4篇
您的检索式：作者名="Xiping Pan"
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| 1 | Erucic acid from Isatis indigotica Fort. suppresses influenza A virus replication and inflammation in vitro and in vivo through modulation of NF-kB and p38 MAPK pathway显示文摘Isatis indigotica Fort.(Ban-Lan-Gen)is an herbal medicine prescribed for influenza treatment.However,its active components and mode of action remain mostly unknown.In the present study,erucic acid was isolated from Isatis indigotica Fort.,and subsequently its underlying mechanism against influenza A virus(IAV)infection was investigated in vitro and in vivo.Our results demonstrated that erucic acid exhibited broad-spectrum antiviral activity against IAV resulting from reduction of viral polymerase transcription activity.Erucic acid was found to exert inhibitory effects on IAV or viral(v)RNA-induced pro-inflam-matory mediators as well as interferons(IFNs).The molecular mechanism by which erucic acid with antiviral and anti-inflammatory properties was attributed to inactivation of NF-kB and p38 MAPK signaling.Furthermore,the NF-kB and p38 MAPK inhibitory effect of erucic acid led to diminishing the transcriptional activity of interferon-stimulated gene factor 3(ISGF-3),and thereby reducing IAV-triggered pro-inflammatory response amplification in IFN-β-sensitized cells.Additionally,IAV-or vRNA-triggered apoptosis of alveolar epithelial A549 cells was prevented by erucic acid.In vivo,erucic acid administration consistently displayed decreased lung viral load and viral antigens expression.Meanwhile,erucic acid markedly reduced CD8+cytotoxic T lymphocyte(CTL)recruitment,pro-apoptotic signaling,hyperactivity of multiple signaling pathways,and exacerbated immune inflammation in the lung,which resulted in decreased lung injury and mortality in mice with a mouse-adapted A/FM/1/47-MA(H1N1)strain infection.Our findings provided a mechanistic basis for the action of erucic acid against IAV-mediated inflammation and injury,suggesting that erucic acid may have a therapeutic potential in the treatment of influenza. | Xiaoli Liang Yuan Huang Xiping Pan Yanbing Hao Xiaowei Chen Haiming Jiang Jing Li Beixian Zhou Zifeng Yang | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 10 |
| 2 | A wideband combined transducer for measuring system in sound tube显示文摘为健全试管系统的一个宽带变换器被介绍,它联合纵的变换器和类 IV flextensional 变换器在低频率改进性能并且拓宽工作乐队。相等的电路被获得并且过去常分析在纵的变换器和 flextensional 变换器之间的联合机制。变换器的一个原型在由有限元素方法优化电声的表演以后被开发。在这个变换器刺激的健全试管的站的波浪被学习了,二件声学的材料样品的健全吸收系数用这个健全试管被测量,它证明变换器能满足声学的材料测量的要求,工作乐队从 1.4 kHz 到 23 kHz。 | PAN Yaozong MO Xiping LIU Yongping CUI Zheng ZHANG Tonggen | 2012 | Chinese Journal of Acoustics2012，31，2： | 9 |
| 3 | Broadband transducer with tube-beam coupling structure显示文摘 | CHAI Yong MO Xiping LIU Yongping PAN Yaozong ZHANG Yunqiang LI Peng | 2018 | Chinese Journal of Acoustics2018，37，2： | 2 |
| 4 | Constrained layer damping treatment of a model support sting显示文摘In transonic wind tunnel tests,the pulsating airflow is prone to induce the first order resonance of the sting support system.The resonance limits the wind tunnel test envelope,makes the test data inaccurate,and brings potential security risks.In this paper,a model support sting with constrained layer damping(CLD)treatment is proposed to reduce the first order resonance response.The CLD treatment mainly consists of material selection and geometric optimization processes.The damping performance of the optimized CLD sting is compared with an AISI 1045 steel sting with the identical diameter in laboratory.The frequency response curves of the CLD sting support system and the AISI 1045 steel sting support system are obtained by sine sweep tests.The test results show that the first order resonance response of the CLD sting support system is 37.3%of that of the AISI 1045 steel sting support system.The first order damping ratios are calculated from the frequency response curves by half power point method.It is found that the first order damping ratio of the CLD sting support system is approximately 2.6 times that of the AISI 1045 steel sting support system. | Jiahao PAN Zhanqiang LIU Xiping KOU Qinghua SONG | 2021 | Chinese Journal of Aeronautics2021，34，8： | 2 |
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