|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased leptin by hypoxic-preconditioning promotes autophagy of mesenchymal stem cells and protects them from apoptosis显示文摘Autophagy is the basic catabolic progress involved in cell degradation of unnecessary or dysfunctional cellular components.It has been proven that autophagy could be utilized for cell survival under stresses.Hypoxic-preconditioning(HPC)could reduce apoptosis induced by ischemia and hypoxia/serum deprivation(H/SD)in bone marrow-derived mesenchymal stem cells(BMSCs).Previous studies have shown that both leptin signaling and autophagy activation were involved in the protection against apoptosis induced by various stress,including ischemia-reperfusion.However,it has never been fully understood how leptin was involved in the protective effects conferred by autophagy.In the present study,we demonstrated that HPC can induce autophagy in BMSCs by increased LC3-II/LC3-I ratio and autophagosome formation.Interestingly,similar effects were also observed when BMSCs were pretreated with rapamycin.The beneficial effects offered by HPC were absent when BMSCs were incubated with autophagy inhibitor,3-methyladenine(3-MA).In addition,down-regulated leptin expression by leptin-shRNA also attenuated HPC-induced autophagy in BMSCs,which in turn was associated with increased apoptosis after exposed to sustained H/SD.Furthermore,increased AMP-activated protein kinase phosphorylation and decreased mammalian target of rapamycin phosphorylation that were observed in HPC-treated BMSCs can also be attenuated by down-regulation of leptin expression.Our data suggests that leptin has impact on HPC-induced autophagy in BMSCs which confers protection against apoptosis under H/SD,possibly through modulating both AMPK and mTOR pathway. | WANG LiHan HU XinYang ZHU Wei JIANG Zhi ZHOU Yu CHEN PanPan WANG JianAn | 2014 | Science China(Life Sciences)2014，57，2： | 8 |
| 2 | The Glutamatergic Postrhinal Cortex–Ventrolateral Orbitofrontal Cortex Pathway Regulates Spatial Memory Retrieval显示文摘A deficit in spatial memory has been taken as an early predictor of Alzheimer’s disease(AD) or mild cognitive impairment(MCI). The uncinate fasciculus(UF) is a long-range white-matter tract that connects the anterior temporal lobe with the orbitofrontal cortex(OFC)in primates. Previous studies have shown that the UF impairment associated with spatial memory deficits may be an important pathological change in aging and AD, but its exact role in spatial memory is not well understood. The pathway arising from the postrhinal cortex(POR) and projecting to the ventrolateral orbitofrontal cortex(vlOFC)performs most of the functions of the UF in rodents.Although the literature suggests an association between spatial memory and the regions connected by the POR–vlOFC pathway, the function of the pathway in spatialmemory is relatively unknown. To further illuminate the function of the UF in spatial memory, we dissected the POR–vlOFC pathway in mice. We determined that the POR–vlOFC pathway is a glutamatergic structure, and that glutamatergic neurons in the POR regulate spatial memory retrieval. We also demonstrated that the POR–vlOFC pathway specifically transmits spatial information to participate in memory retrieval. These findings provide a deeper understanding of UF function and dysfunction related to disorders of memory, as in MCI and AD. | Xinyang Qi Zhanhong Jeff Du Lin Zhu Xuemei Liu Hua Xu Zheng Zhou Cheng Zhong Shijiang Li Liping Wang Zhijun Zhang | 2019 | Neuroscience Bulletin2019，35，3： | 7 |
| 3 | Effect of hydration on the elasticity of mantle minerals and its geophysical implications显示文摘Recent studies have shown that major nominally anhydrous minerals in the Earth's mantle, such as olivine, pyroxene and garnet, can incorporate considerable amounts of water as structurally bound hydroxyl. Even a small amount of water is present in mantle minerals, it can strongly affect a number of physical properties, including density, sound velocity, melting temperature, and electrical conductivities. The presence of water can also influence the dynamic behavior, lead to lateral velocity heterogeneities, and affect the material circulation of the Earth's deep interior. In particular, seismic studies have reported the existence of low-velocity zones in various locations of the Earth's upper mantle and transition zone, which has been expected to be associated with the presence of water in the region. In the past two decades, the effect of water on the elasticity and sound velocities of minerals at relevant pressure-temperature(P-T) conditions of the Earth's mantle attracted extensive interests. Combining the high P-T experimental and theoretical mineralogical results with seismic observations provides crucial constraints on the distribution of water in the Earth's mantle. In this study, we summarize recent experimental and theoretical mineral physics results on how water affects the elasticity and sound velocity of nominally anhydrous minerals in the Earth's mantle, which aims to provide new insights into the effect of hydration on the density and velocity profile of the Earth's mantle, which are of particular importance in understanding of water distribution in the region. | MAO Zhu LI XinYang | 2016 | Science China Earth Sciences2016，59，5： | 5 |
| 4 | Terahertz-dependent evaluation of water content in high-water-cut crude oil using additive-manufactured samplers显示文摘The evaluation of water content in crude oil is of significance to petroleum exploration and transportation.Terahertz(THz) waves are sensitive to fluctuations in the dipole moment of water.However,due to the strong absorption of water in the THz range,it is difficult for the THz spectrum to determine high water content with the common sampler.In this research,micron-grade samplers for THz detection were designed and manufactured using additive manufacturing(AM) technology.Oil-water mixtures with water content from 1.8%to 90.6%were measured with the THz-TDS system using sample cells.In addition,a detailed analysis was performed of the relationships among THz parameters such as signal peak,time delay,and refractive index as well as absorption coefficient and high water content(>60%).Results suggest that the combination of THz spectroscopy and AM technique is effective for water content evaluation in crude oil and can be further applied in the petroleum industry. | LiMei Guan HongLei Zhan XinYang Miao Jing Zhu Kun Zhao | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，4： | 3 |
| 5 | Achieving ultrahigh electrocatalytic NH_(3) yield rate on Fe-doped Bi_(2)WO_(6) electrocatalyst显示文摘NH_(3),derived from electrocatalytic nitrogen reduction reaction(NRR),is promising to satisfy the need of food production and serve as a carbon-free liquid energy carrier in the near future.Yet major challenges remain in enhancing NH_(3) yield rate and conversion efficiency of available electrocatalysts.This work achieved an ultrahigh electrocatalytic NH_(3)yield rate on the_(0.50)Fe-Bi_(2)W0_(6) catalyst by a facile Fe-doped strategy.Up to 289μg·h^(-1)·mg_(cat)^(-1) of NH_(3) formation rate was obtained at-0.75 V vs.RHE,which was reliably quantized by indophenol blue and ^(1)H NMR methods.The impressive result is an order of magnitude higher than that of the reported Fe-and Bi-based catalysts,even more superior than the result of single atom Ru catalyst.The key of the outstanding NRR behaviors on the_(0.50)Fe-Bi_(2)W0_(6) catalyst is the significant hydrogen evolution reaction(HER)suppression and the synergy between Bi and Fe,which can effectively modulate the electron distribution and accelerate the electron transport.This work endows a new insight to further explore the high-performance electrocatalysts toward NRR. | Yongqin Liu Liang Huang Youxing Fang Xinyang Zhu Shaojun Dong | 2021 | Nano Research2021，14，8： | 3 |
| 6 | Thermal spallation in rock revealed by ultraviolet laser-induced voltage显示文摘In the petroleum industry, perforation plays an important role in the exploitation of oil and gas and a considerable number of studies have been conducted with the objective of improving the recovery rates of oil and gas (1,2)Lasers have been used to drill holes in a wide variety of rock types with the advantages of feasibility, cost, benefits, and environmental impact as determined by the Gas Technology Institute [1]. | Jing Zhu HongLei Zhan Kun Zhao XinYang Miao Qiong Zhou WenZheng Yue | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，7： | 2 |
| 7 | Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease显示文摘The parahippocampal gyrus-orbitofrontal cortex(PHG-OFC)circuit in humans is homologous to the postrhinal cortex(POR)-ventral lateral orbitofrontal cortex(vlOFC)circuit in rodents.Both are associated with visuospatial malfunctions in Alzheimer’s disease(AD).However,the underlying mechanisms remain to be elucidated.In this study,we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice,and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging(MRI)in patients on the AD spectrum.We demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD mice.Moreover,MRI measurements of the PHG-OFC circuit had an accuracy of 77.33%for the classification of amnestic mild cognitive impairment converters versus non-converters.Thus,the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD,thereby providing a potential predictor for AD progression and a promising interventional approach for AD. | Lin Zhu Zan Wang Zhanhong Du Xinyang Qi Hao Shu Duan Liu Fan Su Qing Ye Xuemei Liu Zheng Zhou Yongqiang Tang Ru Song Xiaobin Wang Li Lin Shijiang Li Ying Han Liping Wang Zhijun Zhang | 2020 | Neuroscience Bulletin2020，36，8： | 2 |
| 8 | Concentrations and health risks of lead, cadmium, arsenic, and mercury in rice and edible mushrooms in China显示文摘 | Yong Fang Xinyang Sun Wenjian Yang Ning Ma Zhihong Xin Jin Fu Xiaochang Liu Meng Liu Alfred Mugambi Mariga Xuefeng Zhu Qiuhui Hu | 2014 | Food Chemistry2014，，： | 1 |
| 9 | INTEGRABLE COUPLINGS OF THE TB HIERARCHY AND ITS HAMILTONIAN STRUCTURE显示文摘In this paper,we obtain integrable couplings of the TB hierarchy using the new subalgebra of the loop algebra A_3.Then the Hamiltonian structure of the above system is given by the quadratic-form identity. | Zhang Yu Dong Huanhe (College of Information Science and Engineering,Shandong University of Science and Technology,Qingdao 266510,Shandong) Li Zhu (College of Math.and Inform.Science,Xinyang Normal University,Xinyang 464000,Henan) | 2008 | Annals of Differential Equations2008，24，1： | 1 |
| 10 | Tumorspheres derived from prostate cancer cells possess chemoresistant and cancer stem cell properties显示文摘 | Linlin Zhang Min Jiao Lei Li Dapeng Wu Kaijie Wu Xiang Li Guodong Zhu Qiang Dang Xinyang Wang Jer-Tsong Hsieh Dalin He | 2012 | Journal of Cancer Research and Clinical Oncology2012，，4： | 1 |
| 11 | Critical evaluation of the glucose oxidase-like activity of gold nanoparticles stabilized by different polymers显示文摘Polymer stabilizers are widely used to synthesize gold nanoparticles(Au NPs)to prevent their aggregation and improve their stability.Although stabilizers are known to greatly influence both the structure and size of Au NPs,limited efforts explore their effects on the activity of Au NPs for biocatalysis.Herein,different polymers are used as stabilizers to synthesize Au NPs.For the glucose oxidase-like activity,we find that without the spatial barrier from stabilizers,naked Au NPs show significantly high catalytic activity as well as the worst stability.Among the polymers,polyacrylic acid-stabilized Au NPs exhibit the highest activity,whose Vmax(0.74μM·s^(−1))is higher than that of the natural glucose oxidase(0.37μM·s^(−1))due to the smallest particle size(<2 nm)and the weak spatial resistance of polyacrylic acid.These variable catalytic results derive from the comprehensive effects including size,steric hindrance,and electronic effect.However,further selectivity and activity tests have exposed shortcomings.They possess universal activities for aldose oxidation,whereas cannot retain activities in typical physiological environments.Our findings highlight the role of polymer stabilizers in imposing effects on the glucose oxidase-like activity of Au NPs and provide a basis for further Au NPs engineering and applications. | Lili Xu Jinxing Chen Qian Ma Daiyong Chao Xinyang Zhu Ling Liu Jin Wang Youxing Fang Shaojun Dong | 2023 | Nano Research2023，16，4： | 0 |
| 12 | Dynamic and adaptive membrane lipid remodeling in leaves of sorghum under salt stress显示文摘Salt stress limits plant growth and development.In this study,changes in membrane lipids were investigated in leaves of sorghum seedlings subjected to salt stress(150 mmol L^(-1)NaCl).Galactolipids(DGDG and MGDG)accounted for more than 65%of the total glycerolipids in sorghum leaves.The predominance of C36 molecular species in MGDG suggested that sorghum is an 18:3 plant.Under Na Cl treatment,the content of major phospholipids(PC and PE)increased,accompanied by the activation of their metabolism pathways at the transcriptional level.In contrast,the proportion of MGDG and PG dropped drastically,leading to a decreased ratio of plastidic to non-plastidic lipids.An adjustment of glycerolipid pathway between the cytosolic and plastidic compartments was triggered by salt stress,as reflected by the increased conversion of PC to PA,providing precursors for galactolipid synthesis.The elevated DGDG resulted in increased DGDG/MGDG and bilayer/non-bilayer lipid ratios.The double-bond index of PC,PE,and DGDG increased markedly,evidently owing to the increased expression of FAD3 and FAD8.These findings will be helpful for understanding dynamic membrane lipid changes and adaptive lipid remodeling in sorghum response to salt stress. | Shengnan Ge Debin Liu Min Chu Xinyu Liu Yulei Wei Xinyang Che Lei Zhu Lin He Jingyu Xu | 2022 | The Crop Journal2022，10，6： | 0 |
| 13 | THE CRITERIA OF ULTIMATE BOUNDEDNESS FOR NONAUTONOMOUS DIFFUSIVE LOTKA-VOLTERRA SYSTEMS IN TWO HETEROGENEOUS PATCHES显示文摘In this paper, a set of sufficient conditions is obtained for the ultimate boundedness of nonautonomous n-species diffusive Lotka-Volterra sub-models in two heterogeneous patches. The sub-models are the Lotka-Volterra tree systems, including the Lotka-Volterra chain systems and the Lotka-Volterra models between one and multispecies. The criteria in this paper are in explicit forms of the parameters and thus are easily verifiable. | LI Xuezhi (Department of Mathematics, Xinyang Teachers College, Henan 464000, China) GENI Gupur (Deportment of Mathematics, Xinjiang University, Urumqi 830046, China) ZHU Guangtian (Institute of Systems Science, Academy of Mathematics and Systems Science, | 2001 | Journal of Systems Science & Complexity2001，14，2： | 0 |
| 14 | EXACT TRAVELLING WAVE SOLUTIONS TO BBM EQUATION显示文摘Abundant new travelling wave solutions to the BBM (Benjamin-Bona-Mahoni) equation are obtained by the generalized Jacobian elliptic function method. This method can be applied to other nonlinear evolution equations. | Zhu Li, Jingen Yang (College of Math. and Information Science, Xinyang Normal University, Xinyang 464000, Henan) Jirong Shan (Education Bureau of Sishui, Sishui 273200, Shandong) | 2009 | Annals of Differential Equations2009，25，4： | 0 |
| 15 | Dietary host-associated Bacillus subtilis supplementation improves intestinal microbiota,health and disease resistance in Chinese perch(Siniperca chuatsi)显示文摘The purpose of this study was to evaluate the potential of a host-associated Bacillus subtilis 1-C-7 as a probiotic for Chinese perch(Siniperca chuatsi).Four test diets were formulated to contain graded levels of B.subtilis 1-C-7 at 0(CY),0.85×10^(8)(Y1),0.95×10^(9)(Y2)and 0.91×10^(10)(Y3)CFU/kg diet.The test fish with initial weight 30.0±1.2 g were fed the 4 test diets with 3 replicates in an indoor water-flow aquaculture system with 12 net cages(40 fish/cage)for 10 wk.At the conclusion of the feeding trial,the probiotic effects of B.subtilis on Chinese perch were analyzed based on growth performance,serum biochemical indices,histologic morphology of liver and gut,gut microbiota and the resistance to Aero-monas hydrophila.The results showed that the percentage of weight gain had no significant change in the Y1 and Y2 groups(P>0.05)but decreased in the Y3 group compared to that in the CY group(P<0.05).The fish in the Y3 group displayed the highest activity of serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)among these 4 groups(P<0.05).The fish in the CY group had the highest value of malondialdehyde in the liver(P<0.05)and showed severe nuclear migration and vacuolization of hepatocytes.The morphology indicated that all test fish had poor intestinal health.However,the fish in the Y1 group had a relatively normal intestinal histologic structure.The mid gut microbial diversity analysis showed that dietary B.subtilis supplementation increased the abundance of probiotics such as Tenericutes and Bacteroides,whereas it reduced the abundance of pernicious bacteria such as Proteobacteria,Actinobacteria,Thermophilia and Spirochaetes.The challenge test showed that dietary B.subtilis supplementation increased the resistance to A.hydrophila in Chinese perch.In conclusion,dietary supplementation of 0.85×10^(8)CFU/kg B.subtilis 1-C-7 could improve the intestinal microbiota,intestinal health and disease resistance in Chinese perch,but more or excessive supple-mentation could reduce growth performance and have negative effects on health. | Zhehui Ji Chuanzhong Zhu Xinyang Zhu Sainan Ban Lijuan Yu Juan Tian Lixue Dong Hua Wen Xing Lu Ming Jiang | 2023 | Animal Nutrition2023，，2： | 0 |
| 16 | Enhanced electrochemical CO_(2)-to-C_(2+) conversion from synergistic interaction between terrace and step sites on monocrystalline highindex Cu facets显示文摘1. Introduction The increasing global demand for sustainable energy sources and emerging environmental issues have pushed the development of energy conversion and storage technologies to the forefront of chemical research [1,2]. In particular, electrochemical CO_(2) reduction(CO_(2) R) to value-added fuels and chemicals presents a feasible pathway for renewable energy storage and could help mitigate the ever-increasing CO_(2) emissions [3]. | Chenyuan Zhu Zhibin Zhang Lixiang Zhong Siwen Zhao Guoshuai Shi Bowen Wu Huoliang Gu Jing Wu Xinyang Gao Kaihui Liu Liming Zhang | 2022 | Journal of Energy Chemistry2022，31，7： | 0 |
| 17 | Atomically dispersed hierarchically ordered porous Fe-N-C single-atom nanozymes for dyes degradation显示文摘The development of novel nanozymes for environmental contamination remediation is a worthwhile research direction.However,most of the reported nanozymes cannot degrade efficiently due to the limitation of the internal active sites not being able to come into direct contact with contaminants.Therefore,we reported Fe-N-C single-atom nanozymes(SAzymes)with atomically dispersed FeN4 active sites anchored on a three-dimensional hierarchically ordered microporous-mesoporous-macroporous nitrogen doped carbon matrix(3DOM Fe-N-C)for the degradation of a targeted environmental pollutant(rhodamine B(RhB)).The three-dimensional(3D)hierarchically ordered porous structure may accelerate mass transfer and improve the accessibility of active sites.This structure and high metal atom utilization endow Fe-N-C SAzyme with enhanced tri-enzyme-mimic activities,comprising oxidase-mimic,peroxidase-mimic,and catalase-mimic activities.Based on its excellent peroxidase-mimic activity,3DOM Fe-N-C can degrade RhB by hydroxyl radicals(·OH)generated in the presence of hydrogen peroxide.This study provides a new idea for designing porous Fe-N-C SAzymes for environmental contamination remediation. | Shuangli Wu Weiwei Wu Xinyang Zhu Minghua Li Jianguo Zhao Shaojun Dong | 2023 | Nano Research2023，16，8： | 0 |
| 18 | A ferroptosis-inducing iridium(III) complex显示文摘Ferroptosis is a recently emerging non-apoptotic mode of cell death involving the production of iron-dependent reactive oxygen species(ROS).Here we described a mitochondria-targeted iridium(III)complex Ir FN that exhibited potent antiproliferative activity against a variety of cancer cells,especially the A2780 human ovarian cancer cells,through the ferroptosis pathways.Mechanistic studies by label-free quantitative proteomics profiling indicated that heme oxygenase 1(HMOX1)-mediated ferroptosis process was activated by Ir FN.The study on iron-dependent cell death,ROS accumulation,lipid peroxidation,and over released iron further confirmed the ferroptosis processes.m RNA transcription quantification,in vitro over-expression of HMOX1,and RNAi-mediated knock-down experiments suggested that Ir FN activated the over-expression of HMOX1.Our report revealed the first case of anticancer iridium complex leading to ferroptosis,highlighting ferroptosis as a promising approach in future design of metallodrugs. | Xiuxiu Wang Feng Chen Jingyi Zhang Jianxuan Sun Xinyang Zhao Yuelu Zhu Wei Wei Jing Zhao Zijian Guo | 2020 | Science China Chemistry2020，63，1： | 0 |
| 19 | Characterizing the rock perforation process by laser-induced voltage response显示文摘In the petroleum industry,the exploitation of oil and gas is necessarily achieved by perforation,and a considerable number of research studies have been conducted with the objective of improving the recovery rates of oil and gas[1,2].New perforation methods are urgently needed to accelerate the development of energy resources.Drilling rock by laser is a non-contact process that can be used to drill holes in | Jing Zhu XinYang Miao Kun Zhao HongLei Zhan Qiong Zhou WenZheng Yue | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，5： | 0 |
| 20 | THE RATIONALITY OF THE DISCRETE ORDINATES METHOD FOR TIME DEPENDENT NEUTRON TRANSPORT EQUATION显示文摘THERATIONALITYOFTHEDISCRETEORDINATESMETHODFORTIMEDEPENDENTNEUTRONTRANSPORTEQUATIONLIXuezhi;ZHUGuangtian(InstituteofSystemsSci... | LI Xuezhi ZHU Guangtian (Institute of Systems Science, Academia Sinica, Beijing 100080, China)LIANG Benzhong (Department of Mathematics, Xinyang Teachers College, Henan 464000, China) | 1995 | Systems Science and Mathematical Sciences1995，8，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员