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| 1 | Molecular mechanisms of diabetic coronary dysfunction due to large conductance Ca2+-activated K+ channel impairment显示文摘 | WANG Ru-xing SHI Hai-feng CHAI Qiang WU Ying SUN Wei JI Yuan YAO Yong LI Ku-lin ZHANG Chang-ying ZHENG Jie GUO Su-xia LI Xiao-rong LU Tong | 2012 | Chinese Medical Journal2012，，14： | 21 |
| 2 | 江西省农村居民肠道寄生虫感染调查及蛔虫生物流行病学研究显示文摘目的 探讨江西农村居民肠道寄生虫感染现状及蛔虫病生物流行病学特点。 方法 采用粪检、化疗驱虫后收集虫体等方法对江西进贤县鹿塘试区 6 2 5名居民进行了研究。 结果 该试区居民感染 9种肠道寄生虫 ,总感染率为 72 .80 % ,其中蛔虫、钩虫、鞭虫卵的阳性率分别为 5 1.5 2 %、11.80 %和 34 .6 0 %。以噻嘧啶对全体居民治疗后 ,在 5 9.40 %的居民中检获蛔虫 ,感染者平均虫荷为 2 .97条 (范围 1~ 32条 ) ,10 .0 0 %的排虫者可见未成熟蛔虫 ,推算人群每月蛔虫再感染率为 5 .13%。对粪检虫卵假阴性人群的分析显示 ,仅有单性蛔虫寄生者 (单雄或单雌 )占 82 .93% ,有 1条未成熟雌虫和 1~4条雄虫寄生者占 17.0 3%。粪检虫卵假阴性率随着寄生蛔虫数的增加而减少 ,当感染 6条以上蛔虫时 ,无假阴性出现。 结论 该社区人群肠道寄生虫感染率高 ,蛔虫再感染严重 ,有必要进行反复治疗以巩固防治效果 ;由于单性感染或未成熟蛔虫的缘故 ,居民实际蛔虫感染率要高于 Kato- | 曾小军 陈红根 姜唯声 Jong-Y il Chai Tai-Soon Yong 胡自耕 衣方誉 谢峰 尹东 谢曙英 | 2001 | 中国寄生虫病防治杂志2001，14，4： | 20 |
| 3 | Self-assembly of nitrogen-doped TiO2 with exposed {001} facets on a graphene scaffold as photo-active hybrid nanostructures for reduction of carbon dioxide to methane显示文摘明确的锐钛矿 TiO 的定制的合成 < 潜水艇 class= “ a-plus-plus ” > 2 -based 晶体与暴露 { 001 } 方面刺激了由于他们的科学、工艺的重要性世界范围的连续研究兴趣。此处,锐钛矿做氮的 TiO <潜水艇class=“ a-plus-plus ”> 2 ( N-TiO <潜水艇class=“ a-plus-plus ”> 2 ) nanoparticles 与暴露{ 001 }方面在 graphene ( GR )上扔了表( N-TiO <潜水艇class=“ a-plus-plus ”> 2 -001/GR)第一次被综合经由一步舞 solvothermal 用 NH 的合成线路<潜水艇class=“ a-plus-plus ”> 4 F 作为控制形态学的代理人。试验性的结果例示那 GR 一致地被锐钛矿 N-TiO 盖住 < 潜水艇 class= “ a-plus-plus ” > 2 nanoparticles (1017 nm ) ,暴露 { 001 } 方面。百分比暴露 { 001 } 在 N-TiO 的方面 < 潜水艇 class= “ a-plus-plus ” > 2 -001/GR nanocomposites 被计算是 ca。35% 。另外,在吸收边的红移动和在可见轻范围的强壮的吸收由于 Ti-O-C 契约的形成被观察,导致从 3.23 ~ 2.9 eV 的乐队差距的成功的变窄。同样准备的光催化剂的 photocatalytic 活动为公司被评估<潜水艇class=“ a-plus-plus ”>生产 CH 的 2 减小<潜水艇class=“ a-plus-plus ”> 4 面对在周围的温度和气压用下面的水蒸汽一低力量 15 W 节省精力的日光灯作为可见到最通常采用的高力量的氙 lampswhich 的轻 sourcein 对比经济地并且实际上显示了这个过程可行。在所有学习光催化剂之中, N-TiO < 潜水艇 class= “ a-plus-plus ” > 2 -001/GR nanocomposites 展出了最大的 CH < 潜水艇 class= “ a-plus-plus ” > 3.70 摩尔的 4 产量?? | Wee-Jun Ong Lling-Lling Tan Siang-Piao Chai Siek-Ting Yong Abdul Rahman Mohamed | 2014 | Nano Research2014，7，10： | 16 |
| 4 | Metabolic engineering and flux analysis of Corynebacterium glutamicum for L-serine production显示文摘L-Serine plays a critical role as a building block for cell growth, and thus it is difficult to achieve the direct fermentation of L-serine from glucose. In this study, Corynebacterium glutamicum ATCC 13032 was engineered de novo by blocking and attenuating the conversion of L-serine to pyruvate and glycine, releasing the feedback inhibition by L-serine to 3-phosphoglycerate dehydrogenase (PGDH), in combination with the co-expression of 3-phosphoglycerate kinase (PGK) and feedback-resistant PGDH (PGDHr). The resulting strain, SER-8, exhibited a lower specific growth rate and significant differences in L-serine levels from Phase I to Phase V as determined for fed-batch fermentation. The intracellular L-serine pool reached (14.22±1.41) μmol gCDM 1, which was higher than glycine pool, contrary to fermentation with the wild-type strain. Furthermore, metabolic flux analysis demonstrated that the over-expression of PGK directed the flux of the pentose phosphate pathway (PPP) towards the glycolysis pathway (EMP), and the expression of PGDHr improved the L-serine biosynthesis pathway. In addition, the flux from L-serine to glycine dropped by 24%, indicating that the deletion of the activator GlyR resulted in down-regulation of serine hydroxymethyltransferase (SHMT) expression. Taken together, our findings imply that L-serine pool management is fundamental for sustaining the viability of C. glutamicum, and improvement of C1 units generation by introducing the glycine cleavage system (GCV) to degrade the excessive glycine is a promising target for L-serine production in C. glutamicum. | LAI ShuJuan ZHANG Yun LIU ShuWen LIANG Yong SHANG XiuLing CHAI Xin WEN TingYi | 2012 | Science China(Life Sciences)2012，55，4： | 15 |
| 5 | Simulation research on a minimum root-mean-square error rotation-fitting algorithm for gravity matching navigation显示文摘Gravity/inertial combination navigation is a leading issue in realizing passive navigation onboard a submarine. A new rotation-fitting gravity matching algorithm, based on the Terrain Contour Matching (TERCOM) algorithm, is proposed in this paper. The algorithm is based on the principle of least mean-square-error criterion, and searches for a certain matched trajectory that runs parallel to a trace indicated by an inertial navigation system on a gravity base map. A rotation is then made clockwise or counterclockwise through a certain angle around the matched trajectory to look for an optimal matched trajectory within a certain angle span range, and through weighted fitting with another eight suboptimal matched trajectories, the endpoint of the fitted trajectory is considered the optimal matched position. In analysis of the algorithm reliability and matching error, the results from simulation indicate that the optimal position can be obtained effectively in real time, and the positioning accuracy improves by 35% and up to 1.05 nautical miles using the proposed algorithm compared with using the widely employed TERCOM and SITAN methods. Current gravity-aided navigation can benefit from implementation of this new algorithm in terms of better reliability and positioning accuracy. | WANG HuBiao WANG Yong FANG Jian CHAI Hua ZHENG Hui | 2012 | Science China Earth Sciences2012，55，1： | 12 |
| 6 | Chemical investigation of the roots of Polygala sibirica L.显示文摘AIM:To investigate the chemical constituents of the roots of Polygala sibirica L.(Polygalaceae) METHOD:The isolation was performed by solvent extraction and various chromatographic techniques,including silica gel,Sephadex LH-20,ODS,semi-preparative HPLC,and preparative TLC.The chemical structures were elucidated based on extensive spectroscopic analysis,including HR-ESI-MS and 1D- and 2D-NMR spectroscopic data.RESULTS:A total of sixteen compounds,including five xanthones(5,7–10),five saccharide esters(1,3,4,12,13),two flavonoids(14,16),two triterpenoids(11,15),one phenylpropanoid(6),and one benzophenone glycoside(2) were isolated.Their structures were determined as sibiricose A7(1),sibiriphenone A(2),polygalatenoside A(3),polygalatenoside C(4),lancerin(5),3,4,5-trimethoxycinnamic acid(6),6-hydroxy-1,2,3,7-tetramethoxyxanthone(7),1,3,7-trihydroxy-2-methoxyxanthone(8),onjixanthone II(9),1,2,3,6,7-pentamethoxyxanthone(10),presenegenin(11),3'-O-3,4,5-trimethoxycinnamoyl-6-O-4-methoxy benzoyl sucrose(12),tenuifoliside C(13),5,3'-dihydroxy-7,4'-dimethoxyflavonol-3-O-β-D-glucopyranoside(14),tenuifolin(15),and rhamnetin 3-O-β-D-glucopyranoside(16).CONCLUSION:Compounds 1 and 2 are two new compounds from P.sibirica. | ZHOU Yu-Hong ZHANG Shui-Ying GUO Qiang CHAI Xing-Yun JIANG Yong TU Peng-Fei | 2014 | Chinese Journal of Natural Medicines2014，12，3： | 9 |
| 7 | Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation显示文摘The intracellular pathogen Mycobacterium tuberculosis(Mtb)can survive in the host and cause disease by interfering with a variety of cellular functions.The mammalian cell entry 2(mce2)operon of Mtb has been shown to contribute to tuberculosis pathogenicity.However,little is known about the regulatory roles of Mtb Mce2 family proteins towards host cellular functions.Here we show that the Mce2 family protein Mce2E suppressed the macrophage innate immune response and promoted epithelial cell proliferation.Mce2E inhibited activation of the extracellular signal-regulated kinase(ERK)and Jun N-terminal kinase(JNK)mitogen-activated protein kinase(MAPK)signaling pathways in a non-canonical D motif(a MAPK-docking motif)-dependent manner,leading to reduced expression of TNF and IL-6 in macrophages.Furthermore,Mce2E promoted proliferation of human lung epithelium-derived lung adenoma A549 cells by inhibiting K48-linked polyubiquitination of eEF1A1 in aβstrand region-dependent manner.In summary,Mce2E is a novel multifunctional Mtb virulence factor that regulates host cellular functions in a niche-dependent manner.Our data suggest a potential novel target for TB therapy. | Lihua Qiang Jing Wang Yong Zhang Pupu Ge Qiyao Chai Bingxi Li Yi Shi Lingqiang Zhang George Fu Gao Cui Hua Liu | 2019 | Cellular & Molecular Immunology2019，16，4： | 7 |
| 8 | Combined community ecology and floristics,a synthetic study on the upper montane evergreen broad-leaved forests in Yunnan,southwestern China显示文摘The upper montane evergreen broad-leaved forest in Yunnan occurs mainly in the zone of persistent cloud and has a discontinuous,island-like,distribution.It is diverse,rich in endemic species,and likely to be sensitive to climate change.Six 1-ha sampling plots were established across the main distribution area of the upper montane evergreen broad-leaved forest in Yunnan.All trees with d.b.h.>1 cm in each plot were identified.Patterns of seed plant distributions were quantified at the specific,generic and family levels.The forests are dominated by the families Fagaceae,Lauraceae,Theaceae and Magnoliaceae,but are very diverse with only a few species shared between sites.Floristic similarities at the family and generic level were high,but they were low at the specific level,with species complementarity between plots.Diversity varied greatly among sites,with greater species richness and more rare species in western Yunnan than central Yunnan.The flora is dominated by tropical biogeographical elements,mainly the pantropic and the tropical Asian distributions at the family and genus levels.In contrast,at the species level,the flora is dominated by the southwest or the southeast China distributions,including Yunnan endemics.This suggests that the flora of the upper montane forest in Yunnan could have a tropical floristic origin,and has adapted to cooler temperatures with the uplift of the Himalayas.Due to great sensitivity to climate,high endemism and species complementarity,as well as the discontinuous,island-like,distribution patterns of the upper montane forest in Yunnan,the regional conservation of the forest is especially needed. | Hua Zhu Yong Chai Shisun Zhou Lichun Yan Jipu Shi Guoping Yang | 2016 | Plant Diversity2016，38，6： | 6 |
| 9 | AGC1.5 Kinase Phosphorylates RopGEFs to Control Pollen Tube Growth显示文摘在被子植物的两倍授精通过花粉试管要求无法移动的精子的指向的交货到卵。成长尖端的花粉试管的极性与顶端的血浆膜通过植物(ROP-GTP ) 的活跃 Rho GTPases 的动态协会被维持。为 ROP (RopGEFs ) 的 Guanine 核苷酸交换因素催化 ROP 的激活并且从而影响空间与时间的 ROP 发信号。而 RopGEFs 被发现了是 phosphorylated 蛋白质,为他们的 phosphorylation 在负责的 kinases ? vivo 和在花粉试管生长的 RopGEF phosphorylation 的生物后果仍然保持不清楚。我们这里报导细胞质的 kinases 的 Arabidopsis AGC1.5 亚科在花粉试管生长期间为 ROP-GTP 的限制本地化是批评的。AGC1.5 和 AGC1.7 功能的损失在花粉试管发信号的 ROP 下游地导致了活跃 ROP 和有缺点的事件的错误目标。AGC1.5 在容易的领域的保存重量的单位残余经由他们的催化容易的领域和 phosphorylates RopGEFs 与 RopGEFs 交往。AGC1.5 和 AGC1.7 功能的损失在花粉试管导致了 RopGEFs 的错误目标,类似于由 AGC1.5 显示 RopGEFs non-phosphorylatable 的变化引起的显型。一起,我们的结果在花粉试管的极的生长期间提供机械学的卓见进 ROP 的空间与时间的激活。 | En Li Yong Cui Fu-Rong Ge Sen Chai Wei-Tong Zhang Qiang-Nan Feng Liwen Jiang Sha Li Yan Zhang | 2018 | Molecular Plant2018，11，9： | 5 |
| 10 | A fingerprint feature extraction algorithm based on curvature of Bezier curve显示文摘Fingerprint feature extraction is a key step of fingerprint identification. A novel feature extraction algorithm is proposed in this paper, which describes fingerprint feature with the bending information of fingerprint ridges. Ridges in the specific region of fingerprint images are traced firstly in the algorithm, and then these ridges are fit with Bezier curve. Finally, the point that has the maximal curvature on Bezier curve is defined as a feature point. Experimental results demonstrate that this kind of feature points characterize the bending trend of fingerprint ridges effectively, and they are robust to noise, in addition, the extraction precision of this algorithm is also better than the conventional approaches. | Yuan Huaqiang Ye Yangdong Deng Jianguang Chai Xiaoguang Li Yong | 2007 | Progress in Natural Science:Materials International2007，17，11： | 5 |
| 11 | Role of inhibiting LIM-kinase2 in improving erectile function through suppression of corporal fibrosis in a rat model of cavernous nerve injury显示文摘我们评估了 LIM-kinase 2 禁止者(LIMK2i ) 是否能由通过联系 Rho 的卷卷蛋白质 kinase 的正规化压制肉体的纤维变性改进可勃起的功能 1 (ROCK1 ) 在多孔的神经压碎损害(CNCI ) 的一个老鼠模型的 /LIMK2/Cofilin 小径。六十只 11-week-old 男性 Sprague-Dawley 老鼠同等地被划分成五个组:与低剂量的(L) ,中等剂量的(M) ,和高剂量的(H) LIMK2i 对待的假冒的外科(S) , CNCI (I) ,和 CNCI。L, M,和 H 组与 LIMK2i 的每日的 intraperitoneal 注射被对待(2.5, 5.0,和 10.0 mg kg 1 身体重量,分别地) 为在外科以后的 1 个星期。可勃起的反应手术后地在 1 个星期用 electrostimulation 被估计。阴茎纸巾为 Massons 被处理三色的染色的、双 immunofluorescence,和西方的污点试金。在 H 组的可勃起的回答改善了与相比我组织,当 M 组出现了时仅仅偏爱的改进。显著地减少的光滑的肌肉 / 骨胶原比率和为 phospho-LIMK2 积极的成纤维细胞的一个增加的内容在 I 组被注意。M 和 H 组在组织学的改变和 dysregulated LIMK2/Cofilin 小径揭示了重要改进,除了在 M 组的 LIMK2 phosphorylation。LIMK2 的抑制没影响 ROCK1 蛋白质表示。为在 H 组的 phospho-LIMK2 积极的成纤维细胞的内容回到了在 S 组发现的水平,而它没在 M 组织。然而, L 组没展出如此的改进。我们的数据建议特别地与 10.0 mg kg 1 身体重量 LIMK2i 的管理, LIMK2 的抑制能由使 LIMK2/Cofilin 小径正常化改进肉体的纤维变性和可勃起的功能。 | Juhyun Park Sung Yong Cho Kwanjin Park Ji Sun Chai Hwancheol Son Soo Woong Kim Jae-Seung Paick Min Chul Cho | 2018 | Asian Journal of Andrology2018，20，4： | 4 |
| 12 | A hybrid magnetostrictive-piezoelectric barrel-stave projector显示文摘混合 magnetostrictive 压电的桶狭板投影机被设计并且发展。新类型变换器被稀土元素的巨大的 magnetostrictive 材料 Terfenol-D 和 PZT 的联合驾驶压电陶器。在一种紧缩的尺寸以内联合低频率性能的优点,它证明混合投影机由模仿并且测量的结果与单个 magnetostrictive 或压电的司机比那有一个宽广得多的乐队和更高健全的力量。混合投影机的原型在长度在外面的直径和 316 公里有 88 公里的一种尺寸,与一在水下 1.30 kHz,为 -3 dB 带宽的 1.43 的 Q 因素,和在反响的频率的 135.1 dB 的播送电压反应水平的反响的频率。 | CHAI Yong MO Xiping LIU Yongping CUI Zheng | 2006 | Chinese Journal of Acoustics2006，25，4： | 4 |
| 13 | Characterization of the Hot Deformation Behavior of Cu–Cr–Zr Alloy by Processing Maps显示文摘Hot deformation behavior of the Cu–Cr–Zr alloy was investigated using hot compressive tests in the temperature range of 650–850 °C and strain rate range of 0.001–10 s-1. The constitutive equation of the alloy based on the hyperbolic-sine equation was established to characterize the flow stress as a function of strain rate and deformation temperature. The critical conditions for the occurrence of dynamic recrystallization were determined based on the alloy strain hardening rate curves. Based on the dynamic material model, the processing maps at the strains of 0.3, 0.4 and 0.5were obtained. When the true strain was 0.5, greater power dissipation efficiency was observed at 800–850 °C and under0.001–0.1 s-1, with the peak efficiency of 47%. The evolution of DRX microstructure strongly depends on the deformation temperature and the strain rate. Based on the processing maps and microstructure evolution, the optimal hot working conditions for the Cu–Cr–Zr alloy are in the temperature range of 800–850 °C and the strain rate range of 0.001–0.1 s-1. | Yi Zhang Hui-Li Sun Alex A.Volinsky Bao-Hong Tian Zhe Chai Ping Liu Yong Liu | 2016 | Acta Metallurgica Sinica(English Letters)2016，29，5： | 3 |
| 14 | An efficient and convenient method for preparation of disulfides from thiols using air as oxidant catalyzed by Co-Salophen显示文摘<正>Disulfides have been synthesized by oxidation of thiols using air as oxidant catalyzed by Co-Salophen with high yields,mild and neutral conditions,and easy procedures of the catalyst.The products were confirmed by ~1H NMR and IR. | Pin Ji Chai Yong Shu Li Cheng Xia Tan | 2011 | Chinese Chemical Letters2011，22，12： | 3 |
| 15 | Molecular evolution of hepatitis A virus in a human diploid cell line显示文摘AIM: To investigate the hotspots, direction, and the time course of evolution of hepatitis A virus in the process of consecutive cell culture passage in human KMB17 diploid cells. METHODS: Wild type hepatitis A virus H2w was serially propagated in KMB17 cells until passage 30, and the full-length genomes of H2w and its six chosen progenies were determined by directly sequencing RT-PCR products amplified from viral genomic RNA. Alignment comparison of sequences from H2w with its six progenies and phylogenetic analysis of the whole VP1 region from H2w, progenies of H2w, and other cell culture adapted hepatitis A virus were then carried out to obtain data on the molecular evolution of hepatitis A virus in the process of consecutive passage in KMB17 cells. RESULTS: Most of the mutations occurred by passage 5 and several hotspots related to adaptation of the virus during cell growth were observed. After that stage, few additional mutations occurred through the remaining duration of passage in KMB17 cells except for mutation in the virulence determinants, which occurred in the vicinity of passage 15. The phylogenetic analysis of the whole VP1 region suggested that the progenies of H2w evolved closely to other cell culture adapted hepatitis A virus, i.e. MBB, L-A-1, other than its progenitor H2w. CONCLUSION: Hepatitis A virus served as a useful model for studying molecular evolution of viruses in a given environment. The information obtained in this study may provide assistance in cultivating the next generation of a seed virus for live hepatitis A vaccine production. | Cai-Hua Tang Jiang-Sen Mao Shao-Ai Chai Yong Chen Fang-Cheng Zhuang | 2007 | World Journal of Gastroenterology2007，13，34： | 3 |
| 16 | The Malaysian cataract surgery registry:incidence and risk factors of postoperative infectious endophthalmitis over a 7-year period显示文摘AIM:To report the incidence,risk factors and visual outcomes for postoperative endophthalmitis(POE)based on 7-year data from the Malaysian Ministry of Health Cataract Surgery Registry(MOH CSR).METHODS:Data was collected from the web-based MOH CSR.All consecutive cataract surgery patients from 1st June 2008 to 31st December 2014 were identified.Exclusion criteria were traumatic cataract or previous ocular surgery.Demographic data,ocular co-morbidities,intraoperative details and postoperative visual acuity(VA)at final ophthalmological follow-up were noted.All eyes were taken for analysis.Subjects with POE were compared against subjects with no POE for risk factor assessment using multiple logistic regressions.RESULTS:A total of 163 503 subjects were screened.The incidence of POE was 0.08%(131/163 503).Demographic POE risk factors included male gender(OR:2.121,95%CI:1.464-3.015)and renal disease(OR:2.867,95%CI:1.503-5.467).POE risk increased with secondary causes of cataract(OR:3.562,95%CI:1.740-7.288),uveitis(OR:11.663,95%CI:4.292-31.693)and diabetic retinopathy(OR:1.720,95%CI:1.078-2.744).Intraoperative factors reducing POE were shorter surgical time(OR:2.114,95%CI:1.473-3.032),topical or intracameral anaesthesia(OR:1.823,95%CI:1.278-2.602),posterior chamber intraocular lens(PCIOL;OR:4.992,95%CI:2.689-9.266)and foldable IOL(OR:2.276,95%CI:1.498-3.457).POE risk increased with posterior capsule rupture(OR:3.773,95%CI:1.915-7.432)and vitreous loss(OR:3.907,95%CI:1.720-8.873).Postoperative VA of 6/12 or better was achieved in 15.27%(20/131)subjects with POE.CONCLUSION:This study concurs with other studies regarding POE risk factors.Further strengthening of MOH CSR data collection process will enable deeper analysis and optimization of POE treatment. | Yong Zheng Wai Fiona Lee Min Chew Mohamad Aziz Salowi Chai Liang Ang Yong Yuin Chong Tassha Hilda Adnan Pik-Pin Goh | 2018 | International Journal of Ophthalmology(English edition)2018，11，10： | 3 |
| 17 | Mechanisms responsible for the inhibitory effects of epothilone B on scar formation after spinal cord injury显示文摘Scar formation after spinal cord injury is regarded as an obstacle to axonal regeneration and functional recovery.Epothilone B provides moderate microtubule stabilization and is mainly used for anti-tumor therapy.It also reduces scar tissue formation and promotes axonal regeneration after spinal cord injury.The aim of the present study was to investigate the effect and mechanism of the microtubule-stabilizing reagent epothilone B in decreasing fibrotic scarring through its action on pericytes after spinal cord injury.A rat model of spinal cord injury was established via dorsal complete transection at the T10 vertebra.The rats received an intraperitoneal injection of epothilone B(0.75 mg/kg) at 1 and 15 days post-injury in the epothilone B group or normal saline in the vehicle group.Neuron-glial antigen 2,platelet-derived growth factor receptor β,and fibronectin protein expression were dramatically lower in the epothilone B group than in the vehicle group,but β-tubulin protein expression was greater.Glial fibrillary acidic protein at the injury site was not affected by epothilone B treatment.The Basso,Beattie,and Bresnahan locomotor scores were significantly higher in the epothilone B group than in the vehicle group.The results of this study demonstrated that epothilone B reduced the number of pericytes,inhibited extracellular matrix formation,and suppressed scar formation after spinal cord injury. | Wei Zhao Yong Chai Yun Hou Da-wei Wang Jian-qiang Xing Cheng Yang Qing-min Fang | 2017 | Neural Regeneration Research2017，12，3： | 3 |
| 18 | 3D printing of hydroxyapatite/tricalcium phosphate scaffold with hierarchical porous structure for bone regeneration显示文摘Three-dimensional(3D)-printed scaffolds have attracted considerable attention in recent years as they provide a suitable environment for bone cell tissue regeneration and can be customized in shape.Among many other challenges,the material composition and geometric structure have major impacts on the performance of scaffolds.Hydroxyapatite and tricalcium phosphate(HA/TCP),as the major constituents of natural bone and teeth,possess attractive biological properties and are widely used in bone scaffold fabrication.Many fabrication methods have been investigated in attempts to achieve HA/TCP scaffolds with microporous structure enabling cell growth and nutrient transport.However,current 3D printing methods can only achieve the fabrication of HA/TCP scaffolds with certain range of microporous structure.To overcome this challenge,we developed a slurry-based microscale mask image projection stereolithography,allowing us to form a HA/TCP-based photocurable suspension with complex geometry including biomimetic features and hierarchical porosity.Here,the curing performance and physical properties of the HA/TCP suspension were investigated,and a circular movement process for the fabrication of highly viscous HA/TCP suspension was developed.Based on these investigations,the scaffold composition was optimized.We determined that a 30 wt%HA/TCP scaffold with biomimetic hierarchical structure exhibited superior mechanical properties and porosity.Cell proliferation was investigated in vitro,and the surgery was conducted in a nude mouse in vivo model of long bone with cranial neural crest cells and bone marrow mesenchymal stem cells.The results showed our 3D-printed HA/TCP scaffold with biomimetic hierarchical structure is biocompatible and has sufficient mechanical strength for surgery. | Xiangjia Li Yuan Yuan Luyang Liu Yuen‑Shan Leung Yiyu Chen Yuxing Guo Yang Chai Yong Chen | 2020 | Bio-Design and Manufacturing2020，3，1： | 3 |
| 19 | The solar wind plasma upstream of Mars observed by Tianwen-1:Comparison with Mars Express and MAVEN显示文摘On the great journey to Mars,China’s first planetary exploration mission,the Tianwen-1 came within 26 million kilometers of Mars from 31 October 2020 to 25 January 2021 and was getting closer to its destination,the red planet,in search of answers to the cataclysmic climate change that occurred in Martian history.Both the escape of the Martian atmosphere and the loss of surface water were firmly influenced by solar activities.Tianwen-1 provided a unique chance to depict the solar wind streams between Earth and Mars during the minimum of Solar Cycle 25.During the three-month cruise phase of Tianwen-1,the solar wind flows were successively observed at Earth,Tianwen-1,and Mars.After the field of view correction and noise reduction,the solar wind velocity and density measured by Tianwen-1 show good agreement with those at Earth and Mars.The results indicate that the performance of the ion analyzer onboard the Tianwen-1 orbiter is reliable and stable.It is worth looking forward to the joint observations of ion escape with other Mars probes in the following Martian years. | Kai FAN Limei YAN Yong WEI Aibing ZHANG Linggao KONG Markus FRÄNZ Fei HE Lihui CHAI Chongjing YUAN Yuqi WANG Jun ZHONG Zhaojin RONG Zhonghua YAO Yongxin PAN Jun CUI Jiansen HE Wenya LI Binbin TANG Chi WANG | 2022 | Science China Earth Sciences2022，65，4： | 2 |
| 20 | Broadband transducer with tube-beam coupling structure显示文摘 | CHAI Yong MO Xiping LIU Yongping PAN Yaozong ZHANG Yunqiang LI Peng | 2018 | Chinese Journal of Acoustics2018，37，2： | 2 |
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