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| 1 | Exosome-functionalized magnesium-organic framework-based scaffoldswith osteogenic, angiogenic and anti-inflammatory properties foraccelerated bone regeneration显示文摘Exosomes derived from human adipose-derived stem cells (hADSCs-Exos) have shown potential as an effectivetherapeutic tool for repairing bone defects. Although metal-organic framework (MOF) scaffolds are promisingstrategies for bone tissue regeneration, their potential use for exosome loading remains unexplored. In this study,motivated by the potential advantages of hADSCs-Exos and Mg-GA MOF, we designed and synthesized anexosome-functionalized cell-free PLGA/Mg-GA MOF (PLGA/Exo-Mg-GA MOF) scaffold, taking using of thebenefits of hADSCs-Exos, Mg2+, and gallic acid (GA) to construct unique nanostructural interfaces to enhanceosteogenic, angiogenic and anti-inflammatory capabilities simultaneously. Our in vitro work demonstrated thebeneficial effects of PLGA/Exo-Mg-GA MOF composite scaffolds on the osteogenic effects in human bonemarrow-derived mesenchymal stem cells (hBMSCs) and angiogenic effects in human umbilical endothelial cells(HUVECs). Slowly released hADSCs-Exos from composite scaffolds were phagocytosed by co-cultured cells,stabilized the bone graft environment, ensured blood supply, promoted osteogenic differentiation, and acceleratedbone reconstruction. Furthermore, our in vivo experiments with rat calvarial defect model showed thatPLGA/Exo-Mg-GA MOF scaffolds promoted new bone formation and satisfactory osseointegration. Overall, weprovide valuable new insights for designing exosome-coated nanocomposite scaffolds with enhanced osteogenesisproperty. | Yue Kang Chang Xu Ling’ao Meng Xufeng Dong Min Qi Daqing Jiang | 2022 | Bioactive Materials2022，7，12： | 11 |
| 2 | A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells显示文摘Breast cancer is one of the most malignant tumors and is associated with high mortality rates among women.Lycium barbarum polysaccharide(LBP)is an extract from the fruits of the traditional Chinese herb,L.barbarum.LBP is a promising anticancer drug,due to its high activity and low toxicity.Although it has anticancer properties,its mechanisms of action have not been fully established.Ferroptosis,which is a novel anticancer strategy,is a cell death mechanism that relies on iron-dependent lipid reactive oxygen species(ROS)accumulation.In this study,human breast cancer cells(Michigan Cancer Foundation-7(MCF-7)and MD Anderson-Metastatic Breast-231(MDA-MB-231))were treated with LBP.LBP inhibited their viability and proliferation in association with high levels of ferroptosis.Therefore,we aimed to ascertain whether LBP reduced cell viability through ferroptosis.We found that the structure and function of mitochondria,lipid peroxidation,and expression of solute carrier family 7 member 11(SLC7 A11,also known as x CT,the light-chain subunit of cystine/glutamate antiporter system X_(c)^(-))and glutathione peroxidase 4(GPX4)were altered by LBP.Moreover,the ferroptosis inhibitor,Ferrostatin-1(Fer-1),rescued LBP-induced ferroptosis-associated events including reduced cell viability and glutathione(GSH)production,accumulation of intracellular free divalent iron ions and malondialdehyde(MDA),and down-regulation of the expression of x CT and GPX4.Erastin(x CT inhibitor)and RSL3(GPX4 inhibitor)inhibited the expression of x CT and GPX4,respectively,which was lower after the co-treatment of LBP with Erastin and RSL3.These results suggest that LBP effectively prevents breast cancer cell proliferation and promotes ferroptosis via the x CT/GPX4 pathway.Therefore,LBP exhibits novel anticancer properties by triggering ferroptosis,and may be a potential therapeutic option for breast cancer. | Xing DU Jingjing ZHANG Ling LIU Bo XU Hang HAN Wenjie DAI Xiuying PEI Xufeng FU Shaozhang HOU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，4： | 10 |
| 3 | Monte Carlo simulation ofgas phase polymerization of 1,3-butadiene Part Ⅰ:Modeling andprogramming显示文摘 | Ling Jun Ni Xufeng Zhang Yifeng | 2000 | Polymer2000，41，24： | 1 |
| 4 | A face detection and recognition system in color image series显示文摘 | Yang Jie Ling Xufeng Zhu Yitan | | 0，，05： | 1 |
| 5 | Monte Carlo simulation ofgas phase polymerization of 1 , 3-butadiene Part Ⅱ : Kineticsoptimization and confirmation显示文摘 | Ling Jun Ni Xufeng Zhang Yifeng | 2003 | Polymer International2003，52，2： | 1 |
| 6 | Face dection and recognition system in color image series显示文摘 | Yang Jie Ling Xufeng Zhu Yitan | 2008 | Mathematics and computer in sim-ulation2008，77，56： | 1 |
| 7 | The Rise of Colloidal Lead Halide Perovskite Quantum Dot Solar Cells显示文摘CONSPECTUS:The colloidal synthesis of low-dimensional metal halide perovskite quantum dots(PQDs)has endowed the emerging semi-conductors with new peculiarities in optical and electrical properties,such as quantum confinement-induced size tunability,separated perovskite crystallization from film deposition,layer-by-layer processing,improved structural stability,etc.,excavating more potential of the perovskites as a promising candidate for next-generation photovoltaics.The first PQD solar cell was first reported in 2016 by Luther and co-workers,with a high open-circuit voltage of 1.23 V and efficiency of 10.77%,as well as excellent air stability,showing great competitiveness relative to the polycrystalline thin-film analogues.Benefiting from the outstanding properties of perovskites themselves and rational surface manipulation strategies of colloidal PQDs,the PQD solar cells have achieved a record efficiency of 13.4%in 2017 that surpassed all reported QD solar cells.Since then,the PQD solar cells have attracted increasing attention and study and reached a highest certified efficiency of 16.6%to date,indicating its great potential toward stable and efficient perovskite solar cells.However,the insufficient carrier transport between the PQDs because of the remaining long capping ligands has tremendously hindered the performance of the PQD solar cells and their further development.Paradoxically,removing all of the binding ligands of PQDs will break the intact perovskite structure.Balancing the efficient carrier transport and stable crystal structure of PQDs is a crucial and challenging task that needs to be addressed to pursuit a new generation of low-cost photovoltaic technology.This Account summarizes the typical strategies reported from our group to improve the photovoltaic efficiency,as well as long-term stability of the PQD solar cells during the past several years in term of synthesis,composition,and surface chemistry regulation of PQDs and device architecture engineering.We highlight the unique properties of PQDs and corresponding integrated solar cells that distinguish them from their polycrystalline counterparts,including the surface chemistry,structure stability,and fabrication techniques,and meanwhile solve the puzzle of why PQDs can be applied in solar cells.In the end,we discuss the challenges for current PQD solar cells and propose possible solutions to them,and we point out some directions for the future development of PQD solar cells,such as direct synthesis of conductive PQDs,lead-free tandem devices,scalable fabrication,and extended optoelectronic application.We expect that this Account would open up more thorough insights into PQD solar cells and propel this field further. | Xufeng Ling Jianyu Yuan Wanli Ma | 2022 | Accounts of Materials Research2022，3，8： | 0 |
| 8 | In Situ Iodide Passivation Toward Efficient CsPbI_(3) Perovskite Quantum Dot Solar Cells显示文摘All-inorganic CsPbI_3 quantum dots(QDs) have demonstrated promising potential in photovoltaic(PV) applications. However, these colloidal perovskites are vulnerable to the deterioration of surface trap states, leading to a degradation in efficiency and stability. To address these issues, a facile yet effective strategy of introducing hydroiodic acid(HI) into the synthesis procedure is established to achieve high-quality QDs and devices. Through an in-depth experimental analysis, the introduction of HI was found to convert PbI_2 into highly coordinated [PbI_m]~(2-m), enabling control of the nucleation numbers and growth kinetics. Combined optical and structural investigations illustrate that such a synthesis technique is beneficial for achieving enhanced crystallinity and a reduced density of crystallographic defects. Finally, the effect of HI is further reflected on the PV performance. The optimal device demonstrated a significantly improved power conversion efficiency of 15.72% along with enhanced storage stability. This technique illuminates a novel and simple methodology to regulate the formed species during synthesis, shedding light on ofurther understanding solar cell performance, and aiding the design of future novel synthesis protocols for high-performance optoelectronic devices. | Junwei Shi Ben Cohen‑Kleinstein Xuliang Zhang Chenyu Zhao Yong Zhang Xufeng Ling Junjun Guo Doo‑Hyun Ko Baomin Xu Jianyu Yuan Wanli Ma | 2023 | Nano-Micro Letters2023，15，10： | 0 |
| 9 | Disruption of the autism-related gene Pak1 causes stereocilia disorganization,hair cell loss,and deafness in mice显示文摘Several clinical studies have reported that hearing loss is correlated with autism in children.However,little is known about the underlying mechanism between hearing loss and autism.p21-activated kinases(PAKs)are a family of serine/threonine kinases that can be activated by multiple signaling molecules,particularly the Rho family of small GTPases.Previous studies have shown that Pak1 mutations are associated with autism.In the present study,we take advantage of Pak1 knockout(Pak1a/a)mice to investigate the role of PAK1 in hearing function.We find that PAK1 is highly expressed in the postnatal mouse cochlea and that PAK1 deficiency leads to hair cell(HC)apoptosis and severe hearing loss.Further investigation indicates that PAK1 deficiency downregulates the phosphorylation of cofilin and ezrin-radixin-moesin and the expression of b II-spectrin,which further decreases the HC synapse density in the basal turn of cochlea and disorganized the HC stereocilia in all three turns of cochlea in Pak1à/àmice.Overall,our work demonstrates that the autism-related gene Pak1 plays a crucial role in hearing function.As the first candidate gene linking autism and hearing loss,Pak1 may serve as a potential target for the clinical diagnosis of autism-related hearing loss. | Cheng Cheng Yilin Hou Zhonghong Zhang Yanfei Wang Ling Lu Liyan Zhang Pei Jiang Song Gao Qiaojun Fang Chengwen Zhu Junyan Gao Xufeng Liu Wei Xie Zhengping Jia Zhigang Xu Xia Gao Renjie Chai | 2021 | Journal of Genetics and Genomics2021，48，4： | 0 |
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