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| 1 | The regulation of the Treg/Th 17 balance by mesenchyma stem cells in human systemic lupus erythematosus显示文摘 | Dandan Wang Saisai Huang Xinran Yuan Jun Liang Renju Xu Genhong Yao Xuebing Feng Lingyun Sun | 2017 | Cellular & Molecular Immunology2017，14，5： | 44 |
| 2 | Improving acarbose production and eliminating the by-product component C with an efficient genetic manipulation system of Actinoplanes sp.SE50/110显示文摘Theα-glucosidase inhibitor acarbose is commercially produced by Actinoplanes sp.and used as a potent drug in the treatment of type-2 diabetes.In order to improve the yield of acarbose,an efficient genetic manipulation system for Actinoplanes sp.was established.The conjugation system between E.coli carryingØC31-derived integrative plasmids and the mycelia of Actinoplanes sp.SE50/110 was optimized by adjusting the parameters of incubation time of mixed culture(mycelia and E.coli),quantity of recipient cells,donor-to-recipient ratio and the concentration of MgCl2,which resulted in a high conjugation efficiency of 29.4%.Using this integrative system,a cloned acarbose biosynthetic gene cluster was introduced into SE50/110,resulting in a 35%increase of acarbose titer from 2.35 to 3.18 g/L.Alternatively,a pIJ101-derived replicating plasmid combined with the counter-selection system CodA(sm)was constructed for gene inactivation,which has a conjugation frequency as high as 0.52%.Meanwhile,almost all 5-flucytosine-resistant colonies were sensitive to apramycin,among which 75%harbored the successful deletion of targeted genes.Using this replicating vector,the maltooligosyltrehalose synthase gene treY responsible for the accumulation of component C was inactivated,and component C was eliminated as detected by LC-MS.Based on an efficient genetic manipulation system,improved acarbose production and the elimination of component C in our work paved a way for future rational engineering of the acarbose-producing strains. | Qinqin Zhao Huixin Xie Yao Peng Xinran Wang Linquan Bai | 2017 | Synthetic and Systems Biotechnology2017，2，4： | 6 |
| 3 | Rice Chitin Receptor OsCEBiP Is Not a Transmembrane Protein but Targets the Plasma Membrane via a GPI Anchor显示文摘 | Gong, Ben-Qiang Xue, Jiao Zhang, Nannan Xu, Lahong Yao, Xinran Yang, Qiu-Jiao Yu, Yang Wang, Hong-Bin Zhang, Dandan Li, Jian-Feng | 2017 | Molecular Plant2017，10，5： | 3 |
| 4 | BAK1-mediated phosphorylation of canonical G protein alpha during flagellin signaling in Arabidopsis显示文摘Heterotrimeric G proteins consisting of Gα,Gβand Gγare conserved signaling hubs in eukaryotes.Without analogs to canonical animal G protein-coupled receptors,plant cells are thought to use RGS1 and a yet unknown mechanism to regulate the activity of Gα.Meanwhile,the exact role of canonical Gαin plant innate immunity remains controversial.Here,we report multiple immune deficiencies in the null allele of Arabidopsis Gα(GPA1)in response to bacterial flg22 elicitor,clarifying a positive regulatory role of GPA1 in flg22 signaling.We also detect overall increased phosphorylation of GPA1 but reduced phosphorylation at Thr^19 upon flg22 elicitation.Interestingly,flg22 could not induce phosphorylation of GPA1 T19 Aand GPA1 T19D,suggesting that the dynamic Thr^19 phosphorylation is required for GPA1 to respond to flg22.Moreover,flg22-induced GPA1 phosphorylation is largely abolished in the absence of BAK1 in vivo,and BAK1 could phosphorylate GPA1 but not GPA1^T19A in vitro at the phosphorylation sites identified in vivo,suggesting BAK1 is likely the kinase for GPA1 phosphorylation in response to flg22.Furthermore,the T19A mutation could promote flg22-induced association,rather than dissociation,between GPA1 and RGS1.Taken together,our findings shed new insights into the function and regulation of GPA1 in Arabidopsis defense signaling. | Jiao Xue Ben-Qiang Gong Xinran Yao Xiangjuan Huang Jian-Feng Li | 2020 | Journal of Integrative Plant Biology2020，62，5： | 2 |
| 5 | Active switching multiple model method for tracking a noncooperative gliding flight vehicle显示文摘The study investigates the trajectory estimation problem of a noncooperative gliding flight vehicle with complex and atypical maneuvers.An active switching multiple model(ASMM)method is proposed.This method employs a motion behavior model set(MBMS),a motion behavior recognition algorithm,and an active switching estimation and fusion algorithm.First,a recognizable MBMS,which can capture all the motion behaviors of a gliding flight vehicle,is established.Then,a motion behavior recognition algorithm based on recurrent neural networks(RNNs)is developed to obtain the current probability of each motion behavior.Then,an active switching estimation and fusion algorithm is proposed,in which the adopted models are actively chosen at each time instant according to a model selection strategy.Last,the proposed ASMM method is applied to a noncooperative gliding flight vehicle.The simulation results show that the proposed method has higher estimation precision and better dynamic performance. | Tianyu ZHENG Yu YAO Fenghua HE Denggao JI Xinran ZHANG | 2020 | Science China(Information Sciences)2020，63，9： | 1 |
| 6 | Deletion of CHD8 in cerebellar granule neuron progenitors leads to severe cerebellar hypoplasia,ataxia,and psychiatric behavior in mice显示文摘CHD8 is a candidate gene for autism spectrum disorders and neurological development delay.It has been reported to be essential for neurogenesis in the cerebral cortex,but the function of CHD8 in cerebellum has not been comprehensively investigated.The potential relationship of cerebellum dysplasia with psychiatric disorders in patients with CHD8 mutations is still not clear.In this study,we establish different conditional knockout mouse models to investigate the roles of CHD8 in cerebellar development.Mice with neural stem cell-specific Chd8 deletion exhibit significant reduction of cerebellum volume and no layering structure is detected.Genetic deletion of Chd8 in cerebellar granule neuron progenitors(GNPs)leads to cerebellar hypoplasia,absent of proliferation layer and ectopic of Purkinje neuron.However,no substantial cerebellar dysplasia is detected in mice with Purkinje neuron-or oligodendrocyte-specific Chd8 ablation.Single-cell RNA sequencing indicates that ribosome-related genes and pathways are most significantly disrupted in GNPs,indicating the potential mechanism.Importantly,in addition to the ataxia phenotype,mice with GNPspecific Chd8 ablation present a neuropsychiatric phenotype in three-chamber and light/dark tests.Taken together,our results provide insights not only into the function of CHD8 in cerebellar development,but also the pathogenesis of neuropsychiatric disorders in patients with CHD8 mutations. | Xiang Chen Tong Chen Chen Dong Huiyao Chen Xinran Dong Lin Yang Liyuan Hu Huijun Wang Bingbing Wu Ye Yao Yu Xiong Man Xiong Yifeng Lin Wenhao Zhou | 2022 | Journal of Genetics and Genomics2022，49，9： | 1 |
| 7 | Increasing stiffness promotes pulmonary retention of ligand-directed dexamethasone-loaded nanoparticle for enhanced acute lung inflammation therapy显示文摘Inhaled nanoparticles(NPs)need to penetrate the bronchial mucosa to deliver drug payloads deeply in the lung for amplified local therapy.However,the bronchial mucociliary barrier eliminates NPs rapidly,which considerably limits their mucosal penetration.In this study,we find that surface ligand modification and stiffness adjustment of NPs contribute to the significantly enhanced bronchial mucosal absorption and pulmonary retention of inhaled drugs.We utilize neonatal Fc receptor ligand(FcBP)to modify the rationally designed low stiffness NPs(Soft-NP)and high stiffness NPs(Stiff-NP)to target bronchial mucosa.In an acute lung inflammation rat model,after intranasal administration with dexamethasone-loaded NPs,Stiff-NP endowed with FcBP displays superior therapeutic effects.The in vitro data demonstrate that the promotion effect of FcBP to bronchial mucosal absorption of Stiff-NP dominates over Soft-NP.This could be attributed to the higher affinity between ligand-receptor when incorporating FcBP on the Stiff-NP surface.Meanwhile,high stiffness modulates more actin filaments aggregation to mediate endocytosis,along with strengthened Ca2+signal to enhance exocytosis.Conclusively,we highlight that FcBP-modified NPs with higher stiffness would be a potential pulmonary drug delivery system. | Yinglan Yu Shujie Li Yuan Yao Xinran Shen Lian Li Yuan Huang | 2023 | Bioactive Materials2023，，2： | 0 |
| 8 | High photoelectric conversion efficiency and fast relaxation time of FA_(0.4)MA_(0.6)PbI_(3)applied in ultrafast modulation of terahertz waves显示文摘Active control of terahertz(THz)waves is attracting tremendous attentions in terahertz communications and active photonic devices.Perovskite,due to its excellent photoelectric conversion performance and simple manufacturing process,has emerged as a promising candidate for optoelectronic applications.However,the exploration of perovskites in optically controlled THz modulators is still limited.In this work,the photoelectric properties and carrier dynamics of FA_(0.4)MA_(0.6)PbI_(3)perovskite films were investigated by optical pumped terahertz probe(OPTP)system.The ultrafast carrier dynamics reveal that FA_(0.4)MA_(0.6)PbI_(3)thin film exhibits rapid switching and relaxation time within picosecond level,suggesting that FA_(0.4)MA_(0.6)PbI_(3)is an ideal candidate for active THz devices with ultrafast response.Furthermore,as a proof of concept,a FA_(0.4)MA_(0.6)PbI_(3)-based metadevice with integrating plasma-induced transparency(PIT)effect was fabricated to achieve ultrafast modulation of THz wave.The experimental results demonstrated that the switching time of FA_(0.4)MA_(0.6)PbI_(3)-based THz modulator is near to 3.5 ps,and the threshold of optical pump is as low as 12.7μJ cm^(-2).The simulation results attribute the mechanism of ultrafast THz modulation to photo-induced free carriers in the FA_(0.4)MA_(0.6)PbI_(3)layer,which progressively shorten the capacitive gap of PIT resonator.This study not only illuminates the potential of FA_(0.4)MA_(0.6)PbI_(3)in THz modulation,but also contributes to the field of ultrafast photonic devices. | Zhibo Xu Ying Zeng Xinran Zhao Xiaoyin Chen Aoyu Fan Furi Ling Jiang Li Jianquan Yao | 2024 | Journal of Energy Chemistry2024，91，4： | 0 |
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