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| 1 | Whole-body physiology-based pharmacokinetics of caspofungin for general patients, intensive care unit patients and hepatic insufficiency patients显示文摘Caspofungin 是抗真菌的代理人在病人为侵略 candidiasis 作为首要的治疗准许了与的 echinocandin 对到 azoles 的严重的病或最近的暴露中等。在这研究,我们开发了一个整个身体的基于生理学的 pharmacokinetics (WB-PBPK ) 模型预言 caspofungin 的 pharmacokinetics (PK ) ,并且与蒙特卡罗模拟(MCS ) 结合了在病人的不同类型优化 caspofungin 的临床的剂量政体。caspofungin 的一个 WB-PBPK 模型从一般病人,的 4 以前的试用与未加工的数据被造并且验证有孩子呸 B 的特别护理单位(ICU ) 病人,连续肾的代替治疗上的 ICU 病人,温和、中等的肝的 insuffciency (嗨) 病人。MCS 被用来在这些病人优化 caspofungin 的临床的剂量政体。90% 的价值被考虑是为完成最佳的实验治疗的最小的反应(CFR ) 的累积部分。WB-PBPK 模型的模仿的结果在对所有试用的观察价值的好同意。为有 caspofungin 70/50 mg 的将军和 ICU 病人, AUC 和 Cmax 随身体重量(BW ) 的增加被减少并且显示出大变化。MCS 证明所有一般病人不管 BW 完成了 CFR90% 。然而并非有更高的 BW (70 kg ) 的所有 ICU 病人能完成 CFR90% 。与在一般病人的标准剂量政体相比,在有孩子呸 B 的 ICU 病人的 caspofungin 70/35 mg 完成了显著地减少的 AUC 和 Cmax,但是获得了类似的 AUC 和 Cmax 在中等嗨有孩子呸 B 的病人。caspofungin 的 WB-PBPK 模型能正确地预言所有人口的 PK。有 MCS 的联合 WB-PBPK 模型能成功地在所有耐心的人口优化 caspofungin 的临床的剂量政体。 | Qian-ting YANG Ya-jing ZHAI Lu CHEN Tao ZHANG Yan YAN Ti MENG Lei-chao LIU Li-mei CHEN Xue WANG Ya- lin DONG | 2018 | Acta Pharmacologica Sinica2018，39，9： | 3 |
| 2 | Discovery of Late Jurassic Sporopollen Assemblage from the Tamulangou Formation in the Hongqi Sag of the Hailar Basin,Inner Mongolia,China显示文摘Objective The Hailar Basin is situated in the northwestern margin of the Jiamusi-Mongolia Block.It was a continent marginal basin to the south of the Mongolia-Okhotsk Ocean during the Jurassic and Cretaceous.The basement of the basin is a late Paleozoic marine deposit.The filling of the basin is characterized by terrestrial volcanic rocks。 | WAN Chuanbiao XUE Yunfei SUN Yuewu HOU Yanping JIN Yudong ZHANG Xin LI Ti | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 1 |
| 3 | Forecast of the number of patient with end - stage renal disease in the United States to the year 2010 显示文摘 | Xue TI Ma TI Louis TA | 2001 | J Am Sot Nephral2001，12，： | 1 |
| 4 | An orthotopic metastatic prostate canc- er model in SCID mice via grafting of a transplantable human prostate tumor line显示文摘 | Wang Y Xue tI Cutz JC | 2005 | Lab Invest2005，85，11： | 1 |
| 5 | Forecast of the number of patient with end-stage renal disease in the United States to the year 2010显示文摘 | Xue TI Ma TI Louis TA | 2001 | J Am Sot Nephral2001，12，12： | 1 |
| 6 | Identification of a Novel Mutation in Solute Carrier Family 29, Member 3 in a Chinese Patient with H Syndrome显示文摘 | Jia-Wei Liu Nuo Si Lian-Qing Wang Ti Shen Xue-Jun Zeng Xue Zhang Dong-Lai Ma | 2015 | Chinese Medical Journal2015，，10： | 1 |
| 7 | The new X-ray imaging and biomedical application beamline BL13HB at SSRF显示文摘A new X-ray imaging and biomedical application beamline(BL13HB)has been implemented at the Shanghai Radiation Synchrotron Facility(SSRF)as an upgrade to the old X-ray imaging and biomedical application beamline(BL13W1).This is part of the Phase II construction project of the SSRF.The BL13HB is dedicated to 2D and 3D static and dynamic X-ray imaging,with a field of view of up to 48.5 mm×5.2 mm and spatial resolution as high as 0.8μm.A super-bending magnet is used as the X-ray source in BL13HB,which has a maximum magnetic field of 2.293 T.The energy range of monochromatic X-ray photons from a double-multiplayer monochromator was 8–40 keV,and the white beam mode was provided on the beamline for dynamic X-ray imaging and dynamic X-ray micro-CT.While maintaining the previous experimental setup of BL13W1,new equipment was added to the beamline experimental station.The beamline is equipped with different sets of X-ray imaging detectors for several experimental methods such as micro-CT,dynamic micro-CT,and pair distribution function.The experimental station of BL13HB is designed specifically for various in situ dynamic experiments,and BL13HB has been open to users since June 2021. | Jian‑Feng Ji Han Guo Yan‑Ling Xue Rong‑Chang Chen Ya‑Nan Fu Guo‑Hao Du Biao Deng Hong‑Lan Xie Ti‑Qiao Xiao | 2023 | Nuclear Science and Techniques2023，34，12： | 0 |
| 8 | Climate characteristics of the eastern Mongolian Plateau,China during the early Early Cretaceous(145-132 Ma):Palynological evidence from the Tongbomiao Formation in Well Hong-6,Hailar Basin显示文摘This study identified two palynological assemblages,namely Bayanhuasporites-Cycadopites-Protoconiferus and Cicatricosisporites-Cedripites-Perinopollenites,in the Tongbomiao Formation in the Hongqi Sag in the Hailar Basin,Inner Mongolia,China for the first time.The former is distributed in the lower part of the Tongbomiao Formation and is characterized by abundant gymnosperm pollen and diverse fern spores.Among them,the gymnosperm pollen is dominated by Paleoconifer(4.98%-31.62%)and Cycadopite(8.55%-25.23%)pollen grains and also includes other pollen grains such as Classopollis,Parcisporites,Erlianpollis,Callialasporites,and Jiaohepollis.The fern spores in the former palynological assemblage contain Bayanhuasporite(0-8.96%),Granulatisporites(0.93%-6.97%),and some important Cretaceous genera,such as Cicatricosisporites,Concavissimisporites,Densoisporites,Hsuisporites,Foraminisporis,and Leptolepidites.The Cicatricosisporites-Cedripites-Perinopollenites palynological assemblage is distributed in the upper part of the Tongbomiao Formation.Gymnosperm(77.30%),Pinaceae(31.9%),and Paleoconiferus(19.02%)pollen predominate this palynological assemblage,and Quadraeculina,Erlianpollis,and Jiaohepollis pollen are also common in this assemblage.The fern spores in this palynological assemblage include abundant Cicatricosisporites(4.29%).Besides,Concavissimisporites,Aequitriradites,and Leptolepidites are also common in this palynological assemblage.No angiosperm pollen has been found in both palynological assemblages.The identification of both palynological assemblages provides important evidence for the biostratigraphic correlation between the Hailar Basin and its adjacent areas.It also enables the reconstructions of the Berriasian-Valanginian(Early Cretaceous)vegetation and the paleoclimate on the eastern Mongolian Plateau during 141-132 Ma.The vegetation reconstructed on the palynological data of the represented by Hailar Basin in eastern Mongolian Plateau(141.6-141.4 Ma),form conifer forest or conifer broad-leaved mixed forest to conifer forest with shrubs and grassland,the climate belongs to warm temperate and warm-subtropicalt,the highest temperature is estimated to reach 35-38℃.Form 132.3 Ma,the vegetation type is conifer forest,and its paleoclimate is sub-humid warm temperate,the highest temperature is estimated to reach 24-29℃. | Yan Zhang Yun-fei Xue Chun-yang Bu Ti Li Xin Zhang Yu-dong Jin Yue-wu Sun | 2022 | China Geology2022，5，3： | 0 |
| 9 | CRYSTAL STRUCTURE OF THE COPPER(II) COMPLEX OF NEW MACROCYCLIC DIOXOTETRAAMINE LIGAND FUNCTIONALIZED WITH 8-METHYL QUINOLINE PENDANT显示文摘CRYSTALSTRUCTUREOFTHECOPPER(II)COMPLEXOFNEWMACROCYCLICDIOXOTETRAAMINELIGANDFUNCTIONALIZEDWITH8-METHYLQUINOLINEPENDANT￥XianHeB... | Xian He BU Dao Li AN Man Xue YUAN and Yun Ti CHEN (Department of Chemistry, Nankai University,Tianjin 300071) | 1994 | Chinese Chemical Letters1994，5，12： | 0 |
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