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| 1 | Silencing myostatin gene by RNAi in sheep embryos显示文摘 | Dayun Tang Huabin Zhu Jianmin Wu Hanzhong Chen Yan Zhang Xueming Zhao Xiaoliang Chen Weihua Du Dong Wang Xiukun Lin | 2012 | Journal of Biotechnology2012，，3： | 2 |
| 2 | Bromophenols from Marine Algae with Potential Anti-Diabetic Activities显示文摘Marine algae contain various bromophenols with a variety of biological activities,including antimicrobial,anticancer,and anti-diabetic effects.Here,we briefly review the recent progress in researches on the biomaterials from marine algae,emphasizing the relationship between the structure and the potential anti-diabetic applications.Bromophenols from marine algae display their hyperglycemic effects by inhibiting the activities of protein tyrosine phosphatase 1B,α-glucosidase,as well as other mechanisms. | LIN Xiukun LIU Ming | 2012 | Journal of Ocean University of China2012，11，4： | 1 |
| 3 | Silencing myostatin gene by RNAi in sheep embryos显示文摘 | Dayun Tang Huabin Zhu Jianmin Wu Hanzhong Chen Yan Zhang Xueming Zhao Xiaoliang Chen Weihua Du Dong Wang Xiukun Lin | 2012 | Journal of Biotechnology2012，，3： | 1 |
| 4 | In vitro studies of polyethyleneimine coated miRNA microspheres as anticancer agents显示文摘RNA 作为一个基因沉默代理人起重要作用,为临床的处理的一个治疗学的代理人,并且在房间的区别,增长,和发展。然而, RNA 是很困难的工作与由于它的敏感和脆弱。在为基因交货 / 沉默使用 RNA 的另一个障碍是它的否定费用,它由房间膜引起它的排斥,它否定地也被控告。我们的最近的学习证明 miR-125b 是在 glioblastoma (GMB ) 的 upregulated 并且由支持房间增长并且禁止 apoptosis 在 GMB 房间起一个 oncogenic 作用。内长的 miR-125b 能被它的 antisense RNA 分子的 transfection 堵住, miR-125b antisense (miR-125b-AS ) 。因此,米尔 -- 125b-AS 能为癌症治疗作为一个基于 RNA 的代理人被开发。然而,不稳定性远这样在在进房间的交货的存储和困难期间限制了基于 RNA 的治疗的使用。在当前的工作,我们为断然控告的 RNA nanospheres (miR-125b-RNS 和 miR-125b-AS-RNS ) 的准备表明一种短、简单的一步舞技术与 bioavailable 聚合物涂, polyethylenimine (PEI ) 。这些 RNA nanospheres 能没有 liposomes 的使用,直接渗透房间。我们的学习证实进 nanospheres 的那变换 miR-125b 和 miR-125b-AS 是为存储 RNA 的一条可行途径。另外,这研究提供证据那 PEI 涂的 RNA nanospheres 有潜力被用作 anticancer 代理人的一个新奇的班。 | Irena Rytblat Ning Wu Huangli Xu Aharon Gedanken Xiukun Lin | 2016 | Nano Research2016，9，6： | 1 |
| 5 | Chaotic behavior in fractional-order memristor-based simplest chaotic circuit using fourth degree polynomial显示文摘 | Lin Teng Herbert H. C. Iu Xingyuan Wang Xiukun Wang | 2014 | Nonlinear Dynamics . 2014 (1-2)2014，，： | 1 |
| 6 | Chaotic behavior in fractional-order memristor-based simplest chaotic circuit using fourth degree polynomial显示文摘 | Lin Teng Herbert H. C. Iu Xingyuan Wang Xiukun Wang | 2014 | Nonlinear Dynamics2014，，1： | 1 |
| 7 | Oleanolic acid induces protective autophagy in cancer cells throughthe JNK and mTOR pathways显示文摘 | Jia Liu Lanhong Zheng Jiateng Zhong Ning Wu Ge Liu Xiukun Lin | 2014 | Oncology Reports2014，，2： | 1 |
| 8 | Oleanolic acid potentiates the antitumor activity of 5-fluorouracilin pancreatic cancer cells显示文摘 | Jianteng Wei Haizhou Liu Ming Liu Ning Wu Jin Zhao Lin Xiao Lijun Han Edward Chu Xiukun Lin | 2012 | Oncology Reports2012，，4： | 1 |
| 9 | PI3K/Akt/mTOR Signaling as Targets for Developing Anticancer Agents from Marine Organisms显示文摘The PI3K/Akt/mTOR signaling pathway is one of the most frequently dysregulated pathways in cancer.Targeting the PI3K-mediated pathway has been an important strategy for developing novel anticancer agents.In the past decades,more than 40 inhibitors of the PI3K/Akt/mTOR pathway have been developed at different clinical stages.Temsirolimus,everolimus,idelalisib,and copanlisib have been approved for clinical use by the Food and Drug Administration of the United States(FDA).However,the toxic-ity and drug resistance limit their efficiency in the treatment.Novel compounds with greater potency and selectivity,as well as im-proved therapeutic indices with reduced toxicity,are clearly required.Over the past three decades,a lot of bioactive ingredients with anticancer effects by affecting the PI3K-mediated pathways have been found from marine organisms.In the present mini-review,anticancer compounds from marine source that target the PI3K/Akt/mTOR signaling were reviewed.The molecular entities and their modes of action were presented.The marine compounds targeting special factors of the PI3K/Akt/mTOR were highlighted. | GUO Mingyue ZUO Ling QIAO Gan LIU Minghua CAO Shousong LIN Xiukun | 2021 | Journal of Ocean University of China2021，20，3： | 0 |
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