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| 1 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 2 | Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and covaccination as an effective method of prevention of COVID-19 and influenza显示文摘Influenza A virus may circulate simultaneously with the SARS-CoV-2 virus,leading to more serious respiratory diseases during this winter.However,the influence of these viruses on disease outcome when both influenza A and SARS-CoV-2 are present in the host remains unclear.Using a mammalian model,sequential infection was performed in ferrets and in K18-MCE2 mice,with SARS-CoV-2 infection following H1N1.We found that co-infection with H1N1 and SARS-CoV-2 extended the duration of clinical manifestation of COVID-19,and enhanced pulmonary damage,but reduced viral shedding of throat swabs and viral loads in the lungs of ferrets.Moreover,mortality was increased in sequentially infected mice compared with single-infection mice.Compared with singlevaccine inoculation,co-inoculation of PiCoVacc(a SARS-CoV-2 vaccine)and the flu vaccine showed no significant differences in neutralizing antibody titers or virus-specific immune responses.Combined immunization effectively protected K18-MCE2 mice against both H1N1 and SARS-CoV-2 infection.Our findings indicated the development of systematic models of co-infection of H1N1 and SARS-CoV-2,which together notably enhanced pneumonia in ferrets and mice,as well as demonstrated that simultaneous vaccination against HINT and SARS-CoV-2 may be an effective prevention strategy for the coming winter. | Linlin Bao Wei Deng Feifei Qi Qi Lv Zhiqi Song Jiangning Liu Hong Gao Qiang Wei Pin Yu Yanfeng Xu Yajin Qu Fengdi Li Jing Xue Shuran Gong Mingya Liu Guanpeng Wang Shunyi Wang Binbin Zhao Bin Cong Chuan Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 4 |
| 3 | APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells显示文摘APOBEC3 protein families, a DNA cytidine deaminase, were up-regulated in multiple tumors. However, the relationship between Hepatocellular carcinoma(HCC) and APOBEC3B(A3B) remains unknown. It has been confirmed that interleukin-6(IL-6)has significant impacts on oncogenesis of HCC. Here, we reported that the expression of IL-6 was substantially up-regulated by A3 B in HepG2 cells. A3 B induced IL-6 expression through relocating HuR to enhance the IL-6 mRNA stability. Further analysis indicated that IL-6 also increased the expression of A3 B through JAK1/STAT3 signaling pathway, which formed a positive feedback to maintain the continuous expression of A3 B and IL-6, and thereby promoted the prolonged non-resolving inflammation. Collectively, these findings suggest that A3 B is essential for oncogenesis of HCC, and is a potential target for preventive intervention. | Shuran Li Xueyang Bao Duowei Wang Linjun You Xianjing Li Hongbao Yang Jinsong Bian Yun Wang Yong Yang | 2017 | Science China(Life Sciences)2017，60，6： | 2 |
| 4 | Effect of the pineal gland on 5-hydroxytryptamine and γ-aminobutyric acid secretion in the hippocampus of male rats during the summer and winter显示文摘Objective:The present study aimed to investigate the effect of seasonal variation on neurotransmitter release in the hippocampus of normal rats and rats with pineal excision.Methods:Two time points,the summer and winter solstice,which are the longest and shortest days of the year,respectively,were selected.Male Spraguee Dawley rats that underwent a sham operation without pineal excision were included as a control group.The concentrations of 5-hydroxytryptamine(5-HT)andγ-aminobutyric acid(GABA)were determined by radioimmunoassays and enzyme-linked immunosorbent assays,respectively.Results:In the winter,the 5-HT and GABA levels in normal rats exhibited a significant difference compared with those in the operation group(P<.01).A difference was also noted in GABA levels between the normal group and the sham operation group(P<.05).The concentrations of 5-HT and GABA in the hippocampal tissues of the normal group exhibited a seasonal rhythm consisting of elevation during the summer and reduction during the winter(P<.01),while the GABA levels in the sham operation group exhibited a significant difference,with elevation during the summer and reduction during the winter(P<.01).In the operation group,GABA showed the same trend(P<.01).Conclusion:The seasonal rhythm of neurotransmitter secretion by the hippocampus(5-HT and GABA)consisted of elevation during the summer and reduction during the winter.During the winter,the pineal gland exhibited a reverse regulatory effect on the secretion of 5-HT and GABA in the hippocampus,and it exhibited seasonal selectivity with regard to the regulation of 5-HT. | Ting Li Hailu Wang Hewei Zhang Leilei Liu Peipei Li Shuran Ma | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，3： | 2 |
| 5 | Is Habitat Preference Associated with Locomotor Performance in Multiocellated Racerunners(Eremias multiocellata) from a Desert Steppe?显示文摘Locomotor performance in lizards is strongly affected by structural habitat. Understanding this relationship allows us to predict species distributions across habitat types. However, little information is available about the ecological role of the locomotion of multiocellated racerunner(Eremias multiocellata) in the desert steppe ecosystem of Inner Mongolia, China. Herein, we studied the effects of habitat structure on the locomotor performance of this lizard species in the field. We found that the sprint speed of this lizard declined significantly with increasing vegetation coverage. Manipulative experiments were further conducted to examine the effects of branch barriers and surface substrates on the sprint speed of the lizard. We found that the sprint speed was significantly influenced by the surface substrates and branch barriers, and there were no interactions between them. Branch barriers impeded sprint speed, and E. multiocellata showed better locomotor performance on sandy rather than loamy substrates. Our results indicate that E. multiocellata tends to occupy open areas with sandy substrates, but its locomotor performance is not closely associated with habitat preference. | Junhuai BI Yang WANG Shuran LI Zhigao ZENG | 2015 | Asian Herpetological Research2015，6，2： | 2 |
| 6 | An epidemiological survey on neuroses of urban ElderlyinBeijing显示文摘 | Shen Yucun Li Shuran | 1998 | Psychiatryand Clinical Neurosciences1998，52，： | 1 |
| 7 | Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells显示文摘 | Yujuan Shan Lanwei Zhang Yongping Bao Baolong Li Canxia He Mingming Gao Xue Feng Weili Xu Xiaohong Zhang Shuran Wang | 2013 | The Journal of Nutritional Biochemistry2013，，6： | 1 |
| 8 | The Cognitive Subscale of Alzheimer’s Disease Assessment Scale, Chinese Version in Staging of Alzheimer Disease显示文摘 | Huali Wang Xin Yu Shuran Li Yufang Chen Haidong Li Jun He | 2004 | Alzheimer Disease & Associated Disorders2004，，4： | 1 |
| 9 | Thermal-physiological Strategies Underlying the Sympatric Occurrence of Three Desert Lizard Species显示文摘Sympatric reptiles are the ideal system for investigating temperature-driven coexistence. Understanding thermally physiological responses of sympatric lizards is necessary to reveal the physiological mechanisms that underpin the sympatric occurrence of reptiles. In this study, we used three lizard species, Eremias argus, E. multiocellata, and Phrynocephalus przewalskii, which are sympatric in the Inner Mongolia desert steppe, as a study system. By comparing their resting metabolic rates(RMR) and locomotion at different body temperatures, we aimed to better understand their physiological responses to thermal environments, which may explain the sympatric occurrence of these lizards. Our results showed that E. argus had significantly higher RMR and sprint speed than E. multiocellata, and higher RMR than P. przewalskii. In addition, the optimal temperature that maximized metabolic rates and locomotion for E. argus and E. multiocellata was 36°C, whereas for P. przewalskii it was 39°C. Our study revealed the physiological responses to temperatures that justify the sympatric occurrence of these lizards with different thermal and microhabitat preferences and active body temperatures. Eremias argus and E. multiocellata, which have lower body temperatures than P. przewalskii, depend on higher RMR and locomotion to compensate for their lower body temperatures in field conditions. Our study also highlights the importance of using an integrative approach, combining behavior and physiology, to explore the basis of sympatric occurrence in ectothermic species. | Xueqing WANG Shuran LI Li LI Fushun ZHANG Xingzhi HAN Junhuai BI Baojun SUN | 2019 | Asian Herpetological Research2019，10，3： | 1 |
| 10 | Chronic disease prevalence and care among the eld-erly in urban and rural Beijing, China - a 10/66Dementia Research Group cross - sectional survey显示文摘 | Zhaorui liu Emiliano Albanese Shuran Li | 2009 | BMC Public Health2009，9，1： | 1 |
| 11 | C-Reactive Protein and Complement Components in Patients with Pathological Myopia显示文摘 | Qin Long Junjie Ye Ying Li Shuran Wang Yang Jiang | 2013 | Optometry and Vision Science2013，，5： | 1 |
| 12 | Phenotypic consequences of maternally selected nests:a cross-fostering experiment in a desert lizard显示文摘Despite the importance of maternally selected nests in shaping offspring phenotypes,our understanding of how the nest environment affects embryonic development and offspring traits of most non-avian reptiles is rather limited largely due to the logistical difficulty in locating their nests.To identify the relative contributions of environmental(temporal[seasonal]and spatial[nest-site])and intrinsic(clutch)factors on embryonic development and offspring traits,we conducted a cross-fostering experiment by swapping eggs between maternally-selected nests of the toad-headed agama(Phrynocephalus przewalskii)in the field.We found that nest environment explained a large proportion of variation in incubation duration,hatching success,and offspring size and growth.In contrast,clutch only explained a small proportion of variation in these embryonic and offspring traits.More significantly,compared with spatial effects,seasonal effects explained more phenotypic variation in both embryonic development and offspring traits.Eggs laid early in the nesting season had longer incubation durations and produced smaller hatchlings with higher post-hatching growth rates than did later-laid eggs.Consequently,hatchlings from early-laid eggs reached larger body sizes prior to winter.In addition,we found that female toad-headed agama did not select nests specific to reaction norms of their own offspring because hatchlings from original or translocated nests had similar phenotypic traits.Overall,our study demonstrates the importance of seasonal variation in nest environments in determining embryonic development and offspring phenotypes,which has not been widely appreciated at least in non-avian reptiles. | Shuran LI Xin HAO Baojun SUN Junhuai BI Yongpu ZHANG Weiguo DU | 2021 | Integrative Zoology2021，16，5： | 1 |
| 13 | Experimental investigation on the spray characteristics of agricultural full-cone pressure swirl nozzle显示文摘The spray characteristics of a full-cone pressure swirl nozzle have been investigated in this study.The results were defined by Reynolds number,which focuses on the breakup of liquid film,droplet size,velocity,and liquid volume flux under different Reynolds numbers at the near-field spray.The spray structure was visualized using a high-speed camera,and the characteristics of droplets were measured using a Phase Doppler Anemometer(PDA)in both the radial and axial directions.The tests were carried out at varying spray pressures(0.2 to 1.0 MPa),corresponding to different Reynolds numbers(5369 to 12006).It was found that when the Reynolds number rises,the liquid became more unstable after leaving the nozzle,causing the liquid film to break up faster.According to the measurements of PDA,the coalescence of droplets increased due to the centrifugal effect.What’s more,the velocity of the droplets fluctuates significantly in the radial direction,and the droplets with a smaller particle size had a higher average velocity.From the perspective of liquid distribution,the increase in Reynolds number caused the spray liquid to move in the radial direction gradually.In contrast,the liquid volume distribution changed in the radial direction more obviously than in the axial direction,growing to the maximum along the radial direction and gradually reducing.It can provide a reference for selecting operating parameters for actual agricultural spray operations and the design of electrostatic nozzles through the research on breakup and droplet characteristics. | Xiuyun Xue Xufeng Xu Shilei Lyu Shuran Song Xin Ai Nengchao Li Zhenyu Yang Zhen Li | 2023 | International Journal of Agricultural and Biological Engineering2023，16，4： | 0 |
| 14 | Embryonic and post-embryonic responses to high-elevation hypoxia in a low-elevation lizard显示文摘Low-elevation species can migrate toward higher elevations to survive in a warming world.However,animals’responses to hypoxia when migrating to high elevations have rarely been addressed.To identify the response of lowelevation lizards to high-elevation hypoxia,we collected field body temperatures(Tfb)and operative temperatures(Te)of lizards(Eremias argus)from a low-elevation population(1036 m)and a high-elevation population(2036 m),and then determined adult thermal physiology,embryonic development,and hatchling phenotypes after acclimating low-elevation lizards and incubating their eggs in conditions mimicking the low-elevation oxygen condition(18.5%O2)and high-elevation oxygen(hypoxic)condition(16.5%O2).Our study revealed that Tfb and Te were higher for the low-elevation population compared to the high-elevation population.We also found adults from low elevation acclimated to hypoxia preferred lower body temperatures,but did not show changes in locomotor performance or growth.In addition,hypoxia did not affect embryonic development(hatching time and success)or hatchling phenotypes(body size and locomotor performance).These results suggest that adult lizards from low elevations can respond to hypoxia-induced stress when migrating to high elevations by behaviorally thermoregulating to lower body temperatures in order to sustain normal functions.Similarly,low-elevation embryos can develop normally(with unchanged hatching success and offspring phenotypes)under the high-elevation hypoxic condition.This study highlights that low-elevation populations of a species that inhabits a range of elevations can buffer the impact of high-elevation hypoxic conditions to some degree and thus attain similar fitness to the source population. | Xinghan LI Pengfei WU Liang MA Christopher HUEBNER Baojun SUN Shuran LI | 2020 | Integrative Zoology2020，15，4： | 0 |
| 15 | Molecular mechanisms of seasonal photoperiod effects of the pineal gland on the hippocampus in rats显示文摘Background:Based on the theory of“five Zang-organs corresponding to the seasons”in traditional Chinese medicine(TCM),physiological functions including emotions vary with the seasons.We aimed to investigate the seasonal photoperiod effects of melatonin(MT)released from the pineal gland on the MT receptor(MTR)-Gs/Gi-cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)-cAMP response element-binding protein(CREB)signaling pathway in the hippocampus.Methods:Rats were divided into three groups:control,operation(surgery with pineal gland removal),and pseudo-operation groups(same surgery as operation group but without removing pineal gland),and fed at specific time across the four seasons.The levels of MTR,adenylate cyclase(AC),cAMP,PKA,and CREB in the hippocampus were analyzed using ELISA.The concentrations of Gs and Gi were analyzed using Western blot.The expression of CREB mRNA was detected by PCR.Results:For intragroup comparisons,compared with spring,the levels of Gs/Gi in the control group were higher in summer,autumn,and winter(P=.009 in summer;P<.001 in autumn and winter);the levels of MTR,cAMP,PKA,and CREB in the control group were significantly higher in autumn and winter than in spring(all P<.001).The levels of MTR,cAMP,PKA,and CREB in each season were significantly lower in the operation group than in the control group(all P<.05).Significant differences were noted in Gs/Gi levels between the operation group and control group in spring,autumn,and winter(all P<.05).Conclusion:Our findings suggest that MTR-Gs/Gi-cAMP-PKA-CREB signaling pathway is involved in the seasonal photoperiod effects of the pineal gland on the hippocampus and may underpin seasonal changes in emotions.It can support the prevention and treatment of the seasonal onset of mental disorders,and enrich the theory of“five Zang-organs corresponding to the seasons”. | Qi Han Guowen Du Leilei Liu Lepeng Wang Wenna Li Hairong Zhang Yike Sun Pei Zhu Ruisen Hao Shuran Ma | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，2： | 0 |
| 16 | Effects of seasonal changes on T-helper 1/T-helper 2 immune balance and eczema onset in rats显示文摘Objective: To explore the impact of seasonal changes on the T-helper 1(Th1)/T-helper 2(Th2) immune balance of the body in order to elucidate the internal immunological mechanisms underlying seasonal eczema.Methods: Eighty 4-week-old male Sprague-Dawley rats were divided into 5 season groups kept in corresponding season simulation environments, and subdivided into the model group and the control group. The Eczema Area and Severity Index(EASI) and scratching frequency were evaluated. The serum levels of immunoglobulin E(IgE), interleukin-2(IL-2), interleukin-12(IL-12), and interferon-gamma(IFN-γ), interleukin-4(IL-4), interleukin-25(IL-25), and interleukin-31(IL-31), and melatonin(MT), as well as the MT receptor(MTR) levels in the spleen, were detected by enzyme-linked immunosorbent assay analysis. The mRNA expression levels of T-bet and GATA3 were detected by quantitative real-time polymerase chain reaction.Results: EASI scores and the scratching frequency of the model group were higher in the long summer than in the other 4 seasons. Meanwhile, the serum levels of IgE and the Th2 cytokines IL-4, IL-25, and IL-31, as well as GATA3 mRNA expression levels, were high during the long summer in both groups. However, the serum levels of the Th1 cytokines IL-2, IL-12, and IFN-γ, as well as MT, MTR, and T-bet mRNA levels, were lower during the long summer. In all 5 seasonal groups(spring, summer, long summer, autumn, and winter), the levels of all immune factors, especially IL-4 and IL-31, were higher in the model group than those in the control group,while the concentrations of MT and MTR were lower.Conclusion: Under long light, hot, and humid conditions in the long summer, the body is more likely to suffer from Th2-dominated immune imbalance. This is the internal mechanism behind the high incidence and severity of eczema during the long summer. MT and MTR play a key role in the seasonal onset of eczema. | Hairong Zhang Leilei Liu Yike Sun Wenna Li Ruochong Wang Xiao Sun Guangqin Zhu Shuran Ma | 2023 | Journal of Traditional Chinese Medical Sciences2023，10，1： | 0 |
| 17 | Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis显示文摘Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM. | Shuran Fan Ming Qi Qi Qi Qun Miao Lijuan Deng Jinghua Pan Shenghui Qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang Jiapeng Lin Wenyu Lyu Weiqing Deng Yingyin He Xuesong Liu Lvfen Gao Dongmei Zhang Wencai Ye Minfeng Chen | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 18 | Surveillance and examination of microbial contamination in ice cream in China显示文摘This study investigated the microbial contamination of ice cream in China.A total of 2887 ice cream samples were collected from different regions of China.Contamination by the aerobic plate count(APC),coliforms,and three foodborne pathogens,Listeria monocytogenes(L.monocytogenes),Staphylococcus aureus(S.aureus),and Salmonella spp.,was detected in the samples.L.monocytogenes isolates were further analyzed for antibiotic susceptibility and multi-locus sequence typing(MLST).The results showed that APC was more than 10^(5) colony forming units(CFU)/g in 6.10%(176/2887)and coliform was more than 10^(2) CFU/g in 15.69%(453/2887)of all samples.The positive rates of S.aureus,L.monocytogenes,and Salmonella spp.were 0.66%,0.62%,and 0.10%,respectively.Among these,S.aureus contamination was more than 102 CFU/g in two samples,and L.monocytogenes in the positive sample was in the range of 0.3-240 most probable number(MPN)/g.with a median of 4.3 MPN/g.The hygienic status of the packaged samples was much better than that of the bulk samples(P<0.05).Catering samples were more frequently and heavily contaminated than samples from retail and wholesale outlets(P<0.05).No significant differences were observed in samples bought from urban and rural areas(P>0.05).For 18 L.monocytogenes strains isolated from ice cream,the resistance rate of nine antibiotics was 5.56%(1/18).By MLST,the L.monocytogenes strains were classified into nine sequence types(STs),of which ST8 was the most common(six isolates).These results indicate that a potential health risk to the public may be caused by ice cream,particularly in susceptiblepopulations. | Lin Yan Xiaoyan Pei Junjie Miao Ying Li Shuran Yang Zixin Peng Xiaorong Yang Lingling Mei Qingwen Yang Huan Ren Dajin Yang Hongmei Shi | 2022 | Food Quality and Safety2022，6，3： | 0 |
| 19 | Derivation of Benzothiadiazine-1,1-dioxide Scaffolds via Transition Metal-Catalyzed C-H Activation/Annulation显示文摘Comprehensive Summary Benzothiadiazine-1,1-dioxide scaffold is bioactive framework with wild utility and applications.Synthesis of benzothiadiazine-fused isoquinoline derivatives and spiro benzothiadiazine derivatives through transition metal-catalyzed C—H activation/annulation was reported.3-Phenyl-2H-benzothiadiazine-1,1-dioxide was used as the reaction substrate,and vinylene carbonate and 4-diazopyrazolone were used as the coupling reagents,respectively.This strategy provides straightforward access to complex N-heterocycles in a highly efficient and simple manner. | Ruizhi Lai Shuran Xu Qingyao Zhang Hui Zhou Cankun Luo Yuerong Wang Li Hai Yong Wu | 2023 | Chinese Journal of Chemistry2023，41，16： | 0 |
| 20 | Seasonal photoperiodic influence of pineal melatonin on hypothalamic-pituitary-adrenal axis-hippocampal-receptor in male rats显示文摘Background: Based on the effect of seasonal changes on human visceral function, this study investigated the impact of seasonal photoperiod of the pineal body on hypothalamic-pituitary-adrenal axis-hippocampal-receptor in rats, aiming to reveal the mechanism by which pineal gland melatonin regulates the seasonal secretion of hippocampal neurotransmitters.Methods: Vernal equinox, summer solstice, autumn equinox, and winter solstice were selected as four experimental time points, and rats were randomly divided into normal control group, sham operation group, and pinealectomized group. The seasonal changes in corticotropin-releasing hormone(CRH),adrenocorticotropic hormone(ACTH), corticosterone, hypothalamic melatonin receptor(MTR), and hippocampal corticosterone receptor(CORTR) were examined by enzyme-linked immunosorbent assay.Results: Comparing the same group between different seasons, we showed that in the normal control group, CRH, ACTH, corticosterone, and MTR were higher, while CORTR was lower in autumn and winter than in spring(all P <.05). Compared with the normal control group, the pinealectomized group showed higher levels of corticosterone(P =.01), MTR(P =.01), and CORTR(P =.03) during spring;reduced levels of MTR and CORTR(both P <.001) during summer;higher levels of ACTH(P =.001) and MTR(P <.001),and lower levels of CRH(P =.001), corticosterone(P <.001), and CORTR(P =.003) during autumn;and lower levels of CRH(P <.001) and MTR(P =.004), and higher level of ACTH(P <.001) in winter.Conclusions: Seasonal photoperiod acts on the pineal gland to secrete different levels of melatonin,resulting in seasonal changes in the hypothalamic-pituitary-adrenal axis-hippocampal-receptor, which may be the pathophysiological basis for the onset of seasonal affective disorder. | Wenna Li Ting Li Leilei Liu Qi Han Hairong Zhang Yike Sun Ruisen Hao Shuran Ma | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，2： | 0 |
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