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| 1 | APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells显示文摘APOBEC3 protein families, a DNA cytidine deaminase, were up-regulated in multiple tumors. However, the relationship between Hepatocellular carcinoma(HCC) and APOBEC3B(A3B) remains unknown. It has been confirmed that interleukin-6(IL-6)has significant impacts on oncogenesis of HCC. Here, we reported that the expression of IL-6 was substantially up-regulated by A3 B in HepG2 cells. A3 B induced IL-6 expression through relocating HuR to enhance the IL-6 mRNA stability. Further analysis indicated that IL-6 also increased the expression of A3 B through JAK1/STAT3 signaling pathway, which formed a positive feedback to maintain the continuous expression of A3 B and IL-6, and thereby promoted the prolonged non-resolving inflammation. Collectively, these findings suggest that A3 B is essential for oncogenesis of HCC, and is a potential target for preventive intervention. | Shuran Li Xueyang Bao Duowei Wang Linjun You Xianjing Li Hongbao Yang Jinsong Bian Yun Wang Yong Yang | 2017 | Science China(Life Sciences)2017，60，6： | 2 |
| 2 | Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration显示文摘Osteochondral defects(OCD)cannot be efficiently repaired due to the unique physical architecture and the pathological microenvironment including enhanced oxidative stress and inflammation.Conventional strategies,such as the control of implant microstructure or the introduction of growth factors,have limited functions failing to manage these complex environments.Here we developed a multifunctional silk-based hydrogel incorporated with metal-organic framework nanozymes(CuTA@SF)to provide a suitable microenvironment for enhanced OCD regeneration.The incorporation of CuTA nanozymes endowed the SF hydrogel with a uniform microstructure and elevated hydrophilicity.In vitro cultivation of mesenchymal stem cells(MSCs)and chondrocytes showed that CuTA@SF hydrogel accelerated cell proliferation and enhanced cell viability,as well as had antioxidant and antibacterial properties.Under the inflammatory environment with the stimulation of IL-1β,CuTA@SF hydrogel still possessed the potential to promote MSC osteogenesis and deposition of cartilage-specific extracellular matrix(ECM).The proteomics analysis further confirmed that CuTA@SF hydrogel promoted cell proliferation and ECM synthesis.In the full-thickness OCD model of rabbit,CuTA@SF hydrogel displayed successfully in situ OCD regeneration,as evidenced by micro-CT,histology(HE,S/O,and toluidine blue staining)and immunohistochemistry(Col I and aggrecan immunostaining).Therefore,CuTA@SF hydrogel is a promising biomaterial targeted at the regeneration of OCD. | Zhicheng Cao Hongmei Wang Jialin Chen Yanan Zhang Qingyun Mo Po Zhang Mingyue Wang Haoyang Liu Xueyang Bao Yuzhi Sun Wei Zhang Qingqiang Yao | 2023 | Bioactive Materials2023，，2： | 2 |
| 3 | Experiment Study and Interpretation on Relation between Modulus of Rock and Strain Amplitude显示文摘Nonlinear elasticity of the earth medium produces a numerical difference between the dynamic and the static modulus of rock. The dynamic modulus is calculated with the ultrasonic velocity measurement, the small-cycle modulus is calculated with small cycles in the load-unload experiment,the static modulus is calculated from the slope of the stress-strain curve in the large cycle, the Young’s modulus is obtained from the ratio of stress to strain in the measured point. The relationship between the modulus and the strain amplitudes is studied by changing the strain amplitude in the small cycles. The moduli obtained from different measuring methods are thus compared. The result shows that the dynamic modulus is the largest, the small-cycle modulus takes the second place, the static modulus of bigger-cycle is the third, and finally the Young’s modulus is the smallest. Nonlinear modulus of rock is a function of the strain level and strain amplitude. The modulus decreases exponentially with the ascending of the strain amplitude, while increases with the ascending of the strain level. Finally, the basic concept of the P-M model is briefly introduced and the relationship between the modulus and strain amplitude is explained by the rock having different distribution densities and the different open-and-close stresses of the micro-cracks. | Bao Xueyang Shi Xingjue Wen Dan Li Chengbo Wang Xingzhou | 2006 | Earthquake Research in China2006，20，2： | 0 |
| 4 | Global seismic tomography reveals remnants of subducted Tethyan oceanic slabs in the deep mantle显示文摘The Tethyan evolution depicts the continuous process of landmasses separating from the Gondwana continent in the south,drifting northwards,and subsequently colliding with the continents in the north over the past 500 million years.In this process,the Tethyan oceans that formed between the landmass and the southern or northern continents underwent growth,evolution,and eventual closure with the early Cenozoic India-Eurasia collision.However,the Tethyan lithosphere did not disappear but rather continued to evolve after entering into the deep Earth.The current position,morphology,and volume of the subducted Tethyan oceanic slabs in the deep mantle record the latest moment of this continuous evolution,providing critical constraints for Tethyan studies.This paper summarizes and analyzes the results of global-scale whole-mantle seismic tomography in the past nearly two decades,revealing a northwest-southeast seismically high-velocity anomaly,which is linearly distributed at depths of 1000–2000 km beneath the Tethyan realm and referred to as the Tethyan anomaly.By searching for an optimal linear combination of previous global seismic tomographic models to best match the known subducted slabs in the upper mantle,we observe that the Tethyan anomaly extends approximately 8700 km in length and 2600 km in width,exhibiting a parallel structure with northern and southern branches.Combining geological records of oceanic subduction initiation and previous geodynamic studies,this study suggests that the main body of the Tethyan anomaly represents the remnants of the subducted Neo-Tethyan oceanic slabs,which subducted from the Late Jurassic to the early Cenozoic.The northern branch consists of subducted slabs from the Neo-Tethys beneath the southern margin of Eurasia,while the southern branch likely reflects the intra-oceanic subducted slabs of Neo-Tethys during the Cretaceous.The western portion of the Tethyan anomaly may reflect remnants of Paleo-Tethys,while the eastern portion,towards India and the Bay of Bengal,shows signs of subduction towards the core-mantle boundary.Finally,this study discusses the future prospects of whole-mantle seismic tomographic studies focusing on the Tethyan realm. | Zewei WANG Jiashun HU Xueyang BAO Chunquan YU Yingjie YANG Xiaofei CHEN | 2023 | Science China Earth Sciences2023，66，12： | 0 |
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