased when navigation techniques were used in comparison to conventional techniques.Future research in this area should include RCTs with well-planned methodology to limit bias and report on validated,patient-based outcome measures. | Jinshan Tang Ziqiang Zhu Tao Sui Dechao Kong Xiaojian Cao | 2014 | The Journal of Biomedical Research2014，28，3： | 15 |
| 11 | Ammonium removal pathways and microbial community in GAC-sand dual media filter in drinking water treatment显示文摘A GAC-sand dual media filter(GSF) was devised as an alternative solution for drinking water treatment plant to tackle the raw water polluted by ammonium in place of expensive ozone-GAC processes or bio-pretreatments.The ammonium removal pathways and microbial community in the GSFs were investigated.The concentrations of ammonium,nitrite and nitrate nitrogen were monitored along the filter.Total inorganic nitrogen(TIN) loss occurred during the filtration.For 1 mg ammonium removal,the TIN loss was as high as 0.35 mg,DO consumption was 3.06 mg,and alkalinity consumption was 5.55 mg.It was assumed that both nitrification and denitrification processes occur in the filters to fit the TIN loss and low DO consumption.During the filtration,nitritation,nitrification and nitritation-anaerobic ammonium oxidation processes probably occur,while traditional nitrification and denitrification and simultaneous nitrification and denitrification processes may occur.In the GSFs,Nitrosomonas and Nitrospira are likely to be involved in nitrification processes,while Novosphingobium,Comamonadaceae and Oxalobacteraceae may be involved in denitrification processes. | Shuo Feng Shuguang Xie Xiaojian Zhang Zhiyu Yang Wei Ding Xiaobin Liao Yuanyuan Liu Chao Chen | 2012 | Journal of Environmental Sciences2012，24，9： | 14 |
| 12 | Synthesis and Enhanced Photocatalytic Activity of Regularly Shaped Cu2O Nanowire Polyhedra显示文摘一系列唯一的 nanowire 上层建筑, Cu2O nanowire polyhedra,通过一条划算的热水的线路被综合了。nanowire polyhedra 的三种类型,也就是 octahedra,凹面 octahedra,和昆虫,被面对羧基的酸与 o-anisidine 或 o-phenetidine 减少含铜的醋酸盐在高词法的收益(90%) 形成。这些 Cu2O nanowire polyhedra 的体系结构被电子显微镜学检验,它在多面的轮廓以内揭示了订的、高度排列的 Cu2O nanowires。Cu2O nanowire polyhedra 的生长被取向和被羧基的酸的增加调整的 nanowire 分支的生长率控制。比作样品在最近的文学报导了的 Cu2O, Cu2O nanowire octahedra 展览显著地在可见的光下面面对 H2O2 为染料降级提高了 photocatalytic 活动,可能,由于高密度的费用搬运人,从有他们的专辑的分叉的 nanowires 的 photoexcited 组织。另外,在当为染料的直接 photodegradation 的 H2O2 不在时的 Cu2O 的 photocatalytic 活动的最近的文学的讨论似乎可疑。 | Jing Shi Jin LI Xiaojian Huang Yiwei Tan | 2011 | Nano Research2011，4，5： | 12 |
| 13 | Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer显示文摘 | Xin Tian Baofa Sun Chuanyuan Chen Chunchun Gao Ji Zhang XingYu Lu Linchen Wang Xiangnan Li Yurong Xing Ruijuan Liu Xiao Han Zheng Qi Xiaojian Zhang Chuan He Dali Han Yun-Gui Yang Quancheng Kan | 2018 | Cell Research2018，28，5： | 12 |
| 14 | A proposed surface resistance model for the Penman-Monteith formula to estimate evapotranspiration in a solar greenhouse显示文摘Greenhousing is a technique to bridge season gap in vegetable production and has been widely used worldwide. Calculation of water requirement of crops grown in greenhouse and determination of their irrigation schedules in arid and semi-arid regions are essential for greenhouse maintenance and have thus attracted increased attention over the past decades. The most common method used in the literature to estimate crop evapotranspiration(ET) is the Penman-Monteith(PM) formula. When applied to greenhouse, however, it often uses canopy resistance instead of surface resistance. It is understood that the surface resistance in greenhouse is the result of a combined effect of canopy restriction and soil-surface restriction to water vapor flow, and the relative dominance of one restriction over another depends on crop canopy. In this paper, we developed a surface resistance model in a way similar to two parallel resistances in an electrical circuit to account for both restrictions. Also, considering that wind speed in greenhouse is normally rather small, we compared three methods available in the literature to calculate the aerodynamic resistance, which are the r_a^1 method proposed by Perrier(1975a, b), the r_a^2 method proposed by Thom and Oliver(1977), and the r_a^3 method proposed by Zhang and Lemeu(1992). We validated the model against ET of tomatoes in a greenhouse measured from sap flow system combined with micro-lysimeter in 2015 and with weighing lysimeter in 2016. The results showed that the proposed surface resistance model improved the accuracy of the PM model, especially when the leaf area index was low and the greenhouse was being irrigated. We also found that the aerodynamic resistance calculated from the r_a^1 and r_a^3 methods is applicable to the greenhouse although the latter is slightly more accurate than the former. The proposed surface resistance model, together with the r_a^3 method for aerodynamic resistance, offers an improved approach to estimate ET in greenhouse using the PM formula. | GONG Xuewen LIU Hao SUN Jingsheng GAO Yang ZHANG Xiaoxian Shiva K JHA ZHANG Hao MA Xiaojian WANG Wanning | 2017 | Journal of Arid Land2017，9，4： | 12 |
| 15 | Monthly survey of N-nitrosamine yield in a conventional water treatment plant in North China显示文摘A sampling campaign was conducted monthly to investigate the occurrence of N-nitrosamines at a conventional water treatment plant in one city in North China.The yield of N-nitrosamines in the treated water indicated precursors changed greatly after the source water switching.Average concentrations of N-nitrosodimethylamine(NDMA),N-nitrosomorpholine(NMOR),and N-nitrosopyrrolidine(NPYR) in the finished water were6.9,3.3,and 3.1 ng/L,respectively,from June to October when the Luan River water was used as source water,while those of NDMA,N-nitrosomethylethylamine(NMEA),and NPYR in the finished water were 10.1,4.9,and 4.7 ng/L,respectively,from November to next April when the Yellow River was used.NDMA concentration in the finished water was frequently over the 10 ng/L,i.e.,the notification level of California,USA,which indicated a considerable threat to public health.Weak correlations were observed between N-nitrosamine yield and typical water quality parameters except for the dissolved organic nitrogen. | Chengkun Wang Shuming Liu Jun Wang Xiaojian Zhang Chao Chen | 2015 | Journal of Environmental Sciences2015，27，12： | 11 |
| 16 | Analysis of Types and Changes of Village-level Economy in Rural Gongyi City, Henan Province Since 1990显示文摘Based on the research on the rural living standard in China in terms of annual net income per capita, we de-fine six types of village-level economy, i.e. 'to be extremely poor', 'to make a basic living', 'to dress warmly and eat one's fill', 'to try to enrich (to disengage poverty)', 'to be well-off' and 'to be affluent'. The data of average annual net income of all the 292 villages between 1990 and 2004 in rural Gongyi City, Henan Province were collected, veri-fied and classified. By using standard deviation, coefficient of variation and regression analysis, it is found that the Gongyi's rural economy has boosted up remarkably from the relative-poverty and absolute-poverty stages in 1990 to the well-off in 2004. However, the absolute differences between villages present a trend of enlargement, while the rela-tive differences fluctuating. On the other hand, spatial analysis of village-level economy shows that most villages with relatively high economic development level were located along national expressway and most villages with abso-lute-poverty lay in remote mountainous areas in 1990. Since the 1990s, the rapid urbanization and industrialization have had strongly positive effects on rural economic growth. Initial economic foundation, natural resources and tradi-tional techniques also contribute to village economy. From the perspective of geography, villages with location advan-tages, such as near urban center or industrial parks, have more chances for their economic development and the 'core-periphery' economic structure has been presented in the process of rural development. | QIAO Jiajun KONG Yunfeng LI Xiaojian | 2008 | Chinese Geographical Science2008，18，2： | 11 |
| 17 | Global approximation based adaptive RBF neural network control for supercavitating vehicles显示文摘A global approximation based adaptive radial basis function(RBF) neural network control strategy is proposed for the trajectory tracking control of supercavitating vehicles(SV).A nominal model is built firstly with the unknown disturbance.Next, the control scheme is established consisting of a computed torque controller(CTC) for the practical vehicle and an RBF neural network controller to estimate model error between the practical vehicle and the nominal model. The network weights are adapted by employing a Lyapunov-based design. Then it is shown by the Lyapunov theory that the trajectory tracking errors asymptotically converge to a small neighborhood of zero. The control performance of the proposed controller is illustrated by simulation. | LI Yang LIU Mingyong ZHANG Xiaojian PENG Xingguang | 2018 | Journal of Systems Engineering and Electronics2018，29，4： | 11 |
| 18 | Milling stability analysis using the spectral method显示文摘This paper focuses on the development of an efficient semi-analytical solution of chatter stability in milling based on the spectral method for integral equations. The time-periodic dynamics of the milling process taking the regenerative effect into account is formulated as a delayed differential equation with time-periodic coefficients,and then reformulated as a form of integral equation. On the basis of one tooth period being divided into a series of subintervals,the barycentric Lagrange interpolation polynomials are employed to approximate the state term and the delay term in the integral equation,respectively,while the Gaussian quadrature method is utilized to approximate the integral term. Thereafter,the Floquet transition matrix within the tooth period is constructed to predict the chatter stability according to Floquet theory. Experimental-validated one-degree-of-freedom and two-degree-of-freedom milling examples are used to verify the proposed algorithm,and compared with existing algorithms,it has the advantages of high rate of convergence and high computational efficiency. | DING Ye ZHU LiMin ZHANG XiaoJian DING Han | 2011 | Science China(Technological Sciences)2011，54，12： | 11 |
| 19 | Adsorptive desulfurization over hierarchical beta zeolite by alkaline treatment显示文摘Hierarchical beta zeolites with SiO2 /Al2O3 molar ratios of 16 to 25 were obtained by alkaline treatment in NaOH solution. The effects of treatment temperature on crystallinity, textural properties and chemical composites were studied by XRD, N2 sorption, FT-IR and XRF techniques. The desulfurization performance of parent and alkaline-treated beta zeolites was investigated by static absorption in four model fuels, containing four sulfur compounds of different molecular sizes like thiophene (TP), 3-methylthiophene (3-MT), benzothiophene (BT) and dibenzothiophene (DBT), respectively. The crystallinity was observed to be successfully maintained when the treatment temperature was below 50 C. Mesoporosity of beta zeolite was evidently developed with alkaline treatment. The formation of mesopore remarkably improved the desulfurization performance for TP, 3-MT, BT and DBT, especially for DBT with larger molecular diameter. Though the addition of toluene in the model fuels resulted in a significant drop of the desulfurization performance of mesoporous beta zeolite, the introduction of cerium ions to some extent mitigated the effect of toluene, which means that both the adsorbents porous structure and the adsorption mode are responsible for the desulfurization performance. The adsorbent of cerium ion-exchanged mesoporous beta showed about 80% recovery of desulfurization after the first regeneration. | Fuping Tian Xiaojian Yang Yanchun Shi Cuiying Jia Yongying Chen | 2012 | Journal of Natural Gas Chemistry2012，21，6： | 11 |
| 20 | Hypoxia-induced factor-1 alpha upregulates vascular endothelial growth factor C to promote lymphangiogenesis and angiogenesis in breast cancer patients显示文摘Hypoxia-induced factor-1 alpha(HIF-1α)affects many effector molecules and regulates tumor lymphangiogenesis and angiogenesis during hypoxia.The aim of this study was to investigate the role of HIF-1αin the regulation of vascular endothelial growth factor C(VEGF-C)expression and its effect on lymphangiogenesis and angiogenesis in breast cancer.Lymphatic vessel density(LVD),microvessel density(MVD)and the expressions of HIF-1αand VEGF-C proteins were evaluated by immunohistochemistry in 75 breast cancer samples.There was a significant correlation between HIF-1αand VEGF-C(P=0.014,r=0.273,Spearman's coefficient of correlation).HIF-1αand VEGF-C overexpression was significantly correlated with higher LVD(P=0.003 and P=0.017,respectively),regional lymph nodal involvement(P=0.002 and P=0.004,respectively)and advanced tumor,node,metastasis(TNM)classification(P=0.001 and P=0.01,respectively).Higher MVD was observed in the group expressing higher levels of HIF-1αand VEGF-C(P=0.033 and P=0.037,respectively).Univariate analysis showed shorter survival time in patients expressing higher levels of HIF-1αand VEGF-C.HIF-1αwas also found to be an independent prognostic factor of overall survival in multivariate analysis.The results suggest that HIF-1αmay affect VEGF-C expression,thus acting as a crucial regulator of lymphangiogenesis and angiogenesis in breast cancer.This study highlights promising potential of HIF-1αas a therapeutic target against tumor lymph node metastasis. | Xiaojian Ni Yingchun Zhao Jingjing Ma Tiansong Xia Xiaoan Liu Qiang Ding Xiaoming Zha Shui Wang | 2013 | The Journal of Biomedical Research2013，27，6： | 10 |
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