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| 1 | Targeting BMI-1-mediated epitheliale-mesenchymal transition to inhibit colorectal cancer liver metastasis显示文摘Liver is the most common metastatic site for colorectal cancer(CRC),there is no satisfied approach to treat CRC liver metastasis(CRCLM).Here,we investigated the role of a polycomb protein BMI-1 in CRCLM.Immunohistochemical analysis showed that BMI-1 expression in liver metastases was upregulated and associated with T4 stage,invasion depth and right-sided primary tumor.Knockdown BMI-1 in high metastatic HCT116 and LOVO cells repressed the migratory/invasive phenotype and reversed epithelialemesenchymal transition(EMT),while BMI-1 overexpression in low metastatic Ls174 T and DLD1 cells enhanced invasiveness and EMT.The effects of BMI-1 in CRC cells were related to upregulating snail via AKT/GSK-3βpathway.Furthermore,knockdown BMI-1 in HCT116 and LOVO cells reduced CRCLM using experimental liver metastasis mice model.Meanwhile,BMI-1 overexpression in Ls174 T and DLD1 significantly increased CRCLM.Moreover,sodium butyrate,a histone deacetylase and BMI-1 inhibitor,reduced HCT116 and LOVO liver metastasis in immunodeficient mice.Our results suggest that BMI-1 is a major regulator of CRCLM and provide a potent molecular target for CRCLM treatment. | Zhiyao Xu Zhuha Zhou Jing Zhang Feichao Xuan Mengjing Fan Difan Zhou Zhenyu Liuyang Ximei Ma Yiyang Hong Yihong Wang Sherven Sharma Qinghua Dong Guanyu Wang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 8 |
| 2 | New flotation technology research on carbonate-containing hematite,Advanced Materials Research显示文摘 | LUO Ximei YIN Wanzhong MA Yingqiang | 2012 | Advanced Materials Research2012，，454： | 1 |
| 3 | Practice and Thinking on the Construction of Agricultural Science and Education Cooperative Personnel Cultivation Base显示文摘Agricultural science and education cooperative personnel cultivation base is a new personnel cultivation platform built by the Ministry of Agriculture and the Ministry of Education relying on the national modern agricultural industry technology system,to strengthen the close connection between agricultural education and modern agricultural industry. The first batch of agricultural science and education cooperative personnel cultivation bases have been operating for 5 years. Taking Zhanjiang Litchi-Longan Agricultural Science and Education Cooperative Personnel Cultivation Base as an example,it introduced the achievements in the base construction from the perspective of construction cooperators,and discussed measures for improving the base operation. | Ximei SONG Jiaying CHEN Xuelian SANG Xiaowei MA | 2017 | Asian Agricultural Research2017，9，10： | 0 |
| 4 | First Outbreak of Occupational Brucellosis Involving Multiple Clusters--Hubei Province,China,2019显示文摘What is already known on this topic?Human brucellosis,a neglected zoonotic disease,causes more than 500,000 new cases each year globally.The disease is of major public health concern in China,and northern provinces are traditionally endemic areas.What is added by this report?This is the first published outbreak of occupational brucellosis involving multiple clusters in Hubei Province.This investigation characterizes the transmission chain of the outbreak and reveals that provinces south of the Yangtze River are faced with a series of challenges and hurdles to overcome including,but not limited to,health education,law enforcement,and occupational protection.What are the implications for public health practice?In addition to measures aimed at this outbreak,the local agricultural department has issued special notices based on this investigation to adjust and strengthen local eradication program of brucellosis. | Zhong Zhang Yeqing Tong Xinjun Lei Li Liu Zhiqiang Deng Fei Sun Huilai Ma Zhaorui Chang Lijie Zhang Huihui Liu Qi Chen Jianzhong Zheng Haibing Chen Ximei Sun Yang Wu Xuhua Guan | 2020 | China CDC weekly2020，2，39： | 0 |
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