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| 1 | Analysis and external validation of a nomogram to predict peritoneal dissemination in gastric cancer显示文摘Objective:Peritoneal dissemination is difficult to diagnose by conventional imaging technologies.We aimed to construct a nomogram to predict peritoneal dissemination in gastric cancer(GC)patients.Methods:We retrospectively analyzed 1,112 GC patients in Sun Yat-sen University Cancer Center between2001 and 2010 as the development set and 474 patients from The Sixth Affiliated Hospital,Sun Yat-sen University between 2010 and 2016 as the validation set.The clinicopathological variables associated with gastric cancer with peritoneal dissemination(GCPD)were analyzed.We used logistic regression analysis to identify independent risk factors for peritoneal dissemination.Then,we constructed a nomogram for the prediction of GCPD and defined its predictive value with a receiver operating characteristic(ROC)curve.External validation was performed to validate the applicability of the nomogram.Results:In total,250 patients were histologically identified as having peritoneal dissemination.Logistic regression analysis demonstrated that age,sex,tumor location,tumor size,signet-ring cell carcinoma(SRCC),T stage,N stage and Borrmann classification IV(Borrmann IV)were independent risk factors for peritoneal dissemination.We constructed a nomogram consisting of these eight factors to predict GCPD and found an optimistic predictive capability,with a C-index of 0.791,an area under the curve(AUC)of 0.791,and a 95%confidence interval(95%CI)of 0.762-0.820.The results found in the external validation set were also promising.Conclusions:We constructed a highly sensitive nomogram that can assist clinicians in the early diagnosis of GCPD and serve as a reference for optimizing clinical management strategies. | Xijie Chen Shi Chen Xinyou Wang Runcong Nie Dongwen Chen Jun Xiang Yijia Lin Yingbo Chen Junsheng Peng | 2020 | Chinese Journal of Cancer Research2020，32，2： | 6 |
| 2 | A Preliminary Study on Fluid Inclusions and Mineralization of Xitieshan Sedimentary-Exhalative (SEDEX) Lead-Zinc Deposit显示文摘Xitieshan 铅锌存款在 Qaidam 盆的北边缘被定位, Qinghai 省,中国,并且开发了一个完全的海洋的 sedimentary-exhalative 系统。我们形成矿石的液体的初步的学习证明在从代表管子外形的改变的 stockwork 岩石的石英的液体包括有大量温度和咸度。强烈液体活动是 exhalative 系统的管子外形的特征。在在代表发泄近似的外形的厚床的云石招待的 unstratified 矿石身体附近的碳酸盐的液体包括在尺寸大并且有对高温度中等。他们代表 unerupted sub-seafloor 液体活动。在改变的 stockwork 岩石和碳酸盐中的液体有类似的 H2O-NaCl-CO2 系统,两个都属于 sedimentary-exhalative 系统。液体从管子外形移居到 unstratified 矿石身体。液体沸腾引起 CO2 蒸汽和液体 H2O 的分离。当液体移居进 unconsolidated 时,象进液体的海水的某参与一样的厚床的大理石, CO2 的逃跑,减少的温度和压力与形成矿石的材料的高、低的咸度和免职导致液体的 unmixing。二纯粹的液体在 unconsolidated 碳酸盐被套住,形成矿石的材料在 unconsolidated 碳酸盐被扔形成 sedimentary-exhalative 类型 unstratified 矿石身体。unstratified 矿石身体的形成矿石的温度直到显示在有一个巨大的形成矿石的潜力的高温度它的深。 | WANG Lijuan ZHU Xinyou WANG Jingbin DENG Jiniu WANG Yuwang ZHU Heping | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 4 |
| 3 | Analysis of genetic diversity and population structure of peanut cultivars and breeding lines from China,India and the US using simple sequence repeat markers显示文摘Cultivated peanut is grown worldwide as richsource of oil and protein. A broad genetic base is needed for cultivar improvement. The objectives of this study were to develop highly informative simple sequence repeat(SSR)markers and to assess the genetic diversity and population structure of peanut cultivars and breeding lines from different breeding programs in China, India and the US. A total of 111 SSR markers were selected for this study, resulting in a total of 472 alleles. The mean values of gene diversity and polymorphic information content(PIC) were 0.480 and 0.429, respectively.Country-wise analysis revealed that alleles per locus in three countries were similar. The mean gene diversity in the US,China and India was 0.363, 0.489 and 0.47 with an average PIC of 0.323, 0.43 and 0.412, respectively. Genetic analysis using the STRUCTURE divided these peanut lines into two populations(P_1, P_2), which was consistent with the dendrogram based on genetic distance(G_1, G_2) and the clustering of principal component analysis. The groupings were related to peanut market types and the geographic origin with a few admixtures. The results could be used by breeding programs to assess the genetic diversity of breeding materials to broaden the genetic base and for molecular genetics studies. | Hui Wang Pawan Khera Bingyan.Huang Mei Yuan Ramesh Katam Weijian Zhuang Karen Harris-Shultz Kim M.Moore Albert K.Culbreath Xinyou Zhang Rajeev K.Varshney Lianhui Xie Baozhu Guo | 2016 | Journal of Integrative Plant Biology2016，58，5： | 2 |
| 4 | QTL mapping of quality traits in peanut using whole-genome resequencing显示文摘Oil and protein content and fatty acid composition are quality traits in peanut.Elucidating the genetic mechanisms underlying these traits may help researchers to obtain improved cultivars by molecular breeding.Whole-genome resequencing of a recombinant inbred population of 318 lines was performed to construct a high-density linkage map and identify QTL for peanut quality.The map,containing 4561 bin markers,covered 2032 c M with a mean marker density of 0.45 c M.A total of 110 QTL for oil and protein content,and fatty acid composition were mapped on the 18 peanut chromosomes.The QTL q A05.1 was detected in four environments and showed a major phenotypic effect on the contents of oil,protein,and six fatty acids.The genomic region spanned by q A05.1,corresponding to a physical interval of approximately 1.5 Mb,contains two SNPs polymorphic between the parents that could cause missense mutations.The two SNP sites were employed as KASP markers and validated using lines with extremely high and low oil contents.These sites may be useful in the marker-assisted breeding of peanut cultivars with high oil contents. | Ziqi Sun Feiyan Qi Hua Liu Li Qin Jing Xu Lei Shi Zhongxin Zhang Lijuan Miao Bingyan Huang Wenzhao Dong Xiao Wang Mengdi Tian Jingjing Feng Ruifang Zhao Xinyou Zhang Zheng Zheng | 2022 | The Crop Journal2022，10，1： | 2 |
| 5 | Exhalative Lead-Zinc Deposits in Shallow Sea,Southern Xicheng Belt,Gansu Province显示文摘在 Xicheng 泥盆纪盆的南部的带的 SEDEX 类型铅锌存款, Gansu 省已经被识别了。然而,石灰石的沉积环境和铅锌存款发生的在内的 Xihanshui 组的 philite 是沿岸、浅的海。这与在象 Changba-Lijiagou 铅锌存款那样的北带的那些不同,它在深海被形成。礁石和 bioclastic 石灰石在南部的带是普遍的。特别地,他们与铅锌矿石被联系,没有 striae 和 banding 但是巨大或传播的结构。黑烟囱由闪锌矿, ankerite,黄铁矿和方铅矿,黑、粗糙、光线的闪锌矿在发生作为组成,这被发现不规则地有 1040 厘米的宽度的静脉或 cylindricality 在里面中心,和它是用带子结构由好 ankerite 和次要的天青石包围。烟囱的立即的墙岩石,礁石石灰石,是未改变的,外面的礁石和 bioclastic 石灰石强烈地被硅化。那些硅化的礁石和 bioclastic 石灰石主人传播了珞巴族和 Bijiashan 类型的铅锌矿石。exhalative 系统在中间的泥盆纪的 Givetian 发生在一个浅海,这被结束。盐水由于低压力被煮,并且很多铅和锌在在石灰石和 phyllite 之间的接口被驱散并且形成了一张来源床。在三叠纪的时期,元热水的液体沥滤并且从来源床提取了金属,然后搬到并且使矿物化,并且形成象拱门和背斜的反的手足那样的空地巨大并且象 Jianyagou 和 Dengjiashan 那样的静脉矿石打存款。 | ZHU Xinyou WANG Dongbo WEI Zhiguo QIU Xiaoping WANG Ruiting | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 2 |
| 6 | Gemcitabine and cisplatin combination regimen in patients with anthracycline- and taxane-pretreated metastatic breast cancer显示文摘 | Tao Wang Shaohua Zhang Min Zeng Xinyou Lu Ge Shen Shikai Wu Santai Song Zefei Jiang | 2012 | Medical Oncology2012，，1： | 1 |
| 7 | Very-high- performance concrete with ultrafine powders 显示文摘 | Long Guangcheng Wang Xinyou Xie Youjun | 2002 | Cem Concr Rcs2002，32，4： | 1 |
| 8 | Adaptor protein APPL1 links neuronal activity to chromatin remodeling in cultured hippocampal neurons显示文摘Local signaling events at synapses or axon terminals are communicated to the nucleus to elicit transcriptional responses,and thereby translate information about the external environment into internal neuronal representations.This retrograde signaling is critical to dendritic growth,synapse development,and neuronal plasticity.Here,we demonstrate that neuronal activity induces retrograde translocation and nuclear accumulation of endosomal adaptor APPL1.Disrupting the interaction of APPL1 with Importin ocl abolishes nuclear accumulation of APPL1,which in turn decreases the levels of histone acetylation.We further demonstrate that retrograde translocation of APPL1 is required for the regulation of gene transcription and then maintenance of hippocampal late-phase long-term potentiation.Thus,these results illustrate an APPLl-mediated pathway that contributes to the modulation of synaptic plasticity via coupling neuronal activity with chromatin remodeling. | Yu Wu Xinyou Lv Haiting Wang Kai Qian Jinjun Ding Jiejie Wang Shushan Hua Tiancheng Sun Yiting Zhou Lina Yu Shuang Qiu | 2021 | Journal of Molecular Cell Biology2021，13，5： | 1 |
| 9 | Development of Oligo-GISH kits for efficient detection of chromosomal variants in peanut显示文摘Oligo probe staining is a low-cost and efficient chromosome identification technique.In this study,oligo genomic in situ hybridization(Oligo-GISH)technology was established in peanut.Peanut A and B subgenome-specific interspersed repeat(IR)oligo probe sets were developed based on clustering and electronic localization of tandem repeat sequences in the reference genome of Tifrunner.The OligoGISH kit was then used to perform staining of 15 Arachis species.The A-subgenome probe set stained the chromosomes of A-and E-genome Arachis species,the B-subgenome probe set stained those of B-,F-,K-,and E-genome species,and neither set stained those of H-genome species.These results indicate the relationships among the genomes of these Arachis species.The Oligo-GISH kit was also used for batch staining of the chromosomes of 389 seedlings from the irradiated M1generation,allowing 67 translocation and deletion lines to be identified.Subsequent Oligo-FISH karyotyping,FISH using single-copy probe libraries,and trait investigation identified seven homozygous chromosomal variants from the M3generation and suggested that there may be genes on chromosome 4B controlling seed number per pod.These findings demonstrate that the IR probe sets and method developed in this study can facilitate research on distant hybridization and genetic improvement in peanut. | Pei Du Liuyang Fu Qian Wang Tao Lang Hua Liu Suoyi Han Chenyu Li Bingyan Huang Li Qin Xiaodong Dai Wenzhao Dong Xinyou Zhang | 2023 | The Crop Journal2023，11，1： | 0 |
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