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| 1 | The seismic CT method in measuring rock bodies显示文摘地震计算断层摄影术(CT ) 方法从节扫描首先在医药科学使用了的 X 光检查的基本原则被导出。方法在分开的地上凿穿记录在射击和接收装置之间的 P 波浪到达。用从 2D 的速度信息地震 P 波浪到达倒置,我们能在岩石和土壤身体中决定速度的分发。这篇论文介绍使用地震 CT 方法为隧道工程并且到检测岩石的结构的一个实际盒子为做第一到达时间反复的倒置利用 SIRT 算法。与另外的探索方法相比,它更有效、精确。 | Du Lizhi Zhang Xiaopei Niu Jianjun Wang Xuege Feng Guolei | 2006 | Applied Geophysics2006，3，3： | 8 |
| 2 | Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network显示文摘Objective:Drug repurposing,the application of existing therapeutics to new indications,holds promise in achieving rapid clinical effects at a much lower cost than that of de novo drug development.The aim of our study was to perform a more comprehensive drug repurposing prediction of diseases,particularly cancers.Methods:Here,by targeting 4,096 human diseases,including 384 cancers,we propose a greedy computational model based on a heterogeneous multilayer network for the repurposing of 1,419 existing drugs in Drug Bank.We performed additional experimental validation for the dominant repurposed drugs in cancer.Results:The overall performance of the model was well supported by cross-validation and literature mining.Focusing on the top-ranked repurposed drugs in cancers,we verified the anticancer effects of 5 repurposed drugs widely used clinically in drug sensitivity experiments.Because of the distinctive antitumor effects of nifedipine(an antihypertensive agent)and nortriptyline(an antidepressant drug)in prostate cancer,we further explored their underlying mechanisms by using quantitative proteomics.Our analysis revealed that both nifedipine and nortriptyline affected the cancer-related pathways of DNA replication,the cell cycle,and RNA transport.Moreover,in vivo experiments demonstrated that nifedipine and nortriptyline significantly inhibited the growth of prostate tumors in a xenograft model.Conclusions:Our predicted results,which have been released in a public database named The Predictive Database for Drug Repurposing(PAD),provide an informative resource for discovering and ranking drugs that may potentially be repurposed for cancer treatment and determining new therapeutic effects of existing drugs. | Xi Cheng Wensi Zhao Mengdi Zhu Bo Wang Xuege Wang Xiaoyun Yang Yuqi Huang Minjia Tan Jing Li | 2022 | Cancer Biology & Medicine2022，19，1： | 2 |
| 3 | Application of TSD tunnel seismic prediction system in karst area显示文摘TSD is one of the classical methods of tunnel seismic prediction based on higher accuracy multi-wave multi-component seismology.The working principle of the TSD and an application example of the TSD on tunnel prediction in Chongqing are introduced in this paper.This system has two ports for speed signal and acceleration signal,and the equipment is more portable and easy to use.According to the application results we can conclude that the TSD prediction system is accurate and it has the wide application prospect in tunnel seismic detection. | Lizhi DU Xiaopei ZHANG Jianjun NIU Xuege WANG | 2008 | Global Geology2008，11，4： | 1 |
| 4 | Analysis of the land use structure changes based on Lorenz curves显示文摘 | Tang Jie Wang Xuege | 2009 | Environ Monit Assess2009，，151： | 1 |
| 5 | Analysis of the land use structure changes based on Lorenz curves显示文摘 | Tang Jie Wang Xuege | 2009 | Environ Monit Assess2009，，151： | 1 |
| 6 | Current Pattern of Water Ecology and Its Existing Problems in Jilin Province显示文摘Pattern distribution characteristics of water ecology in Jilin Province are introduced, and provincial water ecology problems are revealed from river cut-off and wetland shrinkage, fish resources reduction and habitat fragmentation, water pollution, soil erosion and so on. Relevant suggestions on water ecology protection are proposed, such as implementing relevant laws and policies, controlling total sewage discharge, optimizing water resources allocation, and enhancing wetland protection, fish resources protection, comprehensive management of small watershed and water ecology compensation. The research could provide certain reference for protection and restoration of water ecology in the watershed. | Wu Jisheng Liang Tuanhao Lv Jun Wang Xuege | 2019 | Meteorological and Environmental Research2019，10，4： | 0 |
| 7 | Present Situation of West Wetland in Jilin Province and Countermeasures for Restoration显示文摘The western region of Jilin Province is rich in wetland resources,and its biodiversity is rich. However in recent years,due to the reduction of natural precipitation,human activities and other causes,wetland shrivels and degenerates,biodiversity reduces,and ecosystem security is threatened. In this paper,the rivers and lakes connecting project in western Jilin Province is proposed to restore the damaged wetlands and protect important wetlands. | Wang Xuege Lv Jun Wang Yanmei Wei Chunfeng | 2017 | Meteorological and Environmental Research2017，8，5： | 0 |
| 8 | Application of ultrasonic CT method in nondestructive detection of interior defects in large scale concrete structural member of bridge显示文摘The ultrasonic computed tomography(USCT)method is derived from the basic principles of X-ray section scanning.This method records the arriving times of ultrasonic wave between the probes and the sources to calculate the elastic wave velocity values in the section using the arrival times.Through analyzed the distribution of elastic wave velocity in aim area,the information of the strength and the homogeneity of the investigated zone could be got indirectly.The authors introduced the operational principle of USCT and a practical case of using this method to detect the interior defects in large scale concrete structural member.Compared with other exploration methods,this method is more efficient and accurate. | Xiaopei ZHANG Jianhui QIU Jianjun NIU Lizhi DU Xuege WANG | 2008 | Global Geology2008，11，4： | 0 |
| 9 | Study on Eco-environmental Stress Based on the Method of Entropy-GM(1,1) ——A Case Study in Tongyu County of Jilin Province显示文摘This paper takes the Tongyu County as an example,based on the evaluation indicator system of eco-environmental stress,using the method of the entropy-GM(1,1),the eco-environmental stress is evaluated and forecasted.Results show that the shortage of water resources,the desertification,the salinization,the grassland degeneration and the population increase are major stress factors of eco-environment worsening in the Tongyu County;eco-environmental stress coefficient from 1994 to 2013 in the region was increasing year by year,and the stress degree jumped from level-III to level-IV.The forecast results show that if the measures don't be taken to protect eco-environment,the stress coefficient still grows,and the stress degree aggravates.In view of the above situation,we take the measures to lighten eco-environment stress,and promote the coordinated development of resources,environment and social economy,which is linking rivers and lakes,water resources optimization,preventing and controlling the desertification and the salinization,improving the degenerated grassland. | Wang Xuege Si Ai Wei Chunfeng Lv Jun Wang Yanmei | 2015 | Meteorological and Environmental Research2015，6，3： | 0 |
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