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| 1 | Non-coordination in China′s Urbanization: Assessment and Affecting Factors显示文摘Urbanization is a comprehensive concept,a trinity process that is based on the interactions and mutual influences among the population urbanization,economic urbanization and space urbanization,in which,people are the central and leading players in this process,while economic activities serve as the driving force and space is the carrier—the physical or material setting as well as the product.So the coordination among these processes is crucial for a country or region′s sustainable development.China is experiencing rapid growth of cities and a surge in urban population,with the basic national condition of many people and little land,which calls for a systematic study of the issue of coordinated urbanization from theoretical,methodological and practical perspectives.Based on the concept of urbanization and non-coordination of urbanization,this article built a quantitative method to identify and evaluate the urbanization and non-coordination of urbanization,and made an empirical analysis in China between 2000 and 2008.The results show that the non-coordination overall level of China′s urbanization declined during the study period,because population urbanization,economic urbanization,and space urbanization exhibited different trajectories of change.This study also reveals that performance assessment system,household registration system,and urban land expropriation system,etc.,are the main affecting factors.At the end,we put forward some suggestions to achieve sustainable development of China′s urbanization from the aspects of improving the local government′s objective function,implementing the urban planning system,enforcing public participation aspects and so on. | SUN Pingjun SONG Wei XIU Chunliang LIANG Zhenming | 2013 | Chinese Geographical Science2013，23，6： | 26 |
| 2 | Development of real-time laser-scanning system to detect tree canopy characteristics for variable-rate pesticide application显示文摘Improving pesticide application efficiency is increasingly important in orchard spraying.In this study,a laser-scanning system was designed to acquire gridding volumes of a tree to quantify the geometry characteristics of the tree canopy in real-time.A laser-scanning sensor mounted on a linear guide was utilized to measure the structure of a target tree canopy.A computer was used to receive measurement data from the laser scanner and obtain the movement distance of the laser-scanning sensor from a controller.An algorithm written with VC#program was designed to calculate gridding volumes of trees by recognizing valid measurement data from the laser scanner.Laboratory evaluations were conducted on three kinds of regular objects,and the maximum relative errors of section volumes of the cuboid,triangular prism and cylinder objects were 3.3%,7.9%and 9.4%,respectively,which illustrated that the algorithm could calculate the section volumes in different parts of the objects with high accuracy.A conifer tree and an apple tree were chosen to verify detecting accuracy of the laser-scanning system at variable speeds and grid sizes.The variation coefficients of total volumes for each kind of the tree were 0.078 and 0.041,respectively,which indicated that the laser-scanning system could be applied to provide the gridding volumes of different canopy densities in real-time with good reliability for guiding a variable-rate sprayer. | Cai Jichen Wang Xiu Song Jian Wang Songlin Yang Shuo Zhao Chunjiang | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 14 |
| 3 | Effects of temperature and rare earth content on oxidation resistance of Ni-based superalloy | Xiu SONG Lei WANG Yang LIU Hui-ping MA | 2011 | Progress in Natural Science:Materials International2011，21，3： | 11 |
| 4 | Cross-reactivity of hypervariable region 1 chimera of hepatitis C virus显示文摘AIM: To analyze the amino acid sequences of hypervariable region 1 (HVR1) of HCV isolates in China and to construct a combinatorial chimeric HVR1 protein having a very broad high cross-reactivity.
METHODS: All of the published HVR1 sequences from China were collected and processed with a computer program.Several representative HVR1's sequences were formulated based on a consensus profile and homology within certain subdivision. A few reported HVR1 mimotope sequences were also included for a broader representation. All of them were cloned and expressed in E.coli. The cross-reactivity of the purified recombinant HVR1 antigens was tested by ELISA with a panel of sera from HCV infected patients in China.Some of them were further ligated together to form a combinatorial HVR1 chimera.
RESULTS: Altogether 12 HVR1s were selected and expressed in E. coli and purified to homogeneity. All of these purified antigens showed some cross-reactivity with sera in a 27 HCV positive panel. Recombinant HVR1s of No. 1, 2, 4, and 8# showing broad cross-reactivities and complementarity with each other, were selected for the ligation elements. The chimera containing these 4 HVR1s was highly expressed in E. coli. The purified chimeric antigen could react not only with all the HCV antibody positive sera in the panel but also with 90/91 sera of HCV -infected patients.
CONCLUSION: The chimeric antigen was shown to have a broad cross-reactivity. It may be helpful for solving the problem caused by high variability of HCV, and in the efforts for a novel vaccine against the virus. | Bing-Shui Xiu Shi-Gan Ling Xiao-Guo Song He-Qiu Zhang Kun Chen Cui-Xia Zhu Laboratory of Molecular Virology,Institute of Basic Medical Sciences,Academy of Military Medical Sciences,Beijing 100850,China | 2003 | World Journal of Gastroenterology2003，9，6： | 11 |
| 5 | Vulnerability of Large City and Its Implication in Urban Planning: A Perspective of Intra-urban Structure显示文摘Vulnerability is a new field and analytical tool in the study of urban safety. Analysis and assessment of vulnerability provide a new basis for urban planning. This study constructed a quantitative index system for assessing vulnerability, based on the city′s sensitivity and emergency response capacity. City size, density, and spatial form influence a city′s sensitivity to crises and risks, to which vulnerability is positively related. Levels of socio-economic development, infrastructures, and emergency management contribute to a city′s emergency response capacity, with which vulnerability is inversely associated. Vulnerability of 19 large Chinese cities was assessed. Harbin and Shenzhen demonstrated the highest and lowest vulnerability among 19 cities, while Beijing, Shanghai and Guangzhou ranked the 5th, the 9th and the 12th. Spatially, northern cities tended to be more vulnerable than southern cities. And the differences in vulnerability among cities were explored based on cities′ physical geography conditions, level of socioeconomic development, infrastructures, regional status, history of disaster, history of urban planning and development, government policies, etc. | XIU Chunliang CHENG Lin SONG Wei WU Wei | 2011 | Chinese Geographical Science2011，21，2： | 9 |
| 6 | Bartonella Species Detected in the Plateau Pikas(Ochotona curzoiae) from Qinghai Plateau in China显示文摘Bartonella 种类能感染许多哺乳动物的主人并且在人引起许多疾病,但是在那里有不是在 Ochotonidae 的 Bartonella 感染的报告。这是第一研究在 Qinghai 高原在高原一种短耳野兔检测 Bartonella,提供为对在这个区域的人的 Bartonella 感染的风险评价的基线数据。我们与 18.99% 的积极的率在 Qinghai 的 Binggou 和 Maixiu 区域从 79 只一种短耳野兔获得了 15 Bartonella 紧张。基于基因定序的 Bartonella 柠檬酸盐 synthase (gltA ) 的种系发生的分析,大多数紧张是仔细与 B 有关。taylorii (3/15 ) 和 B。grahamii (12/15 ) 。后者是在人的病原的紧张。我们的结果建议相应预防和控制策略应该在 Qinghai 省被考虑。 | RAO Hua Xiang YU Juan GUO Peng MA Yong Cheng LIU Qi Yong JIAO Ming MA Zhong Wen GE Hua WANG Chun Xiang SONG Xiu Ping SHI Yan LI Dong Mei | 2015 | Biomedical and Environmental Sciences2015，28，9： | 8 |
| 7 | The molecular characterization of maize B chromosome specific AFLPs显示文摘The origin and evolution of B chromosomes could be explained by the specific DNA sequence on them. But the specific sequences known were quite limited. To investigate maize B chromosome sqicific DNA sequeces, maize genomes with and without B chromosomes were analyzed by AFLP. Only 5 markers were found specific to genomes with B chromosomes among about 2000 AFLP markers. Southern hybridization and sequence analysis revealed that only the sequence of M8-2D was a B chromosome specific sequence. This sequence contained the telomeric repeat unit AGGGTTT conserved in plant chromosome telomeres. In addition, the sequence of M8-2D shared low homology to clones from maize chromosome 4 centromere as well. M8-2D were localized to B chromosome centrorneric and telomeric regions. | ZHONG XIA QI, Hui ZENG, Xiu LAN LI, CHENG BIN CHEN, WEN QIN SONG, RUI YANG CHEN The College of Life Sciences, Nankai University, Tianjin 300071, China | 2002 | Cell Research2002，12，1： | 7 |
| 8 | Preparation of dense Ta-LLZO/MgO composite Li-ion solid electrolyte:Sintering, microstructure, performance and the role of MgO显示文摘Cubic phase Li7La3Zr2O12(LLZO),a member of the Li–Garnet family,is a promising solid electrolyte and has been widely studied in recent years.However,LLZO samples prepared via conventional ambient air sintering reported in the published literature often contain large grains with lower than desired(<94%)relative density.In this study,a non-contact method of co-firing with mother powder method is proposed to prepare high-quality Ta-doped LLZO–MgO composite ceramics.By sintering at 1150℃for 5 h,the ceramics can reach relative density of 98.2%,conductivity of 5.17×10^-4 S cm^-1 at 25℃and fracture strength of 150 MPa.The sintered samples have uniform fine-grained microstructure and high critical current densities of 0.75–0.95 mA cm-2 at room temperature in Li–Li symmetry cell with Au modification.In addition,systematic sintering experiments and characterizations are conducted to explore the function of MgO in inhibiting the Ta-LLZO grain growth and its existing form inside the composite ceramics. | Xiao Huang Yang Lu Zhen Song Tongping Xiu Michael EBadding Zhaoyin Wen | 2019 | Journal of Energy Chemistry2019，28，12： | 7 |
| 9 | Carbon-coated manganese dioxide nanoparticles and their enhanced electrochemical properties for zinc-ion battery applications显示文摘In this study, we report the cost-effective and simple synthesis of carbon-coated α-MnO_2nanoparticles(α-MnO_2@C) for use as cathodes of aqueous zinc-ion batteries(ZIBs) for the first time. α-MnO_2@C was prepared via a gel formation, using maleic acid(C_4H_4O_4) as the carbon source, followed by annealing at low temperature of 270 °C. A uniform carbon network among the α-MnO_2 nanoparticles was observed by transmission electron microscopy. When tested in a zinc cell, the α-MnO_2@C exhibited a high initial discharge capacity of 272 m Ah/g under 66 m A/g current density compared to 213 m Ah/g, at the same current density, displayed by the pristine sample. Further, α-MnO_2@C demonstrated superior cycleability compared to the pristine samples. This study may pave the way for the utilizing carbon-coated MnO_2 electrodes for aqueous ZIB applications and thereby contribute to realizing high performance eco-friendly batteries. | Saiful Islam Muhammad Hilmy Alfaruqi Jinju Song Sungjin Kim Duong Tung Pham Jeonggeun Jo Seokhun Kim Vinod Mathew Joseph Paul Baboo Zhiliang Xiu Jaekook Kim | 2017 | Journal of Energy Chemistry2017，26，4： | 6 |
| 10 | High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways显示文摘The increased incidence of systemic lupus erythematosus(SLE)in recent decades might be related to changes in modern dietary habits.Since sodium chloride(NaCl)promotes pathogenic T cell responses,we hypothesize that excessive salt intake contributes to the increased incidence of autoimmune diseases,including SLE.Given the importance of dendritic cells(DCs)in the pathogenesis of SLE,we explored the influence of an excessive sodium chloride diet on DCs in a murine SLE model.We used an induced lupus model in which bone marrow-derived dendritic cells(BMDCs)were incubated with activated lymphocyte-derived DNA(ALD-DNA)and transferred into C57BL/6 recipient mice.We observed that a high-salt diet(HSD)markedly exacerbated lupus progression,which was accompanied by increased DC activation.NaCl treatment also stimulated the maturation,activation and antigenpresenting ability of DCs in vitro.Pretreatment of BMDCs with NaCl also exacerbated BMDC-ALD-DNA-induced lupus.These mice had increased production of autoantibodies and proinflammatory cytokines,more pronounced splenomegaly and lymphadenopathy,and enhanced pathological renal lesions.The p38 MAPK–STAT1 pathway played an important role in NaClinduced DC immune activities.Taken together,our results demonstrate that HSD intake promotes immune activation of DCs through the p38 MAPK–STAT1 signaling pathway and exacerbates the features of SLE.Thus,changes in diet may provide a novel strategy for the prevention or amelioration of lupus or other autoimmune diseases. | Ze Xiu Xiao Xiaojiang Hu Ximei Zhang Zhigang Chen Julie Wang Ke Jin Feng Lin Cao Baoqing Sun Joseph A.Bellanti Nancy Olsen Song Guo Zheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 6 |
| 11 | Formability of AZ31 Mg alloy sheets within medium temperatures显示文摘The stretching tests of the commercial AZ31 Mg alloy were conducted at 130 ℃, 170 ℃, 210 ℃, at the forming speeds of 10 mm/min and 50 mm/min, respectively. The formability of AZ31 sheets at high temperature was evaluated by forming limit diagrams (FLD). The fracture morphologies were analyzed using a scanning electron microscope. The results show that the FLD of AZ31 Mg alloy is affected by the forming temperature, in another word, the formability increases with the increasing of the forming temperature. That may be because the non-basal slip system starts to move by thermal activation at high forming temperature. It is also demonstrated that the formability of the AZ31 Mg alloy is on the decline with the increasing of the forming speed. The slipping performs thoroughly to release the stress during the deformation if the forming speed decreases. In addition, the higher the forming temperature is, the more obvious the effect of the forming speed is. The forming temperature is the main dominating factor on the formability of AZ31 Mg alloy. | Lei Wang Qi Qiao Yang Liu Xiu Song | 2013 | Journal of Magnesium and Alloys2013，1，4： | 5 |
| 12 | Coarsening behavior of γ' and γ'' phases in GH4169 superalloy by electric field treatment显示文摘The coarsening behaviors of γ' and γ'' phases in GH4169 alloy aged at 1023 and 1073 K with electric feld treatment(EFT) were investigated by transmission electron microscopy(TEM) and positron annihilation lifetime spectroscopy(PALS).It is demonstrated that precipitation coarsening occurs,and the growth activation energies of γ' and γ'' phases can be decreased to 115.6 and 198.1 kJ·mol-1,respectively,by applying the electric feld.The formation of a large number of vacancies in the matrix is induced by EFT.Due to the occurrence of vacancy migration,the difusion coefcients of Al and Nb atoms are increased to be 1.6-5.0 times larger than those without EFT at 1023 or 1073 K.Furthermore,the formation of vacancy clusters is promoted by EFT,and the increase in strain energy for the coarsening of γ' and γ'' phases can be counterbalanced by the formation of vacancy clusters. | Lei Wang Yao Wang Yang Liu Xiu Song Xu-dong Lü Bei-jiang Zhang | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，9： | 5 |
| 13 | HBV recurrence lowered by lamivudine/HBIG combination therapy in liver transplant patients:ten-year experience显示文摘BACKGROUND: Lamivudine and hepatitis B immunoglobulin (HBIG) are widely used to treat patients with hepatitis B recurrence after liver transplantation. However, the outcomes are inconclusive. The present study was undertaken to evaluate the effect of combined therapy on patients with hepatitis B recurrence after liver transplantation. METHODS: Twenty-two patients with hepatitis B recurrence after liver transplantation from August 2000 to October 2011 were enrolled in this study. Of these patients, 16 received lamivudine plus HBIG (combination therapy group) and 6 were treated with lamivudine alone (lamivudine-treated group) The clinical features were matched in the two groups. HBV recurrence parameters, HBsAg clearance rate, patient survival rate, and survival time were compared. RESULTS: The average time of follow-up was 47.2 months (range 13-99). Significant difference was noted in the HBsAg clearance rate in the lamivudine-treated and combination therapy groups (50% vs 93.8%, P<0.05). There was no significant difference in the time of HBV recurrence, patient survival rate and survival time between lamivudine-treated and combination therapy groups (P>0.05). CONCLUSION: Compared with lamivudine monotherapy combination therapy significantly increased the HBsAg clearance rate in patients with HBV recurrence after liver transplantation. | Chun-Hui Yuan Dian-Rong Xiu Bin Jiang Zhi-Fei Li Lei Li Shi-Bing Song Tong-Lin Zhang | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 4 |
| 14 | Quality control and evaluation of human immunodeficiency virus antibody assays used for screening donated blood in China显示文摘During 2004, a total of 124 batches of HIV antibody ELISAs from domestic and overseas manufacturers, comprising approximately 60 million tests, were tested for quality and released for screening blood in China. The inter- and intra-batch variation, specificity, and sensitivity were evaluated using a laboratory panel and clinical samples. The inter-batch variation was less than 15% and only 2 of 12 assays had intra-batch variation of less than 20% for 4 dilutions of a control specimen. 257 samples confirmed positive for HIV antibody and 4826 negative samples from different regions in China were used to evaluate the sensitivity and specificity of the assays. The results showed that the sensitivity is in the range from 93.7% to 100% for assays sampled directly from the manufacturers, and 91. 4%-99. 6% for those retrieved from the consumers; the specificity was in the range from 97.88% to 99.97% . The testing environment may vary in different regions of China. Therefore, manufacturers should provide robust assays to satisfy the requirements of these diverse environments, and especially reduce the intra-assay variation and improve the stability of the kits. | You CHUN WANG XIU HUA LI AI JING SONG CHUN TAO ZHANG SI HONG XU FENG ZHANG HONG ZHANG YIN | 2006 | Journal of Microbiology and Immunology2006，4，1： | 4 |
| 15 | Towards a global One Health index: a potential assessment tool for One Health performance显示文摘Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge. | Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou | 2022 | Infectious Diseases of Poverty2022，11，3： | 3 |
| 16 | Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China显示文摘Objective To study the optimal waist circumference(WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome(MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China. | HOU Xin Guo WANG Chuan MA Ze Qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG Wei Qing NING Guang ZHENG Hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li | 2014 | Biomedical and Environmental Sciences2014，27，5： | 3 |
| 17 | Effects of increasing panicle-stage N on yield and N use efficiency of indica rice and its relationship with soil fertility显示文摘Because of the higher nitrogen(N)recovery efficiency(NRE)of panicle-stage fertilization compared with basal and tillering fertilization,increasing the proportion of N topdressing at the booting stage(panicleN)is recommended and commonly practiced in parts of China.To investigate the effects of increasing panicle-N on grain yield and N use efficiency(NUE)and the relationships of the increase and the rice cultivar and soil fertility status,we increased the percentage of panicle-N from 20%to 40%by correspondingly reducing the N amount applied only at the tillering stage in both high-and low-fertility blue clayey paddy fields in 2018 and 2019.Four indica cultivars with diverse panicle types were used,and their grain yield,dry matter accumulation,and NUE were compared.In high-fertility soil,increasing topdressing panicle-N from 20%to 40%reduced tillering ability and reduced the effective panicle numbers of the multi-and medium-panicle cultivars Huanghuazhan(HHZ),C Liangyouhuazhan(CHZ),and Tianyouhuazhan(THZ).These cultivars gave the greatest yield when 30%of N was supplied as panicle fertilizer,whereas the yield,NRE,N agronomic efficiency(NAE),and nitrogen physiological efficiency(NPE)of the heavy-panicle inbred cultivar Yangdao 6(YD6)continued to increase,resulting in improved dry matter accumulation and grain filling in the late growth stage.The yield,NAE,NRE,and NPE of YD6 peaked when the panicle-N constituted 40%.While in low-fertility soil,the multipanicle cultivar HHZ showed the greatest yield when 30%of fertilizer-N was applied once at the panicle initiation(PI)stage,while the medium-panicle cultivar CHZ showed the greatest yield when the panicle-N percentage was 40%.Our results suggest that the percentage of panicle-N fertilizer should not exceed 30%for multipanicle cultivars,while can be appropriately increased to 40%for heavy-panicle indica cultivars.The effect of increasing topdressing panicle-N on the yield of medium-panicle cultivars was related to soil fertility.The optimum panicle-N percentage was 30%in the high-fertility soil and 40%in the low-fertility soil. | Chang Ye Hengyu Ma Xiu Huang Chunmei Xu Song Chen Guang Chu Xiufu Zhang Danying Wang | 2022 | The Crop Journal2022，10，6： | 3 |
| 18 | 大豆异黄酮对Ⅰ型糖尿病甲基乙二醛水平及白内障并发症的影响显示文摘目的:甲基乙二醛(MG)是糖代谢产生的毒性副产物,本研究旨在探讨大豆异黄酮是否通过降低MG的产生而发挥对I型糖尿病的防治作用。方法:链脲佐菌素诱导I型糖尿病大鼠模型,给予含不同剂量大豆异黄酮的大鼠饲料喂养,按大豆异黄酮不同剂量随机分为3组:大豆异黄酮低剂量组(diabetes+LIS),大豆异黄酮高剂量组(diabetes+HIS)及模型组(diabetes)。治疗8周后处死大鼠,留取血清测定血糖、糖化血红蛋白、还原型谷胱甘肽(GSH)、胰岛素水平,HPLC法测定血清MG水平,免疫组化法检测胰岛β细胞胰岛素表达情况。结果:与模型组或diabetes+LIS组大鼠比较,HIS组大鼠血清胰岛素水平明显上升[(2.46±0.35)μg/L vs(0.55±0.04)μg/L or(0.39±0.04)μg/L,均P<0.01],血糖明显下降[(19.50±1.85)mol/L vs(28.24±3.56)mol/L or(26.94±1.82)mmol/L,均P<0.05]、糖化血红蛋白减低[(13.14±3.00)%vs(17.16±2.60)%or(17.29±4.12)%,均P<0.05],血清MG明显降低[(0.77±0.09)nmol/L vs(1.57±0.17)nmol/L or(1.91±0.28)nmol/L,均P<0.05],而血清GSH水平明显增加[(13.26±1.61)mmol/L vs(7.35±1.55)mmol/L or(5.54±1.10)mmol/L,均P<0.01],diabetes+HIS组大鼠胰岛β细胞中胰岛素表达水平也明显增加。Diabetes+HIS组大鼠白内障的发生率明显低于模型组(P<0.05)。模型组与diabetes+LIS组比较,上述指标均无显著差异。结论:大豆异黄酮对I型糖尿病具有治疗作用,并能降低I型糖尿病大鼠白内障的发生率,其机制可能与胰岛素水平增加、MG水平降低及抗氧化作用有关。 | 卢美萍 SONG Xiu -yuan MENG Qing- he | 2010 | 中国病理生理杂志2010，26，5： | 3 |
| 19 | Analysis of a Community-based Intervention to Reduce Heat-related Illness during Heat Waves in Licheng,China:a Quasi-experimental Study显示文摘Objective To reduce health-related threats of heat waves, interventions have been implemented in many parts of the world. However, there is a lack of higher-level evidence concerning the intervention efficacy. This study aimed to determine the efficacy of an intervention to reduce the number of heat-related illnesses. Methods A quasi-experimental design was employed by two cross-sectional surveys in the year 2014 and 2015, including 2,240 participants and 2,356 participants, respectively. Each survey was designed to include one control group and one intervention group, which conducted in Licheng, China. A representative sample was selected using a multistage sampling method. Data, collected from questionnaires about heat waves in 2014 and 2015, were analyzed using a difference-in-difference analysis and cost effectiveness analysis. Outcomes included changes in the prevalence of heat-related illnesses and cost-effectiveness variables. Results Relative to the control participants, the prevalence of heat-related illness in the intervention participants decreased to a greater extent in rural areas than in urban areas(OR=0.495 vs. OR=1.281). Moreover, the cost-effectiveness ratio in the intervention group was less than that in the control group(US$15.06 vs. US$15.69 per participant). Furthermore, to avoid one additional patient, the incremental cost-effectiveness ratio showed that an additional US$14.47 would be needed for the intervention compared to when no intervention was applied. Conclusion The intervention program may be considered a worthwhile investment for rural areas that are more likely to experience heat waves. Meanwhile, corresponding improving measures should be presented towards urban areas. Future research should examine whether the intervention strategies could be spread out in other domestic or international regions where heat waves are usually experienced. | LI Jing XU Xin WANG Jun ZHAO Yun SONG Xiu Ping LIU Zhi Dong CAO Li Na JIANG Bao Fa LIUQiYong | 2016 | Biomedical and Environmental Sciences2016，29，11： | 3 |
| 20 | Monitoring and Assessing Method for Blasting Vibration on Open-pit Slope in Hainan Iron Mine显示文摘A type of velocity sensor CD 1, an auto recording instrument on blasting vibration YBJ 1 and a random signal and vibration analysis system (CRAS) were used to monitor the particle vibration induced by blasting at open pit slope in Hainan Iron Mine. The attenuating rules of blasting ground vibration on slope were developed. By means of the analysis and calculation of the blasting vibration data at open pit slope and the vertical particle vibration velocity assessment method based on the concept of vibration strength, the empirical attenuating equations which can be used for predicting and estimating the damage of slope were derived. | SONG Guang ming 1,SHI Xiu zhi 1,ZHOU Zhi guo 1,CHEN Shou ru 1,XIAO Qing hua 2 (1 College of Resources, Environment and Civil Engineering, Central South University of Technology, Changsha 410083, China 2 Production and Technology Departmen | 2000 | Journal of Central South University2000，12，2： | 3 |
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