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| 1 | Assessing the numbers of SNPs needed to establish molecular IDs and characterize the genetic diversityof soybean cultivars derived from Tokachi nagaha显示文摘The development of a core set of SNP molecular markers that could be widely used in soybean genetic research would greatly facilitate research into the genetic diversity of soybean.We conducted an analysis of Tokachi nagaha and 137 of its descendant soybean cultivars using 4044 SNP markers with the goal of determining the appropriate number of single-nucleotide polymorphisms(SNPs)needed to construct unambiguous molecular IDs and characterize genetic diversity based on a genetic distance matrix correlation method.When the number of SNPs was held constant,the number of accession pairs that could be distinguished increased as the polymorphism informative content(PIC)value of the SNPs increased.A core panel of 20 selected SNPs from 11 linkage groups with a mean PIC value of 0.3703 and a range of 0.3640–0.3749 was able to identify almost all of the accession pairs in our study[9445 pairs(99.92%)].The eight accession pairs that could not be identified with this core SNP set all originated from the same province and some of them had the same parental cultivars.The molecular IDs of the 138 accessions were constructed using the core 20 SNPs.It is known that both the number of SNPs and PIC values should be considered when SNPs are selected for use in the analysis of genetic diversity.In this study,when the PIC value was 0.3460,the correlation coefficient between the genetic distance matrices associated with a panel of 200 SNPs and the total population was>0.800,indicating satisfactory correlation.Our high-accuracy,high-resolution core SNP panel for germplasm fingerprinting and our findings about assessing genetic diversity will likely markedly improve the management and utilization efficiency of soybean germplasm resources. | Zhangxiong Liu Jun Li Xuhong Fan Nang Myint Phyu Sin Htwe Shuming Wang Wen Huang Jiyu Yang Lili Xing Lijun Chen Yinghui Li Rongxia Guan Ruzhen Chang Dechun Wang Lijuan Qiu | 2017 | The Crop Journal2017，5，4： | 10 |
| 2 | Carbon emissions induced by farmland expansion in China during the past 300 years显示文摘Scientific assessment of the accounting over carbon in the terrestrial ecosystem in the process land use/land cover changes caused by human activities will help reduce the uncertainty in estimating carbon emissions from the terrestrial ecosystem. This study employs a bookkeeping model to estimate the carbon emissions from farmland reclamation in China during the past 300 years based on the annual rate of land use changes(derived from historical natural vegetation, farmland data), preset carbon density and coefficients of disturbance curves. We find out that:(1) there was a net increase of 79.30×10~4km^2 in national farmland; about 65% of reclaimed farmland had been forest land and 26% of that had been grass land previously;(2) the total amount of carbon emissions from farmland expansion in China had been between 2.94 and 5.61 Pg with the median 3.78 Pg during the past 300 years; specifically, carbon emissions of vegetation were 1.58 Pg while those of soil ranged from 1.35 Pg to4.03 Pg with the median 2.20 Pg;(3) carbon emissions vary greatly across various ecosystems: the emissions were most from forest land, and then grass land and swamps, and the least from shrubs; deserts functioned more likely to be carbon stock in the process of land reclamation;(4) along the time line, carbon emissions had decreased first and then increased while the peak emissions occurred in the first half of 20 th century; and spatially, carbon emissions were most released in Northeast and Southwest China; Northwest China was of the minimum carbon emissions. | Xuhong YANG Xiaobin JIN Xiaomin XIANG Yeting FAN Jing LIU Wei SHAN Yinkang ZHOU | 2019 | Science China Earth Sciences2019，62，2： | 2 |
| 3 | Oxygen vacancies enriched nickel cobalt based nanoflower cathodes: Mechanism and application of the enhanced energy storage显示文摘The rational design of oxygen vacancies and electronic microstructures of electrode materials for energy storage devices still remains a challenge. Herein, we synthesize nickel cobalt-based oxides nanoflower arrays assembled with nanowires grown on Ni foam via the hydrothermal process followed annealing process in air and argon atmospheres respectively. It is found that the annealing atmosphere has a vital influence on the oxygen vacancies and electronic microstructures of resulting NiCo_(2)O_(4) (NCO-Air) and CoNiO_(2) (NCO-Ar) products, which NCO-Ar has more oxygen vacancies and larger specific surface area of 163.48 m^(2)/g. The density functional theory calculation reveals that more oxygen vacancies can provide more electrons to adsorb –OH free anions resulting in superior electrochemical energy storage performance. Therefore, the assembled asymmetric supercapacitor of NCO-Ar//active carbon delivers an excellent energy density of 112.52 Wh/kg at a power density of 558.73 W/kg and the fabricated NCO-Ar//Zn battery presents the specific capacity of 180.20 mAh/g and energy density of 308.14 Wh/kg. The experimental measurement and theoretical calculation not only provide a facile strategy to construct flower-like mesoporous architectures with massive oxygen vacancies, but also demonstrate that NCO-Ar is an ideal electrode material for the next generation of energy storage devices. | Jiahui Ye Xingwu Zhai Long Chen Wen Guo Tiantian Gu Yulin Shi Juan Hou Fei Han Yi Liu Changchun Fan Gang Wang Shanglong Peng Xuhong Guo | 2021 | Journal of Energy Chemistry2021，30，11： | 2 |
| 4 | Application of formal safety assessment in planning VTS显示文摘To ensure that limited resources are allocated more effectively to reduce marine risks, formal safety assessment (FSA), a proactive method, is introduced in planning a vessel traffic system (VTS). Based on the data of Wuhan port, some new solutions based on risk-indices are put forward. The weighted number of traffic accidents is predicted after the future weighted vessel traffic volume is estimated by analyzing the trend of trade development. To analyze risk acceptability, the as-low-as-reasonably-practicable (ALARP) matrix is transformed into a new model containing two parameters: the future weighted vessel traffic volume and the future weighted number of traffic accidents. The new risk control options (RCOs)can be identified by a revised Domino model with several feedback loops from all system levels to close a limited window of accident opportunity. The results indicate that the four most beneficial RCOs are a wider sub-area 1 channel, a VTS bridges area, a dredging sub-area 2 main route, and a VTS QSX anchorage to the 3rd bridge. The FSA is a method that is effective in evaluating the rationality, necessity and cost-effectiveness of VTS projects. | Tang, Xuhong Fan, Yaotian Cai, Cunqiang | 2008 | Journal of Southeast University(English Edition)2008，24，S1： | 0 |
| 5 | An efficient microreactor with continuous serially connected micromixers for the synthesis of superparamagnetic magnetite nanoparticles显示文摘A new microreactor with continuous serially connected micromixers(CSCM)was tailored for the coprecipitation process to synthesize Fe_(3)O_(4) nanoparticles.Numerical simulation reveals that the two types of CSCM microchannels(V-typed and U-typed)proposed in this work exhibited markedly better mixing performances than the Zigzag and capillary microchannels due to the promotion of Dean vortices.Complete mixing was achieved in the V-typed microchannel in 2.7 s at an inlet Reynolds number of 27.Fe_(3)O_(4) nanoparticles synthesized in a planar glass microreactor with the V-typed microchannel,possessing an average size of 9.3 nm and exhibiting superparamagnetism,had obviously better dispersity and uniformity and higher crystallinity than those obtained in the capillary microreactor.The new CSCM microreactor developed in this work can act as a potent device to intensify the synthesis of similar inorganic nanoparticles via multistep chemical precipitation processes. | Wenting Fan Fang Zhao Ming Chen Jian Li Xuhong Guo | 2023 | Chinese Journal of Chemical Engineering2023，59，7： | 0 |
| 6 | Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia显示文摘Seizures due to cortical dysplasia are notorious for their poor prognosis even with medications and surgery,likely due to the widespread seizure network.Previous studies have primarily focused on the disruption of dysplastic lesions,rather than remote regions such as the hippocampus.Here,we first quantified the epileptogenicity of the hippocampus in patients with late-stage cortical dysplasia.We further investigated the cellular substrates leading to the epileptic hippocampus,using multiscale tools including calcium imaging,optogenetics,immunohistochemistry and electrophysiology.For the first time,we revealed the role of hippocampal somatostatin-positive interneurons in cortical dysplasia-related seizures.Somatostatin-positive were recruited during cortical dysplasia-related seizures.Interestingly,optogenetic studies suggested that somatostatin-positive interneurons paradoxically facilitated seizure generalization.By contrast,parvalbumin-positive interneurons retained an inhibitory role as in controls.Electrophysiological recordings and immunohistochemical studies revealed glutamate-mediated excitatory transmission from somatostatin-positive interneurons in the dentate gyrus.Taken together,our study reveals a novel role of excitatory somatostatin-positive neurons in the seizure network and brings new insights into the cellular basis of cortical dysplasia. | Yang Zheng Cenglin Xu Jinyi Sun Wenjie Ming Sijie Dai Yuying Shao Xiaoyun Qiu Menghan Li Chunhong Shen Jinghong Xu Fan Fei Jiajia Fang Xuhong Jiang Guoqing Zheng Weiwei Hu Yi Wang Shuang Wang Meiping Ding Zhong Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 7 | Glycogen synthase kinase-3 as a key regulator of cognitive function显示文摘Glycogen synthase kinase-3(GSK-3)is a highly conserved and multifunctional serine/threonine protein kinase widely distributed in eukaryotic cells.GSK-3 is originally thought to be an enzyme that regulates glycogen synthesis.It was subsequently found that GSK-3 influences many critical cellular functions,such as cell structure,neural plasticity,gene expression,and neuronal survival.Recently,GSK-3 has been found to be associated with cognition,and its dysregulation leads to cognitive impairments in many diseases,including Alzheimer's disease,diabetes,depression,Parkinson's disease,and others.In this review,we summarized the current knowledge about the structure of GSK-3,the regulation of GSK-3 activity,and its role in cognitive function and cognitiverelated disease. | Xuhong Fan Zhenyu Zhao Deming Wang Ji Xiao | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 0 |
| 8 | Optimization of Callus Induction Conditions from Immature Embryos of Maize under Stress显示文摘The embryos of maize(Zea mays L.)inbred lines GS02,GS07,GS08,GS11 and GS15 were used as receptor materials to optimize the receptor system from the aspects of genotype,medium components and stress(PEG6000,mannitol,salt and low phosphorus).The results showed that GS07 had the highest induction rate(95.2%).Orthogonal test analysis showed that the best combination of medium components in induction was A2B3C1D3(2),namely,the concentration of 2,4-dichlorophenoxy acetic acid(2,4-D)was 4 mg·mL^(-1),the concentration of L-Proline(L-Pro)was 0.8 mg·mL^(-1),and the concentration of silver nitrate(AgNO3)was 10 mg·mL^(-1)(or 5 mg·mL).Interestingly,we found that the optimal medium supplemented with 30 g·L^(-1)PEG6000 or 80 g·L^(-1)mannitol was suitable for antioxidant enzyme activity and malondialdehyde(MDA)content in GS07 callus.Exogenous 10 mmol·L^(-1)Ca^(2+)in the medium components with 100 mmol·L^(-1)sodium chloride(NaCl)could improve the activity of antioxidant enzymes in GS07 callus.Callus of GS07 could divide normally and grow well in medium components with 27 mg·L^(-1)KH_(2)PO_(4).This study enhanced the adaptability of maize callus to stress and optimized the culture conditions. | Xiaotong Wei Xuhong Fan Xuan Lu Liyuan Han Honglin Zhang Siyan Liu Jing Qu Shuyan Guan Yiyong Ma | 2022 | Phyton-International Journal of Experimental Botany2022，91，9： | 0 |
| 9 | Continuous-flow enzymatic synthesis of chiral lactones in a three-dimensional microfluidic reactor显示文摘A new continuous-flow process for the enzymatic synthesis of optically pureγ-lactones,which are used as flavors and fragrances in the food and cosmetic industries,was developed in a three-dimensional microfluidic reactor.The microchannels(175 mm in length,0.9 mm in depth,and 1.72 mL in volume)were carved precisely inside a single borosilicate glass(90 mm×75 mm×12 mm)with ultrafast femtosecond laser micromachining.The flow field analysis and reaction simulation showed that the mixing of substrates and enzymes was enhanced,allowing the adjustment of residence time in a wide window.SmCR_(V4),a carbonyl reductase with excellent catalytic activity and enantioselectivity towardγ/δ-keto acids,was employed for the asymmetric synthesis of various chiral lactones.30 mmol/L(R)-γ-decalactone(3g)can be obtained in 26 s with a space-time yield(STY)up to 16,877 g L^(-1)d^(-1),which is 14.4 times higher than the highest STY of batch reaction reported previously.This continuous-flow process was applied to the synthesis of 6 chiral lactones.In addition,the scaled-up synthesis of 3g was carried out in 6 cascade microreactors continuously for 6 h,demonstrating the feasibility and stability of the 3D continuous-flow process in enzymatic synthesis of optically pure compounds. | Xuelei Deng Meng Fan Miao Wu Xiaoyan Zhang Ya Cheng Jianye Xia Yingping Zhuang Weiping Zhu Xuhong Qian Yunpeng Bai | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 10 | FAST discovery of an extremely radio-faint millisecond pulsar from the Fermi-LAT unassociated source 3FGL J0318.1+0252显示文摘High sensitivity radio searches of unassociated γ-ray sources have proven to be an effective way of finding new pulsars. Using the Five-hundred-meter Aperture Spherical radio Telescope(FAST) during its commissioning phase, we have carried out a number of targeted deep searches of Fermi Large Area Telescope(LAT) γ-ray sources. On February 27, 2018 we discovered an isolated millisecond pulsar(MSP), PSR J0318+0253, coincident with the unassociated γ-ray source 3 FGL J0318.1+0252. PSR J0318+0253 has a spin period of 5.19 ms, a dispersion measure(DM) of 26 pc cm-3 corresponding to a DM distance of about 1.3 kpc, and a period-averaged flux density of(~11±2) μJy at L-band(1.05-1.45 GHz). Among all high energy MSPs, PSR J0318+0253 is the faintest ever detected in radio bands, by a factor of at least ~4 in terms of L-band fluxes. With the aid of the radio ephemeris, an analysis of 9.6 years of Fermi-LAT data revealed that PSR J0318+0253 also displays strong γ-ray pulsations. Follow-up observations carried out by both Arecibo and FAST suggest a likely spectral turn-over around 350 MHz. This is the first result from the collaboration between FAST and the Fermi-LAT teams as well as the first confirmed new MSP discovery by FAST, raising hopes for the detection of many more MSPs. Such discoveries will make a significant contribution to our understanding of the neutron star zoo while potentially contributing to the future detection of gravitational waves, via pulsar timing array(PTA) experiments. | Pei Wang Di Li Colin J.Clark Pablo M.Saz Parkinson Xian Hou Weiwei Zhu Lei Qian Youling Yue Zhichen Pan Zhijie Liu Xuhong Yu Shanping You Xiaoyao Xie Qijun Zhi Hui Zhang Jumei Yao Jun Yan Chengmin Zhang Kwok Lung Fan Paul S.Ray Matthew Kerr David A.Smith Peter F.Michelson Elizabeth C.Ferrara David J.Thompson Zhiqiang Shen Na Wang FAST&Fermi-LAT Collaboration | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 0 |
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