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| 1 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 2 | A Two-Level Predictive Event-Related Potential-Based Brain-Computer Interlace显示文摘 | Xu Yarning Nakajima Y | 2013 | IEEE Transactions on Biomedical Engineering2013，60，10： | 1 |
| 3 | Spectral Properties and Thermal Stability of Er-doped Oxyfluoride Silicate Glasses for Broadband Optical Amplifier显示文摘 | Xu S Q Yarn Z M Dai S X | 2003 | Joumal of Alloys and Compounds2003，，361： | 1 |
| 4 | H∞ state feedback control for discrete singular systems显示文摘 | Xu Shengyuan Yarn Chengwu | 2000 | IEEE Transactions on Automatic Control2000，45，7： | 1 |
| 5 | Nonlinear information aggregation via evidential reasoning in multiattribute decision analysis under uncertainty显示文摘 | Yarn J B Xu D L | 2002 | IEEE Transactions on Systems Man and Cybernetics2002，32，3： | 1 |
| 6 | Sensitive and selective acetone sensor based on its cataluminescence from nano-La2O3 surface 显示文摘 | Li Tang Li Yarning Xu Kailai | 2008 | Sensors and Actuators B2008，，132： | 1 |
| 7 | DNA damaging activity of ellagic acid derivatives显示文摘 | Xu Yarning Deng Jingzhen Ma Ji | 2003 | Bioorganic & Medicinal Chemistry2003，11，： | 1 |
| 8 | Mechanistic lnsights into the Interactions of Ras Subfamily GTPases withthe SPN Domain of Autism-associated SHANK3显示文摘of main observation and conclusion The active Ras subfamily GTPases,R apl and Ras,can be specifically recognized by the SPN domain of SHANK3,mutations of which are associated with many neuropsychiatric diseases such as autism spectrum disorder(ASD).However,the mechanistic bases underlying the interactions of SHANK3 SPN and those Ras subfamily proteins are still elusive.Here,we reported the crystal structures of SHANK3 SPN in complex with the GTP-bound Raplb and the Ras-mimetic Raplb E30D/K31E double mutant.In addition to uncovering the detailed molecular mechanism governing the specific interactions of SHANK3 SPN with those Ras subfamily proteins,the determined structures also reveal a general binding mode between SHANK3 SPN and its associated Ras subfamily proteins.Finally,our study also provides mechanistic insights into two ASD-causing R12C and L68P mutations found in the SPN domain of SHANK3,and expands our understanding of the etiology of neuropsychiatric diseases caused by defective SHANK3. | Xiaolong Xu Jianping Liu Yingli Wang Yarn Wang Xinyu Gong Lifeng Pan | 2020 | Chinese Journal of Chemistry2020，38，12： | 0 |
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