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| 1 | Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。 | Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong | 2017 | Cell Research2017，27，10： | 61 |
| 2 | Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model显示文摘 | Yiwu Yan Zhen Zou Yang Sun Xiao Li Kai-Feng Xu Yuquan Wei Ningyi Jin Chengyu Jiang | 2013 | Cell Research2013，23，2： | 36 |
| 3 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 4 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 5 | Histological Subtypes of Lung Cancer in Chinese Males from 2000 to 2012显示文摘Objective To characterize the histological and epidemiological features of male lung cancer patients in China. Methods The demographic and histological information about male lung cancer patients identified from 2000-01-01 to 2012-12-31,was collected from the Cancer Hospital of the Chinese Academy of Medical Sciences. Relative frequencies(RF) were estimated for major histological subtypes and compared according to the years of diagnosis and birth. Results The RF of adenocarcinoma(ADC) increased from 21.96% to 43.36% and the RF of squamous cell carcinoma(SCC) decreased from 39.11% to 32.23% from 2000 to 2012 in the 15 427 male lung cancer patients included in this study(Z=17.909,P<0.0001; Z=-6.117,P<0.0001). The RF of ADC increased from 28.72% in 2000-2004,36.88% in 2005-2008 to 48.61% in 2009-2012 in patients born after 1960. The age-adjusted RF of ADC in 2007-2012 increased consistently in all the investigated areas. Conclusion The increased RF of ADC in male lung cancer patients highlights the need for further investigation of the etiologic factors of these tumors. Smoke-free policies rather than modifying tobacco products should be enforced. | ZOU Xiao Nong LIN Dong Mei WAN Xia CHAO Ann FENG Qin Fu DAI Zhen YANG Gong Huan LV Ning | 2014 | Biomedical and Environmental Sciences2014，27，1： | 19 |
| 6 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 7 | Comprehensive analysis of NAC transcription factors in diploid Gossypium: sequence conservation and expression analysis uncover their roles during fiber development显示文摘Determining how function evolves following gene duplication is necessary for understanding gene expansion.Transcription factors(TFs)are a class of proteins that regulate gene expression by binding to specific cis-acting elements in the promoters of target genes,subsequently activating or repressing their transcription.In the present study,we systematically examined the functional diversification of the NAC transcription factor(NAC-TFs)family by analyzing their chromosomal location,structure,phylogeny,and expression pattern in Gossypium raimondii(Gr)and G.arboreum(Ga).The 145 and 141 NAC genes identified in the Gr and Ga genomes,respectively,were annotated and divided into 18 subfamilies,which showed distinct divergence in gene structure and expression patterns during fiber development.In addition,when the functional parameters were examined,clear divergence was observed within tandem clusters,which suggested that subfunctionalization had occurred among duplicate genes.The expression patterns of homologous gene pairs also changed,suggestive of the diversification of gene function during the evolution of diploid cotton.These findings provide insights into the mechanisms underlying the functional differentiation of duplicated NAC-TFs genes in two diploid cotton species. | Haihong Shang Zhongna Wang Changsong Zou Zhen Zhang Weijie Li Junwen Li Yuzhen Shi Wankui Gong Tingting Chen Aiying Liu Juwu Gong Qun Ge Youlu Yuan | 2016 | Science China(Life Sciences)2016，59，2： | 12 |
| 8 | Design and performance analysis of orthogonal coding signal in MIMO-SAR显示文摘Multi-input multi-output (MIMO) radar which has evident advantages in many applications is a new radar system.Applying the MIMO technique to the earth observing synthetic aperture radar (SAR) system offers effective ways for the improvement of high resolution and wide swath imaging and ground moving target indication (GMTI) systems.Designing the optimal orthogonal waveform is a crucial problem in the research on MIMO radar.First,the index definition of synthetic integrated side-lobe level ratio (ISLR) is proposed by focusing on the SAR application and considering the cross-correlation energy influences between orthogonal coding signals with the same frequency band.Second,it is theoretically demonstrated that the performance of synthetic ISLR of orthogonal coding signals with the same frequency band cannot meet the demands of SAR imaging,which has been proved by one-dimensional numerical simulation. Third,it has been shown through numerical simulation that the performance of synthetic ISLR of orthogonal coding signals still cannot be improved by dealing with the mismatched filtering.Finally,a set of orthogonal phase coding signals are designed for multiple MIMO-SAR antennas.The conclusions are verified through MIMO-SAR imaging and InSAR simulation experiments. | ZOU Bo DONG Zhen LIANG DianNong | 2011 | Science China(Information Sciences)2011，54，8： | 11 |
| 9 | Applying the China-PAR Risk Algorithm to Assess 10-year Atherosclerotic Cardiovascular Disease Risk in Populations Receiving Routine Physical Examinations in Eastern China显示文摘Objective To assess the 10-year Atherosclerotic Cardiovascular Disease(ASCVD) risk score among adults in eastern China using the China-PAR equation which formulated primarily for the Chinese population. Methods Data from 72,129 individuals from 35-74 years old who received routine physical examinations in eastern China were analyzed in this study. The 10-year risk scores were calculated using the China-PAR equation. The chi-square test and logistic regression were then performed to evaluate the association between the selected risk factors and overall CVD risk. Results The mean 10-year ASCVD risk scores were 3.82% ± 3.76% in men and 1.30% ± 1.65% in women based on the China-PAR equation. Overall, 20% of men and 3.5% of women were intermediate-risk, and 7.3% of men and 0.3% of women were high-risk. Waist to hip ratio(WHR) [OR = 1.16(CI 95% = 1.06-1.26)], waist to height ratio(WHtR) [OR = 1.16(CI 95% = 1.05-1.28)], non-high-density lipoprotein cholesterol(non-HDL-C) [OR = 1.23(CI 95% = 1.09-1.39)], and total cholesterol(TC)/HDL-C [OR = 1.68(CI 95% = 1.46-1.94)] were more strongly associated with CVD risk than body-mass index(BMI), waist circumference(WC), and TC alone. Conclusion Male-specific prevention and treatment strategies for ASCVD are needed in eastern China. In addition, WHR, WHtR, non-HDL-C, and TC/HDL-C which not included in the the China-PAR equation were also independently associated with 10-year ASCVD risk score categories. | LI Hui Hua HUANG Shan LIU Xing Zhen ZOU Da Jin | 2019 | Biomedical and Environmental Sciences2019，32，2： | 9 |
| 10 | Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study显示文摘People with schizophrenia exhibit impaired social cognitive functions, particularly emotion regulation. Abnormal activations of the ventral medial prefrontal cortex (vMPFC) during emotional tasks have been demonstrated in schizophrenia, suggesting its important role in emotion processing in patients. We used the resting-state functional connectivity approach, setting a functionally relevant region, the vMPFC, as a seed region to examine the intrinsic functional interactions and communication between the vMPFC and other brain regions in schizophrenic patients. We found hypo-connectivity between the vMPFC and the medial frontal cortex, right middle temporal lobe (MTL), right hippocampus, parahippocampal cortex (PHC) and amygdala. Further, there was a decreased strength of the negative connectivity (or anticorrelation) between the vMPFC and the bilateral dorsal lateral prefrontal cortex (DLPFC) and pre-supplementary motor areas. Among these connectivity alterations, reduced vMPFC-DLPFC connectivity was positively correlated with positive symptoms on the Positive and Negative Syndrome Scale, while vMPFC-right MTL/PHC/amygdala functional connectivity was positively correlated with the performance of emotional regulation in patients. These findings imply that communication and coordination throughout the brain networks are disrupted in schizophrenia. The emotional correlates of vMPFC connectivity suggest a role of the hypo-connectivity between these regions in the neuropathology of abnormal social cognition in chronic schizophrenia. | Feng-Mei Fan Shu-Ping Tan Fu-De Yang Yun-Long Tan Yan-Li Zhao Nan Chen Bin-Bin Li Chong-Sheng Song Yun-Hui Wang Zhen Jin Dong-Feng Zhou Michael P. Milham Yi-Zhuang Zou Xi-Nian Zuo | 2013 | Neuroscience Bulletin2013，29，1： | 9 |
| 11 | Apparent diffusion coefficient-based histogram analysis differentiates histological subtypes of periampullary adenocarcinoma显示文摘BACKGROUND For periampullary adenocarcinoma,the histological subtype is a better prognostic predictor than the site of tumor origin.Intestinal-type periampullary adenocarcinoma(IPAC)is reported to have a better prognosis than the pancreatobiliary-type periampullary adenocarcinoma(PPAC).However,the classification of histological subtypes is difficult to determine before surgery.Apparent diffusion coefficient(ADC)histogram analysis is a noninvasive,nonenhanced method with high reproducibility that could help differentiate the two subtypes.AIM To investigate whether volumetric ADC histogram analysis is helpful for distinguishing IPAC from PPAC.METHODS Between January 2015 and October 2018,476 consecutive patients who were suspected of having a periampullary tumor and underwent magnetic resonance imaging(MRI)were reviewed in this retrospective study.Only patients who underwent MRI at 3.0 T with different diffusion-weighted images(b-values=800 and 1000 s/mm^2)and who were confirmed with a periampullary adenocarcinoma were further analyzed.Then,the mean,5th,10th,25th,50th,75th,90th,and 95th percentiles of ADC values and ADCmin,ADCmax,kurtosis,skewness,and entropy were obtained from the volumetric histogram analysis.Comparisons were made by an independent Student's t-test or Mann-Whitney U test.Multiple-class receiver operating characteristic curve analysis was performed to determine and compare the diagnostic value of each significant parameter.RESULTS In total,40 patients with histopathologically confirmed IPAC(n=17)or PPAC(n=23)were enrolled.The mean,5th,25th,50th,75th,90th,and 95th percentiles and ADCmax derived from ADC1000 were significantly lower in the PPAC group than in the IPAC group(P<0.05).However,values derived from ADC800 showed no significant difference between the two groups.The 75th percentile of ADC1000 values achieved the highest area under the curve(AUC)for differentiating IPAC from PPAC(AUC=0.781;sensitivity,91%;specificity,59%;cut-off value,1.50×10^-3 mm^2/s).CONCLUSION Volumetric ADC histogram analysis at a b-value of 1000 s/mm2 might be helpful for differentiating the histological subtypes of periampullary adenocarcinoma before surgery. | Jing-Yu Lu Hao Yu Xian-Lun Zou Zhen Li Xue-Mei Hu Ya-Qi Shen Dao-Yu Hu | 2019 | World Journal of Gastroenterology2019，25，40： | 6 |
| 12 | Silencing MYH9 blocks HBx-induced GSK3βubiquitination and degradation to inhibit tumor stemness in hepatocellular carcinoma显示文摘MYH9 has dual functions in tumors.However,its role in inducing tumor stemness in hepatocellular carcinoma(HCC)is not yet determined.Here,we found that MYH9 is an effective promoter of tumor stemness that facilitates hepatocellular carcinoma pathogenesis.Importantly,targeting MYH9 remarkably improved the survival of hepatocellular carcinoma-bearing mice and promoted sorafenib sensitivity of hepatocellular carcinoma cells in vivo.Mechanistic analysis suggested that MYH9 interacted with GSK3βand reduced its protein expression by ubiquitin-mediated degradation,which therefore dysregulated theβ-catenin destruction complex and induced the downstream tumor stemness phenotype,epithelial–mesenchymal transition,and c-Jun signaling in HCC.C-Jun transcriptionally stimulated MYH9 expression and formed an MYH9/GSK3β/β-catenin/c-Jun feedback loop.X protein is a hepatitis B virus(HBV)-encoded key oncogenic protein that promotes HCC pathogenesis.Interestingly,we observed that HBV X protein(HBX)interacted with MYH9 and induced its expression by modulating GSK3β/β-catenin/c-Jun signaling.Targeting MYH9 blocked HBX-induced GSK3βubiquitination to activate theβ-catenin destruction complex and suppressed cancer stemness and EMT.Based on TCGA database analysis,MYH9 was found to be elevated and conferred poor prognosis for hepatocellular carcinoma patients.In clinical samples,high MYH9 expression levels predicted poor prognosis of hepatocellular carcinoma patients.These findings identify the suppression of MYH9 as an alternative approach for the effective eradication of CSC properties to inhibit cancer migration,invasion,growth,and sorafenib resistance in HCC patients.Our study demonstrated that MYH9 is a crucial therapeutic target in HCC. | Xian Lin Ai-min Li Yong-Hao Li Rong-Cheng Luo Yu-Jiao Zou Yi-Yi Liu Chen Liu Ying-Ying Xie Shi Zuo Zhan Liu Zhen Liu Wei-Yi Fang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 6 |
| 13 | Serum LDH level may predict outcome of chronic lymphocytic leukemia patients with a 17p deletion: a retrospective analysis of prognostic factors in China显示文摘Objective:This study aims to evaluate the natural history of patients with chronic lymphocytic leukemia(CLL)and a 17p deletion(17p-)and identify the predictive factors within this subgroup.Methods:The sample of patients with CLL were analyzed by fluorescence in situ hybridization for deletions in chromosome bands 11q22,13q14 and 17p13;trisomy of bands 12q13;and translocation involving band 14q32.The data from 456 patients with or without a 17p-were retrospectively collected and analyzed.Results:The overall response rate(ORR)in patients with a 17p-was 56.9%,and patients with a high percentage of 17p-(defined as more than 25%of cells harbouring a 17p-)had a lower ORR.The median overall survival(OS)in patients with a 17p-was 78.0 months,which was significantly shorter than the OS in patients without this genetic abnormality(median 162.0 months,P<0.001).Within the subgroup with a 17p-,the progression-free survival was significantly shorter in patients at Binet stage B-C and patients with elevated lactate dehydrogenase(LDH),B symptoms,unmutated IGHV and a high percentage of 17p-.Conclusions:These results indicated that patients with a 17p-CLL have a variable prognosis that might be predicted using simple clinical and laboratory characteristics. | Heng Li Wenjie Xiong Huimin Liu Shuhua Yi Zhen Yu Wei Liu Rui Lyu Tingyu Wang Dehui Zou Zengjun Li Lugui Qiu | 2017 | Chinese Journal of Cancer Research2017，29，2： | 6 |
| 14 | Novel endo-to exo-isomerization of dicyclopentadiene显示文摘Endo-dicyclopentadiene was isomerized to exo-isomer by thermal treatment at evaluated temperature and pressure. The reaction temperature and pressure are key factors for this novel isomerization. This result may have great potential for practical application. | Xiang Wen Zhang Kai Jiang Qiang Jiang Ji Jun Zou Li Wang Zhen Tao Mi | 2007 | Chinese Chemical Letters2007，18，6： | 5 |
| 15 | Alda-1 treatment promotes the therapeutic effect of mitochondrial transplantation for myocardial ischemia-reperfusion injury显示文摘Mitochondrial damage is a critical driver in myocardial ischemia-reperfusion(I/R)injury and can be alleviated via the mitochondrial transplantation.The efficiency of mitochondrial transplantation is determined by mitochondrial vitality.Because aldehyde dehydrogenase 2(ALDH2)has a key role in regulating mitochondrial homeostasis,we aimed to investigate its potential therapeutic effects on mitochondrial transplantation via the use of ALDH2 activator,Alda-1.Our present study demonstrated that time-dependent internalization of exogenous mitochondria by cardiomyocytes along with ATP production were significantly increased in response to mitochondrial transplantation.Furthermore,Alda-1 treatment remarkably promoted the oxygen consumption rate and baseline mechanical function of cardiomyocytes caused by mitochondrial transplantation.Mitochondrial transplantation inhibited cardiomyocyte apoptosis induced by the hypoxia-reoxygenation exposure,independent of Alda-1 treatment.However,promotion of the mechanical function of cardiomyocytes exposed to hypoxia-reoxygenation treatment was only observed after mitochondrial Alda-1 treatment and transplantation.By using a myocardial I/R mouse model,our results revealed that transplantation of Alda-1-treated mitochondria into mouse myocardial tissues limited the infarction size after I/R injury,which was at least in part due to increased mitochondrial potential-mediated fusion.In conclusion,ALDH2 activation in mitochondrial transplantation shows great potential for the treatment of myocardial I/R injury. | Xiaolei Sun Rifeng Gao Wenjia Li Yongchao Zhao Heng Yang Hang Chen Hao Jiang Zhen Dong Jingjing Hu Jin Liu Yunzeng Zou Aijun Sun Junbo Ge | 2021 | Bioactive Materials2021，6，7： | 5 |
| 16 | Highly efficient K-Fe/C catalysts derived from metal-organic frameworks towards ammonia synthesis显示文摘Fe-based catalysts have been discovered as the best elementary metal-based heterogeneous catalysts for the ammonia synthesis in industrial application during the last century.Herein,a novel and scalable strategy is developed to prepare the K-promoted Fe/C catalyst with extremely high Fe loading (> 50 wt.%) through pyrolysis of the Fe-based metal-organic framework (MOF) xerogel.The obtained K-Fe/C catalysts exhibited superior activity and stability towards ammonia synthesis.The weight-specific reaction rate of Fe/C with K2O as promoter can achieve 12.4 mmol·g-1·h-1 at 350 ℃ and 30.4 mmol·g-1·h-1 at 400 ℃,approximately four and two times higher than that of the commercial fused-iron catalyst (3.4 mmol·g-1·h-1 at 350 ℃ and 16.7 mmol·g-1·h-1 at 400 ℃) under the same condition,respectively.The excellent performance of K-Fe/C can be ascribed to the inherited structure derived from the metal-organic frame precursors and the promotion of potassium,which can modify the binding energy of reactant molecules on the Fe surface,transfer electrons to iron for effective activation of nitrogen,prevent agglomeration of Fe nanoparticle (NPs) and restrain side reaction of carbon matrix to methane. | Pengqi Yan Wenhan Guo Zibin Liang Wei Meng Zhen Yin Siwei Li Mengzhu Li Mengtao Zhang Jie Yan Dequan Xiao Ruqiang Zou Ding Ma | 2019 | Nano Research2019，12，9： | 4 |
| 17 | Effect and Safety of Kangfuyan Capsules(抗妇炎胶囊)for Relieving Chronic Pelvic Pain:A Multicenter,Randomized,Controlled,Double-Blind,Parallel-Group Clinical Trial显示文摘Objective To evaluate the effect and safety of Kangfuyan Capsules(抗妇炎胶囊)for treating pelvic inflammatory disease(PID)in patients with chronic pelvic pain(CPP)in a multicenter,randomized,controlled,double-blind,parallel-group clinical trial.Methods Totally,240 PID patients with CPP were randomized into 2 groups using a computer generated random number at a 1:1 ratio from 10 hospitals in China between September 2014 and November 2015.Patients received either oral Kangfuyan Capsules or Gongyanping Capsules(宫炎平胶囊,control);the regimen for both groups comprised 4 capsules(3 times daily)for 12 weeks,with follow-up visit 4 weeks after treatment.The visual analogue scale(VAS)scores,clinical responses,remarkable cure rates for each symptom,and quality of life scores were assessed at baseline,and after 1,2,and 3 months.Adverse events were also recorded.Results The VAS scores were significantly lower(P<0.05),whereas the clinical responses,remarkable cure rates for lower abdominal pain,uterine tenderness,adnexal mass,and adnexal tenderness,and Health-related quality of life(EQ-5D)scores were higher in the Kangfuyan group than in the control group at 3 months(P<0.05).Common treatment-related adverse events included high hepatic enzyme levels,reduced hemoglobin levels,and elevated platelet counts,although all the adverse events were either mild or moderate in severity.Conclusion Compared with Gongyanping therapy,Kangfuyan therapy yielded markedly better analgesia effects for CPP caused by PID,with obvious long-term efficacy and good safety.(Registration No.ChiCTR190022732) | LIU Zhao-hui JIN Zhe ZHAO Hong LU Yao ZHEN Hui ZOU Ting | 2021 | Chinese Journal of Integrative Medicine2021，27，12： | 4 |
| 18 | Observation of high-Q optomechanical modes in the mounted silica microspheres显示文摘An efficient method to mount a coupled silica microsphere and tapered fiber system is proposed and demonstrated experimentally. For the purpose of optomechanical studies, high-quality-factor optical(Q_o~ 10~8) and mechanical modes(Q_m~ 0.87 × 10~4) are maintained after the mounting process. For the mounted microsphere, the coupling system is more stable and compact and, thus, is beneficial for future studies and applications based on optomechanical interactions. Especially, the packaged optomechanical system, which is tested in a vacuum chamber,paves the way toward quantum optomechanics research in cryostat. | Zhen Shen Zhong-Hao Zhou Chang-Ling Zou Fang-Wen Sun Guo-Ping Guo Chun-Hua Dong Guang-Can Guo | 2015 | Photonics Research2015，3，5： | 4 |
| 19 | Comparative analysis of peptidoglycan recognition proteins in endoparasitoid wasp Microplitis mediator显示文摘Peptidoglycan 识别蛋白质(PGRP ) 是明确地在很多病原体的表面上认出 peptidoglycans (PGN ) 的天生的有免疫力的受体的一个家庭。这里,我们从 endoparasitoid 黄蜂识别了并且描绘六 PGRP, Microplitis 调停人(MmePGRPs ) 。在 parasitoid 黄蜂理解 PGRP 的角色,我们分析了他们的进化关系和 orthology,表示与克积极、否定的细菌和真菌在不同发展阶段,和 transcriptional 表示追随者感染期间介绍。MmePGRP-S1 显著地响应病原的感染被导致。这提示了我们评估 RNA 干扰的效果调停的基因特定 MmePGRP-S1 击倒。MmePGRP-S1 (iMmePGRP-S1 ) 击倒戏剧性地影响的 wasps’由小球菌 luteus 的幸存追随者挑战,对克积极的细菌在有免疫力的回答显示这特别 PGRP 的参与。这个行动是可能的被使用费小径调停,但是机制尚待坚定。MmePGRP-S1 不在由 iMmePGRP-S1 黄蜂的幸存率显示了的抗真菌的免疫起一个重要作用。这研究在经济地重要的 hymenopteran 种类 M 提供 PGRP 的全面描述。调停人。 | Rui-Juan Wang Zhe Lin Hong Jiang Jiancheng Li Tusar T. Saha Ziyun Lu Zhiqiang Lu Zhen Zou | 2017 | Insect Science2017，24，1： | 4 |
| 20 | A fast and versatile cross-linking strategy via o-phthalaldehyde condensation for mechanically strengthened and functional hydrogels显示文摘Fast and catalyst-free cross-linking strategy is of great significance for construction of covalently cross-linked hydrogels.Here,we report the condensation reaction between o-phthalaldehyde(OPA)and N-nucleophiles(primary amine,hydrazide and aminooxy)for hydrogel formation for the first time.When four-arm poly(ethylene glycol)(4 a PEG)capped with OPA was mixed with various N-nucleophile-terminated 4 aPEG as building blocks,hydrogels were formed with superfast gelation rate,higher mechanical strength and markedly lower critical gelation concentrations,compared to benzaldehyde-based counterparts.Small molecule model reactions indicate the key to these cross-links is the fast formation of heterocycle phthalimidine product or isoindole(bis)hemiaminal intermediates,depending on the N-nucleophiles.The second-order rate constant for the formation of phthalimidine linkage(4.3 M-1s-1)is over 3000 times and 200 times higher than those for acylhydrazone and oxime formation from benzaldehyde,respectively,and comparable to many cycloaddition click reactions.Based on the versatile OPA chemistry,various hydrogels can be readily prepared from naturally derived polysaccharides,proteins or synthetic polymers without complicated chemical modification.Moreover,biofunctionality is facilely imparted to the hydrogels by introducing amine-bearing peptides via the reaction between OPA and amino group. | Zhen Zhang Chaoliang He Yan Rong Hui Ren Tianran Wang Zheng Zou Xuesi Chen | 2021 | National Science Review2021，8，4： | 4 |
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