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| 1 | Leptin-induced vascular smooth muscle cell proliferation via regulating cell cycle, activating ERK1/2 and NF-κB显示文摘Leptin 是首先涉及食物吸入和精力开销的规定的肽荷尔蒙。最近的研究建议了 leptin 是为包括动脉粥样硬化和高血压的心血管的疾病的风险因素之一。脉管的光滑的肌肉房间(VSMC ) 在动脉的内层的变厚并且脉管的改变起一个重要作用。在这研究,我们在 VSMC 房间周期规定和可能的小径上调查了 leptin 的效果。我们发现 leptin 刺激了 VSMC 增长并且增加了房间前进到 S 和 G2/M 阶段。cyclinD1 的表示, phosphorylated 细胞外的调整信号的 kinase 1/2 (ERK1/2 ) ,和原子因素(NF )-Bp65 被增加。有 leptin 对手三元组异种的房间的处理稀释了导致 leptin 的 ERK1/2 和 NF-B 激活。这些结果建议 leptin 由从 G1 把转变提升到 S 阶段和 ERK1/2 和 NF-B 小径刺激了 VSMC 增长可能贡献这行列。 | Fen Huang Xiaofang Xiong Huabin Wang Sha You Hesong Zeng | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 20 |
| 2 | Minimally invasive surgery alone compared with intensity-modulated radiotherapy for primary stage I nasopharyngeal carcinoma显示文摘Background:The National Comprehensive Cancer Network guidelines recommend intensity-modulated radiotherapy(IMRT)as the primary curative treatment for newly diagnosed nasopharyngeal carcinoma(NPC),but the radiation-related complications and relatively high medical costs remain a consequential burden for the patients.Endoscopic nasopharyngectomy(ENPG)was successfully applied in recurrent NPC with radiation free and relatively low medical costs.In this study,we examined whether ENPG could be an effective treatment for localized stage I NPC.Methods:Ten newly diagnosed localized stage I NPC patients voluntarily received ENPG alone from June 2007 to September 2017 in Sun Yat-sen University Cancer Center.Simultaneously,the data of 329 stage I NPC patients treated with IMRT were collected and used as a reference cohort.The survival outcomes,quality of life(QOL),and medical costs between two groups were compared.Results:After a median follow-up of 59.0 months(95%CI 53.4-64.6),no death,locoregional recurrence,or distant metastasis was observed in the 10 patients treated with ENPG.The 5-year overall survival,local relapse-free survival,regional relapse-free survival,and distant metastasis-free survival among the ENPG-treated patients was similar to that among the IMRT-treated patients(100%vs.99.1%,100%vs.97.7%,100%vs.99.0%,100%vs.97.4%,respectively,P>0.05).In addition,compared with IMRT,ENPG was associated with decreased total medical costs($4090.42±1502.65 vs.$12620.88±4242.65,P<0.001)and improved QOL scores including dry mouth(3.3±10.5 vs.34.4±25.8,P<0.001)and sticky saliva(3.3±10.5 vs.32.6±23.3,P<0.001).Conclusions:ENPG alone was associated with promising long-term survival outcomes,low medical costs,and satisfactory QOL and might therefore be an alternative strategy for treating newly diagnosed localized stage I NPC patients who refused radiotherapy.However,the application of ENPG should be prudent,and prospective clinical tri-als were needed to further verify the results. | You-Ping Liu Xing Lv Xiong Zou Yi-Jun Hua Rui You Qi Yang Le Xia Shao-Yan Guo Wen Hu Meng-Xia Zhang Si-Yuan Chen Mei Lin Yu-Long Xie Li-Zhi Liu Rui Sun Pei-Yu Huang Wei Fan Xiang Guo Ming-Huang Hong Ming-Yuan Chen | 2019 | Cancer Communications2019，39，1： | 17 |
| 3 | Increased Serum Cystatin C in Early Parkinson’s Disease with Objective Sleep Disturbances显示文摘 | Kang-Ping Xiong Yong-Ping Dai Jing Chen Jin-Min Xu Yi Wang Ping Feng Shou-Jiang You Chun-Feng Liu | 2018 | Chinese Medical Journal2018，，8： | 16 |
| 4 | Cloning and characterization of a potato StAN11 gene involved in anthocyanin biosynthesis regulation显示文摘Anthocyanins are a class of products of plant secondary metabolism and are responsible for tubers color in potato.The biosynthesis of anthocyanins is a complex Researchbiological process,in which multiple genes are involved including structural genes and regulatory genes.In this study,StAN11,a WD40-repeat gene,was cloned from potato cultivar Chieftain(Solanum tuberosum L.).StAN11(HQ599506)contained no intron and its open reading frame(ORF)was 1,029 bp long,encoding a putative protein of 342 amino acids.In order to verify its role in anthocyanin biosynthesis,StAN11 was inserted behind the CaMV-35S promoter of pCMBIA1304 and the recombination vector was introduced into the potato cultivar Désirée plants by Agrobacterium-mediated transformation.The color of transgenic tuber skin was significantly deepened,compared to the wild-type control,which was highly consistent with the accumulation of anthocyanin and expression of StAN11 in transgenic lines tuber skin.Further analysis on the expression of Flavonone-3-hydroxylase(F3H),Dihydroflavonol reductase(DFR),Anthocyanidin synthase(ANS),and Flavonoid 3-O-glucosyl transferase(3GT)in transgenic plants revealed that only DFR was upregulated.This result suggested that StAN11 regulated anthocyanin biosynthesis in potato by controlling DFR expression and accumulation of anthocyanin could be increased through overexpression of StAN11 in the tubers with the genetic background of anthocyanin biosynthesis. | Wang Li Bing Wang Man Wang Min Chen Jing-Ming Yin Ghullam Murtaza Kaleri Rui-Jie Zhang Tie-Niu Zuo Xiong You Qing Yang | 2014 | Journal of Integrative Plant Biology2014，56，4： | 13 |
| 5 | A curative-intent endoscopic surgery for postradiation nasopharyngeal necrosis in patients with nasopharyngeal carcinoma显示文摘Background:Postradiation nasopharyngeal necrosis(PRNN)is a severe complication after radiotherapy in patients with nasopharyngeal carcinoma(NPC),which can severely affect the quality of life and threaten the patient’s life.Only 13.4%-28.6%of patients can be cured by traditional repeated endoscopic debridement.Here,we introduced an innovative curative-intent endoscopic surgery for PRNN patients and evaluated its clinical efficacy.Methods:Clinical data of 72 PRNN patients who underwent radical endoscopic necrectomy,followed by reconstruc-tion using a posterior pedicle nasal septum and floor mucoperiosteum flap were analyzed to determine the efficacy of this surgery.The endpoints were complete re-epithelialization of the nasopharyngeal defect,relief of headache,and overall survival(OS).Results:All surgeries were successfully performed without any severe postoperative complications or death.The median value of numeric rating scales of pain decreased from 8 before surgery to 0 after surgery(P<0.001).Fifty-one patients(70.8%)achieved complete re-epithelialization of the nasopharyngeal defect.The number of cycles of radiotherapy(odds ratio[OR],7.254;95%confidence interval[CI]1.035-50.821;P=0.046),postoperative pathological result(OR,34.087;95%CI 3.168-366.746;P=0.004),and survival status of flap(OR,261.179;95%CI 17.176-3971.599;P<0.001)were independent risk factors of re-epithelialization of the nasopharyngeal defects.Postoperative patho-logical result(hazard ratio[HR],5.018;95%CI 1.970-12.782;P=0.001)was an independent prognostic factor for OS.The 2-year OS rate of the entire cohort was 77.9%.Conclusion:Curative-intent endoscopic necrectomy followed by construction using the posterior pedicle nasal septum and floor mucoperiosteum flap is a novel,safe,and effective treatment of PRNN in patients with NPC. | Xiong Zou Shun-Lan Wang You-Ping Liu Yan-Ling Liu Ru-Hai Zou Yi-Nuan Zhang Rui You Qi Yang Yu-Long Xie Mei Lin Pei-Yu Huang Rou Jiang Meng-Xia Zhang Chao-Nan Qian Hai-Qiang Mai Ling Guo Ming-Huang Hong Ming-Yuan Chen | 2018 | Cancer Communications2018，38，1： | 11 |
| 6 | Preparation of highly conductive graphene-coated glass fibers by sol-gel and dip-coating method显示文摘In order to fabricate highly-conductive glass fibers using graphene as multi-functional coatings, we reported the preparation of graphene-coated glass fibers with high electrical conductivity through solgel and dip-coating technique in a simple way. Graphene oxide (GO) was partially reduced to graphene hydrosol, and then glass fibers were dipped and coated with the reduced GO (rGO). After repeated solgel and dip-coating treatment, the glass fibers were fully covered with rGO coatings, and consequently exhibited increased hydrophobicity and high electrical conductivity. The graphene-coated fibers exhibited good electrical conductivity of 24.9 S/cm, being higher than that of other nanocarbon-coated fibers and commercial carbon fibers, which is mainly attributed to the high intrinsic electrical conductivity of rGO and full coverage of fiber surfaces. The wettability and electrical conductivity of the coated fibers strongly depended on the dip-coating times and coating thickness, which is closely associated with coverage degree and compact structure of the graphene coatings. By virtue of high conductivity and easy operation, the graphene-coated glass fibers have great potential to be used as flexible conductive wires, highly-sensitive sensors, and multi-functional fibers in many fields. | Minghe Fang Xuhai Xiong Yabin Hao Tengxin Zhang Han Wang Hui-Ming Cheng You Zeng | 2019 | Journal of Materials Science & Technology2019，35，9： | 8 |
| 7 | Upregulation of Mark3 and Rpgripl mRNA expression by jujuboside A in mouse hippocampus显示文摘瞄准:在 hippocampus.Methods 在 modulating geneexpression 上调查 jujuboside A (JuA ) 的效果:老鼠的自发的活动被监视,并且 thedifferential 显示聚合酶链反应被改编在老鼠 hippocampus.Results 由 JuA 屏蔽表示差别的 genesmodulated:JuA 显著地减少了全部的 activityintensity (P > 0.01 对控制) 在 80 mg/kg,和基因 MAP/microtubuleaffinity-regulating kinase3 (Mark3 ) 和视网膜炎 pigmentosa GTPase 的剂量,管理者交往 proteinl (Rpgripl )是由在鼠标 hippocampus.Conclusion 的 JuA 的 upregulated :JuA 有禁止的 effecton 老鼠的自发的活动,和 JuA 调整了 Mark3 和 Rpgrip1 inthe 老鼠马头鱼尾的怪兽的抄写。 | Cheng WANG Zi-li YOU Qing XIA Tao XIONG Yang XIA De-zhong YAO | 2007 | Acta Pharmacologica Sinica2007，28，3： | 8 |
| 8 | A novel deletion mutation, c.1296delT in the BCOR gene, is associated with oculo-facio-cardio-dental syndrome显示文摘The purpose of the present study was to analyze the clinical phenotypes of a girl with oculo-facio-cardio-dental(OFCD)syndrome and to identify the potential pathogenic mutation responsible for her disease. The patient underwent detailed clinical examinations and phenotype data were collected over a follow-up period of 9 years. Mutation analysis of the candidate gene BCOR was performed with polymerase chain reaction and Sanger sequencing. BCOR of 60 unrelated normal individuals were also sequenced as a control group. Clinical phenotyping and follow-up study results indicate that this patient had multiple system anomalies including ocular, facial, cardiac, dental, and limb malformations. In addition, papilloma of the choroid plexus was identified, which represents the first report of this phenotype in an OFCD patient. A novel deletion mutation, c.1296 delT in exon4 of the BCOR gene, was identified in this patient and was not found in her parents or in 60 normal unrelated individuals. This deletion was a frameshift mutation and is proposed to encode a premature stop codon, thus producing a truncated protein. Our patient fitted the diagnostic criteria for OFCD syndrome and we report the first papilloma of the choroid plexus in an OFCD patient, expanding the recognized phenotypic spectrum of this disease. Meanwhile, we identified a novel deletion mutation that may cause OFCD syndrome. | Jingshang Zhang Hongyan Jia Jinda Wang Ying Xiong Jing Li Xiaoxia Li Jing Zhao Xiaohui Zhang Qisheng You Guyu Zhu Frank F.Tsai Mark Espina Xiuhua Wan | 2019 | Science China(Life Sciences)2019，62，1： | 6 |
| 9 | Encapsulating metal organic framework into hollow mesoporous carbon sphere as efficient oxygen bifunctional electrocatalyst显示文摘Applying metal organic frameworks(MOFs) in electrochemical systems is a currently emerging field owing to the rich metal nodes and highly specific surface area of MOFs. However, the problems for MOFs that need to be solved urgently are poor electrical conductivity and low ion transport. Here we present a facile in situ growth method for the rational synthesis of MOFs@hollow mesoporous carbon spheres(HMCS)yolk–shell-structured hybrid material for the first time. The size of the encapsulated Zeolitic Imidazolate Framework-67(ZIF-67) is well controlled to 100 nm due to the spatial confinement effect of HMCS, and the electrical conductivity of ZIF-67 is also increased significantly. The ZIF@HMCS-25% hybrid material obtained exhibits a highly efficient oxygen reduction reaction activity with 0.823 V(vs. reversible hydrogen electrode) half-wave potential and an even higher kinetic current density(JK= 13.8 m A cm-2) than commercial Pt/C. ZIF@HMCS-25% also displays excellent oxygen evolution reaction performance and the overpotential of ZIF@HMCS-25% at 10 m A cm-2 is 407 m V. In addition, ZIF@HMCS-25% is further employed as an air electrode for a rechargeable Zn–air battery, exhibiting a high power density(120.2 m W cm-2 at 171.4 m A cm-2) and long-term charge/discharge stability(80 h at 5 m A cm-2). This MOFs@HMCS yolk–shell design provides a versatile method for the application of MOFs as electrocatalysts directly. | Wanfeng Xiong Hongfang Li Hanhui You Minna Cao Rong Cao | 2020 | National Science Review2020，7，3： | 6 |
| 10 | Reservoir Characteristics and Genetic Mechanisms of the Mesozoic Granite Buried Hills in the Deep-water of the Qiongdongnan Basin,Northern South China Sea显示文摘Due to its structure,rock and mineral composition,fluid and other factors,the granite Buried Hill Reservoir is highly heterogeneous with a complex longitudinal structure and a reservoir space made up of a combination of dissolution pores and fractures.This paper is based on current understanding of tectonic evolution in the northern part of the South China Sea,in conjunction with the seismic phase characteristics.It is determined that the meshed fault system was formed by three stages of movement-tectonic compression orogeny during the Indochinese epoch,strike-slip compression-tension during the Yanshanian Period,early fracture extension activation during the Himalayan-which controlled the distribution of the Buried Hill Reservoir.Drilling revealed two types of buried hills,faulted anticline and fault horst,their longitudinal structure and the reservoir space type being significantly different.The mineral composition,reservoir space and diagenetic characteristics of the reservoir rocks and minerals were analyzed by lithogeochemistry,micro section and logging etc.,it thus being determined that the Mesozoic rocks of the Songnan Low Uplift in the Qiongdongnan Basin are mainly composed of syenogranite,granodiorite,monzogranite,which is the material basis for the development of the Buried Hill Reservoir.The content of felsic and other brittle minerals is more than 70%,making it easy for it to be transformed into fractures.At the same time,the weathering resistance of granodiorite and monzogranite is weaker than that of syenogranite,which is easily weathered and destroyed,forming a thick sand gravel weathering zone.With increasing depth of burial,weathering and dissolution gradually weaken,the deep acidic fluid improving the reservoir property of internal fractures and expanding the vertical distribution range of the reservoirs.The research results lay a foundation for the exploration of Buried Hill in the deep-water area of the Qiongdongnan Basin. | YOU Li XU Shouli MAO Xuelian ZHONG Jia JIAO Yaoqi XIONG Xiaofeng | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 5 |
| 11 | Prognostic value of lymphovascular invasion in Bismuth-Corlette type Ⅳ hilar cholangiocarcinoma显示文摘AIM To assess the prognostic value of lymphovascular invasion(LVI)in Bismuth-Corlette typeⅣhilar cholangiocarcinoma(HC)patients. METHODS A retrospective analysis was performed on 142consecutively recruited typeⅣHC patients undergoing radical resection with at least 5 years of followup.Survival analysis was performed by the KaplanMeier method,and the association between the clinicopathologic variables and survival was evaluated by log-rank test.Multivariate analysis was adopted to identify the independent prognostic factors for overall survival(OS)and disease-free survival(DFS).Multiple logistic regression analysis was performed to determine the association between LVI and potential variables. RESULTS LVI was confirmed histopathologically in 29(20.4%)patients.Multivariate analysis showed that positive resection margin(HR=6.255,95%CI:3.485-11.229,P<0.001),N1 stage(HR=2.902,95%CI:1.132-7.439,P=0.027),tumor size>30 mm(HR=1.942,95%CI:1.176-3.209,P=0.010)and LVI positivity(HR=2.799,95%CI:1.588-4.935,P<0.001)were adverse prognostic factors for DFS.The independent risk factors for OS were positive resection margin(HR=6.776,95%CI:3.988-11.479,P<0.001),N1 stage(HR=2.827,95%CI:1.243-6.429,P=0.013),tumor size>30 mm(HR=1.739,95%CI:1.101-2.745,P=0.018)and LVI positivity(HR=2.908,95%CI:1.712-4.938,P<0.001).LVI was associated with N1 stage and tumor size>30 mm.Multiple logistic regression analysis indicated that N1 stage(HR=3.312,95%CI:1.338-8.198,P=0.026)and tumor size>30 mm(HR=3.258,95%CI:1.288-8.236,P=0.013)were associated with LVI. CONCLUSION LVI is associated with N1 stage and tumor size>30mm and adversely influences DFS and OS in typeⅣHC patients. | Bei Li Xian-Ze Xiong Yong Zhou Si-Jia Wu Zhen You Jiong Lu Nan-Sheng Cheng | 2017 | World Journal of Gastroenterology2017，23，36： | 5 |
| 12 | Intrauterine growth restriction alters growth performance, plasma hormones,and small intestinal microbial communities in growing-finishing pigs显示文摘Background: The interaction of the gut microbiota with key metabolic and physiological processes may be associated with poor growth outcomes in animals born with intrauterine growth restriction(IUGR).Results: Growth performance, plasma hormone concentrations, and intestinal microbiota composition were analyzed in IUGR pigs and in normal birth weight(NBW) pigs when the NBW pigs reached 25, 50, and 100 kg of body weight(BW). Compared to NBW pigs, IUGR pigs had lower initial, weaned, and final BW, and lower average daily gain and average daily feed intake in all the considered time points. In the 25 kg BW group, IUGR pigs had higher concentrations of plasma ghrelin and pancreatic polypeptide(PP), but lower insulin concentration than NBW pigs, while the situation was reversed in the 50 kg BW group. As compared to NBW pigs, IUGR pigs had higher microbial alpha diversity in the jejunum and ileum;in the 50 and 100 kg BW groups, IUGR pigs had higher Firmicutes abundance but lower Proteobacteria abundance in the jejunum, and lower Lactobacillus abundance in the jejunum and ileum;in the 25 kg BW group, IUGR pigs showed higher unclassified Ruminococcaceae abundance in the ileum;and in 25 and 50 kg BW groups, IUGR pigs showed lower Ochrobactrum abundance in the jejunum.Spearman's correlation revealed that Lactobacillus was negatively correlated with growth performance, while unclassified Ruminococcaceae was positively correlated. Predictive metagenomic analysis detected significantly different expression of genes in the intestinal microbiota between IUGR and NBW pigs, suggesting different metabolic capabilities between the two groups.Conclusions: Growing-finishing IUGR pigs showed lower growth performance, higher microbial alpha diversity, and differences in plasma hormone concentrations compared to NBW pigs. Alterations in the abundance of Firmicutes,Proteobacteria, Ruminococcaceae, Lactobacillus, and Ochrobactrum in the small intestine may be associated with IUGR, and may therefore serve as a future target for gut microbiota intervention in growing-finishing IUGR pigs. | Liang Xiong Jinming You Wanghong Zhang Qian Zhu Francois Blachier Yulong Yin Xiangfeng Kong | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 5 |
| 13 | Anti-BCMA CAR T-cell therapy CT103A in relapsed or refractory AQP4-IgG seropositive neuromyelitis optica spectrum disorders:phase 1 trial interim results显示文摘Chimeric antigen receptor(CAR)T-cell therapy that targets B-cell maturation antigen(BCMA)have great potentials in autoimmune diseases and could be novel therapeutics for relapsed/refractory neuromyelitis optica spectrum disorder(NMOSD).To evaluate the safety and efficacy of the CT103A,a self-developed BCMA-targeting CAR construct against BCMA,in patients with AQP4-IgG seropositive NMOSD,an ongoing,investigator-initiated,open-label,single-arm,phase 1 clinical trial is conducted at our center.In total,12 patients were administered with a CAR-BCMA infusion.Ten of the 12 patients dosed were women(83.3%),with a median age of 49.5 years(range,30-67).were The most common events of grade 3 or higher were hematologic toxic effects.Seven patients(58%)developed infections,but no grade 4 infections occurred.Cytokine release syndrome was reported in all patients with only events of grade 1 or 2 observed.During the follow-up of a median 5.5 months,11 patients had no relapse;all patients generally reported improvement in disabilities and quality-of-life outcomes;11 patients’AQP-4 antibodies in serum showed a downward trend by the cutoff date.CAR T-cell expansion was associated with responses,and persisted more than 6 months post-infusion in 17%of the patients.In summary,CAR T-cell therapy shows a manageable safety profile and therapeutic potentials for patients with relapsed/refractory AQP4-IgG seropositive NMOSD.Another expansion phase is currently underway to determine the safety and efficacy of CAR T-BCMA infusion in patients with other neuro-inflammatory diseases. | Chuan Qin Dai-Shi Tian Luo-Qi Zhou Ke Shang Liang Huang Ming-Hao Dong Yun-Fan You Jun Xiao Ying Xiong Wen Wang Hao Pang Jing-Jing Guo Song-Bai Cai Di Wang Chun-Rui Li Min Zhang Bi-Tao Bu Wei Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 4 |
| 14 | Protectin DX Exhibits Protective Effects in Mouse Model of Lipopolysaccharide-Induced Acute Lung Injury显示文摘 | Wen Tan Lin Chen Ya-Xin Wang Li-Sha HU Wei Xiong You Shang Shang-Long Yao | 2018 | Chinese Medical Journal2018，，10： | 4 |
| 15 | Genome-Wide Identification of Zn_(2)Cys_(6 ) Class Fungal-Specific Transcription Factors(ZnFTFs)and Functional Analysis of UvZnFTFI in Ustilaginoidea virens显示文摘Transcription factors(TFs)orchestrate the regulation of cellular gene expression and thereby determine cell functionality.In this study,we analyzed the distribution of TFs containing domains,which named as ZnFTFs,both in ascomycete and basidiomycete fungi.We found that ZnFTFs were widely distributed in these fungal species,but there was more expansion of the ZnFTF class in Ascomycota than Basidiomycota.We identified 40 ZnFTFs in Ustilaginoidea virens,and demonstrated the involvement of UvZnFTF1 in vegetative growth,conidiation,pigment biosynthesis and pathogenicity.RNA-Seq analysis suggested that UvZnFTF1 may regulate different nutrient metabolism pathways,the production of secondary metabolites,and the expression of pathogen-host interaction genes and secreted protein-encodi ng genes.Analysis of the distributi on of differe nt fungal TFs in U.virens further dem on strated that UvZnFTFs make up a large TF family and may play essential biological roles in U.virens. | SONG Tianqiao ZHANG Xiong ZHANG You LIANG Dong YAN Jiaoling YU Junjie YU Mina CAO Huijuan YONG Mingli PAN Xiayan QI Zhongqiang DU Yan ZHANG Rongsheng LIU Yongfeng | 2021 | Rice science2021，28，6： | 4 |
| 16 | Elucidating the various multi-phosphorylation statuses of protein functional regions by 193-nm ultraviolet photodissociation显示文摘Ultraviolet photodissociation is a high-energy fast excitation method in mass spectrometry and has been successfully applied for the elucidation of sequences and structures of biomolecules. However, its ability to distinguish the phosphorylation sites isomers of multi-phosphopeptides has been not systematically investigated until now. A 193-nm ultraviolet laser dissociation mass spectrometry system was established in this study and applied to elucidate the complex multi-phosphorylation statuses mimicking the functional regions of Sic1, Gli3 and Tau. The numbers of matched fragment ions and phosphorylation site-determining ions were improved on average 123% and 104%, respectively, by utilizing the ultraviolet photodissociation strategy, comparing to the typically utilized collision induced dissociation strategy.Finally, 94% phosphorylation sites within various statuses were unambiguously elucidated. | Zheyi Liu You Jiang Chunlei Xiao Xingchuang Xiong Tao Wang Jinan Li Fangjun Wang Xiang Fang Xueming Yang | 2018 | Chinese Chemical Letters2018，29，5： | 3 |
| 17 | Effectiveness Analysis on the Physical Activity and the Health Benefit of a Community Population Based Program显示文摘Objective To evaluate the community-based health promotion effect of physical activity. Methods The residents aged 18 and above from two communities in Gongshu District of Hangzhou City, Zhejiang province, were randomly selected and recruited for the multi-strategy and comprehensive physical activity intervention. Questionnaire survey, physical check up and blood biochemistry were conducted. Results After this two-year intervention, the time of the participant spent on weekly physical activity of moderate intensity increased from 464 min to 542 min (P<0.05), with an average increase of 78 min. Time spent in walking every week increased from 533 min to 678 min (P<0.05), with an average increase of 145 min. The body weight, waistline, blood pressure and heart rate all reduced significantly (P<0.05); the vital capacity increased significantly (P<0.05); and the related biochemical indicators were also improved. Conclusion Comprehensive and evidence-based physical activity interventions targeting community population can improve the levels of physical activity, related body measurement and biochemical indicators. | JIANG Ying Ying YANG Zheng Xiong NI Rong ZHU You Qun LI Zhi Yu YANG Li Chen ZHAI Yi ZHAO Wen Hua | 2013 | Biomedical and Environmental Sciences2013，26，6： | 3 |
| 18 | Design of Pd{111}-TiO_2 interface for enhanced catalytic efficiency towards formic acid decomposition显示文摘Supports are commonly implemented in the industrial application of heterogeneous catalysts to improve the stability and recyclability of catalysts.The supported catalysts often show the enhanced activity and selectivity in various catalytic reactions.However,the specific contributions of electronic and steric effects to a catalytic system often remain elusive due to the lack of well-defined model systems.In this work,two types of uniform Pd nanocrystals covered by{111}facets in tetrahedral and octahedral shapes,respectively,are synthesized with identical chemical environment and loaded on Ti O_2supports to form hybrid structures(Pd{111}-Ti O_2)towards the application of formic acid decomposition.Our observation suggests that the polarization effect at the interface of Pd-Ti O_2enhances its activity in formic acid decomposition.Moreover,the Pd tetrahedrons-Ti O_2hybrid structure whose Pd{111}-Ti O_2interface possesses a larger angle shows higher catalytic activity,owing to the reduced steric effect as compared to Pd octahedrons-Ti O_2.This study reveals the nature of interface effects in formic acid decomposition,and provides a guidance for the related catalyst design. | Yang You Hao Huang Song Xia Zijian Cai Panyiming Liu Chengming Wang Ran Long Li Song Yujie Xiong | 2018 | Science China Chemistry2018，61，9： | 2 |
| 19 | Perovskite-type B-site Bi-doped ceramic membranes for oxygen separation显示文摘Novel mixed conducting oxides, B-site Bi-doped perovskites were exploited and synthesized. Cubic perovskite structures were formed for BaBi0.2COyFe0.8-yO3-δ (y≤0.4) and BaBixCo0.2Fe0.8-xO3-δ (x=0.1 -0.5). The materials exhibited considerable high oxygen permeability at high temperature. The oxygen permeation flux of BaBi0.2Co0.35Fe0.45O3-δmembrane reached about0.77×106 mol/cm2 ·s under an air/helium oxygen partial pressure gradient at 900 ℃, which was much higher than that of other bismuth-contained mixed conducting membranes. The permeation fluxes of the materials increased with the increase of cobalt content, but no apparent simple relationship was found with the bismuth content. The materials also demonstrated excellent reversibility of oxygen adsorption and desorption. Stable time-related oxygen permeation fluxes were found for BaBi0.2Co0. | Zongping Shao You Cong Guoxing Xiong Shishan Sheng Weishen Yang | 2000 | Chinese Science Bulletin2000，45，10： | 2 |
| 20 | Histological examination of frozen sections for patients with acute cholecystitis during cholecystectomy显示文摘BACKGROUND:Unexpected gallbladder cancer may present with acute cholecystitis-like manifestations.Some authors recommended that frozen section analysis should be performed during laparoscopic cholecystectomy for all cases of acute cholecystitis.Others advocate selective use of frozen section analysis based on gross examination of the specimen by the surgeon.The aim of the present study was to evaluate whether surgeons could effectively identify suspected gallbladder with macroscopic examination alone.If not,is routine frozen section analysis worth advocating?METHODS:A total of 1162 patients with acute cholecystitis who had undergone simple cholecystectomy in our hospital from February 2009 to February 2014 were enrolled in the study.The data of patients with acute cholecystitis especially those with concurrent gallbladder cancer in terms of clinical characteristics,operative records,frozen section diagnosis and histopathology reports were analyzed.RESULTS:Thirteen patients with acute cholecystitis were found to have concurrent gallbladder cancer,with an incidence of 1.1%in acute cholecystitis.Forty patients with acute cholecystitis were suspected to have gallbladder cancer by macroscopic examination and specimens were taken for frozen section analysis.Six patients with gallbladder cancer were correctly identified by macroscopic examination alone but 7patients with gallbladder cancer missed,including 3 patients with advanced cancer(2 T3 and 1 T2).Meanwhile,in 6 gallbladder cancer specimens sent for frozen section analysis,3 early gallbladder cancers(2 Tis and 1 T1a)were missed by frozen section analysis.However,the remaining 3 patients with advanced gallbladder cancers(2 T3 and 1 T2)were correctly diagnosed.CONCLUSIONS:The incidence of comorbidity of gallbladder cancer and acute cholecystitis is higher than that of non-acute cholecystitis.The accurate diagnosis of gallbladder cancer by surgeons is poor and frozen section analysis is necessary. | Zhen You Wen-Jie Ma Yi-Lei Deng Xian-Ze Xiong Anuj Shrestha Fu-Yu Li Nan-Sheng Cheng | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，3： | 2 |
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