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| 1 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 2 | Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarclnoma显示文摘有证据建议那刺激滤泡的荷尔蒙(FSH ) 能由在癌症细胞增加脉管的 endothelial 生长因素(VEGF ) 表示便于卵巢的癌症的 neovascularization,尽管这个过程的内在的分子的机制不是众所周知的。因此,我们在卵巢的癌症房间线 SKOV-3 和 ES-2 在 VEGF 表示上调查了 FSH 的效果。有 FSH 的治疗显著地在一个剂量依赖者和时间依赖者举止增加了 VEGF 表示。另外, FSH 治疗提高了 survivin 和组织缺氧可诱导的 factor-1 (HIF-1 ) 的表示。survivin 或 HIF-1 击倒压制的 VEGF 表示,但是 survivin 仅仅击倒禁止的刺激 FSH 的 VEGF 表示。有 LY294002 的预告的处理,一个 phosphoinositide 3-kinase (PI3K )/AKT 禁止者,抵销 FSH,而是治疗与 U0126 导致的 survivin 的提高的表示,激活 mitogen 的蛋白质 kinase/extracellular 调整信号的 kinase 禁止者,没有如此的效果。我们进一步证明卵巢的浆液的 cystadenocarcinoma 样品有积极 AKT 和比的染色的 phosphorylated AKT (pAKT ) 蛋白质的许多更高的发生良性的卵巢的 cystadenoma 取样了(p < 0.01 ) 。5 年的幸存率仅仅在有卵巢的浆液的 cystadenocarcinoma 的病人是大约 15% 有 AKT 和 pAKT 表示,而它在没有 AKT 或 pAKT 表示的那些是大约 80% 。一起拿,这些结果显示 FSH 由 upregulating 增加 VEGF 的表示 survivin 的表示,它被发信号的 PI3K/AKT 激活小径。在 survivin 和 VEGF 的刺激 FSH 的表示理解 PI3K/AKT 小径的角色将为与卵巢的浆液的 cystadenocarcinoma 为病人评估预后并且为对这疾病追求有效治疗是有益的。 | Yan Huang Keqin Hua Xianrong Zhou Hongyan Jin Xiaojun Chen Xin Lu Yinhua Yu Xiliang Zha Youji Feng | 2008 | Cell Research2008，18，7： | 17 |
| 3 | COMPUTATIONAL FLUID DYNAMICS RESEARCH ON PRESSURE LOSS OF CROSS-FLOW PERFORATED MUFFLER显示文摘The pressure loss of cross-flow perforated muffler has been computed with the procedure of physical modeling,simulation and data processing. Three-dimensional computational fluid dynam-ics (CFD) has been used to investigate the relations of porosities,flow velocity and diameter of the holes with the pressure loss. Accordingly,some preliminary results have been obtained that pressure loss increases with porosity descent as nearly a hyperbolic trend,rising flow velocity of the input makes the pressure loss increasing with parabola trend,diameter of holes affects little about pressure loss of the muffler. Otherwise,the holes on the perforated pipes make the air flow gently and meanly,which decreases the air impact to the wall and pipes in the muffler. A practical perforated muffler is used to illustrate the available of this method for pressure loss computation,and the comparison shows that the computation results with the method of CFD has reference value for muffler design. | HU Xiaodong ZHOU Yiqi FANG Jianhua MAN Xiliang ZHAO Zhengxu | 2007 | Chinese Journal of Mechanical Engineering2007，20，2： | 14 |
| 4 | Identification of immunoreactive proteins of Brucella melitensis by immunoproteomics显示文摘Infection with Brucella causes brucellosis, a chronic disease in humans, which induces abortion and sterility in livestock. Among the different Brucella species, Brucella melitensis is considered the most virulent and is the predominant species associated with outbreaks in China. To date, no safe human vaccine is available against Brucella infection. The currently used live vaccines against Brucella in livestock induce antibodies that interfere with the diagnosis of field infection in vaccinated animals, which is harmful to eradication programs. However, there is as yet no complete profile of immunogenic proteins of B. melitensis. Towards the development of a safer, equally efficacious, and field infection-distinguishable vaccine, we used immunoproteomics to identify novel candidate immunogenic proteins from B. melitensis M5. Eighty-eight immunoreactive protein spots from B. melitensis M5 were identified by Western blotting and were assigned to sixty-one proteins by mass spectrometry, including many new immunoreactive proteins such as elongation factor G, F0F1 ATP synthase subunit beta, and OMP1. These provide many candidate immunoreactive proteins for vaccine development. | ZHAO ZhongPeng YAN Fang JI WenHui LUO DeYan LIU Xin XING Li DUAN YueQiang YANG PengHui SHI XiuMin LI Zhong WANG XiLiang | 2011 | Science China(Life Sciences)2011，54，9： | 12 |
| 5 | Intersection delay estimation from floating car data via principal curves: a case study on Beijing's road network显示文摘在大城市里可靠地在道路网络上估计即时旅行时间是一项紧迫的任务,尽管漂浮的汽车数据广泛地被用来反映真实交通。当前漂浮的汽车数据主要被用来在道路片断上估计即时交通条件,并且为拐弯延期评价做了很少。然而,道路交叉上的拐弯延期在现代城市里在道路网络上显著地作出贡献到全面旅行时间。在这篇论文,我们在场计算拐弯的一个技术框架与漂流汽车数据在道路网络上推迟。首先,与 GPS 收集的独创漂浮汽车数据装备了 taxies 基于 Hadoop 和 MongoDB 与一个分布式的系统被清洗并且匹配到一张街地图。第二,精制轨道数据集合在 96 次间隔之中被散布(从 0:00 ~ 23:59 ) 。所有与轨道片断轨道过去了的交叉被连接,并且组成了一件实验样品,当动脉的街上的交叉特殊被选择形成另一件实验样品时。第三,一个主要基于曲线的算法被介绍在给定的交叉估计拐弯延期。说服的算法统计上是不仅适合真实交通调节,而且对数据稀疏和失踪的数据问题感觉迟钝,它当前与收集技术的广泛地使用的漂浮的汽车数据是几乎不可避免的。我们采用了在 2011 在北京城市里从三月收集到 6 月的漂浮的汽车数据,它包含在数据体积为大约 600 GB 从大约 20000 辆装备 GPS 的出租车和说明产生的超过 260 万条轨道。结果显示出主要曲线我们介绍了的基于的算法在传统的方法上占主导地位,例如吝啬、中部的基于的途径,并且保持更高的评价精确性(大约 10%a [欧元] “ 15% 在 RMSE 更高) ,以及反映交通拥挤的变化趋势。与在交叉的旅行延期的评价结果,我们在三种次情形分析了拐弯延期的时间空间的分发(0:00a [欧元] “ 0:15, 8:15a [欧元] “ 8:30 和 12:00a [欧元] “ 12:15 ) 。它显示在一个在北京的单个旅行期间,道路网络上的一般水准 60% 旅行时间在交叉上被浪费,并且这种状况在白天是甚至更坏的。尽管 400 主要交叉仅仅拿 2.7% 所有交叉,他们占据大约 18% 旅行时间[出版摘要] | Xiliang LIU Feng LU Hengcai ZHANG Peiyuan QIU | 2013 | Frontiers of Earth Science2013，7，2： | 10 |
| 6 | COVID-19: a new challenge for human beings显示文摘Since December 2019,just a month before the Chinese Spring Festival,multiple cases of pneumonia of unknown etiology appeared in Wuhan,Hubei Province,China.Later,a novel coronavirus was identified in a bronchoalveolar lavage fluid sample from the Wuhan Seafood Market using metagenomic next-generation sequencing technology.1 On February 11,2020,the virus was named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)by the International Committee on Taxonomy of Viruses(ICTV).SARS-CoV-2 is the seventh member of the coronavirus family that can infect humans after the emergence of severe acute respiratory syndrome coronavirus(SARS-CoV)and Middle East respiratory syndrome coronavirus(MERS-CoV). | Penghui Yang Xiliang Wang | 2020 | Cellular & Molecular Immunology2020，17，5： | 9 |
| 7 | Up-regulation of prohibitin 1 is involved in the proliferation and migration of liver cancer cells显示文摘Although prohibitin 1(PHB) is known to be associated with tumors,there are few studies regarding the role of PHB in hepatocellular carcinoma.An earlier glycoproteomics study of ours showed that PHB is over-expressed in MHCC97-H cells,a highly metastatic liver cancer cell line,and can be captured by wheat germ agglutinin.In the present study,western blotting and reverse transcription-PCR experiments showed an approximately 2-fold up-regulation in the expression of PHB in MHCC97-H cells.However,PHB was not significantly up-regulated in MHCC97-L cells,a low-metastatic liver cancer cell line.When PHB was over-expressed in MHCC97-L cells,cell proliferation was inhibited by 35% and migration increased about 2-fold.The results of this study show that PHB is up-regulated in MHCC97-H cells and is associated with both proliferation and migration of liver cancer cells. | XU ZhiBin WU JinHong ZHA XiLiang | 2011 | Science China(Life Sciences)2011，54，2： | 8 |
| 8 | Long-term effects of mowing on plasticity and allometry of Leymus chinensis in a temperate semi-arid grassland,China显示文摘Mowing is an important land management practice for natural semi-arid regions.A growing body of empirical evidence shows that different mowing regimes affect the functioning of grassland ecosystems.However,the responses of plant functional traits to long-term mowing and their allometric scaling under long-term mowing are poorly understood.For a better understanding of the effects of mowing on grassland ecosystems,we analyzed the allometric traits of leaves and stems of Leymus chinensis(Trin.) Tzvel.,a dominant grass species in eastern Eurasian temperate grassland,at different mowing intensities(no clipping,clipping once every two years,once a year and twice a year).Experiments were conducted on plots established over a decade ago in a typical steppe of Xilinhot,Inner Mongolia,China.Results showed that most of the functional traits of L.chinensis decreased with the increased mowing intensity.The responses of leaves and stems to long-term mowing were asymmetric,in which leaf traits were more stable than stem traits.Also significant allometric relationships were found among most of the plant functional traits under the four mowing treatments.Sensitive traits of L.chinensis(e.g.leaf length and stem length) were primary indicators associated with aboveground biomass decline under high mowing intensity.In conclusion,the allometric growth of different functional traits of L.chinensis varies with different long-term mowing practices,which is likely to be a strategy used by the plant to adapt to the mowing disturbances. | LI Xiliang HOU Xiangyang REN Weibo Taogetao BAOYIN LIU Zhiying Warwick BADGERY LI Yaqiong WU Xinhong XU Huimin | 2016 | Journal of Arid Land2016，8，6： | 7 |
| 9 | A fully automatic registration approach based on contour and SIFT for HJ-1 images显示文摘To achieve a fully automatic registration between HJ-1 CCD images and HJ-1 infrared images is a difficult task as it must deal with the varying illuminations and resolutions of the images,different perspectives,and the local deformations within the images.In this paper,aimed at those registration issues,a fully automatic registration approach based on contour and SIFT is proposed.The registration technique performs a pre-registration process using contour feature matching algorithm that decides the overlapping region between a reference image and an input image.Once the coarse regions are obtained,it performs a fine registration process based on SIFT detector and a local adaptive matching strategy.In the fine registration process,image blocking theory is used,which not only speeds up the features extraction and matching,but also makes the matching point pairs distributed uniformly in images,and further improves the accuracy of input image rectification.Experiments with visible images and infrared images from HJ-1A/B demonstrate the efficiency and the accuracy of the proposed technique for multisource remote sensing images registration. | NI XiLiang CAO ChunXiang DING Lin JIANG Tao ZHANG Hao JIA HuiCong LI GuangHe ZHAO Jian CHEN Wei JI Wei XU Min GAO MengXu ZHENG Sheng TIAN Rong LIU Cheng LI Sha | 2012 | Science China Earth Sciences2012，55，10： | 5 |
| 10 | Direct Comparative Analyses of 10X Genomics Chromium and Smart-seq2显示文摘Single-cell RNA sequencing(scRNA-seq)is generally used for profiling transcriptome of individual cells.The droplet-based 10X Genomics Chromium(10X)approach and the plate-based Smart-seq2 full-length method are two frequently used scRNA-seq platforms,yet there are only a few thorough and systematic comparisons of their advantages and limitations.Here,by directly comparing the scRNA-seq data generated by these two platforms from the same samples of CD45cells,we systematically evaluated their features using a wide spectrum of analyses.Smart-seq2 detected more genes in a cell,especially low abundance transcripts as well as alternatively spliced transcripts,but captured higher proportion of mitochondrial genes.The composite of Smart-seq2 data also resembled bulk RNA-seq data more.For 10X-based data,we observed higher noise for mRNAs with low expression levels.Approximately 10%30%of all detected transcripts by both platforms were from non-coding genes,with long non-coding RNAs(lncRNAs)accounting for a higher proportion in 10X.10X-based data displayed more severe dropout problem,especially for genes with lower expression levels.However,10X-data can detect rare cell types given its ability to cover a large number of cells.In addition,each platform detected distinct groups of differentially expressed genes between cell clusters,indicating the different characteristics of these technologies.Our study promotes better understanding of these two platforms and offers the basis for an informed choice of these widely used technologies. | Xiliang Wang Yao He Qiming Zhang Xianwen Ren Zemin Zhang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，2： | 4 |
| 11 | Preparation of Ni/bentonite catalyst and its applications in the catalytic hydrogenation of nitrobenzene to aniline显示文摘Ni supported on bentonite was prepared by the impregnation method with different nickel contents, applied to the hydrogenation of nitrobenzene to aniline in a fixed-bed reactor, and it was characterized by X-ray diffraction(XRD), H_2-temperature programmed reduction(H_2-TPR), and X-ray photoelectron spectrometry(XPS). The results showed that Ni/bentonite catalyst with 20 wt% nickel content provided a higher conversion of nitrobenzene and selectivity of aniline compared to other catalysts. Ni O was the precursor of the active component of the catalyst, and the small crystallite size as well as the highly dispersed Ni O on the Ni/bentonite-20 catalyst, contributed to the catalytic performance. The hydrogenation of nitrobenzene was carried out at 300 °C with a H_2 gaseous hourly space velocity of 4800 ml·(g cat)^(-1)·h^(-1)and a nitrobenzene liquid hourly space velocity of4.8 ml·(g cat)^(-1)·h^(-1)over Ni/bentonite-20. A 95.7% nitrobenzene conversion and 98.8% aniline selectivity were obtained. While the nitrobenzene liquid hourly space velocity was 4.8 ml·(g cat)^(-1)·h^(-1), the yield of aniline was more than 95.0% during a 10-hour reaction. | Yuexiu Jiang Xiliang Li Zuzeng Qin Hongbing Ji | 2016 | Chinese Journal of Chemical Engineering2016，24，9： | 4 |
| 12 | A holistic approach to aligning geospatial data with multidimensional similarity measuring显示文摘Semantically aligning the heterogeneous geospatial datasets(GDs)produced by different organizations demands efficient similarity matching methods.However,the strategies employed to align the schema(concept and property)and instances are usually not reusable,and the effects of unbalanced information tend to be neglected in GD alignment.To solve this problem,a holistic approach is presented in this paper to integrally align the geospatial entities(concepts,properties and instances)simultaneously.Spatial,lexical,structural and extensional similarity metrics are designed and automatically aggregated by means of approval voting.The presented approach is validated with real geographical semantic webs,Geonames and OpenStreetMap.Compared with the well-known extensional-based aligning system,the presented approach not only considers more information involved in GD alignment,but also avoids the artificial parameter setting in metric aggregation.It reduces the dependency on specific information,and makes the alignment more robust under the unbalanced distribution of various information. | Li Yu Peiyuan Qiu Xiliang Liu Feng Lu Bo Wan | 2018 | International Journal of Digital Earth2018，11，8： | 4 |
| 13 | Acupuncture inhibits cue-induced heroin craving and brain activation显示文摘Previous research using functional MRI has shown that specific brain regions associated with drug dependence and cue-elicited heroin craving are activated by environmental cues. Craving is an important trigger of heroin relapse, and acupuncture may inhibit craving. In this study, we performed functional MRI in heroin addicts and control subjects. We compared differences in brain activation between the two groups during heroin cue exposure, heroin cue exposure plus acupuncture at the Zusanli point (ST36) without twirling of the needle, and heroin cue exposure plus acupuncture at the Zusanli point with twirling of the needle. Heroin cue exposure elicited significant activation in craving-related brain regions mainly in the frontal lobes and callosal gyri. Acupuncture without twirling did not significantly affect the range of brain activation induced by heroin cue exposure, but significantly changed the extent of the activation in the heroin addicts group. Acupuncture at the Zusanli point with twirling of the needle significantly decreased both the range and extent of activation induced by heroin cue exposure compared with heroin cue exposure plus acupuncture without twirling of the needle. These experimental findings indicate that presentation of heroin cues can induce activation in craving-related brain regions, which are involved in reward, learning and memory, cognition and emotion. Acupuncture at the Zusanli point can rapidly suppress the activation of specific brain regions related to craving, supporting its potential as an intervention for drug craving. | Xinghui Cai Xiaoge Song Chuanfu Li Chunsheng Xu Xiliang Li Qi Lu | 2012 | Neural Regeneration Research2012，7，33： | 4 |
| 14 | Harnack inequality and derivative formula for SDE driven by fractional Brownian motion显示文摘In the paper, Harnack inequality and derivative formula are established for stochastic differential equation driven by fractional Brownian motion with Hurst parameter H < 1/2. As applications, strong Feller property, log-Harnack inequality and entropy-cost inequality are given. | FAN XiLiang | 2013 | Science China Mathematics2013，56，3： | 3 |
| 15 | Energy and economic impacts of an international multi-regional carbon market显示文摘The establishment of a global multi-regional carbon market is considered to be a cost effective approach to facilitate global emission abatement and has been widely concerned.The ongoing planned linkage between the European Union's carbon market and a new emission trading system in Australia in 2015 would be an important attempt to the practice of building up an international carbon market across different regions.To understand the abatement effect of such a global carbon market and to study its energy and economic impact on different market participants,this article adopts a global dynamic computable general equilibrium model with a detailed representation of the interactions between energy and economic systems.Our model includes 20 economic sectors and 19 regions,and describes in detail 17 energy technologies.Bundled with fossil fuel consumptions,the emission permits are considered to be essential inputs in each of the production and consumption activities in the economic system to simulate global carbon market policies.Carbon emission permits are endogenously set in the model,and can be traded between sectors and regions.Considering the current development of the global carbon market,this study takes 2020 as the study period.Four scenarios(reference scenario,independent carbon market scenario,Europe Union(EUh-Australia scenario,and China-EU-Australia scenario) are designed to evaluate the impact of the global carbon market involving China,the EU,and Australia.We find that the carbon price in the three countries varies a lot,from $32/tCO_2 in Australia,to $17.5/tCO_2 in the EU,and to $10/tCO_2 in China.Though the relative emission reduction(3%) in China is lower than that in the EU(9%) and Australia(18%),the absolute emission reduction in China is far greater than that in the EU and Australia.When China is included in the carbon market,which already includes the EU and Australia,the prevailing global carbon price falls from $22 per ton carbon dioxide(CO_2) to $12/tCO_2,due to the relatively lower abatement cost in China.Seventy-one percent of the EU's and eighty-one percent of Australia's domestic reduction burden would be transferred to China,increasing 0.03%of the EU's and 0.06%of Australia's welfare.The emission constraint improves the energy efficiency of China's industry sector by 1.4%,reduces coal consumption by3.3%,and increases clean energy by 3.5%. | Tianyu Qi Yuanzhe Yang Xiliang Zhang | 2015 | Chinese Journal of Population,Resources and Environment2015，13，1： | 3 |
| 16 | Prediction of blasting mean fragment size using support vector regression combined with five optimization algorithms显示文摘The main purpose of blasting operation is to produce desired and optimum mean size rock fragments.Smaller or fine fragments cause the loss of ore during loading and transportation,whereas large or coarser fragments need to be further processed,which enhances production cost.Therefore,accurate prediction of rock fragmentation is crucial in blasting operations.Mean fragment size(MFS) is a crucial index that measures the goodness of blasting designs.Over the past decades,various models have been proposed to evaluate and predict blasting fragmentation.Among these models,artificial intelligence(AI)-based models are becoming more popular due to their outstanding prediction results for multiinfluential factors.In this study,support vector regression(SVR) techniques are adopted as the basic prediction tools,and five types of optimization algorithms,i.e.grid search(GS),grey wolf optimization(GWO),particle swarm optimization(PSO),genetic algorithm(GA) and salp swarm algorithm(SSA),are implemented to improve the prediction performance and optimize the hyper-parameters.The prediction model involves 19 influential factors that constitute a comprehensive blasting MFS evaluation system based on AI techniques.Among all the models,the GWO-v-SVR-based model shows the best comprehensive performance in predicting MFS in blasting operation.Three types of mathematical indices,i.e.mean square error(MSE),coefficient of determination(R^(2)) and variance accounted for(VAF),are utilized for evaluating the performance of different prediction models.The R^(2),MSE and VAF values for the training set are 0.8355,0.00138 and 80.98,respectively,whereas 0.8353,0.00348 and 82.41,respectively for the testing set.Finally,sensitivity analysis is performed to understand the influence of input parameters on MFS.It shows that the most sensitive factor in blasting MFS is the uniaxial compressive strength. | Enming Li Fenghao Yang Meiheng Ren Xiliang Zhang Jian Zhou Manoj Khandelwal | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，6： | 3 |
| 17 | Experiment study of a quartz tube falling particle receiver显示文摘这篇论文论述特殊设计的掉落的粒子接收装置的试验性的评估。一个石英试管在设计,粒子没被风与征服被使用。集中的太阳的放射被吸收并且由稳固的粒子变换成热精力流动里面石英试管。几个实验被进行在太阳的炉子系统上测试接收装置的动态热表演。在实验期间,最大的粒子温度上升是 212C,与 61.2% 的效率,它在小规模粒子接收装置与 0.2 m 的掉落的距离显示出好热表演。平均插头粒子温度被直接正常的发光(DNI ) 影响,象风那样的另外的因素加速。当更小的稳固的粒子更容易在螺旋石英试管困住时,稳固的粒子与更高的温度获得更大的粘性。,当稳固的粒子的温度增加,硅碳化物的热能力与粒子温度的上升变得更大,硅碳化物的温度上升减少。 | Tianjian WANG Fengwu BAI Shunzhou CHU Xiliang ZHANG Zhifeng WANG | 2017 | Frontiers in Energy2017，11，4： | 3 |
| 18 | Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils显示文摘Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the world.IAV infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully elucidated.In this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and mice.FGF2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling pathway.FGF2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and activation.More importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected mice.Based on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting neutrophils.Thus,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection. | Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan Yang Li Xing Lingna Zhao Shanshan Zhou Min Xia Chengyu Jiang Xiliang Wang Penghui Yang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 19 | Response of BALB/c mice to a monovalent influenza A (H1N1) 2009 split vaccine显示文摘新奇流行性感冒 A (H1N1 ) 2009 病毒出现了到原因第一第二十一个世纪流行。流行性感冒 A (H1N1 ) 病毒引起的疾病爆发关于潜力推动了担心为一流行并且对流行性感冒 A 的这种子类型驾驶了疫苗的发展。在这研究,我们开发了一支一价的流行性感冒 A (H1N1 ) 裂口疫苗并且在 BALB/c 老鼠评估了它的效果。老鼠与包含红血球凝聚素的疫苗的 2 剂量皮下地被使免疫(哈) 独自一个或哈加铝氢氧化物(艾尔(哦) 3 ) 助手。有改变剂量的免疫哈(3.75, 7.5, 15, 30, 45 或 60 渭 g ) 被执行导致抵销抗体的生产。疫苗的得到的强壮的红血球凝聚抑制(嗨) 并且助手的 microneutralization,和增加扩充了抗体反应。初步的安全评估证明疫苗不是有毒的逍遥法外剂量(包含 60 渭 g HA+600 渭 g 艾尔的 0.5 ml (哦) 3 或 60 渭 g 哈) 。而且,疫苗被发现在 120 渭 g HA+1200 渭 g 艾尔的剂量安全(哦) 3 或 120 渭 g 哈在在老鼠的 1.0 ml。在结论,现在的学习作为公共健康干预为流行性感冒 A (H1N1 ) 种痘的临床的评估提供支持减轻一可能流行。另外,我们疫苗的进一步的评估在首领或人在这研究使用了的调查结果支持。 | Penghui Yang Li Xing Chong Tang Weihong Jia Zhongpeng Zhao Kun Liu Xiao Gao Xiliang Wang | 2010 | Cellular & Molecular Immunology2010，7，2： | 2 |
| 20 | Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy——lysosomal pathway显示文摘Nonalcoholic fatty liver disease(NAFLD) is characterized by hepatic steatosis and insulin resistance and there are currently no approved drugs for its treatment.Hyperactivation of mTOR complex1(mTORCl) and subsequent impairment of the transcription factor EB(TFEB)-mediated autophagy-lysosomal pathway(ALP) are implicated in the development of NAFLD.Accordingly,agents that augment hepatic TFEB transcriptional activity may have therapeutic potential against NAFLD.The objective of this study was to investigate the effects of nuciferine,a major active component from lotus leaf,on NAFLD and its underlying mechanism of action.Here we show that nuciferine activated ALP and alleviated steatosis,insulin resistance in the livers of NAFLD mice and palmitic acid-challenged hepatocytes in a TFEB-dependent manner.Mechanistic investigation revealed that nuciferine interacts with the Ragulator subunit hepatitis B X-interacting protein and impairs the interaction of the Ragulator complex with Rag GTPases,thereby suppressing lysosomal localization and activity of mTORC1,which activates TFEB-mediated ALP and further ameliorates hepatic steatosis and insulin resistance.Our present results indicate that nuciferine may be a potential agent for treating NAFLD and that regulation of the mTORCl-TFEB-ALP axis could represent a novel pharmacological strategy to combat NAFLD. | Xiliang Du Chiara Di Malta Zhiyuan Fang Taiyu Shen Xiaodi Niu Meng Chen Bo Jin Hao Yu Lin Lei Wenwen Gao Yuxiang Song Zhe Wang Chuang Xu Zhijun Cao Guowen Liu Xinwei Li | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 2 |
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