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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | The first all-season sample set for mapping global land cover with Landsat-8 data显示文摘We report the world's first all-season training and validation sample sets for global land cover classification with Landsat-8 data.Prior to this,such samples were only available at a single date primarily from the growing season.It is unknown how much limitation such a single-date sample has to mapping global land cover in other seasons of the year.To answer this question,we selected available Landsat-8 images from four seasons and collected training and validation samples from them.We compared the performances of training samples in different seasons using Random Forest algorithm.We found that the use of training samples from any individual season would result in the best overall classification accuracy when validated by samples in the same season.The global overall accuracy from combined best seasonal results was 67.2% when classifying the 11 Level-1 classes in the Finer Resolution Observation and Monitoring of Global Land Cover(FROM-GLC) classification system.The use of training samples from all seasons(named all-season training sample set hereafter) produced an overall accuracy of 67.0%.We also tested classification within 10° latitude 60° longitude zones using all-season training subsample within each zone and obtained an overall accuracy of 70.2%.This indicates that properly grouped subsamples in space can help improve classification accuracies.All the results in this study seem to suggest that it is possible to use an all-season training sample set to reach global optimality with universal applicability in classifying images acquired at any time of a year for global land cover mapping. | Congcong Li Peng Gong Jie Wang Zhiliang Zhu Gregory S. Biging Cui Yuan Tengyun Hu Haiying Zhang Qi Wang Xuecao Li Xiaoxuan Liu Yidi Xu Jing Guo Caixia Liu Kwame O. Hackman Meinan Zhang Yuqi Cheng Le Yu Jun Yang Huabing Huang Nicholas Clinton | 2017 | Science Bulletin2017，62，7： | 21 |
| 3 | Separation of light hydrocarbons with ionic liquids: A review显示文摘Light hydrocarbons(C1–C4) are fundamental raw materials in the petroleum and chemical industry. Separation and purification of structurally similar paraffin/olefin/alkyne mixtures are important for the production of highpurity or even polymer-grade light hydrocarbons. However, traditional methods such as cryogenic distillation and solvent absorption are energy-intensive and environmentally unfriendly processes. Ionic liquids(ILs) as a new alternative to organic solvents have been proposed as promising green media for light hydrocarbon separation due to their unique tunable structures and physicochemical properties resulting from the variations of the cations and anions such as low volatility, high thermal stability, large liquidus range, good miscibility with light hydrocarbons, excellent molecular recognition ability and adjustable hydrophylicity/hydrophobicity. In this review, the recent progresses on the light hydrocarbon separation using ILs are summarized, and some parameters of ILs that influence the separation performance are discussed. | Yuqi Huang Yuanbin Zhang Huabin Xing | 2019 | Chinese Journal of Chemical Engineering2019，27，6： | 11 |
| 4 | Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis显示文摘 | Yi Lu Shanshan Xie Wen Zhang Cheng Zhang Cheng Gao Qiang Sun Yuqi Cai Zhangqi Xu Min Xiao Yanjun Xu Xiao Huang Ximei Wu Wei Liu Fudi Wang Yibin Kang Tianhua Zhou | 2017 | Cell Research2017，27，12： | 9 |
| 5 | Cytosolic delivery of the immunological adjuvant PolyⅠ:C and cytotoxic drug crystals via a carrier-free strategy significantly amplifies immune response显示文摘Co-delivery of chemotherapeutics and immunostimulant or chemoimmunotherapy is an emerging strategy in cancer therapy.The precise control of the targeting and release of agents is critical in this methodology.This article proposes the asynchronous release of the chemotherapeutic agents and immunostimulants to realize the synergistic effect between chemotherapy and immunotherapy.To obtain a proof-of-concept,a co-delivery system was prepared via a drug-delivering-drug(DDD)strategy for cytosolic co-delivery of Poly I:C,a synthetic ds RNA analog to activate RIG-I signaling,and PTX,a commonly used chemotherapeutics,in which pure PTX nanorods were sequentially coated with Poly I:C and mannuronic acid via stimulating the RIG-I signaling axis.The co-delivery system with a diameter of 200 nm enables profound immunogenicity of cancer cells,exhibiting increased secretion of cytokines and chemokines,pronounced immune response in vivo,and significant inhibition of tumor growth.Also,we found that intracellularly sustained release of cytotoxic agents could elicit the immunogenicity of cancer cells.Overall,the intracellular asynchronous release of chemotherapeutics and immunomodulators is a promising strategy to promote the immunogenicity of cancer cells and augment the antitumor immune response. | Xiaoqing Du Yuqi Hou Jia Huang Yan Pang Chenlu Ruan Wei Wu Chenjie Xu Hongwei Zhang Lifang Yin Wei He | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 3 |
| 6 | Impact of type 2 diabetes mellitus on short-term and long-term outcomes of patients with esophageal squamous cell cancer undergoing resection: a propensity score analysis显示文摘Background:The association between type 2 diabetes mellitus(T2DM)and the risk of esophageal cancer remains unclear.The present study aimed to evaluate the impact of T2DM on short-term outcomes and long-term survival in patients with esophageal squamous cell cancer(ESCC).Methods:The present retrospective study included 862 patients diagnosed with ESCC between January 2001 and December 2010.Among them,280 patients had T2DM.A 1:1 propensity score-matched cohort consisting of 280 patients with and 280 without T2DM was selected from the 862 patients.The associations between T2DM and clinico-pathologic characteristics were assessed using theχ2 or Fisher’s exact test.Survival of ESCC patients with and without T2DM was calculated by using the Kaplan-Meier method and compared by using the Cox regression model between the two groups.Results:The occurrence rate of anastomotic leakage was significantly higher in patients with T2DM than in those without T2DM(P<0.001).In the subgroup with weight loss rate≤5.05%,ESCC patients with T2DM had a signifi-cant longer overall survival than did those without T2DM(P=0.003),whereas in the subgroup with weight loss rate>5.05%,the patients without T2DM showed a longer survival(P=0.001).Univariate and multivariate analysis results showed that T2DM was not an independent prognostic factor for patient survival.Conclusions:Type 2 diabetes mellitus is not an independent prognostic factor in patients with ESCC.However,the combination of T2DM with severe weight loss would be a predictor of poor prognosis. | Wang Yao Yuqi Meng Mingjian Lu Wenzhe Fan Jinhua Huang Jiaping Li Zhihua Zhu | 2018 | Cancer Communications2018，38，1： | 2 |
| 7 | Programmable DNA-responsive microchip for the capture and release of circulating tumor cells by nucleic acid hybridization显示文摘 | Shan Guo Haiyan Huang Xujing Deng Yuqi Chen Zhuoran Jiang Min Xie Songmei Liu Weihua Huang Xiang Zhou | 2018 | Nano Research2018，11，5： | 2 |
| 8 | OsCBL1 Modulates Lateral Root Elongation in Rice via Affecting Endogenous Indole-3-Acetic Acid Biosynthesis显示文摘Root growth is important for plants to efficiently acquire water and mineral nutrients from soil.Root system architecture(RSA),which is determined mainly by root branching through lateral root formation and root angles,has a significant influence on root growth.Generally,the growth and development of roots are regulated by numerous plant hormones,which respond to external environmental stimulation through com- | Jing Yang Xiaomu Zhang Yunqing Huang Yuqi Feng Yangsheng Li | 2015 | Journal of Genetics and Genomics2015，42，6： | 2 |
| 9 | Zebrafish hhex-null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1显示文摘The hepatopancreatic duct (HPD) system links the liver and pancreas to the intestinal tube and is composed of the extrahepatic biliary duct, gallbladder, and pancreatic duct. Haematopoietically expressed-homeobox (Hhex) protein plays an essential role in the establishment of HPD;however, the molecular mechanism remains elusive. Here, we show that zebrafish hhex-null mutants fail to develop the HPD system characterized by lacking the biliary marker Annexin A4 and the HPD marker sox9b. The hepatobiliary duct part of the mutant HPD system is replaced by an intrahepatic intestinal tube characterized by expressing the intestinal marker fatty acid-binding protein 2a (fabp2a). Cell lineage analysis showed that this intrahepatic intestinal tube is not originated from hepatocytes or cholangiocytes. Further analysis revealed that cdx1b and pdx1 are expressed ectopically in the intrahepatic intestinal tube and knockdown of cdx1b and pdx1 could restore the expression of sox9b in the mutant. Chromatin-immunoprecipitation analysis showed that Hhex binds to the promoters of pdx1 and cdx1b genes to repress their expression. We therefore propose that Hhex, Cdx1b, Pdx1, and Sox9b form a genetic network governing the patterning and morphogenesis of the HPD and digestive tract systems in zebrafish. | Ce Gao Weidong Huang Yuqi Gao Li Jan Lo Lingfei Luo Honghui Huang Jun Chen Jinrong Peng | 2019 | Journal of Molecular Cell Biology2019，11，6： | 2 |
| 10 | Molecular dynamics simulation of PNPLA3 I148M polymorphism reveals reduced substrate access to the catalytic cavity显示文摘 | Yong‐Ning Xin Yuqi Zhao Zhong‐Hua Lin Xiangjun Jiang Shi‐Ying Xuan Jingfei Huang | 2012 | Proteins2012，，3： | 2 |
| 11 | Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network显示文摘Objective:Drug repurposing,the application of existing therapeutics to new indications,holds promise in achieving rapid clinical effects at a much lower cost than that of de novo drug development.The aim of our study was to perform a more comprehensive drug repurposing prediction of diseases,particularly cancers.Methods:Here,by targeting 4,096 human diseases,including 384 cancers,we propose a greedy computational model based on a heterogeneous multilayer network for the repurposing of 1,419 existing drugs in Drug Bank.We performed additional experimental validation for the dominant repurposed drugs in cancer.Results:The overall performance of the model was well supported by cross-validation and literature mining.Focusing on the top-ranked repurposed drugs in cancers,we verified the anticancer effects of 5 repurposed drugs widely used clinically in drug sensitivity experiments.Because of the distinctive antitumor effects of nifedipine(an antihypertensive agent)and nortriptyline(an antidepressant drug)in prostate cancer,we further explored their underlying mechanisms by using quantitative proteomics.Our analysis revealed that both nifedipine and nortriptyline affected the cancer-related pathways of DNA replication,the cell cycle,and RNA transport.Moreover,in vivo experiments demonstrated that nifedipine and nortriptyline significantly inhibited the growth of prostate tumors in a xenograft model.Conclusions:Our predicted results,which have been released in a public database named The Predictive Database for Drug Repurposing(PAD),provide an informative resource for discovering and ranking drugs that may potentially be repurposed for cancer treatment and determining new therapeutic effects of existing drugs. | Xi Cheng Wensi Zhao Mengdi Zhu Bo Wang Xuege Wang Xiaoyun Yang Yuqi Huang Minjia Tan Jing Li | 2022 | Cancer Biology & Medicine2022，19，1： | 2 |
| 12 | Characteristics of fat metabolism in skeletal muscle of rats after hypobaric hypoxic acclimation显示文摘Objective: To investigate the characteristics of fat metabolism in rat skeletal muscle after hypobaric hypoxia acclimation. Methods: Sprague-Dawley rats were divided into 3 groups randomly: control group (H0), hypoxic 5-day group (H5), and hypoxic 15-day group (H15). Animals of H5 and 15 groups were exposed to hypobaric hypoxia chamber simulating 5 000 m high altitude for 5 d or 15 d respectively, 23 h per day. H0 group stayed outside of chamber. The level of fatty acid oxidation and uptake, and glucose oxidation were examined, and the level of non-esterified fatty acids (NEFA), ATP and phosphocreatine (PCr) were also assayed in rat skeletal muscles. Results: The contents of ATP and PCr in H5 group were lower than those in H0 and H15 groups (P<0.05), while there was no significant difference between H0 and H15. Compared with H0, the blood NEFA level in all hypoxia groups was increased significantly (P<0.05). The muscle NEFA level in H15 group was greatly higher than that in H0 and H5 groups. The rates of fatty acid oxidation and uptake in H15 group were significantly higher than those in H0 and H5 groups (P<0.05), and the rate of glucose oxidation in all hypoxia groups was significantly decreased than that in H0 group (P<0.05). Conclusion: It is concluded that the enhanced fat oxidation may be one of the mechanisms in the maintenance of energy homeostasis after hypobaric hypoxic acclimation. | Mao Sunzhong Gao Yuqi Chen Jian Liu Fuyi Gao Wenxiang Huang Jian Liao Weigong Cai Mingchun | 2008 | Journal of Medical Colleges of PLA(China)2008，23，5： | 2 |
| 13 | All-optically reeonfigurable and tunable fiber surface grating for in-fiber devices: a wideband tunable filter 显示文摘 | Yu Jianhui Han Yuqi Huang Hankai | 2014 | Opt Express2014，22，5： | 1 |
| 14 | Using a global reference sample set and a cropland map for area estimation in China显示文摘A technically transparent and freely available reference sample set for validation of global land cover mapping was recently established to assess the accuracies of land cover maps with multiple resolutions.This sample set can be used to estimate areas because of its equal-area hexagon-based sampling design.The capabilities of these sample set-based area estimates for cropland were investigated in this paper.A 30-m cropland map for China was consolidated using three thematic maps(cropland,forest and wetland maps)to reduce confusion between cropland and forest/wetland.We compared three area estimation methods using the sample set and the 30 m cropland map.The methods investigated were:(1)pixel counting from a complete coverage map,(2)direct estimation from reference samples,and(3)model-assisted estimation combining the map with samples.Our results indicated that all three methods produced generally consistent estimates which agreed with cropland area measured from an independent national land use dataset.Areas estimated from the reference sample set were less biased by comparing with a National Land Use Dataset of China(NLUD-C).This study indicates that the reference sample set can be used as an alternative source to estimate areas over large regions. | YULe LI XueCao LI CongCong ZHAO YuanYuan NIU ZhenGuo HUANG HuaBing WANG Jie CHENG YuQi LU Hui SI YaLi YU ChaoQing FU HaoHuan GONG Peng | 2017 | Science China Earth Sciences2017，60，2： | 1 |
| 15 | Periodically hydrologic alterations decouple the relationships between physicochemical variables and chlorophyll-a in a dam-induced urban lake显示文摘Periodically hydrologic alterations driven by seasonal change and water storage capacity management strongly modify physicochemical properties and chlorophyll-a(Chl-a)and their interactions in dam-induced lakes.However,the extent and magnitude of these changes still remain unclear.This study aimed to determine the effects of periodically hydrologic alterations on physicochemical variables and Chl-a in the dam-induced urban Hanfeng Lake,upstream of Three Gorges Reservoir.Shifts in Chl-a and 13 physicochemical variables were recorded monthly in the lake from January 2013 to December 2014.Chl-a was neither seasonal nor inter-annual differences while a few physical variables such as flow velocity(V)exhibited significantly seasonal variabilities,and chemical variables like total nitrogen(TN),nitrate-nitrogen(NO3-N),total phosphorus(TP),dissolved silica(DSi)were markedly inter-annual differences.Higher TN:TP(40:1)and lower NO3-N:DSi(0.8:1)relative to balanced stoichiometric ratios suggested changes in composition of phytoplankton communities and potentially increased proportion of diatom in Hanfeng Lake.Chl-a was predicable by combination of dissolved oxygen(DO),TN and DSi in dry season,and by V alone in wet season.During the whole study period,Chl-a was solely negatively correlated with TN:TP,indicating decline in N concentration and increase in P could therefore increase Chl-a.Our results highlight pronounced decoupling of linkages between Chl-a and physicochemical variables affected by periodically hydrologic alterations in dam-induced aquatic systems. | Tianyang Li Yuqi Zhang Binghui He Bing Yang Qi Huang | 2021 | Journal of Environmental Sciences2021，33，1： | 1 |
| 16 | Object-oriented change detection based on the Kolmogorov–Smirnov test using high-resolution multispectral imagery显示文摘 | Yuqi Tang Liangpei Zhang Xin Huang | 2011 | International Journal of Remote Sensing2011，，20： | 1 |
| 17 | Identification of close relationship between atmospheric oxidation and ozone formation regimes in a photochemically active region显示文摘Understanding ozone(O_(3))formation regime is a prerequisite in formulating an effective O_(3)pollution control strategy.Photochemical indicator is a simple and direct method in identifying O_(3)formation regimes.Most used indicators are derived from observations,whereas the role of atmospheric oxidation is not in consideration,which is the core driver of O_(3)formation.Thus,it may impact accuracy in signaling O_(3)formation regimes.In this study,an advanced three-dimensional numerical modeling system was used to investigate the relationship between atmospheric oxidation and O_(3)formation regimes during a long-lasting O_(3)exceedance event in September 2017 over the Pearl River Delta(PRD)of China.We discovered a clear relationship between atmospheric oxidative capacity and O_(3)formation regime.Over eastern PRD,O_(3)formation was mainly in a NO x-limited regime when HO_(2)/OH ratio was higher than 11,while in a VOC-limited regime when the ratio was lower than 9.5.Over central and western PRD,an HO_(2)/OH ratio higher than 5 and lower than 2 was indicative of NO x-limited and VOC-limited regime,respectively.Physical contribution,including horizontal transport and vertical transport,may pose uncertainties on the indication of O_(3)formation regime by HO_(2)/OH ratio.In comparison with other commonly used photochemical indicators,HO_(2)/OH ratio had the best performance in differentiating O_(3)formation regimes.This study highlighted the necessities in using an atmospheric oxidative capacity-based indicator to infer O_(3)formation regime,and underscored the importance of characterizing behaviors of radicals to gain insight in atmospheric processes leading to O_(3)pollution over a photochemically active region. | Kaihui Zhao Huihong Luo Zibing Yuan Danni Xu Yi Du Shu Zhang Yuqi Hao Yonghua Wu Jianping Huang Ying Wang Rongsheng Jiang | 2021 | Journal of Environmental Sciences2021，33，4： | 1 |
| 18 | Near-infrared light-triggered micelles for fast controlled drug release in deep tissue 显示文摘 | Cao Jie Huang Shanshan Chen Yuqi | 2013 | Biomaterials2013，34，26： | 1 |
| 19 | Expression and purification of a novel ZNF191 zinc finger protein显示文摘 | Yuqi Liu Long Yu Wenhao Yu Shaolin Shi Bingyun Sun Guojun Wu Zhongxian Huang | 1999 | Science in China Series B: Chemistry1999，，3： | 1 |
| 20 | Femtosecond laser fabrication of nanograting-based distributed fiber sensors for extreme environmental applications显示文摘The femtosecond laser has emerged as a powerful tool for micro-and nanoscale device fabrication. Through nonlinear ionization processes, nanometer-sized material modifications can be inscribed in transparent materials for device fabrication. This paper describes femtosecond precision inscription of nanograting in silica fiber cores to form both distributed and point fiber sensors for sensing applications in extreme environmental conditions. Through the use of scanning electron microscope imaging and laser processing optimization,high-temperature stable, Type II femtosecond laser modifications were continuously inscribed,point by point, with only an insertion loss at 1 d B m~(-1) or 0.001 d B per point sensor device.High-temperature performance of fiber sensors was tested at 1000℃, which showed a temperature fluctuation of ±5.5℃ over 5 days. The low laser-induced insertion loss in optical fibers enabled the fabrication of a 1.4 m, radiation-resilient distributed fiber sensor. The in-pile testing of the distributed fiber sensor further showed that fiber sensors can execute stable and distributed temperature measurements in extreme radiation environments. Overall, this paper demonstrates that femtosecond-laser-fabricated fiber sensors are suitable measurement devices for applications in extreme environments. | Mohan Wang Kehao Zhao Jingyu Wu Yuqi Li Yang Yang Sheng Huang Jieru Zhao Thomas Tweedle David Carpenter Guiqiu Zheng Qingxu Yu Kevin P Chen | 2021 | International Journal of Extreme Manufacturing2021，3，2： | 1 |
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