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| 1 | Petrogenesis of highly fractionated I-type granites in the Zayu area of eastern Gangdese, Tibet: Constraints from zircon U-Pb geochronology, geochemistry and Sr-Nd-Hf isotopes显示文摘The Cretaceous granitoids in the middle and northern Gangdese, Tibet are generally interpreted as the products of anatexis of thickened deep crust genetically associated with the Lhasa-Qiangtang collision. This paper reports bulk-rock major element, trace element and Sr-Nd isotopic data, zircon U-Pb age data, and zircon Hf isotopic data on the Zayu pluton in eastern Gangdese, Tibet. These data shed new light on the petrogenesis of the pluton. Our SHRIMP zircon U-Pb age dates, along with LA-ICPMS zircon U-Pb age dates recently reported in the literature, indicate that the Zayu pluton was emplaced at about 130 Ma, coeval with Early Cretaceous magmatic rocks in other areas of eastern Gangdese (e.g., Rawu, Baxoi areas) and the Middle Gangdese. The Zayu pluton samples lack amphibole and muscovite, and are compositionally characterized by high SiO2 (69.9%―76.8%), K2O (4.4%―5.7%), and low P2O5 (0.05%―0.12%). These samples also have A/CNK values of 1.00-1.05, and are enriched in Rb, Th, U, and Pb, and depleted in Ba, Nb, Ta, Sr, P, Ti, and Eu. These geochemical features suggest that the Zayu pluton samples are metaluminous to slightly peraluminous and are of highly fractionated I-type granite. The Zayu pluton samples have high εNd(t) values (-10.9--7.6) and low initial 87Sr/86Sr ratios (0.7120- 0.7179) relative to melts derived from mature continental crust in the Gangdese (e.g., Ningzhong Early Jurassic strongly peraluminous granite). The Zayu pluton samples are heterogeneous in zircon εHf(t) values (-12.8--2.9), yielding ancient zircon Hf crustal model ages of 1.4―2.0 Ga. The data obtained in this study together with the data in the recent literature suggest that the Early Cretaceous granitoids in eastern Gangdese represent the eastward extension of the Early Cretaceous magmatism in the middle Gangdese, and that the Lhasa micro-continent block with ancient basement may extend for ~2000 km from east to west. Zircon Hf isotopic data and bulk-rock zircon saturation temperature (789-821℃) indicate that mantle-derived materials likely played a role in the generation of the Zayu pluton. We propose that the Zayu pluton was most likely generated in a setting associated with southward sub- duction of the Bangong-Nujiang ocean floor, where mantle wedge-derived magmas may have providedthe heat and material for the anatexis of ancient crust of the Lhasa micro-continent, resulted in hybrid melts (i.e., mantle-derived basaltic magmas + crust-derived felsic magmas). Such hybrid melts with subsequent fractional crystallization are responsible for the highly evolved Zayu pluton (crust thick- ening is not a prerequisite). | ZHU DiCheng MO XuanXue WANG LiQuan ZHAO ZhiDan NIU Yaoling ZHOU ChangYong YANG YueHeng | 2009 | Science China Earth Sciences2009，52，9： | 107 |
| 2 | Geochronologic Constraints on the Magmatic Underplating of the Gangdisê Belt in the India-Eurasia Collision: Evidence of SHRIMP II Zircon U-Pb Dating显示文摘丰富的小 mafic 侵入发生沿着 theGangdise magmatic 与 granitoids 联系了带。除了在 granitoid plutons 以内的许多分离斑粝岩身体, agabbro 辉岩地区沿着 Gangdise 带的南部的边缘发生到 theYarlung Zangbo 缝术的北方。mafic 侵入地区空间地对应于一个强壮的空中地磁学的异例,它扩大约 1400 km。mafic 侵入由斑粝岩和粗玄岩的间歇地分布式的小身体和堤组成与辉岩,橄榄石辉岩, pegmatitic 辉岩和角闪岩积累。许多证据显示 Gangdise gabbro-pyroxeniteassemblage 是最可能的结果在导出披风的岩浆的 plating 下面。详细的地调查和 mafic 岩石的系统的采样在六个地点被进行,沿着 mafic intrusive 地区的 theLhasa-Xigaze 片断,并且被标明日期的锆石虾 II U-Pb 跟随。除了二岁,样品以前出版了(47.0 +- 1 个妈和 48.9 +- 1.1 妈) ,四斑粝岩取样的留下的同位素年龄是 51.6 +- 1.3Ma, 52.5 +- 3.0 妈, 50.2 +-第 4.2Maa 49.9 +- 1.1Ma。年龄(47-52.5 妈) 提供的这些的范围在 Gangdise 下面在 plating 下面岩浆预定的 Eocene 上的 geochronologic 限制在 ca 系上带子。50 妈。这在 plating 下面 eventpost 过时到 1500 万年的印度欧亚大陆大陆碰撞的开始并且与岩浆混合的一个过程是同时期的。虾 II U-Pb 同位素分析也从一些锆石谷物发现几老年,主要在 479-526 妈的一个范围(加权的平均年龄 503+- 10 妈) ,当时,因此关于先存在的下地壳产出信息在 maficmagma 的 plating 下面发生。在 plating 下面的岩浆在印度欧亚大陆的碰撞期间是为外壳的生长的主要机制之一,这被相信,可能相应及时到 the14-16 的形成 km 厚“外壳披风过渡地区”由 Vp = 6.85-6.9 km/s 描绘了。 | DONG Guochen MO Xuanxue ZHAO Zhidan GUO Tieying WANG Liangliang CHEN Tao | 2005 | Acta Geologica Sinica(English Edition)2005，79，6： | 50 |
| 3 | Geochronology and Nd and Pb isotope characteristics of gabbro dikes in the Luobusha ophiolite, Tibet显示文摘We report a combined internal and whole-rock Sm-Nd isochron age, and Nd and Pb isotopic data for gabbro dikes of the Luobusha ophiolite in Tibet. The Sm-Nd isochron of data for two whole rocks and plagioclase and clinopyroxene separates from one of the rocks yields a Middle Jurassic age of (177±31) Ma (with an initial εNd(t) = +8), which provides a significant bound on the time of formation of the Luobusha ophiolite. The Nd and Pb isotopic charac-teristics of the dike indicate an Indian-Ocean-type isotopic affinity, and we conclude that the Luobusha ophiolite formed in an oceanic setting during the Middle Jurassic. | ZHOU Su MO Xuanxue J.J.Mahoney ZHANG Shuangquan GUO Tieyjing ZHAO Zhidan | 2002 | Chinese Science Bulletin2002，47，2： | 38 |
| 4 | The Sequence of Magmatic-Tectonic Events and Orogenic Processes of the Yanshan Belt, North China显示文摘This paper emphasizes that the interactive constraints of geology and isotopic dating is the best approach to construct the geological event sequence, and has compiled 106 data of reasonable isotopic ages for the igneous rocks of the Yanshan belt. We propose a sequence of mgmatic-tectonic events in the Jurassic-Cretaceous Yanshan orogen of North China. Five orogenic episodes are divided, (1) pre-and initial orogenic episode (Early Jurassic); (2) early orogenic episode (Middle Jurassic); (3) peak orogenic episode (Late Jurassic); (4) late orogenic episode (early Early Cretaceous),and (5) post-orogenic episode. Each episode is a short cycle, all of the orogenic processes construct a longer cycle, and they, in general, followed a counter-clockwise (ccw) PTt path. Finally, it is suggested that the Yanshanian movement was so intensive that the magmatism and tectonic deformation had involved all the lithosphere thickness and the lateAchaean-formed cratonic lithosphere had been significantly reworked. | DENG Jinfu, SU Shangguo, MO Xuanxue, ZHAO Guochun, XIAO Qinghiu, JI Guangyi,QIU Ruizhao, ZHAO Hailing, LUO Zhaohua, WANG Yang and LIU Cui China University of Geosciences, Beijing 100083 and Key Laboratory of Lithospheric Tectonics and Lithoprobe Techniques, Ministry of Education of China | 2004 | Acta Geologica Sinica(English Edition)2004，78，1： | 35 |
| 5 | Evolution of Circum-Pacific Basins andVolcanic Belts in East China and Their Geodynamic Background显示文摘Evolution of Circum-Pacific Basins andVolcanic Belts in East China andTheir Geodynamic Background￥LiSitian(FacultyofEarthReso... | Li Sitian(Faculty of Earth Resources, China University of Geosciences, Wuhan 430074)Mo Xuanxue(Department of Geology and Mineral Resources, China University of Geosciences, Beijing 100083 )Yang Shigong(Faculty of Earth Resources, China University of Geosc | 1995 | Journal of Earth Science1995，14，1： | 15 |
| 6 | Mineral Chemistry and Crystallization Conditions of the Late Cretaceous Mamba Pluton from the Eastern Gangdese, Southern Tibetan Plateau显示文摘The Late Cretaceous Mamba granodiorite belongs to a part of the Mesozoic Gangdese continental magmatic belt. No quantitative mineralogical study has been made hitherto, and hence the depth at which it formed is poorly constrained. Here we present mineralogical data for the Mamba pluton, including host rocks and their mafic microgranular enclaves(MMEs), to provide insights into their overall crystallization conditions and information about magma mixing. All amphiboles in the Mamba pluton are calcic, with ~B(Ca+Na)>1.5, and Si=6.81–7.42 apfu for the host rocks and Si=6.77–7.35 apfu for the MMEs. The paramount cation substitutions in amphibole include edenite type and tschermakite type. Biotites both in the host rocks and the MMEs collectively have high Mg O(13.19 wt.%–13.03 wt.%) contents, but define a narrow range of Al apfu(atoms per formula unit) variations(2.44–2.57). The oxygen fugacity estimates are based on the biotite compositions cluster around the NNO buffer. The calculated pressure ranges from 1.2 to 2.1 kbar according to the aluminum-in-hornblende barometer. The computed pressure varies from 0.9 to 1.3 kbar based on the aluminum-in-biotite barometer which corresponds to an average depth of ca. 3.9 km. Besides, the estimates of crystallization pressures vary from 0.8 to 1.4 kbar based on the amphibole barometer proposed by Ridolfi et al.(2010), which can be equivalent to the depths ranging from 3.1 to 5.2 km. The MMEs have plagioclase oscillatory zonings and quartz aggregates, probably indicating the presence of magma mixing. Besides, core-to-rim element variations(Rb, Sr, Ba, and P) for the K-feldspar megacrysts serve as robust evidence to support magma mixing and crystal fractionation. This indicates the significance of the magma mixing that contributes to the formation of K-feldspar megacryst zonings in the Mamba pluton. | Xiaowei Li Xuanxue Mo Mark Scheltens Qi Guan | 2016 | Journal of Earth Science2016，27，4： | 11 |
| 7 | Petrogenesis and tectonic implications of early Paleozoic granitoids in East Kunlun belt: Evidences from geochronology, geochemistry and isotopes显示文摘The East Kunlun Orogenic Belt(EKOB) provides an important link to reconstruct the evolution of the Proto-Tethys and Paleo-Tethys realm. The EKOB is marked by widespread Early Paleozoic magmatism.Here we report the petrology, bulk geochemistry, zircon Ue Pb dating and, Lue Hf and SreN d isotopic data of the Early Paleozoic granitic rocks in Zhiyu area of the southern EKOB. Based on the zircon U-Pb dating, these granitoids, consisting of diorite, granodiorite and monzogranite, were formed during 450 -430 Ma the Late Ordovician to Middle Silurian. The diorite and granodiorite are high Sr/Y ratio as adakitic affinities, and the monzogranite belongs to highly fractionated I-type. Their(^(87)Sr/^(86)Sr)ivalues range from 0.7059 to 0.7085, εNd(t) values from -1.6 to -6.0 and the zircon εHf(t) values show large variations from +9.1 to -8.6 with Hf model ages(T_(DM2)) about 848 Ma and 1970 Ma. The large variations of whole-rock Nd and zircon Hf isotopes demonstrate strong isotopic heterogeneity of the source regions which probably resulted from multi-phase underplating of mantle-derived magmas. Geochemical and isotopic studies proved that the diorite and granodiorite had been derived from partial melting of heterogeneous crustal source with variable contributions from ancient continental crust and juvenile components, and the monzogranites were representing fractional crystallization and crustal contamination for arc magma. The Early Paleozoic adakitic rocks and high-K calc-alkaline granitoids in the southern EKOB were likely emplaced in a continental marginal arc setting possibly linked to the southwards subduction of the Paleo Kunlun Ocean and the magma generation is linked to partial melting of thickened continental crust induced by underplating of mantle-derived magmas. | Guochen Dong Mingfei Luo Xuanxue Mo Zhidan Zhao Liangqiong Dong Xuehui Yu Xin Wang Xiaowei Li Xiongfei Huang Yanbin Liu | 2018 | Geoscience Frontiers2018，9，5： | 10 |
| 8 | ^(40)Ar/^(39)Ar dating for Cenozoic kamafugite from western Qinling in Gansu Province显示文摘40Ar/39Ar ages were determined for 6 phlogopite samples from a kamafugite pipe occurring in western Qinling, yielding a time span of 22 to 23 Ma for kamafugite eruption. Together with known geochronological data for the Qinghai-Tibet Plateau (QTP) and its peripheral regions, it is concluded that these Cenozoic potassic-ultrapotassic volcanic rocks are products of post-collisional volcanism. The age of the Cenozoic volcanic rocks in western Qinling partly overlaps that of potassic volcanics from the Gandise belt, reflecting the northward migration of the post-collisional volcanism in QTP. The age data not only confirm the temporal and spatial migration of post-collisional volcanism in QTP, but also provide geochronological constraints on the geodynamic set- ting at depth and the regimes of the tectonic evolution since Neogene in western Qinling regions. | YU Xuehui ZHAO Zhidan ZHOU Su MO Xuanxue ZHU Deqing WANG Yonglei | 2006 | Chinese Science Bulletin2006，51，13： | 7 |
| 9 | Metamorphic peridotite and rock series of ophiolite belt in Mt. Ailao, Yunnan Province显示文摘The metamophic peridotite of ophiolite belt in Mt. Ailao is composed of lherzolite and harzburgite. The former shows the charateristics of primary pyrolite and the latter shows those of deleted (relict)pyrolite. By partial melting of lherzolite, two primary magmas: tholeiitic magma and picrite-basalt magma are formed. The former evoluted into gabbro-diabase-pyroxenic basalt rock series and show the characteristics of MORB; while the latter evoluted into gabbro-diorite-albite basalt-picrite basalt one, and show the characteristics of para-MORB. | Shen Shangyue Wei Qirong Cheng Huilan Mo Xuanxue | 1998 | Chinese Science Bulletin1998，43，11： | 6 |
| 10 | Porphyry mineralization in the Tethyan orogen显示文摘The Tethyan metallogenic domain(TMD),as one of the three major domains in the world,extends over 10000 km from east to west,and has developed several world-class metallogenic belts,such as the Gangdese porphyry Cu belt,the Sanjiang metallogenic belt,the Iran porphyry Cu belt,the Pakistan porphyry Cu belt,the southeastern European epithermal gold deposit belt,and the Southeast Asian Sn belt.The formation and evolution of the TMD is mainly controlled by the multi-stage subduction of Tethys oceanic slabs,the opening and closing of several small ocean basins,and continent-continent collision.The Tethys oceans include the Proto-Tethys(Cambrian-Silurian),Paleo-Tethys(Carbonaceous-Triassic)and Neo-Tethys(Jurassic to Cretaceous),which in turn are formed by rifting from the Gondwana land at different times in different micro-continents.With a series of geological processes such as oceanic opening and closing,continental collision and post-collisional reworking with intraplate deformation,various types of ore deposits are developed in the TMD,including porphyry deposits,epithermal deposits,VMS deposits,chromite deposits,Sn deposits and orogenic gold deposits.The metallogenic processes of the TMD can be categorized into three stages.(1)Oceanic subduction:With the subduction of the oceanic slab and dehydration of basalt and sediments,the asthenospheric mantle was metasomatized with preliminary enrichment in metals under oxidized condition.(2)Continental subduction:Continental collision induced partial melting of the mantle wedge enriched the metals and water in mafic melts,which ascended from subarc depths to the lower crust,locally to the shallow crust for hydrothermal mineralization.(3)Post-collisional reworking:Partial melting of the mafic intrusives in the lower crust produced felsic melts under oxidized and water-rich conditions,which underwent crystal fractionation and transferred water and metals into hydrothermal fluids for mineralization.The large-scale porphyry mineralization in the TMD mainly occurs in the Miocene,which is an important scientific issue worthy of further study in the future.How is the metal enriched in the processes of gradual maturity of the crust,and how does large-scale mineralization occur in a collisional orogen where there is no subduction and dehydration of oceanic slabs anymore to supply S and Cl?These are still important questions in the study of porphyry mineralization in the Tethyan orogen.The application of hyperspectral and mineralogical studies of alteration assemblages is beneficial for prospecting and exploration in the TMD. | Rui Wang Dicheng Zhu Qing Wang Zengqian Hou Zhiming Yang Zhidan Zhao Xuanxue Mo | 2020 | Science China Earth Sciences2020，63，12： | 5 |
| 11 | Experimental study on electrical conductivity of dunite at high temperature and pressure——The evidence of electrical conductivity of cold mantle in the Gaize-Lugu area显示文摘The electrical conductivities of the dunite from the Qinghai-Xizang (Tibetan) Plateau were measured with the impedance spectra method at 1.0-4.0 GPa and 643-1093 K. The experimental results indicated that activation enthalpies of the dunite are smaller than 0.9 eV, the conduction mechanism in dunite may be attributed to the mixed electrical conduction involving grain interiors and boundaries. On the basis of the results of this experiment, we can deduce that there exists cold mantle in the area of Gaize-Lugu in the Qinghai-Xizang (Tibetan) Plateau by reverse methods from the magnetotelluric sounding data (conductivity-depths profile) available for western Tibet. The result provides the present cold mantle viewpoint with strong proof on the basis of high temperature and pressure experiments. | WANG Duojun LI Heping LIU Congqiang ZHAO Zhidan MO Xuanxue GUO Tieying SU Gengli DING Dongye | 2001 | Chinese Science Bulletin2001，46，24： | 5 |
| 12 | Discriminating characters of ore-forming intrusions in the super-large Chalukou porphyry Mo deposit,NE China显示文摘The Chalukou porphyry Mo deposit, located in the Great Hinggan Range, is the largest Mo deposit in northeast China, although the age and genesis of the associated magmatic intrusions remain debated.Here we report zircon U-Pb ages and trace elements, whole rock geochemistry and Sre Nd isotope data with a view to understand the relationship between the magmatism and molybdenum mineralization.Zircon U-Pb analysis yield an age of 475 Ma for rhyolite in the older strata, 168 Ma for the premineralization monzogranite, and 154 Ma for the syn-mineralization granite porphyry. The granite porphyry and quartz porphyry are considered as the ore-forming intrusions. These rocks are peraluminous, alkali-calcic, and belong to high-K to shoshonitic series with a strong depletion of Eu. They also display characteristics of I-type granites. The rocks exhibit wide variations of(87 Sr/86 Sr)iin the range of 0.705426 -0.707363, and ε_(Nd)(t) of -3.7 to 0.93. Zircon REE distribution patterns show characteristics between crust and the mantle, implying magma genesis through crust-mantle interaction. The Fe_2O_3/FeO values(average 1) for the whole rock and EuN/Eu*Nvalues(average 0.45), Ce^(4+)/Ce^(3+) values(average 301)for zircon grains from the granite porphyry are higher than those from other lithologies. These features suggest that the ore-forming intrusions(syn-mineralization porphyry) had higher oxygen fugacity conditions than those of the pre-mineralization and post-mineralization rocks. The Chalukou Mo deposit formed in relation to the southward subduction of the Mongol-Okhotsk Ocean. Our study suggests that the subduction-related setting, crust-mantle interaction, and the large-scale magmatic intrusion were favorable factors to generate the super-large Mo deposits in this area. | Peixin Duan Cui Liu Xuanxue Mo Jinfu Deng Jinhua Qin Yu Zhang Shipan Tian | 2018 | Geoscience Frontiers2018，9，5： | 3 |
| 13 | Yanshanian Magma-Tectonic-Metallogenic Belt in East China of Circum-Pacific Domain(Ⅰ):Igneous Rocks and Orogenic Processes显示文摘Yanshanianmagma-tectonic-metalogenicbeltoftheEastChinaisapartofthecircum-Pacificdomain.Alotofpapershavebeenpublishedtodiscuss... | Deng Jinfu Mo Xuanxue Zhao Hailing Luo Zhaohua Zhao Guochun Department of Geology and Mineral Resources, China University of Geosciences, Beijing 100083 | 1999 | Journal of Earth Science1999，18，1： | 3 |
| 14 | Petrogenesis of Kejie Granite in the Northern Changning-Menglian Zone, Western Yunnan: Constraints from Zircon U-Pb Geochronology, Geochemistry and Hf Isotope显示文摘The Kejie pluton is located in the north of the Changning-Menglian suture zone. The rock types are mainly biotite-granite. Zircon LA-ICP-MS U-Pb dating indicates that the Kejie pluton emplaced at about 80–77 Ma, Late Cretaceous. The Kejie pluton samples are characterized by high SiO2(71.68%–72.47%), K2O(4.73%–5.54%), total alkali(K2O + Na2O = 8.21%–8.53%), K2O/Na2O ratios(1.36–1.94) and low P2O5(0.13%–0.17%), with A/CNK of 1.025–1.055; enriched in U, Th, and K, depleted in Ba, Nb, Sr, Ti, P and Eu. They are highly fractionated, slightly peraluminous I-type granite. The two samples of the Kejie pluton give a large variation of εHf(t) values(-5.04 to 1.96) and Hf isotope crustal model ages of 1.16–1.5 Ga. Zircon Hf isotopes and zircon saturation temperatures of whole-rock(801°C–823°C) show that the mantle-derived materials maybe have played a vital role in the generation of the Kejie pluton. The Kejie pluton was most likely generated in a setting associated with the eastward subduction of the neo-Tethys ocean, where intrusion of mantle wedge basaltic magmas in the crust caused the anatexis of the latter, forming hybrid melts, which subsequently experienced high-degree fractional crystallization. | NIE Fei DONG Guochen MO Xuanxue WANG Xia FAN Wenyu DONG Meiling ZHU Huaping | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 3 |
| 15 | Contribution of syncollisional felsic magmatism to continental crust growth: A case study of the Paleogene Linzizong volcanic Succession in southern Tibet显示文摘 | Xuanxue Mo Yaoling Niu Guochen Dong Zhidan Zhao Zengqian Hou Su Zhou Shan Ke | 2008 | Chemical Geology2008，，1： | 2 |
| 16 | Evolutionary biogeography on Ophiocordyceps sinensis:An indicator of molecular phylogeny to geochronological and ecological exchanges显示文摘The fungus Ophiocordyceps sinensis is endemic to the vast region of the Qinghai-Tibetan plateau(QTP).The unique and complex geographical environmental conditions have led to the 'sky island' distribution structure of O.sinensis.Due to limited and unbalanced sample collections,the previous data on O.sinensis regarding its genetic diversity and spatial structure have been deemed insufficient.In this study,we analyzed the diversity and phylogeographic structures of O.sinensis using internally transcribed spacer region(ITS) and 5-locus datasets by a large-scale sampling.A total of 111 haplotypes of ITS sequences were identified from 948 samples data of the fungus O.sinensis,with representing high genetic diversity,and 8 phylogenetic clades were recognized in O.sinensis.Both the southeastern Tibet and the northwestern Yunnan were the centers of genetic diversity and genetic differentiation of the fungus,and they were inferred as the glacial refugia in the Quaternary.Three distribution patterns were identified to correspond to the 8 clades,including but not limited to the coexistence of widely and specific local distributive structures.It also revealed that the differentiation pattern of O.sinensis did not fit for the isolation-by-distance model.The differentiation into the 8 clades occurred between 1.56 Myr and6.62 Myr.The ancestor of O.sinensis most likely originated in the late Miocene(6.62 Myr) in the northwestern Yunnan,and the Scene A-C of the Qinghai-Tibetan movements may have played an important role in the differentiation of O.sinensis during the late Miocene-Pliocene periods.Our current results provide a much clearer and detailed understanding of the genetic diversity and geographical spatial distribution of the endemic alpine fungus O.sinensis.It also revealed that the geochronology resulting from paleogeology could be cross-examined with biomolecular clock at a finer scale. | Yongdong Dai Changkui Wu Feng Yuan Yuanbing Wang Luodong Huang Zihong Chen Wenbo Zeng Yao Wang Zhuliang Yang Pusheng Zeng Paul Lemetti Xuanxue Mo Hong Yu | 2020 | Geoscience Frontiers2020，11，3： | 2 |
| 17 | Enhancement of naked FIX minigene expression by chloroquine in mice显示文摘AIM: To study the effect of chloroquine on the expression of human clotting factor IX (hFIX) in mice. METHODS:Hydrodynamics-based naked DNA plasmid administration was performed by tail vein injection of 10 g of pCMV-hFIX and chloroquine (0, 100, 200, and 500 mol/L) in 2.2 mL of Ringer solution within 6-7 s, the level andstability of hFIX expression, liver damage and toxicity were then examined. RESULTS: The maximum expression ofhFIX level was 4.41.8 mg/L at 8 h after injection, 9.71.6 mg/L at 24 h only existed in 200 mol/L chloroquine-treated animals, which is 3-4 fold higher than that of control (P<0.01). There is no significant difference observedamong all the treated groups, 3 d later. Transaminase level and liver histological study showed the damage of liverwas not related to chloroquine (P>0.05). CONCLUSION: Chloroquine can enhance and sustain exogenous geneexpression in vivo without side effect under our experimental conditions. | Hong-yanCHEN Huan-zhangZHU BinLU XuanXU Ji-huaYAO QiSHEN Jing-lunXUE | 2004 | Acta Pharmacologica Sinica2004，25，5： | 2 |
| 18 | Double Convective Hydrothermal System beneath Massive Sulfide Orebody in Gacun Deposit,Southwestern China显示文摘The Gacun Kuroko-type deposit, Southwestern China, is hosted in rhyolitic rocks associated with the underlying mafic rocks occurred in the ~1000 m deep fault-hounded basin within the intra-arc rifting zone which formed on the Triassic Yidun island-arc. Two vertically separated alteration systems are recognized: one is conformable or semiconformable alteration zone developed in ~150 m thick mafic unit 1-1.5 km below the massive sulfde orehody; the other is discordant alteration pipe directly surrounded around stockwork ore within rhyolitic unit. The lower conformable alteration zone extending for several kilometers along strike is characterized by silicification and epidotization which result in the development of quartz vein and quartz-epidote vein systems in mafic lava flows and replacement of primary minerals and groundmass in spilitized mafic volcanics and dikes by quartz, epidote-group minerals and sodic plagiocluse. Sulfides often occur in the vein system and altered mafic volcanics. Quartz | Hou ZengqianInstitute of Mineral Deposits, CAGS, Beijing 100037Mo Xuanxue Department of Geology and Mineral Resources, China University of Geosdences, Beijing 100083Urabe Tetsuro Geological Survey of Japan, Higash 1-1-3, Tsukuba, Ibaraki, 305, Japan | 1995 | Journal of Earth Science1995，14，2： | 2 |
| 19 | Volcanism in Sanjiang Tethyan Orogenic Belt:New Facts and Concepts显示文摘Sanjiang area in Southwestern China is tectonically sit-uated at the east end of Himalaya-Tethys tectonic do-main and at the conjunction of Tethyan MountainChain and Circum-Pacific Mountain Chain.It is one ofthe key areas to understand the global tectonics and alsoone of gigantic metallogenic provinces in China and evenin the world.Volcanism had occurred during the periodof time from Proterozoic to Cenozoic.The most impor-tant and active periods of volcanism,however,areCarboniferous,Permian and Triassic.The pattern ofspatial distribution of Sanjiang volcanic rocks andophiolites can essentially be described as that severalintra——continental micro-massif volcanic districts arerespectively sandwiched between each two of four couplingophiolite—are volcanic belts,which are successively fromwest to east:Dingqing-Nujiang belt,Laneangjiangbelt,Jinshajiang belt and Ganzi-Litang belt.Fourtectono-magmatic types of volcanic rocks have been recognized in Sanjiang area as | Mo Xuanxue Lu Fengxiang Deng JinfuChina University of Geosciences , Wuhan 430074 | 1991 | Journal of Earth Science1991，10，1： | 2 |
| 20 | Mantle contributions to crustal thickening during continental collision: Evidence from Cenozoic igneous rocks in southern Tibet显示文摘 | Xuanxue Mo Zengqian Hou Yaoling Niu Guochen Dong Xiaoming Qu Zhidan Zhao Zhiming Yang | 2006 | LITHOS2006，，1： | 2 |
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