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| 1 | Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor显示文摘 | Lijie Wang Wei Xue Lei Yan Xiaosa Li Jia Wei Miaomiao Chen Jing Wu Bei Yang Li Yang Jia Chen | 2017 | Cell Research2017，27，10： | 26 |
| 2 | 重复经颅磁刺激治疗抑郁症的机制研究进展(英文)显示文摘概述:抑郁障碍是目前最常见的心理健康问题之一。然而,对于该疾病的基于机制的治疗方法仍然是难以捉摸的。重复经颅磁刺激(rTMS)是一种非侵入性的程序,它可以以一种脉冲磁场来刺激大脑中的电活动,被认为是一种有效的抑郁症治疗方式。在这里,我们回顾了关于rTMS治疗抑郁症的临床和基础研究的主要发现,包括它的抗抑郁疗效,基本原理,调节神经回路、神经递质和脑网络、海马神经发生、和突出的功效,以及分子通路。 | Zhengwu PENG Cuihong ZHOU Shanshan XUE Jie BAI Shoufen YU Xiaosa LI Huaning WANG Qingrong TAN | 2018 | 上海精神医学2018，30，2： | 13 |
| 3 | APOBEC:From mutator to editor显示文摘APOBECs(apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) are a family of cytidine deaminases that prefer single-stranded nucleic acids as substrates. Besides their physiological functions,APOBEC family members have been found to cause hypermutations of cancer genomes, which could be correlated with cancer development and poor prognosis. Recently, APOBEC family members have been combined with the versatile CRISPR/Cas9 system to perform targeted base editing or induce hypermutagenesis. This combination improved the CRISPR/Cas9-mediated gene editing at single-base precision, greatly enhancing its usefulness. Here, we review the physiological functions and structural characteristics of APOBEC family members and their roles as endogenous mutators that contribute to hypermutations during carcinogenesis. We also review the various iterations of the APOBEC-CRISPR/Cas9 gene-editing tools, pointing out their features and limitations as well as the possibilities for future developments. | Bei Yang Xiaosa Li Liqun Lei Jia Chen | 2017 | Journal of Genetics and Genomics2017，44，9： | 8 |
| 4 | Novel thin-film composite membranes with improved water flux from sulfonated cardo poly (arylene ether sulfone)bearing pendant amino groups 显示文摘 | Guang Chen Shenghai Li Xiaosa Zhang | 2008 | Journal of Membrane Science2008，310，： | 1 |
| 5 | Novel thin-film composite membranes with improved water flux from sulfonated cardo poly(arylene ether sulfone) bearing pendant amino groups 显示文摘 | Chen Guang Li Shenghai Zhang Xiaosa | 2008 | Journal of Membrane Science2008，310，： | 1 |
| 6 | Polyamide thinfilm composite membranes prepared from a novel triamine 3, 5diaminoN( 4aminophenyl )benzamide monomer and mphenylenediamine 显示文摘 | Wang Haifeng Li Lei Zhang Xiaosa | 2010 | J Membr Sci2010，353，： | 1 |
| 7 | 显示文摘 | Li Lei Zhang Suobo Zhang Xiaosa | 2009 | Journal of Menbrane Science2009，335，： | 1 |
| 8 | A tunable genome editing system of the prime editor mediated by dihydrofolate reductase显示文摘The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(CRISPR/Cas)system was discovered in bacteria and archaea as an adaptive immunity system to protect against exogenous DNA(Barrangou et al.,2007).This system has been developed into a powerful gene editing tool for eukaryotic genome manipulation that has therapeutic opportunities against hereditary diseases(Cong et al.,2013),especially monogenic diseases. | Shu Liu Xiaoyue Duan Feng Peng Yafang Wang Yang Liu Xiaoling Wan Jingfa Zhang Xiaosa Li Xiaodong Sun | 2023 | Journal of Genetics and Genomics2023，50，3： | 0 |
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