| 1 | Characteristics of distribution of Mycobacterium tuberculosis lineages in China显示文摘The genotyping methods of Mycobacterium tuberculosis would dramatically improve our understanding of the molecular epidemiology of tuberculosis. 3,929 isolates, from a National Survey of Drug-Resistant Tuberculosis in 2007 in China, were successfully genotyped by large sequence polymorphisms and 15 loci variable number tandem repeats. We found that 2,905(2,905/3,929, 73.9%) cases belonged to Lineage 2, dominated in the east and central regions, 975 cases(975/3,929, 24.8%) were Lineage 4, highly prevailed in the west regions, and 36 and 13 cases were Lineage 3 and Lineage 1, respectively. We also explored the associations between lineages(Lineage 2 vs. Lineage 4) and clinical characteristics by logistic regression. For Lineage 2, the risk factors were Han-ethnicity population and fever. However, for Lineage 4, they were occupation(farmer), and degree of education(non-literate). Fully understanding of the distribution of Mycobacterium tuberculosis lineage and its risk factors would play a critical role in tuberculosis prevention, control, and treatment. | Haixia Chen Li He Chao Cai Jingyi Liu Junnan Jia Liang Ma Hairong Huang Lixia Wang Xumin Ni Jimin Gao Weimin Li | 2018 | Science China(Life Sciences)2018，61，6： | 7 |
| 2 | Models, methods and tools for ancestry inference and admixture analysis显示文摘背景基因混合指在种以内在二之间杂交或更以前孤立的人口的过程或后果。比作象变化,基因飘移,和自然选择那样的许多另外的进化驱动力,基因混合是为塑造人口 genomic 的快机制差异。特别地,混合导致在不同人口被修理了的基因变体的再结合,它有许多进化、医药的含意。不管多么的结果,精确地重建是挑战性的人口混合历史并且人口混合动力学理解。在这评论,我们为祖先推理和混合分析提供模型,方法,和工具的概述。许多方法和工具为混合分析使用了的结论原来被开发分析人的数据,而是这些方法能直接也被使用或稍微修改了也学习非人类的种类。 | Kai Yuan Ying Zhou Xumin Ni Yuchen Wang Chang Liu Shuhua Xu | 2017 | Frontiers of Electrical and Electronic Engineering in China2017，5，3： | 0 |
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