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| 1 | Radial shock wave therapy in the treatment of chronic constriction injury model in rats: a preliminary study显示文摘 | Fu Miao Cheng Hao Li Duoyi Yu Xiaotong Ji Nan Luo Fang | 2014 | Chinese Medical Journal2014，，5： | 13 |
| 2 | Antibacterial metals and alloys for potential biomedical implants显示文摘Metals and alloys,including stainless steel,titanium and its alloys,cobalt alloys,and other metals and alloys have been widely used clinically as implant materials,but implant-related infection or inflammation is still one of the main causes of implantation failure.The bacterial infection or inflammation that seriously threatens human health has already become a worldwide complaint.Antibacterial metals and alloys recently have attracted wide attention for their long-term stable antibacterial ability,good mechanical properties and good biocompatibility in vitro and in vivo.In this review,common antibacterial alloying elements,antibacterial standards and testing methods were introduced.Recent developments in the design and manufacturing of antibacterial metal alloys containing various antibacterial agents were described in detail,including antibacterial stainless steel,antibacterial titanium alloy,antibacterial zinc and alloy,antibacterial magnesium and alloy,antibacterial cobalt alloy,and other antibacterial metals and alloys.Researches on the antibacterial properties,mechanical properties,corrosion resistance and biocompatibility of antibacterial metals and alloys have been summarized in detail for the first time.It is hoped that this review could help researchers understand the development of antibacterial alloys in a timely manner,thereby could promote the development of antibacterial metal alloys and the clinical application. | Erlin Zhang Xiaotong Zhao Jiali Hu Ruoxian Wang Shan Fu Gaowu Qin | 2021 | Bioactive Materials2021，6，8： | 13 |
| 3 | Lactate metabolism in human health and disease显示文摘The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism,as identified by studies on the Warburg effect.The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells,organs and tissues.Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao’s research group in 2019.Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation,neural excitation,inflammation and other biological processes.An indispensable substance for various physiological cellular functions,lactate plays a regulatory role in different aspects of energy metabolism and signal transduction.Therefore,a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research.This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes,as well as a comprehensive overview of the effects of lactylation in various diseases,particularly inflammation and cancer. | Xiaolu Li Yanyan Yang Bei Zhang Xiaotong Lin Xiuxiu Fu Yi An Yulin Zou Jian-Xun Wang Zhibin Wang Tao Yu | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 9 |
| 4 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 5 | On the linear complexity of generalized cyclotomic sequences of order four over Zpq显示文摘 | BAI Enjian FU Xiaotong XIAO Guozhen | 2005 | IEICE Transactions on Fundamentals of Electronics Conmmnieations and Computer Sciences2005，88，1： | 1 |
| 6 | Tauroursodeoxycholic acid(TUDCA)improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets显示文摘Background:Tauroursodeoxycholic acid(TUDCA),a hydrophilic bile acid,is the main medicinal component of bear bile and is commonly used to treat a variety of hepatobiliary diseases.Meanwhile,TUDCA has been shown to modulate the intestinal barrier function and alleviate DSS-induced colitis in mice.However,the effect of TUDCA on the intestinal barrier of weaned piglets remains largely unclear.Methods:The weaned piglets and porcine IPEC-J2 intestinal epithelial cells were used to investigate the effects of TUDCA on intestinal barrier function in weaned piglets and explore the possible underlying mechanisms.In vivo,72 healthy weaned piglets were randomly allocated into 2 groups according to their gender and body weight,and piglets were fed the basal diet with 0(control,CON)and 200 mg/kg TUDCA for 30 d,respectively.Three female and three male piglets reflecting the average bodyweight were slaughtered in each group and samples were collected.In vitro,IPEC-J2 cells were subjected to 100μmol/L TUDCA to explore the possible underlying mechanisms.Results:Our results demonstrated that dietary TUDCA supplementation significantly reduced the diarrhea incidence of weaned piglets,possibly attributing to the TUDCA-enhanced intestinal barrier function and immunity.In addition,TUDCA supplementation altered serum metabolites and the relative abundance of certain gut bacteria,which might contribute to the improved intestinal barrier function.Furthermore,the in-vitro results showed that TUDCA improved the E.coli-induced epithelial barrier impairment of IPEC-J2 cells and increased Takeda G-coupled protein receptor 5(TGR5)protein expression.However,knockdown of TGR5 and inhibition of myosin light chain kinase(MLCK)pathway abolished the TUDCA-improved epithelial barrier impairment in E.coli-treated IPEC-J2 cells,indicating the involvement of TGR5-MLCK in this process.Conclusions:These findings showed that TUDCA improved intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets,suggesting the potential application of TUDCA in improving gut health in piglet production. | Min Song Fenglin Zhang Yiming Fu Xin Yi Shengchun Feng Zhichang Liu Dun Deng Qiang Yang Miao Yu Canjun Zhu Xiaotong Zhu Lina Wang Ping Gao Gang Shu Xianyong Ma Qingyan Jiang Songbo Wang | 2022 | Journal of Animal Science and Biotechnology2022，13，6： | 1 |
| 7 | An insight into aggregation kinetics of polystyrene nanoplastics interaction with metal cations显示文摘Once inevitably released into the aquatic environment,polystyrene nanoplastics(PS-NPs)will present complicated environmental behaviors,of which the aggregation is a key process determining their environmental fate and impact.In this study,the aggregation kinetics of different sizes(30 nm and 100 nm)of PS-NPs with metal cations(Na^(+),K^(+),Ca^(2+),Mg^(2+)and Pb^(2+))at different solution pH(3,6 and 8)were investigated.The results showed that the aggregation of PS-NPs increased with cation concentration.Taking Pb^(2+)as an example,the adsorption behavior of cations onto PS-NPs was determined by transmission electron microscopy(TEM)and energy dispersive X-ray(EDX)spectroscopy,which demonstrated Pb^(2+)could be adhered onto the surface of PS-NPs with the effect of charge neutralization.The critical coagulation concentrations(CCC)of smaller PS-NPs were higher than that of larger PS-NPs for monovalent cations,whereas a different pattern is observed for divalent cations.It was suggested that there were other factors that DLVO theory does not consider affect the stability of NPs with different particle sizes.In addition,it should be noted that PS-NPs had the capacity of adsorbing large amounts of heavy metal cations and carried them transport to a long distance,and the corresponding ecological risks need to further elucidate. | Yucheng Zhang Xiaotong Su Nora FYTam Xiaolan Lao Meiling Zhong Qihang Wu Huifang Lei Zihui Chen Zhang Li Jie Fu | 2022 | Chinese Chemical Letters2022，33，12： | 1 |
| 8 | On the linear complexity of generalized cyclotomic sequences of order four over Zpq 显示文摘 | BAI Enjian FU Xiaotong XIAO Guozhen | 2005 | IEICE Transactions on Fundamentals of Electronics Communications and Computer Sciences2005，88，1： | 1 |
| 9 | Morphological characteristics of Neoseiulus setarius Ma,Meng&Fan,sp.nov.(Acari:Phytoseiidae)from China显示文摘The genus Neoseiulus Hughes,1948 is one of the largest genera in Phytoseiidae and contains more than 364 valid species in the world.In this paper,a new species N.setarius Ma,Meng&Fan,sp.nov.is described based on both adult female and male specimens collected from Setaria viridis(L.)Beauv.(Gramineae),in Inner Mongolia of China.The adult females of the new species are characterized by having a fully reticulated dorsal shield,barbed Z5,bellshaped spermathecal calyx with a short basal stalk.Furthermore,seta R1 is off dorsal idiosomal shield in adult males. | Min Ma Yu Liu Yujing Li Xiaotong Fu Qinghai Fan Ruixia Meng | 2023 | Zoological Systematics2023，48，2： | 0 |
| 10 | Distribution of O^(+)and O_(2)^(+) fluxes and their escape rates in the near-Mars magnetotail:A survey of MAVEN observations显示文摘Tailward ion outflows in the Martian-induced magnetotail are known to be one of the major channels for Martian atmospheric escape.On the basis of nearly 6.5 years of observations from the Mars Atmosphere and Volatile EvolutioN(MAVEN)mission,we investigate the statistical distribution of tailward and Marsward fluxes of heavy ions(i.e.,O^(+),and O_(2)^(+))in the near-Mars magnetotail and explore their characteristic responses to the corotating interaction region(CIR),solar wind dynamic pressure,and local magnetic field intensity.Our results show that the tailward fluxes of oxygen ions and molecular oxygen ions in the magnetotail are significantly greater than their Marsward fluxes and that the tailward flux of molecular oxygen ions is generally larger than that of oxygen ions.Furthermore,the tailward ion flux distribution exhibits dependence on the CIR,solar wind dynamic pressure,and local magnetic field strength in a manner stronger than the Marsward ion flux distribution.According to the distribution of tailward ion fluxes,we calculate the corresponding escape rates of heavy ions and show that when the CIR occurs,the total escape rates of oxygen ions and molecular oxygen ions increase by a factor of~2 and~1.2,respectively.We also find that the escape rates of heavy ions increase with the enhancement of solar wind dynamic pressure,whereas the overall effect of the local magnetic field is relatively weak.Our study has important implications for improved understanding of the underlying mechanisms responsible for the Martian atmospheric escape and the evolution of the Martian atmospheric climate. | HengLe Du Xing Cao BinBin Ni Song Fu Xin Ma XiaoTong Yun MinYi Long Qiong Luo | 2022 | Earth and Planetary Physics2022，6，6： | 0 |
| 11 | Crystalline inclusion complexes formed between the drug diflunisal and block copolymers显示文摘The solid form of drugs plays a central role in optimizing the physicochemical properties of drugs,and new solid forms will provide more options to achieve the desirable pharmaceutical profiles of drugs.Recently,certain drugs have been found to form crystalline inclusion complexes(ICs) with multiple types of linear polymers,representing a new subcategory of pharmaceutical solids.In this study,we used diflunisal(DIF) as the model drug host and extended the guest of drug/polymer ICs from homopolymers to block copolymers of poly(ethylene glycol)(PEG) and poly(s-caprolactone)(PCL).The block length in the guest copolymers showed a significant influence on the formation,thermal stability and dissolution behavior of the DIF ICs.Though the PEG block could hardly be included alone,it could indeed be included in the DIF ICs when the PCL block was long enough.The increase of the PCL block length produced IC crystals with improved thermal stability.The dissolution profiles of DIF/block copolymer ICs exhibited gradually decreased aqueous solubility and dissolution rate with the increasing PCL block length.These results demonstrate the possibility of using drug/polymer ICs to modulate the desired pharmaceutical profiles of drugs in a predictable and controllable manner. | Zhi Zhong Xiaotong Yang Xiao-Bin Fu Ye-Feng Yao Bao-Hua Guo Yanbin Huang Jun Xu | 2017 | Chinese Chemical Letters2017，28，6： | 0 |
| 12 | Proton pitch angle distributions in the Martian induced magnetosphere: A survey of Tianwen-1 Mars Ion and Neutral Particle Analyzer observations显示文摘The pitch angle distributions of ions and electrons can be affected by various processes;thus,they can serve as an important indicator of the physical mechanisms driving the dynamics of space plasmas.From observations from the Mars Ion and Neutral Particle Analyzer onboard the Tianwen-1 orbiter,we calculated the pitch angle distributions of protons in the Martian induced magnetosphere by using information from the magnetohydrodynamically simulated magnetic field,and we statistically analyzed the spatial occurrence pattern of different types of pitch angle distributions.Even though no symmetrical features were seen in the dataset,we found the dominance of the field-aligned distribution type over the energy range from 188 to 6232 eV.Maps of the occurrence rate showed the preferential presence of a trapped-like distribution at the lower altitudes of the surveyed nightside region.Although our results are more or less restricted by the adopted magnetic field,they indicate the complexity of the near-Mars proton pitch angle distributions and infer the possibility of wave–particle interactions in the Martian induced magnetosphere. | TaiFeng Jin BinBin Ni LingGao Kong AiBing Zhang Lei Li Song Fu Xing Cao WenYa Li BinBin Tang LiangHai Xie YiTeng Zhang ShuYue Pang XiaoTong Yun HengLe Du FuHao Qiao LiMin Wang JiJie Ma | 2023 | Earth and Planetary Physics2023，7，5： | 0 |
| 13 | Mechanism of NURP1 in temozolomide resistance in hypoxiatreated glioma cells via the KDM3A/TFEB axis显示文摘Temozolomide(TMZ)resistance is a major obstacle in glioma treatment.Nuclear protein-1(NUPR1)is a regulator of glioma progression.This study investigated the mechanism of NUPR1 in TMZ resistance in hypoxiatreated glioma cells and its mechanism in modulating autophagy.We treated TMZ-resistant cells U251-TMZ and T98G-TMZ to normoxia or hypoxia and silenced NUPR1 in hypoxia-treated U251-TMZ and T98G-TMZ cells to assess cell viability,proliferation,apoptosis,LC3-II/LC3-I and p62 expressions,and autophagic flux under different concentrations of TMZ.We found that hypoxia upregulated NUPR1 expression and autophagy while NUPR1 silencing suppressed hypoxia-induced TMZ resistance and autophagy in glioma cells.We also investigated the interaction between NUPR1 and lysine demethylase 3A(KDM3A),as well as the enrichments of KDM3A and H3 lysine 9 dimethylation(H3K9me2)in the transcription factor EB(TFEB)promoter region.Our results suggest that hypoxia-induced NUPR1 promotes TFEB transcription by binding to KDM3A and reducing H3K9me2 levels,thereby augmenting glioma cell autophagy and TMZ resistance.Moreover,the overexpression of KDM3A or TFEB promoted glioma cell autophagy.In a xenograft tumor model,silencing NUPR1 suppressed TMZ resistance in glioma cells in vivo.Overall,our findings highlight a mechanism by which NUPR1 enhances glioma cell autophagy and TMZ resistance via the KDM3A/TFEB axis. | TAO LI XIN FU JIE WANG WEI SHANG XIAOTONG WANG LINYUN ZHANG JUN LI | 2023 | Oncology Research2023，31，3： | 0 |
| 14 | Station of Profibus Communication Board Based on STM32显示文摘In the 250 MeV cyclotron,the communication between the LLRF and control system buses is required.The hardware of the control system is the PLC module,so an embedded IOC board is required as the communication module for the interaction between the control system bus and the low level.The IOC board is an | WEI Junyi LU Xiaotong YIN Zhiguo GONG Pengfei GUO Juanjuan FU Xiaoliang | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 15 | Anonymity Revocable Proxy Signature Scheme显示文摘 | FU Xiaotong XIAO Guozhen | 2006 | Chinese Journal of Electronics2006，15，4： | 0 |
| 16 | Study on Microwave Attenuation Through Special Foam Cloud显示文摘 | JIN Liangan WANG Xiaotong FU Jianguo CHENG Jin | 2005 | Chinese Journal of Electronics2005，14，4： | 0 |
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